ES2125466T3 - Analogos de la vitamina d. - Google Patents

Analogos de la vitamina d.

Info

Publication number
ES2125466T3
ES2125466T3 ES94921070T ES94921070T ES2125466T3 ES 2125466 T3 ES2125466 T3 ES 2125466T3 ES 94921070 T ES94921070 T ES 94921070T ES 94921070 T ES94921070 T ES 94921070T ES 2125466 T3 ES2125466 T3 ES 2125466T3
Authority
ES
Spain
Prior art keywords
vitamin
group
azida
sub
triazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94921070T
Other languages
English (en)
Inventor
Robert Henry Hesse
Malathi Ramgopal
Gaddam Subba Reddy
Sundara Katugam Srinivas Setty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Application granted granted Critical
Publication of ES2125466T3 publication Critical patent/ES2125466T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

NUEVOS DERIVADOS DE VITAMINA D DE 1 AL -HIDROXI EN LOS QUE LA CADENA LATERAL DE POSICION 17 LLEVA UN AZIDA O UN GRUPO 1,2,3TRIAZOL OPCIONALMENTE SUSTITUIDO, QUE INCLUYE COMPUESTOS DE LA FORMULA GENERAL (I) DONDE R{SUP,1} REPRESENTA UN GRUPO METILO QUE TIENE CONFIGURACION {AL}- O {BE}-; W REPRESENTA UN ENLACE DE VALENCIA O UN GRUPO ALQUILENO C{SUB, 1}-C{SUB, 5}; X REPRESENTA AZIDA O UN GRUPO DE TRIAZOL OPCIONALMENTE SUSTITUIDO; Y A= REPRESENTA UNA CARACTERISTICA DE MITAD DE CICLOHEXILIDENO DEL ANILLO A DE VITAMINA D DE 1{AL}-HIDROXILADA O UN ANALOGO DEL MISMO. COMPUESTOS ACTIVOS DE LA INVENCION MUESTRAN ACTIVIDAD DE MODULACION CELULAR MIENTRAS MUESTRAN UNA FALTA SUSTANCIAL DE EFECTO CALCEMICO.
ES94921070T 1993-07-23 1994-07-22 Analogos de la vitamina d. Expired - Lifetime ES2125466T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939315253A GB9315253D0 (en) 1993-07-23 1993-07-23 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2125466T3 true ES2125466T3 (es) 1999-03-01

Family

ID=10739292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94921070T Expired - Lifetime ES2125466T3 (es) 1993-07-23 1994-07-22 Analogos de la vitamina d.

Country Status (20)

Country Link
US (2) US5872140A (es)
EP (1) EP0710227B1 (es)
JP (1) JPH09500637A (es)
KR (1) KR100321415B1 (es)
CN (1) CN1043883C (es)
AT (1) ATE172451T1 (es)
AU (1) AU690565B2 (es)
CA (1) CA2167837A1 (es)
CZ (1) CZ20796A3 (es)
DE (1) DE69414115T2 (es)
DK (1) DK0710227T3 (es)
ES (1) ES2125466T3 (es)
FI (1) FI113535B (es)
GB (1) GB9315253D0 (es)
HU (1) HU221597B (es)
IL (1) IL110415A (es)
NO (1) NO314453B1 (es)
NZ (1) NZ268659A (es)
WO (1) WO1995003273A1 (es)
ZA (1) ZA945427B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19619036A1 (de) * 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
ES2240159T3 (es) 1999-09-29 2005-10-16 Colotech A/S Prevencion del cancer colorrectal.
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6555573B2 (en) * 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US20030105031A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Methods for the treatment of skin disorders
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
NZ539777A (en) * 2002-11-04 2008-02-29 Ocean Nutrition Canada Ltd Microcapsules having multiple shells and method for the preparation thereof
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
US20080206316A1 (en) * 2005-01-27 2008-08-28 Colin Barrow Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof
WO2006117675A1 (en) * 2005-01-27 2006-11-09 Ocean Nutrition Canada Ltd. Fatty acid-benzenediol derivatives and methods of making and using thereof
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
US20100055281A1 (en) * 2006-04-07 2010-03-04 Ocean Nutrition Canada Limited Emulsions and Microcapsules With Substances Having Low Interfacial Tension, Methods of Making and Using Thereof
MX306461B (es) * 2006-06-05 2013-01-07 Ocean Nutrition Canada Ltd Microcapsulas con cubiertas mejoradas
AU2008205325B2 (en) 2007-01-10 2013-09-12 Dsm Nutritional Products Ag Vegetarian microcapsules
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
MX339746B (es) 2009-01-27 2016-06-08 Berg Llc Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia.
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
US8987235B2 (en) 2011-05-17 2015-03-24 Wisconsin Alumni Research Foundation N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
WO2014194133A1 (en) 2013-05-29 2014-12-04 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN104926739B (zh) * 2015-06-09 2017-06-27 南京理工大学 基于氮杂环修饰的维生素d2衍生物、合成及应用
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67153A (en) * 1981-11-02 1986-12-31 Res Inst Medicine Chem Intermediates in the production of vitamin d analogues and method for their production
DE4141746A1 (de) * 1991-12-13 1993-06-17 Schering Ag 20-methyl-substituierte vitamin d-derivate
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
US5446635A (en) * 1993-06-24 1995-08-29 Quarton, Inc. Laser assembly for marking a line on a workpiece for guiding a cutting tool

Also Published As

Publication number Publication date
CA2167837A1 (en) 1995-02-02
DK0710227T3 (da) 1999-06-28
GB9315253D0 (en) 1993-09-08
CN1129441A (zh) 1996-08-21
AU690565B2 (en) 1998-04-30
ATE172451T1 (de) 1998-11-15
HU221597B (hu) 2002-11-28
NO314453B1 (no) 2003-03-24
ZA945427B (en) 1995-08-24
CN1043883C (zh) 1999-06-30
NO960251D0 (no) 1996-01-22
JPH09500637A (ja) 1997-01-21
NZ268659A (en) 1996-09-25
HUT73846A (en) 1996-09-30
FI960303A0 (fi) 1996-01-22
CZ20796A3 (en) 1996-10-16
WO1995003273A1 (en) 1995-02-02
DE69414115D1 (de) 1998-11-26
DE69414115T2 (de) 1999-04-08
HU9600136D0 (en) 1996-03-28
NO960251L (no) 1996-03-22
US6013814A (en) 2000-01-11
US5872140A (en) 1999-02-16
AU7193994A (en) 1995-02-20
IL110415A0 (en) 1996-03-31
IL110415A (en) 2000-01-31
FI113535B (fi) 2004-05-14
KR100321415B1 (ko) 2002-11-13
EP0710227A1 (en) 1996-05-08
FI960303A (fi) 1996-03-22
EP0710227B1 (en) 1998-10-21

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