ES2122275T3 - Derivados amidicos de la vitamina d. - Google Patents

Derivados amidicos de la vitamina d.

Info

Publication number
ES2122275T3
ES2122275T3 ES94914472T ES94914472T ES2122275T3 ES 2122275 T3 ES2122275 T3 ES 2122275T3 ES 94914472 T ES94914472 T ES 94914472T ES 94914472 T ES94914472 T ES 94914472T ES 2122275 T3 ES2122275 T3 ES 2122275T3
Authority
ES
Spain
Prior art keywords
group
sup
sub
vitamin
valencia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94914472T
Other languages
English (en)
Inventor
Robert Henry Hesse
Sundara Katugam Srinivas Setty
Malathi Ramgopal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Application granted granted Critical
Publication of ES2122275T3 publication Critical patent/ES2122275T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NUEVOS DERIVADOS DE VITAMINA D DE 1 AL -HIDROXI Y SUS ANALOGOS 20-EPI, QUE COMPRENDEN COMPUESTOS DE FORMULA GENERAL (I) DONDE R{SUP,1} Y R{SUP,2}, QUE PUEDEN SER EL MISMO O DIFERENTE, REPRESENTA CADA UNO UN ATOMO DE HIDROGENO O UN GRUPO ALIFATICO, CICLOALIFATICO, ARALIFATICO O ARILO O JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN INCORPORADOS FORMAN UN GRUPO HETEROCICLICO; R{SUP,3} REPRESENTA UN GRUPO METILO QUE TIENEN CONFIGURACION {AL}- O {BE}-; X REPRESENTA UN ENLACE DE VALENCIA O UN GRUPO ALQUILENO C{SUB, 1-2}; Y REPRESENTA -O, -S, -CH{SUB, 2}- O -NR- DONDE R ES UN ATOMO DE HIDROGENO O UN GRUPO ORGANICO; Z REPRESENTA UN ENLACE DE VALENCIA O UN GRUPO ALQUILENO C{SUB, 1-3}; Y A= REPRESENTA UNA CARACTERISTICA DE MITAD DE CICLOHEXILIDENO DEL ANILLO A DE UNA VITAMINA D 1{AL}-HIDROXILADA O ANALOGO DE LA MISMA, CON LA CONDICION DE QUE CUANDO -X-Y-ZJUNTAS REPRESENTEN UN GRUPO ALQUILENO QUE CONTENGA HASTA 4 ATOMOS DE CARBONO A= NO LLEVE UN GRUPO DE METILENO EXOCICLICO EN LA POSICION 10. COMPUESTOS ACTIVOS DE LA INVENCION EXHIBEN ACTIVIDAD DE MODULACION CELULAR MIENTRAS EXHIBEN UNA FALTA SUSTANCIAL DEL EFECTO CALCEMICO.
ES94914472T 1993-05-07 1994-05-06 Derivados amidicos de la vitamina d. Expired - Lifetime ES2122275T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309422A GB9309422D0 (en) 1993-05-07 1993-05-07 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2122275T3 true ES2122275T3 (es) 1998-12-16

Family

ID=10735089

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94914472T Expired - Lifetime ES2122275T3 (es) 1993-05-07 1994-05-06 Derivados amidicos de la vitamina d.

Country Status (20)

Country Link
US (1) US5756733A (es)
EP (1) EP0696275B1 (es)
JP (1) JP3703099B2 (es)
KR (1) KR100321414B1 (es)
CN (1) CN1093852C (es)
AT (1) ATE169617T1 (es)
AU (1) AU678246B2 (es)
CA (1) CA2162272A1 (es)
CZ (1) CZ291238B6 (es)
DE (1) DE69412476T2 (es)
DK (1) DK0696275T3 (es)
ES (1) ES2122275T3 (es)
FI (1) FI112361B (es)
GB (1) GB9309422D0 (es)
HU (1) HUT74165A (es)
IL (1) IL109595A (es)
NO (1) NO309187B1 (es)
NZ (1) NZ265665A (es)
WO (1) WO1994026707A1 (es)
ZA (1) ZA943162B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405715D0 (en) * 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
DE69523182T2 (de) * 1995-06-06 2002-02-07 Pfizer Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
GB9623569D0 (en) * 1996-11-13 1997-01-08 Immunodiagnostic Systems Ltd Vitamin D immumoassay systems
US6043385A (en) * 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
GB9804861D0 (en) * 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
KR100676106B1 (ko) * 1998-10-23 2007-02-28 데이진 가부시키가이샤 비타민 ｄ3 유도체 및 그것을 사용하는 염증성 호흡기질환 치료제
PT1666026E (pt) * 1999-02-08 2012-03-15 Intarcia Therapeutics Inc Veículos viscosos não aquosos biocompatíveis monofásicos e métodos para a preparação dos mesmos
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
EP1220676B1 (en) 1999-09-29 2005-05-04 Colotech A/S Prevention of colorectal cancer
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
ES2364623T3 (es) * 2000-06-15 2011-09-08 Chugai Seiyaku Kabushiki Kaisha Derivados de vitamina d que poseen un átomo 22-oxa o 22-tia, una cadena lateral c17 sustituida con un grupo ácido, éster o amida y un enlace doble 16(17).
WO2001096293A1 (fr) * 2000-06-15 2001-12-20 Chugai Seiyaku Kabushiki Kaisha Derives de vitamine d
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
JP4527408B2 (ja) * 2002-04-26 2010-08-18 シェーリング コーポレイション ムスカリン性アンタゴニスト
KR20160112018A (ko) 2006-06-02 2016-09-27 니뽄 신야쿠 가부시키가이샤 9,10-세코프레그난 유도체 및 의약
WO2009117831A1 (en) * 2008-03-27 2009-10-01 The Royal Institution For The Advancement Of Learning/Mcgill University Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
US9290447B2 (en) 2011-05-03 2016-03-22 Wisconsin Alumni Research Foundation (20R) and (20S)-24-(p-toluenesulfonyloxy)-25,26,27-trinorvitamin D3 analogs and their uses
WO2012158794A1 (en) 2011-05-17 2012-11-22 Wisconsin Alumni Research Foundation N-cyclopropyl-(20r)-2-methylene-19,26,27-trinor-25-aza-vitamin d analogs and their uses
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
US9338493B2 (en) 2014-06-30 2016-05-10 Apple Inc. Intelligent automated assistant for TV user interactions
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8929059D0 (en) * 1989-12-22 1990-02-28 Leo Pharm Prod Ltd Chemical compounds
CZ288031B6 (cs) * 1991-11-07 2001-04-11 Research Institute For Medicine And Chemistry Amidové deriváty vitaminu D, způsob výroby a farmaceutické prostředky s jejich obsahem

Also Published As

Publication number Publication date
CN1093852C (zh) 2002-11-06
FI955316A (fi) 1995-12-22
GB9309422D0 (en) 1993-06-23
IL109595A0 (en) 1994-08-26
NO954426D0 (no) 1995-11-06
ZA943162B (en) 1995-04-13
EP0696275B1 (en) 1998-08-12
NZ265665A (en) 1997-05-26
CA2162272A1 (en) 1994-11-24
NO954426L (no) 1996-01-08
AU6683294A (en) 1994-12-12
DK0696275T3 (da) 1998-11-09
HUT74165A (en) 1996-11-28
WO1994026707A1 (en) 1994-11-24
AU678246B2 (en) 1997-05-22
US5756733A (en) 1998-05-26
CN1125436A (zh) 1996-06-26
FI955316A0 (fi) 1995-11-06
EP0696275A1 (en) 1996-02-14
HU9503190D0 (en) 1996-01-29
JP3703099B2 (ja) 2005-10-05
DE69412476T2 (de) 1999-03-11
CZ290395A3 (en) 1996-06-12
NO309187B1 (no) 2000-12-27
CZ291238B6 (cs) 2003-01-15
JPH08509971A (ja) 1996-10-22
IL109595A (en) 1999-04-11
DE69412476D1 (de) 1998-09-17
FI112361B (fi) 2003-11-28
ATE169617T1 (de) 1998-08-15
KR100321414B1 (ko) 2002-12-05

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