FI955128A0 - Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi - Google Patents
Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksiInfo
- Publication number
- FI955128A0 FI955128A0 FI955128A FI955128A FI955128A0 FI 955128 A0 FI955128 A0 FI 955128A0 FI 955128 A FI955128 A FI 955128A FI 955128 A FI955128 A FI 955128A FI 955128 A0 FI955128 A0 FI 955128A0
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- erythropoietin analog
- analog compositions
- compositions
- erythropoietin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5507693A | 1993-04-29 | 1993-04-29 | |
PCT/US1994/004755 WO1994025055A1 (en) | 1993-04-29 | 1994-04-29 | Erythropoietin analog compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
FI955128A0 true FI955128A0 (fi) | 1995-10-27 |
FI955128A FI955128A (fi) | 1995-10-27 |
Family
ID=21995426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI955128A FI955128A (fi) | 1993-04-29 | 1995-10-27 | Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi |
Country Status (13)
Country | Link |
---|---|
US (1) | US5888772A (zh) |
EP (1) | EP0744953A4 (zh) |
JP (1) | JPH08509614A (zh) |
KR (1) | KR960701650A (zh) |
CN (1) | CN1125401A (zh) |
AU (1) | AU697453B2 (zh) |
BR (1) | BR9406490A (zh) |
CA (1) | CA2161651A1 (zh) |
CZ (1) | CZ286046B6 (zh) |
FI (1) | FI955128A (zh) |
HU (1) | HUT73876A (zh) |
NO (1) | NO954342L (zh) |
WO (1) | WO1994025055A1 (zh) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
KR100400637B1 (ko) * | 1996-02-06 | 2004-03-10 | 씨제이 주식회사 | 생물학적으로유용한펩타이드 |
US5835382A (en) * | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
PT964702E (pt) * | 1996-08-02 | 2006-12-29 | Ortho Mcneil Pharm Inc | Polipéptidos tendo um único polímero solúvel em água ligado ao n-terminal por covalência |
US6967092B1 (en) | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
US5952226A (en) * | 1996-11-05 | 1999-09-14 | Modex Therapeutiques | Hypoxia responsive EPO producing cells |
DE69824039T2 (de) | 1997-12-08 | 2005-08-18 | Lexigen Pharmaceuticals Corp., Lexington | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
CN1318092C (zh) * | 1998-04-15 | 2007-05-30 | 利思进药品公司 | 含有抗体-细胞因子融合蛋白和血管生成抑制剂的免疫治疗用组合物 |
ATE339507T1 (de) | 1998-06-15 | 2006-10-15 | Gtc Biotherapeutics Inc | Erythropoietin-analog-menschliches serum-albumin fusionsprotein |
AU2346900A (en) * | 1998-11-30 | 2000-06-19 | Eli Lilly And Company | Erythropoietic compounds |
DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
US7309687B1 (en) | 1999-04-13 | 2007-12-18 | The Kenneth S. Warren Institute, Inc. | Methods for treatment and prevention of neuromuscular and muscular conditions by peripherally administered erythropoietin |
US7345019B1 (en) | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
DK1200479T3 (da) * | 1999-08-09 | 2006-05-15 | Emd Lexigen Res Ct Corp | Multiple cytokin-antistof-komplekser |
JP2003514552A (ja) * | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
CN1406249B (zh) | 2000-02-11 | 2010-06-16 | 默克专利股份有限公司 | 增加基于抗体的融合蛋白的循环半衰期 |
ATE368475T1 (de) * | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
AU2001278905B2 (en) * | 2000-09-08 | 2004-12-16 | Gryphon Therapeutics, Inc. | Synthetic erythropoiesis stimulating proteins |
US7118737B2 (en) * | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
DE60138404D1 (de) | 2000-09-25 | 2009-05-28 | Baylor College Medicine | Verbessertes system zur regulation der transgenexpression |
US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
US7767643B2 (en) * | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
PL206701B1 (pl) * | 2001-03-07 | 2010-09-30 | Merck Patent Gmbh | Immunoglobulinowe białko fuzyjne, kodujący je kwas nukleinowy, replikujący wektor ekspresji zawierający taki kwas nukleinowy, eukariotyczna komórka gospodarza zawierająca taki wektor ekspresji oraz sposób zwiększania ekspresji takiego białka fuzyjnego |
WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
PL205352B1 (pl) | 2001-05-03 | 2010-04-30 | Merck Patent Gmbh | Rekombinowane przeciwciało specyficzne dla nowotworu |
JP4795640B2 (ja) * | 2001-12-04 | 2011-10-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 調節された選択性を有する免疫サイトカイン |
EA010200B1 (ru) * | 2002-07-01 | 2008-06-30 | Дзе Кеннет С. Уоррен Инститьют, Инк. | Рекомбинантные тканезащитные цитокины и кодирующие их нуклеиновые кислоты для защиты, восстановления и усиления чувствительных клеток, тканей и органов |
DE10234192B4 (de) | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
ES2343518T3 (es) * | 2002-09-09 | 2010-08-03 | Hanall Biopharma Co., Ltd. | Polipeptidos interferon alfa modificados resistentes a proteasas. |
AU2003298187B2 (en) * | 2002-12-17 | 2010-09-16 | Merck Patent Gmbh | Humanized antibody (H14.18) of the mouse 14.18 antibody binding to GD2 and its fusion with IL-2 |
EP1608672A4 (en) * | 2003-04-02 | 2007-11-21 | Epimmune Inc | PEPTIDES, POLYPEPTIDES AND PROTEINS OF REDUCED IMMUNOGENICITY AND METHODS OF PRODUCTION THEREOF |
MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
US7645733B2 (en) * | 2003-09-29 | 2010-01-12 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions |
CN1902222A (zh) * | 2003-12-31 | 2007-01-24 | 默克专利有限公司 | 具有改善药物代谢动力学的Fc-促红细胞生成素融合蛋白质 |
DE102004004509B4 (de) | 2004-01-23 | 2010-07-01 | Epoplus Gmbh Co.Kg | Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden |
US7588745B2 (en) * | 2004-04-13 | 2009-09-15 | Si Options, Llc | Silicon-containing products |
MX2008014744A (es) | 2006-05-19 | 2009-02-10 | Glycofi Inc | Composiciones de eritrocpoyetina. |
WO2008065372A2 (en) | 2006-11-28 | 2008-06-05 | Nautilus Biotech, S.A. | Modified erythropoietin polypeptides and uses thereof for treatment |
CN103113464B (zh) * | 2007-07-02 | 2014-08-20 | 沈阳三生制药有限责任公司 | 天然人促红细胞生成素类似物 |
US20100298219A1 (en) * | 2008-01-22 | 2010-11-25 | Anthony Cerami | Method of treating cancer, neoplastic disorders, and symptoms thereof with compounds |
EP2247743B1 (en) | 2008-02-08 | 2016-04-06 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
MX346001B (es) | 2008-09-26 | 2017-03-01 | Ambrx Inc | Polipeptidos de eritropoyetina animal modificados y sus usos. |
US20100272816A1 (en) | 2009-04-27 | 2010-10-28 | Wolfgang Rudinger | Microcapsules comprising liver cells and erythropoietin, methods for preparing said microcapsules and methods for treating a patient comprising applying said microcapsules to the patient |
US20130034875A1 (en) * | 2009-10-01 | 2013-02-07 | Toto Ltd. | Dna construct, and process for production of recombinant cho cell using same |
CN102205114B (zh) * | 2011-04-29 | 2012-12-12 | 中国人民解放军第三军医大学 | 促红细胞生成素来源肽在制备治疗神经系统自身免疫性疾病的药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
DE3923963A1 (de) * | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
-
1994
- 1994-04-29 HU HU9503088A patent/HUT73876A/hu unknown
- 1994-04-29 AU AU67785/94A patent/AU697453B2/en not_active Ceased
- 1994-04-29 WO PCT/US1994/004755 patent/WO1994025055A1/en not_active Application Discontinuation
- 1994-04-29 CN CN94192423A patent/CN1125401A/zh active Pending
- 1994-04-29 US US08/537,754 patent/US5888772A/en not_active Expired - Fee Related
- 1994-04-29 KR KR1019950704746A patent/KR960701650A/ko not_active Application Discontinuation
- 1994-04-29 JP JP6524574A patent/JPH08509614A/ja active Pending
- 1994-04-29 CZ CZ952844A patent/CZ286046B6/cs not_active IP Right Cessation
- 1994-04-29 CA CA002161651A patent/CA2161651A1/en not_active Abandoned
- 1994-04-29 BR BR9406490A patent/BR9406490A/pt not_active Application Discontinuation
- 1994-04-29 EP EP94915954A patent/EP0744953A4/en not_active Withdrawn
-
1995
- 1995-10-27 FI FI955128A patent/FI955128A/fi unknown
- 1995-10-30 NO NO954342A patent/NO954342L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ286046B6 (cs) | 1999-12-15 |
WO1994025055A1 (en) | 1994-11-10 |
AU697453B2 (en) | 1998-10-08 |
EP0744953A1 (en) | 1996-12-04 |
AU6778594A (en) | 1994-11-21 |
JPH08509614A (ja) | 1996-10-15 |
HU9503088D0 (en) | 1995-12-28 |
HUT73876A (en) | 1996-10-28 |
EP0744953A4 (en) | 1998-05-06 |
KR960701650A (ko) | 1996-03-28 |
CA2161651A1 (en) | 1994-11-10 |
BR9406490A (pt) | 1996-03-05 |
NO954342D0 (no) | 1995-10-30 |
US5888772A (en) | 1999-03-30 |
FI955128A (fi) | 1995-10-27 |
CN1125401A (zh) | 1996-06-26 |
NO954342L (no) | 1995-10-30 |
CZ284495A3 (en) | 1996-02-14 |
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