FI955128A - Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi - Google Patents
Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi Download PDFInfo
- Publication number
- FI955128A FI955128A FI955128A FI955128A FI955128A FI 955128 A FI955128 A FI 955128A FI 955128 A FI955128 A FI 955128A FI 955128 A FI955128 A FI 955128A FI 955128 A FI955128 A FI 955128A
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- erythropoietin analog
- analog compositions
- compositions
- erythropoietin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5507693A | 1993-04-29 | 1993-04-29 | |
PCT/US1994/004755 WO1994025055A1 (en) | 1993-04-29 | 1994-04-29 | Erythropoietin analog compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
FI955128A0 FI955128A0 (fi) | 1995-10-27 |
FI955128A true FI955128A (fi) | 1995-10-27 |
Family
ID=21995426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI955128A FI955128A (fi) | 1993-04-29 | 1995-10-27 | Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi |
Country Status (13)
Country | Link |
---|---|
US (1) | US5888772A (fi) |
EP (1) | EP0744953A4 (fi) |
JP (1) | JPH08509614A (fi) |
KR (1) | KR960701650A (fi) |
CN (1) | CN1125401A (fi) |
AU (1) | AU697453B2 (fi) |
BR (1) | BR9406490A (fi) |
CA (1) | CA2161651A1 (fi) |
CZ (1) | CZ286046B6 (fi) |
FI (1) | FI955128A (fi) |
HU (1) | HUT73876A (fi) |
NO (1) | NO954342D0 (fi) |
WO (1) | WO1994025055A1 (fi) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
KR100400637B1 (ko) * | 1996-02-06 | 2004-03-10 | 씨제이 주식회사 | 생물학적으로유용한펩타이드 |
US5835382A (en) | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
PT964702E (pt) * | 1996-08-02 | 2006-12-29 | Ortho Mcneil Pharm Inc | Polipéptidos tendo um único polímero solúvel em água ligado ao n-terminal por covalência |
US6967092B1 (en) | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
US5952226A (en) * | 1996-11-05 | 1999-09-14 | Modex Therapeutiques | Hypoxia responsive EPO producing cells |
ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
RU2229305C2 (ru) * | 1998-04-15 | 2004-05-27 | Лексиген Фармасьютикэлс Корпорейшн | Усиление иммунных ответов, опосредованных белками, слитыми из антитела и цитокина, посредством совместного введения ингибитора ангиогенеза |
WO1999066054A2 (en) | 1998-06-15 | 1999-12-23 | Genzyme Transgenics Corp. | Erythropoietin analog-human serum albumin fusion protein |
AU2346900A (en) * | 1998-11-30 | 2000-06-19 | Eli Lilly And Company | Erythropoietic compounds |
DE19857609A1 (de) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
US7410941B1 (en) | 1999-04-13 | 2008-08-12 | The Kenneth S. Warren Institute, Inc. | Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin |
US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
HUP0202442A3 (en) * | 1999-08-09 | 2005-01-28 | Lexigen Pharmaceuticals Corp L | Multiple cytokine-antibody complexes |
US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
AU2154401A (en) * | 1999-11-12 | 2001-05-30 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
ES2269366T3 (es) | 2000-02-11 | 2007-04-01 | Merck Patent Gmbh | Mejoramiento de la vida media en circulacion de proteinas de fusion basadas en anticuerpos. |
AU7172901A (en) * | 2000-06-29 | 2002-01-14 | Lexigen Pharm Corp | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
US7118737B2 (en) * | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
AU2001278905B2 (en) * | 2000-09-08 | 2004-12-16 | Gryphon Therapeutics, Inc. | Synthetic erythropoiesis stimulating proteins |
AU2001296354A1 (en) | 2000-09-25 | 2002-04-02 | Baylor College Of Medicine | Improved system for regulation of transgene expression |
US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
US7767643B2 (en) * | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
DK1366067T3 (da) * | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
WO2002079415A2 (en) * | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
RU2306320C9 (ru) * | 2001-05-03 | 2008-01-27 | Мерк Патент Гмбх | Рекомбинантное опухолеспецифичное антитело (варианты) и его применение |
RU2312677C9 (ru) * | 2001-12-04 | 2008-03-27 | Мерк Патент Гмбх | Иммуноцитокины с модулированной селективностью |
AU2003251770B9 (en) * | 2002-07-01 | 2009-06-04 | H. Lundbeck A/S | Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs |
DE10234192B4 (de) | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
AU2003263552A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
DK1572748T3 (da) * | 2002-12-17 | 2010-08-23 | Merck Patent Gmbh | Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2 |
EP1608672A4 (en) * | 2003-04-02 | 2007-11-21 | Epimmune Inc | PEPTIDES, POLYPEPTIDES AND PROTEINS OF REDUCED IMMUNOGENICITY AND METHODS OF PRODUCTION THEREOF |
SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
US7459152B2 (en) * | 2003-04-23 | 2008-12-02 | Rush University Medical Center | Erythropoietin administration to improve graft survival |
CA2539440A1 (en) * | 2003-09-29 | 2005-04-14 | Warren Pharmaceuticals, Inc. | Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions |
KR20060124656A (ko) * | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Fc-에리스로포이에틴 융합단백질 |
DE102004004509B4 (de) | 2004-01-23 | 2010-07-01 | Epoplus Gmbh Co.Kg | Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden |
US7588745B2 (en) * | 2004-04-13 | 2009-09-15 | Si Options, Llc | Silicon-containing products |
CA2652578A1 (en) | 2006-05-19 | 2007-11-29 | Glycofi, Inc. | Erythropoietin compositions |
WO2008065372A2 (en) | 2006-11-28 | 2008-06-05 | Nautilus Biotech, S.A. | Modified erythropoietin polypeptides and uses thereof for treatment |
CN103113464B (zh) * | 2007-07-02 | 2014-08-20 | 沈阳三生制药有限责任公司 | 天然人促红细胞生成素类似物 |
WO2009094202A1 (en) * | 2008-01-22 | 2009-07-30 | Warren Pharmaceuticals Inc. | Method of treating cancer, neoplastic disorders, and symptoms thereof with compounds |
MX344166B (es) | 2008-02-08 | 2016-12-07 | Ambrx Inc | Leptina-polipeptidos modificados y sus usos. |
EP3216800A1 (en) | 2008-09-26 | 2017-09-13 | Ambrx, Inc. | Modified animal erythropoietin polypeptides and their uses |
US20100272816A1 (en) | 2009-04-27 | 2010-10-28 | Wolfgang Rudinger | Microcapsules comprising liver cells and erythropoietin, methods for preparing said microcapsules and methods for treating a patient comprising applying said microcapsules to the patient |
US20130034875A1 (en) * | 2009-10-01 | 2013-02-07 | Toto Ltd. | Dna construct, and process for production of recombinant cho cell using same |
CN102205114B (zh) * | 2011-04-29 | 2012-12-12 | 中国人民解放军第三军医大学 | 促红细胞生成素来源肽在制备治疗神经系统自身免疫性疾病的药物中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
DE3923963A1 (de) * | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
-
1994
- 1994-04-29 BR BR9406490A patent/BR9406490A/pt not_active Application Discontinuation
- 1994-04-29 EP EP94915954A patent/EP0744953A4/en not_active Withdrawn
- 1994-04-29 CN CN94192423A patent/CN1125401A/zh active Pending
- 1994-04-29 WO PCT/US1994/004755 patent/WO1994025055A1/en not_active Application Discontinuation
- 1994-04-29 CA CA002161651A patent/CA2161651A1/en not_active Abandoned
- 1994-04-29 KR KR1019950704746A patent/KR960701650A/ko not_active Application Discontinuation
- 1994-04-29 JP JP6524574A patent/JPH08509614A/ja active Pending
- 1994-04-29 CZ CZ952844A patent/CZ286046B6/cs not_active IP Right Cessation
- 1994-04-29 AU AU67785/94A patent/AU697453B2/en not_active Ceased
- 1994-04-29 HU HU9503088A patent/HUT73876A/hu unknown
- 1994-04-29 US US08/537,754 patent/US5888772A/en not_active Expired - Fee Related
-
1995
- 1995-10-27 FI FI955128A patent/FI955128A/fi unknown
- 1995-10-30 NO NO954342A patent/NO954342D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ284495A3 (en) | 1996-02-14 |
CZ286046B6 (cs) | 1999-12-15 |
AU697453B2 (en) | 1998-10-08 |
CN1125401A (zh) | 1996-06-26 |
NO954342L (no) | 1995-10-30 |
FI955128A0 (fi) | 1995-10-27 |
NO954342D0 (no) | 1995-10-30 |
JPH08509614A (ja) | 1996-10-15 |
EP0744953A4 (en) | 1998-05-06 |
KR960701650A (ko) | 1996-03-28 |
US5888772A (en) | 1999-03-30 |
HUT73876A (en) | 1996-10-28 |
BR9406490A (pt) | 1996-03-05 |
EP0744953A1 (en) | 1996-12-04 |
WO1994025055A1 (en) | 1994-11-10 |
HU9503088D0 (en) | 1995-12-28 |
AU6778594A (en) | 1994-11-21 |
CA2161651A1 (en) | 1994-11-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI955128A (fi) | Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi | |
FI961599A (fi) | 1N-alkyyli-N-aryylipyrimidiiniamiineja ja niiden johdannaisia | |
BR9403948A (pt) | Composição de matéria | |
BR9403946A (pt) | Composição de matéria | |
FI944832A0 (fi) | Farmaseuttinen koostumus | |
BR1100824A (pt) | Composto e composição farmacêutica | |
FI955144A (fi) | Päällystetyt farmaseuttiset koostumukset | |
FI941663A (fi) | Trikriittisen pisteen omaava koostumus | |
FI951197A (fi) | Mikrobisidiset koostumukset ja menetelmät | |
PT703954E (pt) | Composicoes de derivados de polifenois e sua preparacao | |
DK0565078T3 (da) | Hærdelig sammensætning | |
EE04681B1 (et) | 3,6-poolketaalid 9a-asaliidide klassist, nende valmistamismeetod ja farmatseutiline kompositsioon | |
FI942932A (fi) | Farmaseuttinen koostumus ja menetelmä sen valmistamiseksi | |
ITMI932540A0 (it) | Composizione farmaceutica | |
KR960705557A (ko) | 항미생물 방법 및 화장품 조성물(antimicrobial method and cosmetic composition) | |
FI943734A (fi) | Uudet makrolidit ja niiden käyttö | |
EE9900034A (et) | Arüültsükloalkaankarboksüülestrid, nende kasutamine, farmatseutilised kompositsioonid ja valmistamine | |
FI941914A (fi) | 2-amino-4-kinoliinidihydropyridiinejä, menetelmiä niiden valmistamiseksi ja niiden käyttö | |
FI955123A (fi) | Kolestyramiinia sisältävä koostumus ja menetelmä tämän valmistamiseksi | |
FI970657A0 (fi) | Koostumuksia ja menetelmiä tuhohyönteisten torjumiseksi | |
LV10579A (lv) | Farmaceitiska kompozicija | |
BR8806983A (pt) | Composicao de pintura e aplicacao | |
EE9500029A (et) | Farmatseutiline pihustatav kompositsioon ja selle saamise meetod | |
IT1227901B (it) | Composizioni polimeriche e loro metodo di preparazione | |
FI943748A (fi) | Koostumus ja menetelmä sappitiehyeiden puhdistamiseksi |