FI943734A - Uudet makrolidit ja niiden käyttö - Google Patents

Uudet makrolidit ja niiden käyttö Download PDF

Info

Publication number
FI943734A
FI943734A FI943734A FI943734A FI943734A FI 943734 A FI943734 A FI 943734A FI 943734 A FI943734 A FI 943734A FI 943734 A FI943734 A FI 943734A FI 943734 A FI943734 A FI 943734A
Authority
FI
Finland
Prior art keywords
new macrolides
macrolides
new
Prior art date
Application number
FI943734A
Other languages
English (en)
Swedish (sv)
Other versions
FI943734A0 (fi
Inventor
Axel Zeeck
Kai Uwe Bindseil
Claudia Boddien
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI943734A0 publication Critical patent/FI943734A0/fi
Publication of FI943734A publication Critical patent/FI943734A/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/08Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/58Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound through only acyclic carbon atoms to a non-saccharide heterocyclic ring, e.g. bleomycin, phleomycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI943734A 1993-08-16 1994-08-12 Uudet makrolidit ja niiden käyttö FI943734A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH243593 1993-08-16

Publications (2)

Publication Number Publication Date
FI943734A0 FI943734A0 (fi) 1994-08-12
FI943734A true FI943734A (fi) 1995-02-17

Family

ID=4233741

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943734A FI943734A (fi) 1993-08-16 1994-08-12 Uudet makrolidit ja niiden käyttö

Country Status (13)

Country Link
US (1) US5610178A (fi)
EP (1) EP0639644A1 (fi)
JP (1) JPH07157433A (fi)
KR (1) KR950005306A (fi)
CN (1) CN1106401A (fi)
AU (1) AU683067B2 (fi)
CA (1) CA2130044A1 (fi)
FI (1) FI943734A (fi)
HU (1) HUT70524A (fi)
IL (1) IL110659A0 (fi)
NZ (1) NZ264219A (fi)
SG (1) SG49853A1 (fi)
ZA (1) ZA946125B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2152765A1 (en) * 1994-06-30 1995-12-31 Jeroen Elisabeth-Joseph Knops Methods for treating a physiological disorder associated with beta amyloid peptide
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
EP1154771A4 (en) * 1999-02-26 2005-04-20 Nitromed Inc INHIBITORS OF THE PROTON NITROSIS AND NITROSYL PUMP, COMPOSITIONS AND METHODS OF USE
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
AU4682700A (en) * 1999-04-30 2000-11-17 Research Corporation Technologies, Inc. Bone targeting agents for osteoporosis
DE10040052A1 (de) * 2000-08-11 2002-03-07 Univ Eberhard Karls Verwendung von Protonenpumpen-Hemmern zur Behandlung von Entzündungen, insbesondere von Erkrankungen des Bewegungsapparates
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
CA2494536C (en) * 2002-07-31 2011-10-04 Mercian Corporation A 12-membered ring macrolide active substance
US7211590B2 (en) * 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US8463852B2 (en) * 2006-10-06 2013-06-11 Oracle International Corporation Groupware portlets for integrating a portal with groupware systems
CN101939012B (zh) * 2008-02-08 2015-04-22 巴斯利尔药物股份公司 通过抑制pde而介导的用于治疗疾病的大环内酯类
EP2501378A1 (en) * 2009-11-17 2012-09-26 Veera, Swati Use of macrocyclic lactone derivatives for the treatment of inflammatory disorders
CN116745276A (zh) * 2020-12-16 2023-09-12 密歇根大学董事会 Nef下调抑制剂
WO2024073129A1 (en) * 2022-09-30 2024-04-04 Sherman David H Novel plecomacrolide derivatives for mhc-i nef downmodulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8903529D0 (sv) * 1989-10-24 1989-10-24 M Hersloef Medical use
JPH0559046A (ja) * 1991-06-26 1993-03-09 Ajinomoto Co Inc 免疫調節剤
US5273979A (en) * 1991-08-01 1993-12-28 Merck & Co., Inc. C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent

Also Published As

Publication number Publication date
HU9402361D0 (en) 1994-10-28
JPH07157433A (ja) 1995-06-20
HUT70524A (en) 1995-10-30
CA2130044A1 (en) 1995-02-17
US5610178A (en) 1997-03-11
NZ264219A (en) 1995-03-28
SG49853A1 (en) 2001-07-24
KR950005306A (ko) 1995-03-20
AU683067B2 (en) 1997-10-30
ZA946125B (en) 1995-02-16
AU6899994A (en) 1995-02-23
FI943734A0 (fi) 1994-08-12
EP0639644A1 (de) 1995-02-22
CN1106401A (zh) 1995-08-09
IL110659A0 (en) 1994-11-11

Similar Documents

Publication Publication Date Title
FI961599A (fi) 1N-alkyyli-N-aryylipyrimidiiniamiineja ja niiden johdannaisia
EE9700209A (et) Dihüdropürimidiinid ja nende kasutamine
FI944310A0 (fi) Heteroaryyliamino- ja heteroaryylisuolfonamidosubstituoituja 3-bentsyyliaminometyylipiperidiinejä ja vastaavia yhdisteitä
FI942333A0 (fi) Silyylillä silloitetut metalloseenit ja niiden käyttö
FI960635A (fi) Elektrodi ja sen valmistus
FI953479A0 (fi) 1-aryylipyrimidiinijohdannaiset ja niiden farmaseuttinen käyttö
FI942993A0 (fi) Organoaluminoksituote ja sen käyttö
DE69425782T2 (de) Hyterosalpingographie und selektive Salpingographie
FI941137A (fi) 2-debentsoyyli-2-asyylitaksolijohdannaisia ja menetelmiä niiden valmistamiseksi
ITMI940144A0 (it) Soluzioni e loro preparazione
BR9407549A (pt) Absorvente feminino
FI944624A0 (fi) 4-aryyliaminobentsopyraani- ja niiden kaltaisia yhdisteitä
BR9506832A (pt) N-pirazolilanilinas e n-pirazolilaminopiridinas
BR9610109A (pt) Fecho e uso mesmo
FI972245A0 (fi) Meso-monojodisubstituoidut tetramakrosykliset yhdisteet sekä niiden valmistus- ja käyttömenetelmät
BR1100834A (pt) Piridopirimidinas substituìdas e antihipertensivos
FI943734A0 (fi) Uudet makrolidit ja niiden käyttö
ID19147A (id) Ksilanase dan pemakaiannya
DE59403737D1 (de) Drehkreuz
FI955679A0 (fi) Piperidiinijohdannaisia, niiden valmistus ja käyttö
FI935559A0 (fi) Foerfarande foer faestning av haordmetallstift i en borrkrona och en borrkrona
FI961869A (fi) Rokotteen suunnittelu ja valmistus
FI1031U1 (fi) En troakar
ITMI921571A1 (it) Azaciclo e azabiciclo alchiliden idrossilamine
BR9205281A (pt) Pentapeptideos imuno-reguladores e neuro-reguladores

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: NOVARTIS AG