FI95378B - Förfarande för framställning av terapeutiskt användbara i bensoringen trisubstituerade bensoxazoloner - Google Patents
Förfarande för framställning av terapeutiskt användbara i bensoringen trisubstituerade bensoxazoloner Download PDFInfo
- Publication number
- FI95378B FI95378B FI903655A FI903655A FI95378B FI 95378 B FI95378 B FI 95378B FI 903655 A FI903655 A FI 903655A FI 903655 A FI903655 A FI 903655A FI 95378 B FI95378 B FI 95378B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- fluoro
- compound
- benzoxazolone
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Claims (11)
1. Förfarande för framställning av terapeutiskt användbara trisubstituerade bensoxazoloner med formeln (I) 5 och farmaceutiskt godtagbara salter därav, H\ l1 J.N 1 0V (I) Y3 där Rz är en grupp med formeln 15 -(CH2)b - Ar eller -(CH2)B - Het där m är ett heltal 1-6 och Ar är fenyl, som eventuellt är substltuerad med en eller flera radikaler frän gruppen 20 Cx-C3-alkyl, Cx-C3-alkoxi, C1-C3-alkyltio, halogen, Cx-C2-alkylamino eller hydroxyl; Het är furyl, tienyl, pyridyl, pyrrolyl, imidazolyl, pyranyl, oxazolyl eller indazolyl; och Yx, Y2 och Y3 oberoende av varandra är väte, Cx-C3-al-kyl, halogen eller Cx-C3-alkoxi eller trifluormetyl; förut-. 25 satt, att tvä av symbolerna Yx, Y2 och Y3 alltid är andra än väte, kännetecknat därav, att en aldehyd med formeln Ar-(CH2 )b_x-CH0 eller Het-(CH2 )„.1-CH0 30 där Ar, Het och m betecknar samma som ovan, kondenseras med en förening, som har formeln (V) Il i UI L tilli 114«· 29 95378 HoN 1 0v ,K>" Y3 H och den erhällna iminen reduceras för erhällande av en förening med formeln (I). 10
2. Förfarande enllgt patentkravet 1, känne- t e c k n a t därav, att för att päskynda kondenseringen används ett dehydraterande medel, och iminen reduceras med en metallhydrid.
3. Förfarande enligt patentkravet 2, känne-15 tecknat därav, att kondenseringen utförs vid en temperatur mellan rumstemperatur och ungefär refluxe-ringstemperatur under en tid av cirka 1-6 timmar, och iminen reduceras med en metallhydrid.
4. Förfarande enligt patentkravet 3, känne-20 tecknat därav, att föreningen med formeln (I) är 6- bensylamino-4-fluor-5-mety1-2-bensoxazolon.
5. Förfarande enligt patentkravet 3, känne-tecknat därav, att föreningen med formeln (I) är 6-bensylamino-5-fluor-4-metyl-2-bensoxazolon. 25
6. Förening, som har formeln YtV- Y3 där R är amino eller nitro och Ylt Y2 och Y3 oberoende av varandra är väte, Cj-C3-alkyl, C^-C^-alkoxi eller halogen, 35 förutsatt, att tvä av grupperna Y1# Y2 och Y3 alltid är and-ra än väte.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18868389 | 1989-07-20 | ||
| JP1188683A JPH0678327B2 (ja) | 1989-07-20 | 1989-07-20 | ４，５，６，７，―四置換ベンゾオキサゾロン類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI903655A0 FI903655A0 (sv) | 1990-07-19 |
| FI95378B true FI95378B (sv) | 1995-10-13 |
| FI95378C FI95378C (sv) | 1996-01-25 |
Family
ID=16228012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI903655A FI95378C (sv) | 1989-07-20 | 1990-07-19 | Förfarande för framställning av terapeutiskt användbara i bensoringen trisubstituerade bensoxazoloner |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5071863A (sv) |
| EP (1) | EP0409484B1 (sv) |
| JP (1) | JPH0678327B2 (sv) |
| KR (1) | KR930002099B1 (sv) |
| AT (1) | ATE106877T1 (sv) |
| AU (1) | AU616608B2 (sv) |
| CA (1) | CA2021421A1 (sv) |
| DE (1) | DE69009607T2 (sv) |
| DK (1) | DK0409484T3 (sv) |
| ES (1) | ES2055332T3 (sv) |
| FI (1) | FI95378C (sv) |
| HU (1) | HU206101B (sv) |
| IE (1) | IE63203B1 (sv) |
| IL (1) | IL95085A (sv) |
| NO (1) | NO903230L (sv) |
| NZ (1) | NZ234583A (sv) |
| PT (1) | PT94750A (sv) |
| ZA (1) | ZA905677B (sv) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674524B1 (fr) * | 1991-03-25 | 1993-05-21 | Adir | Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US20040192669A1 (en) | 2000-04-13 | 2004-09-30 | Rosenfeld Mark J. | Novel compounds for use in weight loss and appetite suppression in humans |
| US7794761B2 (en) * | 2000-04-13 | 2010-09-14 | Seroctin Research & Technology, Inc. | Methods for inducing anti-anxiety and calming effects in animals and humans |
| US7524877B2 (en) | 2003-11-20 | 2009-04-28 | Seroctin Research & Technology, Inc. | Compounds for use in weight loss and appetite suppression in humans |
| JP4695012B2 (ja) * | 2006-04-21 | 2011-06-08 | セイコークロック株式会社 | アラーム時計 |
| MY153606A (en) | 2008-08-05 | 2015-02-27 | Daiichi Sankyo Co Ltd | Imidazopyridin-2-one derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3256293A (en) * | 1964-02-05 | 1966-06-14 | Monsanto Co | 3-(phenylcarbamoyl) benzoxazolinones-2 |
| US3657265A (en) * | 1968-06-21 | 1972-04-18 | Olin Corp | Process for preparing benzoxazolones from aromatic nitro compounds |
| CS167359B2 (sv) * | 1971-09-28 | 1976-04-29 | ||
| US4227915A (en) * | 1978-05-18 | 1980-10-14 | Monsanto Company | N-Substituted oxobenzothiazoline and oxobenzoxazoline derivatives and their use as plant growth regulants |
| JPS57123103A (en) * | 1981-01-26 | 1982-07-31 | Hokko Chem Ind Co Ltd | Agricultural and horticultural fungicide |
| GB8325370D0 (en) * | 1983-09-22 | 1983-10-26 | Fujisawa Pharmaceutical Co | Benzoxazoline and benzothiazoline derivatives |
| JPS6293283A (ja) * | 1985-10-18 | 1987-04-28 | Idemitsu Kosan Co Ltd | ベンゾオキサゾロン誘導体，その製造方法およびそれを有効成分とする農園芸用殺菌剤 |
| US4835166A (en) * | 1986-06-09 | 1989-05-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents |
| DK288287A (da) * | 1986-06-09 | 1987-12-10 | Pfizer | Heterocycliske forbindelser samt farmaceutiske praeparater til behandling af allergiske eller inflammatoriske tilstande |
| IL93473A0 (en) * | 1989-02-28 | 1990-11-29 | Pfizer | Antiinflammatory benzoxazolones |
-
1989
- 1989-07-20 JP JP1188683A patent/JPH0678327B2/ja not_active Expired - Lifetime
-
1990
- 1990-07-12 DK DK90307618.0T patent/DK0409484T3/da active
- 1990-07-12 ES ES90307618T patent/ES2055332T3/es not_active Expired - Lifetime
- 1990-07-12 DE DE69009607T patent/DE69009607T2/de not_active Expired - Fee Related
- 1990-07-12 AT AT90307618T patent/ATE106877T1/de active
- 1990-07-12 EP EP90307618A patent/EP0409484B1/en not_active Expired - Lifetime
- 1990-07-13 IL IL9508590A patent/IL95085A/en not_active IP Right Cessation
- 1990-07-18 PT PT94750A patent/PT94750A/pt not_active Application Discontinuation
- 1990-07-18 US US07/554,625 patent/US5071863A/en not_active Expired - Fee Related
- 1990-07-18 CA CA002021421A patent/CA2021421A1/en not_active Abandoned
- 1990-07-19 IE IE263090A patent/IE63203B1/en not_active IP Right Cessation
- 1990-07-19 NZ NZ234583A patent/NZ234583A/en unknown
- 1990-07-19 FI FI903655A patent/FI95378C/sv not_active IP Right Cessation
- 1990-07-19 KR KR1019900010969A patent/KR930002099B1/ko not_active IP Right Cessation
- 1990-07-19 NO NO90903230A patent/NO903230L/no unknown
- 1990-07-19 ZA ZA905677A patent/ZA905677B/xx unknown
- 1990-07-20 AU AU59193/90A patent/AU616608B2/en not_active Ceased
- 1990-07-20 HU HU904565A patent/HU206101B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2055332T3 (es) | 1994-08-16 |
| EP0409484A2 (en) | 1991-01-23 |
| KR930002099B1 (ko) | 1993-03-26 |
| IE902630A1 (en) | 1991-02-27 |
| JPH0352875A (ja) | 1991-03-07 |
| NO903230L (no) | 1991-01-21 |
| CA2021421A1 (en) | 1991-01-21 |
| IE63203B1 (en) | 1995-04-05 |
| DE69009607T2 (de) | 1994-09-22 |
| ZA905677B (en) | 1992-02-26 |
| ATE106877T1 (de) | 1994-06-15 |
| JPH0678327B2 (ja) | 1994-10-05 |
| DE69009607D1 (de) | 1994-07-14 |
| EP0409484B1 (en) | 1994-06-08 |
| IL95085A (en) | 1994-10-21 |
| HU206101B (en) | 1992-08-28 |
| HUT57745A (en) | 1991-12-30 |
| FI903655A0 (sv) | 1990-07-19 |
| IL95085A0 (en) | 1991-06-10 |
| AU616608B2 (en) | 1991-10-31 |
| NO903230D0 (no) | 1990-07-19 |
| DK0409484T3 (da) | 1994-07-04 |
| EP0409484A3 (en) | 1991-05-15 |
| FI95378C (sv) | 1996-01-25 |
| NZ234583A (en) | 1991-12-23 |
| AU5919390A (en) | 1991-01-24 |
| US5071863A (en) | 1991-12-10 |
| KR910002818A (ko) | 1991-02-26 |
| HU904565D0 (en) | 1990-12-28 |
| PT94750A (pt) | 1991-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: PFIZER INC. |