FI950467L - Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi - Google Patents

Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi Download PDF

Info

Publication number
FI950467L
FI950467L FI950467A FI950467A FI950467L FI 950467 L FI950467 L FI 950467L FI 950467 A FI950467 A FI 950467A FI 950467 A FI950467 A FI 950467A FI 950467 L FI950467 L FI 950467L
Authority
FI
Finland
Prior art keywords
treatment
optically pure
allergic diseases
pure isomers
terfenadine metabolites
Prior art date
Application number
FI950467A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950467A7 (fi
FI950467A0 (fi
Inventor
James W Young
Nancy M Gray
Raymond L Woosley
Yiwang Chen
Original Assignee
Sepracor Inc
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27129882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI950467(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sepracor Inc, Univ Georgetown filed Critical Sepracor Inc
Publication of FI950467A0 publication Critical patent/FI950467A0/fi
Publication of FI950467A7 publication Critical patent/FI950467A7/fi
Publication of FI950467L publication Critical patent/FI950467L/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
FI950467A 1992-08-03 1993-08-03 Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi FI950467L (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92415692A 1992-08-03 1992-08-03
US92418292A 1992-08-03 1992-08-03
PCT/US1993/007260 WO1994003170A1 (en) 1992-08-03 1993-08-03 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Publications (3)

Publication Number Publication Date
FI950467A0 FI950467A0 (fi) 1995-02-02
FI950467A7 FI950467A7 (fi) 1995-03-31
FI950467L true FI950467L (fi) 1995-03-31

Family

ID=27129882

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950467A FI950467L (fi) 1992-08-03 1993-08-03 Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi

Country Status (24)

Country Link
US (1) US5375693A (da)
EP (4) EP1688142A1 (da)
JP (6) JP3041954B2 (da)
KR (1) KR950702420A (da)
AT (3) ATE363283T1 (da)
AU (3) AU675240B2 (da)
BR (1) BR9306841A (da)
CA (1) CA2141572C (da)
CZ (1) CZ27495A3 (da)
DE (5) DE69334008T2 (da)
DK (3) DK0815860T3 (da)
ES (3) ES2086270T5 (da)
FI (1) FI950467L (da)
GB (1) GB2284351B (da)
GR (3) GR960300024T1 (da)
HK (1) HK1045806B (da)
HU (1) HU226242B1 (da)
NO (1) NO310644B1 (da)
PL (1) PL174373B1 (da)
PT (2) PT815860E (da)
RO (1) RO116043B1 (da)
RU (1) RU2167657C2 (da)
SK (1) SK12495A3 (da)
WO (1) WO1994003170A1 (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2134211C (en) * 1992-05-11 1999-06-29 James K. Woodward Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
EP1688142A1 (en) 1992-08-03 2006-08-09 Sepracor Inc. Terfenadine carboxylate and the treatment of dermal irritation
EP1369409B1 (en) 1993-06-24 2006-04-05 AMR Technology, Inc. Process for preparing compounds useful as intermediates
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
EP1178041A1 (en) 1994-05-18 2002-02-06 Aventis Pharmaceuticals Inc. Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US5455049A (en) * 1995-01-04 1995-10-03 Ascent Pharmaceuticals, Inc. Terfenadine oral powder
DK0812195T3 (da) * 1995-02-28 2003-03-03 Aventis Pharma Inc Farmaceutisk sammensætning til piperidinoalkanolforbindelser
GB9513972D0 (en) * 1995-07-08 1995-09-06 Merck Sharp & Dohme Pharmaceutical compositions
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5733756A (en) * 1996-01-05 1998-03-31 Celgene Corporation Lactams and processes for stereoselective enrichment of lactams, amides, and esters
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6355656B1 (en) 1995-12-04 2002-03-12 Celgene Corporation Phenidate drug formulations having diminished abuse potential
US5908850A (en) * 1995-12-04 1999-06-01 Celgene Corporation Method of treating attention deficit disorders with d-threo methylphenidate
US5922736A (en) 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
JP4344405B2 (ja) * 1997-08-26 2009-10-14 アベンティス・ファーマスーティカルズ・インコーポレイテッド ピペリジノアルカノール−鬱血除去剤の組合せ用医薬組成物
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
DE19913862C2 (de) * 1999-03-26 2003-04-10 Forschungszentrum Juelich Gmbh Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen
DE10007203A1 (de) * 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
IL158334A0 (en) * 2001-04-09 2004-05-12 Teva Pharma Polymorphs of fexofenadine hydrochloride
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
IL159266A0 (en) * 2001-06-18 2004-06-01 Reddys Lab Ltd Dr Crystalline forms of fexofenadine and processes for the preparation thereof
WO2003020274A1 (en) * 2001-08-30 2003-03-13 Aventis Pharmaceuticals Inc. Treatment of atopic dermatitis
US20040044038A1 (en) * 2002-06-10 2004-03-04 Barnaba Krochmal Polymorphic form XVI of fexofenadine hydrochloride
TWI326214B (en) * 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
RU2238081C1 (ru) * 2003-07-14 2004-10-20 Открытое акционерное общество "Московская фармацевтическая фабрика" Средство антиконгестивного действия
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
JP4515121B2 (ja) 2004-03-15 2010-07-28 東芝テック株式会社 ワイヤドットプリンタヘッド及びワイヤドットプリンタ
JP4473021B2 (ja) 2004-03-22 2010-06-02 東芝テック株式会社 窒化層形成方法、磁気回路形成部材、アーマチュア、ワイヤドットプリンタヘッド及びワイヤドットプリンタ
JP2007532687A (ja) * 2004-04-26 2007-11-15 テバ ファーマシューティカル インダストリーズ リミティド フェキソフェナジン塩酸塩の結晶形およびその製造方法
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US7498443B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
JP2008514641A (ja) * 2004-09-28 2008-05-08 テバ ファーマシューティカル インダストリーズ リミティド 結晶形フェキソフェナジン、およびその調製方法
US20060127421A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment using D-threo methylphenidate
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
CA2683316A1 (en) * 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20150238473A1 (en) * 2012-09-27 2015-08-27 University Of Rochester Methods and compositions for treating infection
KR102597910B1 (ko) * 2015-03-26 2023-11-02 재클린 엠. 이베르센 숙취상태와 연관된 증상들을 억제하기 위한 방법 및 조성물
DE102017130361A1 (de) 2017-12-18 2019-07-04 Lsp Innovative Automotive Systems Gmbh Statorzahn und Stator mit guter elektrischer Isolierung und gleichzeitig sehr hoher Wärmeleitfähigkeit zur Leistungssteigerung von Elektromotoren

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US880801A (en) † 1908-03-03 Harold Larsen Vibrator.
US922890A (en) † 1907-03-26 1909-05-25 Peder Joergen Hansen Stream-motor.
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4552899A (en) † 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4829064A (en) † 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4996061A (en) † 1987-10-07 1991-02-26 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol-decongestant combination
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
DK0635004T3 (da) * 1992-04-10 2002-11-11 Merrell Pharma Inc 4-Diphenylmethylpiperidinderivater og fremgangsmåde til fremstilling deraf
CA2134211C (en) 1992-05-11 1999-06-29 James K. Woodward Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
EP1688142A1 (en) 1992-08-03 2006-08-09 Sepracor Inc. Terfenadine carboxylate and the treatment of dermal irritation
EP1369409B1 (en) * 1993-06-24 2006-04-05 AMR Technology, Inc. Process for preparing compounds useful as intermediates
DK0705245T3 (da) * 1993-06-25 2003-04-14 Merrell Pharma Inc Nye mellemprodukter til fremstilling af antihistaminiske 4-diphenylmethyl/diphenylmethoxy-piperidinforbindelser
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
CA2128821A1 (en) * 1993-07-27 1995-01-28 Dilip J. Gole Freeze-dried pharmaceutical dosage form and process for separation thereof
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate

Also Published As

Publication number Publication date
DE69316660T2 (de) 1998-05-07
EP0701443B2 (en) 2000-11-22
KR950702420A (ko) 1995-07-29
DK1214937T3 (da) 2007-09-17
HK1045806A1 (en) 2002-12-13
JP2000086515A (ja) 2000-03-28
DE701443T1 (de) 1997-01-30
DE69334008D1 (de) 2006-05-24
DE69334145T2 (de) 2008-01-24
EP0815860A2 (en) 1998-01-07
JP2000086516A (ja) 2000-03-28
JPH08500348A (ja) 1996-01-16
PL174373B1 (pl) 1998-07-31
EP1214937B1 (en) 2007-05-30
GB2284351B (en) 1996-11-27
FI950467A7 (fi) 1995-03-31
JP2000086514A (ja) 2000-03-28
JP2000086512A (ja) 2000-03-28
NO950374D0 (no) 1995-02-01
JP3288662B2 (ja) 2002-06-04
HUT71889A (en) 1996-02-28
GR3035417T3 (en) 2001-05-31
EP0815860A3 (en) 1998-01-14
RU95107881A (ru) 1996-11-27
JP3288660B2 (ja) 2002-06-04
DE9320925U1 (de) 1995-08-31
ES2086270T3 (es) 1998-03-01
NO950374L (no) 1995-03-29
DK0815860T3 (da) 2006-08-14
ES2257757T3 (es) 2006-08-01
CA2141572C (en) 2001-02-06
EP0815860B1 (en) 2006-04-12
AU675240B2 (en) 1997-01-30
SK12495A3 (en) 1997-01-08
ES2284740T3 (es) 2007-11-16
JP3288661B2 (ja) 2002-06-04
AU1842999A (en) 1999-04-29
HK1045806B (en) 2008-03-14
ATE162399T1 (de) 1998-02-15
AU4798693A (en) 1994-03-03
GB2284351A (en) 1995-06-07
GB9502183D0 (en) 1995-03-22
EP1214937A3 (en) 2002-10-30
DE69334145D1 (de) 2007-07-12
DK0701443T4 (da) 2000-12-18
AU7182296A (en) 1997-01-30
DK0701443T3 (da) 1998-02-09
DE69316660D1 (de) 1998-02-26
JP3041954B2 (ja) 2000-05-15
JP2000086513A (ja) 2000-03-28
WO1994003170A1 (en) 1994-02-17
HU226242B1 (en) 2008-07-28
ATE322899T1 (de) 2006-04-15
CA2141572A1 (en) 1994-02-17
JP3037697B2 (ja) 2000-04-24
EP1214937A2 (en) 2002-06-19
GR960300024T1 (en) 1996-05-31
US5375693A (en) 1994-12-27
RU2167657C2 (ru) 2001-05-27
RO116043B1 (ro) 2000-10-30
FI950467A0 (fi) 1995-02-02
PT1214937E (pt) 2007-07-25
PT815860E (pt) 2006-08-31
ATE363283T1 (de) 2007-06-15
DE69334008T2 (de) 2006-10-19
EP0701443B1 (en) 1998-01-21
EP1688142A1 (en) 2006-08-09
CZ27495A3 (en) 1996-09-11
PL307339A1 (en) 1995-05-15
DE69316660T3 (de) 2001-04-05
ES2086270T5 (es) 2001-02-01
ES2086270T1 (es) 1996-07-01
EP0701443A1 (en) 1996-03-20
BR9306841A (pt) 1998-12-08
NO310644B1 (no) 2001-08-06
HU9500313D0 (en) 1995-03-28
GR3026530T3 (en) 1998-07-31

Similar Documents

Publication Publication Date Title
FI950467L (fi) Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi
KR100344712B1 (ko) 알러지성및염증성질환의치료에유용한화합물
FI944549A0 (fi) Allergisten ja tulehdussairauksien hoidossa käyttökelpoiset yhdisteet
FI962249A7 (fi) Substituoituja pyratsolyylibentseenisulfonamideja tulehduksen hoitoa varten
FI963696L (fi) Geeli ihosairauksien hoitoon ja ihon desinfiointiin
DE69626539D1 (de) topische Verwendung von Vitamin D zur Behandlung von Augenerkrankungen
FI954718A7 (fi) Heterosykliset johdannaiset iskeemian ja vastaavien sairauksien hoitam iseksi
FI943625A0 (fi) Menetelmiä tulehduksellisten ihotautien hoitamiseksi
FI954541A7 (fi) Keratinosyyttikasvutekijän terapeuttisia käyttöjä
FI910413A7 (fi) Tooppiset valmisteet ihmisen kynsien hoitamiseksi
FI933902A7 (fi) Substituoidut sykloheksaanijohdannaiset sairauksien hoitamiseksi
NO953254D0 (no) Substituerte azolonderivater for behandling av sykdommer forårsaket av helikobakter
DE69434777D1 (de) Verwendung von Relaxin zur Herstellung von therapeutischen Mitteln
FI910854A7 (fi) Vektoreita ja yhdisteitä humaaniproteiini-C:n glykosylaatiomutanttien ilmentämiseksi
FI955786A7 (fi) Luonnontuotteiden ja vastaavien yhdisteiden käyttö sydän- ja verisuonisairauksien hoitoon
DK99993D0 (da) Treatment and prophylaxis of diseases caused by parasites or bacteria
FI925544A7 (fi) Bentsoehappojohdannaisia leukotrieeniin liittyvien sairauksien hoitami seen
NO942756D0 (no) Behandling av glaucoma
DE69418931D1 (de) Verwendung von VIP und deren Analogen und Fragmenten zur Behandlung von neurodegenerativen Krankheiten
FI923744A7 (fi) Menetelmä ja välituotteita 6-fluoribentsisotiatsolien valmistamiseksi
FI945119A7 (fi) Menetelmä 3(S)-metyyliheptaanihapon valmistamiseksi ja välituotteet
NO961496D0 (no) Behandling av allergiske sykdommer med terfenadinkarboksylat
DE69323981D1 (de) Verfahren zur Herstellung von optisch aktiven 4-Mercapto-2-pyrrolidionderivat und Zwischenprodukt dafür
FI955702L (fi) Syklopropaaniestereiden valmistus
DK31292D0 (da) Treatment and prophylaxis of diseases caused by parasites or bacteria