FI945186A - Uusi uuttomenetelmä luonnossa esiintyvien makrolidien talteenottamiseksi - Google Patents

Uusi uuttomenetelmä luonnossa esiintyvien makrolidien talteenottamiseksi Download PDF

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Publication number
FI945186A
FI945186A FI945186A FI945186A FI945186A FI 945186 A FI945186 A FI 945186A FI 945186 A FI945186 A FI 945186A FI 945186 A FI945186 A FI 945186A FI 945186 A FI945186 A FI 945186A
Authority
FI
Finland
Prior art keywords
macrolide
solvent
solution
impurities
recovery
Prior art date
Application number
FI945186A
Other languages
English (en)
Swedish (sv)
Other versions
FI112378B (fi
FI945186A0 (fi
Inventor
Constantine Gletsos
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of FI945186A0 publication Critical patent/FI945186A0/fi
Publication of FI945186A publication Critical patent/FI945186A/fi
Application granted granted Critical
Publication of FI112378B publication Critical patent/FI112378B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
FI945186A 1993-11-05 1994-11-03 Uusi uuttomenetelmä luonnossa esiintyvien makrolidien talteenottamiseksi FI112378B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14809693A 1993-11-05 1993-11-05
US14809693 1993-11-05

Publications (3)

Publication Number Publication Date
FI945186A0 FI945186A0 (fi) 1994-11-03
FI945186A true FI945186A (fi) 1995-05-06
FI112378B FI112378B (fi) 2003-11-28

Family

ID=22524259

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945186A FI112378B (fi) 1993-11-05 1994-11-03 Uusi uuttomenetelmä luonnossa esiintyvien makrolidien talteenottamiseksi

Country Status (25)

Country Link
US (1) US5508398A (fi)
EP (1) EP0652219B1 (fi)
JP (1) JP4202433B2 (fi)
KR (1) KR100393952B1 (fi)
CN (1) CN1037772C (fi)
AT (1) ATE202356T1 (fi)
AU (1) AU7759594A (fi)
BR (1) BR9404265A (fi)
CA (1) CA2134844C (fi)
CZ (1) CZ291865B6 (fi)
DE (1) DE69427513T2 (fi)
DK (1) DK0652219T3 (fi)
ES (1) ES2157239T3 (fi)
FI (1) FI112378B (fi)
GR (1) GR3036207T3 (fi)
HU (1) HU222576B1 (fi)
IL (1) IL111424A (fi)
NZ (1) NZ264852A (fi)
PT (1) PT652219E (fi)
RU (1) RU2152998C2 (fi)
SG (1) SG48919A1 (fi)
SK (1) SK130494A3 (fi)
TW (1) TW408125B (fi)
UA (1) UA41884C2 (fi)
ZA (1) ZA948641B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
IT1289815B1 (it) * 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
KR20040086369A (ko) 2002-02-13 2004-10-08 비오갈 기오기스제르갸르 알티. 바이오매터로부터 마크롤라이드를 추출하는 방법
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
DE60315723T2 (de) * 2002-07-16 2008-06-19 Biotica Technology Ltd. Herstellung von Polyketiden und anderen natürlichen Produkten
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
TR200500302T3 (tr) 2003-03-31 2005-04-21 Biogal Gyogyszergyar Rt. Makrolidlerin kristalizasyonu ve saflaştırılması.
KR20060052874A (ko) * 2003-07-24 2006-05-19 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 정제 방법
WO2005019226A1 (en) * 2003-08-26 2005-03-03 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
US20050112786A1 (en) * 2003-11-25 2005-05-26 Qing Wang Method of immobilizing a substance of interest to a solid phase
CA2548297C (en) * 2003-12-05 2011-06-14 Biocon Limited Process for the purification of macrolides
JP5032974B2 (ja) * 2004-03-02 2012-09-26 ワイス・エルエルシー マクロライドおよびその製造方法
AU2005219389A1 (en) * 2004-03-02 2005-09-15 Wyeth Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents
JP4620405B2 (ja) * 2004-08-02 2011-01-26 アサヒビール株式会社 酵母変異株、グルタチオン高含有酵母の製造方法、その培養物、その分画物、酵母エキスおよびグルタチオン含有飲食品
AR050374A1 (es) 2004-08-20 2006-10-18 Wyeth Corp Forma polimorfica de rafampicina
WO2006060616A1 (en) * 2004-12-01 2006-06-08 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Processes for producing crystalline macrolides
MX2007005868A (es) * 2004-12-22 2007-07-04 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Metodo de purificar tacrolimus.
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
DE602007006601D1 (de) * 2006-03-15 2010-07-01 Teva Gyogyszergyar Zartkoeruee Verfahren zur reinigung von tacrolimus
KR100740582B1 (ko) * 2006-09-27 2007-07-19 한국과학기술연구원 가스크로마토그래피-질량분석기를 이용한 두 생체시료군 간대사체 차별성 분석 방법
JP2010509317A (ja) * 2006-11-10 2010-03-25 バイオコン リミテッド 純粋な形態のラパマイシンならびにこの回収方法および精製方法
CN102070652B (zh) * 2011-02-21 2012-05-02 西南大学 一种从发酵液中分离提取西罗莫司的方法
WO2014072984A1 (en) 2012-11-06 2014-05-15 Natco Pharma Limited Improved process for isolation and purification of rapamycin from fermentation broth
CN108976245B (zh) * 2017-11-09 2020-08-07 北大方正集团有限公司 一种雷帕霉素的提取方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
GB9125660D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound

Also Published As

Publication number Publication date
HU222576B1 (hu) 2003-08-28
EP0652219A1 (en) 1995-05-10
JP4202433B2 (ja) 2008-12-24
US5508398A (en) 1996-04-16
HUT71122A (en) 1995-11-28
NZ264852A (en) 1995-12-21
SG48919A1 (en) 1998-05-18
KR950014311A (ko) 1995-06-15
GR3036207T3 (en) 2001-10-31
CA2134844A1 (en) 1995-05-06
CZ291865B6 (cs) 2003-06-18
TW408125B (en) 2000-10-11
DE69427513D1 (de) 2001-07-26
EP0652219B1 (en) 2001-06-20
CZ267494A3 (en) 1995-05-17
CN1037772C (zh) 1998-03-18
SK130494A3 (en) 1995-07-11
JPH07184674A (ja) 1995-07-25
FI112378B (fi) 2003-11-28
ES2157239T3 (es) 2001-08-16
IL111424A0 (en) 1994-12-29
UA41884C2 (uk) 2001-10-15
AU7759594A (en) 1995-05-18
ZA948641B (en) 1996-05-02
DE69427513T2 (de) 2001-11-22
FI945186A0 (fi) 1994-11-03
BR9404265A (pt) 1995-07-04
DK0652219T3 (da) 2001-08-27
RU94039281A (ru) 1997-03-27
KR100393952B1 (ko) 2003-12-11
HU9403164D0 (en) 1994-12-28
IL111424A (en) 1999-10-28
CA2134844C (en) 2007-10-16
RU2152998C2 (ru) 2000-07-20
PT652219E (pt) 2001-09-28
ATE202356T1 (de) 2001-07-15
CN1109058A (zh) 1995-09-27

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