FI944823A0 - Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel - Google Patents

Galantaminderivat, förfarande för framställning av dessa och användning av dessa i läkemedel

Info

Publication number
FI944823A0
FI944823A0 FI944823A FI944823A FI944823A0 FI 944823 A0 FI944823 A0 FI 944823A0 FI 944823 A FI944823 A FI 944823A FI 944823 A FI944823 A FI 944823A FI 944823 A0 FI944823 A0 FI 944823A0
Authority
FI
Finland
Prior art keywords
compounds
drugs
preparation
galantamine derivatives
galantamine
Prior art date
Application number
FI944823A
Other languages
English (en)
Finnish (fi)
Other versions
FI944823A (sv
FI108722B (sv
Inventor
Jr Raymond J Kosley
Larry Davis
Veronica Taberna
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI944823A0 publication Critical patent/FI944823A0/sv
Publication of FI944823A publication Critical patent/FI944823A/sv
Application granted granted Critical
Publication of FI108722B publication Critical patent/FI108722B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI944823A 1993-10-15 1994-10-13 Förfarande för framställning av alkylkarbonyl- och alkoxikarbonylderivat av 4a,5,9,10,11,12-hexahydro-11-metyl-6H-bensofuro[3a,3,2-ef][2]bensazepin-3,6-diol FI108722B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/137,444 US6316439B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors
US13744493 1993-10-15

Publications (3)

Publication Number Publication Date
FI944823A0 true FI944823A0 (sv) 1994-10-13
FI944823A FI944823A (sv) 1995-04-16
FI108722B FI108722B (sv) 2002-03-15

Family

ID=22477461

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944823A FI108722B (sv) 1993-10-15 1994-10-13 Förfarande för framställning av alkylkarbonyl- och alkoxikarbonylderivat av 4a,5,9,10,11,12-hexahydro-11-metyl-6H-bensofuro[3a,3,2-ef][2]bensazepin-3,6-diol

Country Status (23)

Country Link
US (1) US6316439B1 (sv)
EP (1) EP0649846B1 (sv)
JP (1) JP2664343B2 (sv)
KR (1) KR100227957B1 (sv)
CN (1) CN1039910C (sv)
AT (1) ATE211474T1 (sv)
AU (1) AU696170B2 (sv)
CA (1) CA2118172C (sv)
CZ (1) CZ283731B6 (sv)
DE (1) DE69429570T2 (sv)
DK (1) DK0649846T3 (sv)
EG (1) EG20726A (sv)
ES (1) ES2170759T3 (sv)
FI (1) FI108722B (sv)
IL (1) IL111275A (sv)
NO (1) NO307464B1 (sv)
NZ (1) NZ264682A (sv)
PL (1) PL177549B1 (sv)
PT (1) PT649846E (sv)
RO (1) RO114134B1 (sv)
RU (1) RU2109743C1 (sv)
TW (1) TW289754B (sv)
ZA (1) ZA948061B (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US6670356B2 (en) * 1999-12-10 2003-12-30 Bonnie Davis Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
CN100343258C (zh) * 2001-04-30 2007-10-17 美国拜尔公司 新的4－氨基－5,6－取代的噻吩并[2,3－d]嘧啶化合物
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) * 2002-05-21 2004-12-16 Nastech Pharmaceutical Company Inc. Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
WO2005065661A2 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galanthamine
CA2552114A1 (en) * 2003-12-31 2005-07-21 Actavis Group Hf Solid dosage formulations of galantamine
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
CN101087618A (zh) * 2004-12-23 2007-12-12 航行药物公司 醋酸亮丙瑞林和乙酰胆碱酯酶抑制剂或nmda受体抑制剂在阿尔茨海默氏病治疗中的应用
PL1895994T3 (pl) * 2005-05-13 2011-02-28 Alza Corp Wielowarstwowy system podawania leków z barierą zabezpieczającą przed wypływaniem materiału ze zbiornika
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2007035941A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal galantamine delivery system
CN102007129B (zh) 2008-04-14 2014-05-07 神经动力生命科学公司 用作治疗人类脑疾病的前药的雪花胺衍生物
US20120184532A1 (en) * 2009-07-23 2012-07-19 Shire Llc Galantamine amino acid and peptide prodrugs and uses thereof
CA2949395C (en) * 2014-05-16 2024-01-02 Synaptec Development Llc Clearance of amyloid.beta.
EP4029867A1 (en) 2021-01-13 2022-07-20 Alpha Cognition Inc. Solid forms of galantamine benzoate gluconate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
ATE411026T1 (de) * 1987-05-04 2008-10-15 Bonnie Davis Mittel zur behandlung der alzheimer-krankheit
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
EP0515301A3 (en) 1991-05-14 1993-06-16 Ernir Snorrason Improvements in benzodiazepine treatment by cholinesterterase inhibitors
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
IL111275A (en) 2003-01-12
NO943895D0 (no) 1994-10-14
DE69429570T2 (de) 2002-08-29
TW289754B (sv) 1996-11-01
JPH07188239A (ja) 1995-07-25
JP2664343B2 (ja) 1997-10-15
EP0649846B1 (en) 2002-01-02
CA2118172A1 (en) 1995-04-16
KR100227957B1 (ko) 1999-11-01
RO114134B1 (ro) 1999-01-29
PT649846E (pt) 2002-06-28
CN1039910C (zh) 1998-09-23
RU94036745A (ru) 1996-12-10
IL111275A0 (en) 1994-12-29
PL305457A1 (en) 1995-04-18
ES2170759T3 (es) 2002-08-16
DK0649846T3 (da) 2002-04-15
ATE211474T1 (de) 2002-01-15
CZ283731B6 (cs) 1998-06-17
FI944823A (sv) 1995-04-16
US6316439B1 (en) 2001-11-13
NO943895L (no) 1995-04-18
CA2118172C (en) 2000-01-04
FI108722B (sv) 2002-03-15
NO307464B1 (no) 2000-04-10
RU2109743C1 (ru) 1998-04-27
CZ254594A3 (en) 1995-07-12
EP0649846A1 (en) 1995-04-26
ZA948061B (en) 1995-06-06
AU7581394A (en) 1995-05-04
AU696170B2 (en) 1998-09-03
NZ264682A (en) 1995-07-26
KR950011445A (ko) 1995-05-15
DE69429570D1 (de) 2002-02-07
PL177549B1 (pl) 1999-12-31
EG20726A (en) 1999-12-29
CN1108657A (zh) 1995-09-20

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

PC Transfer of assignment of patent

Owner name: AVENTISUB II INC.

Free format text: AVENTISUB II INC.

MA Patent expired