FI943941A - Bensodiazepinderivat användbara som CCK-receptorantagonister - Google Patents

Bensodiazepinderivat användbara som CCK-receptorantagonister Download PDF

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Publication number
FI943941A
FI943941A FI943941A FI943941A FI943941A FI 943941 A FI943941 A FI 943941A FI 943941 A FI943941 A FI 943941A FI 943941 A FI943941 A FI 943941A FI 943941 A FI943941 A FI 943941A
Authority
FI
Finland
Prior art keywords
benzodiazepine derivatives
receptor antagonists
pct
derivatives useful
cck receptor
Prior art date
Application number
FI943941A
Other languages
English (en)
Finnish (fi)
Other versions
FI943941A0 (sv
FI121234B (sv
Inventor
Hamish Ryder
Graeme Semple
David Alan Kendrick
Michael Szelke
Masato Satoh
Mitsuaki Ohta
Keiji Miyata
Akito Nishida
Original Assignee
Yamanouchi Pharma Co Ltd
Ferring Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9204221A external-priority patent/GB2264492B/en
Application filed by Yamanouchi Pharma Co Ltd, Ferring Res Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of FI943941A0 publication Critical patent/FI943941A0/sv
Publication of FI943941A publication Critical patent/FI943941A/sv
Application granted granted Critical
Publication of FI121234B publication Critical patent/FI121234B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI943941A 1992-02-27 1994-08-26 Förfarande för framställning av 1,4-bentsodiazepinderivat FI121234B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9204221A GB2264492B (en) 1992-02-27 1992-02-27 Benzodiazepine derivatives
GB9204221 1992-02-27
GB929212740A GB9212740D0 (en) 1992-02-27 1992-06-16 Benzodiazephine derivatives
GB9212740 1992-06-16
GB9300404 1993-02-26
PCT/GB1993/000404 WO1993016999A1 (en) 1992-02-27 1993-02-26 Benzodiazepin derivatives useful as cck-receptor antagonists

Publications (3)

Publication Number Publication Date
FI943941A0 FI943941A0 (sv) 1994-08-26
FI943941A true FI943941A (sv) 1994-10-26
FI121234B FI121234B (sv) 2010-08-31

Family

ID=26300386

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943941A FI121234B (sv) 1992-02-27 1994-08-26 Förfarande för framställning av 1,4-bentsodiazepinderivat

Country Status (18)

Country Link
US (2) US5688943A (sv)
EP (1) EP0628033B1 (sv)
JP (1) JP2571344B2 (sv)
CN (1) CN1051079C (sv)
AT (1) ATE245632T1 (sv)
AU (1) AU672390B2 (sv)
CA (1) CA2129990C (sv)
DE (1) DE69333108T2 (sv)
DK (1) DK0628033T3 (sv)
ES (1) ES2203616T3 (sv)
FI (1) FI121234B (sv)
HU (1) HU224012B1 (sv)
IL (1) IL104853A (sv)
NO (1) NO311215B1 (sv)
PT (1) PT628033E (sv)
RU (1) RU2139282C1 (sv)
TW (1) TW438783B (sv)
WO (1) WO1993016999A1 (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0609306A1 (en) * 1991-10-24 1994-08-10 MERCK SHARP & DOHME LTD. Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
GB2282594A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
GB2282595A (en) * 1993-08-25 1995-04-12 Yamanouchi Pharma Co Ltd Benzodiazepine derivatives
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
AUPO284396A0 (en) * 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
JPWO2002092096A1 (ja) * 2001-05-11 2004-08-26 山之内製薬株式会社 抗腫瘍剤
US7524837B2 (en) 2003-05-12 2009-04-28 Janssen Pharmaceutica N.V. Benzotriazapinone salts and methods for using same
JP5197361B2 (ja) * 2005-06-06 2013-05-15 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 睡眠障害を処置するための組成物および方法
CN101669557B (zh) * 2009-08-20 2012-07-25 杭州六易科技有限公司 一种清热解毒凉茶的制作方法
KR101435729B1 (ko) * 2009-09-28 2014-09-01 닛뽕소다 가부시키가이샤 함질소 헤테로 고리 화합물 및 그의 염, 그리고 농원예용 살균제
CN106163527A (zh) 2013-11-22 2016-11-23 Cl生物科技有限责任公司 用于治疗和预防骨质疏松症的胃泌素拮抗剂
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives
WO2018049129A1 (en) * 2016-09-09 2018-03-15 On Target Laboratories, LLC Cholecystokinin 2 receptor targeted nir imaging and use thereof
US10881667B2 (en) * 2018-10-30 2021-01-05 City University Of Hong Kong Method and composition for treating epilepsy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA2026856A1 (en) * 1989-10-05 1991-04-06 Mark G. Bock 3-substituted-1,4-benzodiazepines useful as oxytocin
CA2032226A1 (en) * 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
IE904560A1 (en) * 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
US5218115A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists

Also Published As

Publication number Publication date
AU672390B2 (en) 1996-10-03
DE69333108T2 (de) 2004-04-15
DK0628033T3 (da) 2003-11-10
JP2571344B2 (ja) 1997-01-16
CN1051079C (zh) 2000-04-05
TW438783B (en) 2001-06-07
HUT67963A (en) 1995-05-29
RU2139282C1 (ru) 1999-10-10
FI943941A0 (sv) 1994-08-26
DE69333108D1 (de) 2003-08-28
IL104853A0 (en) 1993-06-10
NO311215B1 (no) 2001-10-29
AU3639193A (en) 1993-09-13
NO943133L (no) 1994-08-24
ATE245632T1 (de) 2003-08-15
NO943133D0 (no) 1994-08-24
JPH07505121A (ja) 1995-06-08
US5688943A (en) 1997-11-18
HU224012B1 (hu) 2005-04-28
CN1075717A (zh) 1993-09-01
US5962451A (en) 1999-10-05
HU9402212D0 (en) 1994-09-28
IL104853A (en) 1997-11-20
ES2203616T3 (es) 2004-04-16
WO1993016999A1 (en) 1993-09-02
EP0628033A1 (en) 1994-12-14
CA2129990A1 (en) 1993-09-02
PT628033E (pt) 2003-12-31
RU94038255A (ru) 1996-07-10
CA2129990C (en) 2006-01-10
FI121234B (sv) 2010-08-31
EP0628033B1 (en) 2003-07-23

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