FI943574A - Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi - Google Patents

Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi Download PDF

Info

Publication number
FI943574A
FI943574A FI943574A FI943574A FI943574A FI 943574 A FI943574 A FI 943574A FI 943574 A FI943574 A FI 943574A FI 943574 A FI943574 A FI 943574A FI 943574 A FI943574 A FI 943574A
Authority
FI
Finland
Prior art keywords
pyrimidines
preparation
compounds containing
drug resistance
containing drugs
Prior art date
Application number
FI943574A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI943574A0 (fi
Inventor
Armin Heckel
Uwe Bamberger
Annerose Mauz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of FI943574A0 publication Critical patent/FI943574A0/fi
Publication of FI943574A publication Critical patent/FI943574A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI943574A 1993-08-02 1994-08-01 Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi FI943574A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4325900A DE4325900A1 (de) 1993-08-02 1993-08-02 Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
FI943574A0 FI943574A0 (fi) 1994-08-01
FI943574A true FI943574A (fi) 1995-02-03

Family

ID=6494272

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943574A FI943574A (fi) 1993-08-02 1994-08-01 Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi

Country Status (22)

Country Link
US (1) US5618814A (fr)
EP (1) EP0645390A1 (fr)
JP (1) JPH0789963A (fr)
KR (1) KR950005828A (fr)
CN (1) CN1041091C (fr)
AU (1) AU683888B2 (fr)
BG (1) BG98931A (fr)
CA (1) CA2129179A1 (fr)
CZ (1) CZ184594A3 (fr)
DE (1) DE4325900A1 (fr)
EE (1) EE9400255A (fr)
FI (1) FI943574A (fr)
HU (1) HUT70957A (fr)
IL (1) IL110509A (fr)
NO (1) NO301479B1 (fr)
NZ (1) NZ264133A (fr)
PL (1) PL304512A1 (fr)
RO (1) RO113557B1 (fr)
RU (1) RU94028278A (fr)
SK (1) SK91594A3 (fr)
TW (1) TW251286B (fr)
ZA (1) ZA945689B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US7618975B2 (en) * 2003-07-03 2009-11-17 Myriad Pharmaceuticals, Inc. 4-arylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof
DE102004002557A1 (de) * 2004-01-17 2005-08-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (fr) 2005-01-03 2006-07-13 Myriad Genetics Inc. Composes et utilisation therapeutique associee
CN115650827B (zh) * 2022-10-27 2024-03-15 戊言医药科技（上海）有限公司 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069211D1 (en) * 1979-07-03 1984-10-25 Thomae Gmbh Dr K 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them
DE2931573A1 (de) * 1979-08-03 1981-02-26 Thomae Gmbh Dr K Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3833392A1 (de) * 1988-10-01 1990-04-05 Thomae Gmbh Dr K Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
HU9402253D0 (en) 1994-09-28
CN1106405A (zh) 1995-08-09
AU683888B2 (en) 1997-11-27
JPH0789963A (ja) 1995-04-04
PL304512A1 (en) 1995-02-06
KR950005828A (ko) 1995-03-20
BG98931A (en) 1995-09-29
ZA945689B (en) 1996-02-01
IL110509A (en) 1998-01-04
IL110509A0 (en) 1994-10-21
CA2129179A1 (fr) 1995-02-03
NZ264133A (en) 1996-05-28
NO301479B1 (no) 1997-11-03
FI943574A0 (fi) 1994-08-01
SK91594A3 (en) 1995-04-12
EE9400255A (et) 1996-02-15
EP0645390A1 (fr) 1995-03-29
AU6881394A (en) 1995-02-09
DE4325900A1 (de) 1995-02-09
TW251286B (fr) 1995-07-11
NO942853L (no) 1995-02-03
RO113557B1 (ro) 1998-08-28
US5618814A (en) 1997-04-08
CN1041091C (zh) 1998-12-09
HUT70957A (en) 1995-11-28
NO942853D0 (fr) 1994-08-01
RU94028278A (ru) 1996-08-27
CZ184594A3 (en) 1995-02-15

Similar Documents

Publication Publication Date Title
EE9800278A (et) Pürimido[5,4-d]pürimidiinid, neid ühendeid sisaldavad ravimid, nende kasutamine ja valmistamismeetodid
EE9800289A (et) Pürimido[5,4-d]pürimidiinid, neid ühendeid sisaldavad ravimid, nende kasutamine ja valmistamismeetodid
FI943574A (fi) Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
BR9710808A (pt) Derivados biciclicos 6,6 ou 6,7 contendo pirito ou pirimido substitu¡dos
DE69621166D1 (de) Elektrostatisch bindender makromolekulärer Mizellen-Typ Wirkstoffträger mit daran gebundenem Wirkstoff
AU627912B2 (en) Oil-in-water emulsions containing polyethylene
FI954884A0 (fi) Välineet tavaroiden väliaikaiseksi varastoimiseksi
FI103666B1 (fi) Menetelmä bifenyylijohdannaisen valmistamiseksi
PL322452A1 (en) 6-arylpyrasole [3,4-d]pyrimidin-4-ones, preparations containing such compounds and methods of mking use of them
DE59310116D1 (de) Verfahren zur Herstellung von Cholinchlorid enthaltenden Pulvern, diese Pulver und ihre Verwendung
FI981709A0 (fi) Menetelmä 5-substituoitujen 2-amino-4-okso-pyrrolo/2,3-d/-pyrimidiinien valmistamiseksi
FI934749A0 (fi) Foerfarande foer framstaellning av aromatiska brommetylfoereningar
DE68925270D1 (de) Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidinderivate und diese enthaltende Arzneimittel
DE69325073T2 (de) Borazinderivate von Hydridopolysilazanpolymeren
ATE207907T1 (de) Verwendung von tricyclischen 1,4-dihydro-1,4- dioxo-1h-naphalen derivaten, neue verbindungen und ihre therapeutische verwendung
DE68919154D1 (de) Benzodiazepinverbindungen und ihre Verwendung als Arzneimittel.
DE68902811D1 (de) Pharmazeutische zusammensetzungen mit einem gehalt an labdan-di-terpenoid-derivaten und pyrimido(6,1-a)isochinolin-4-on-derivaten und ihre anwendung.
FI950874A0 (fi) Uudet polyjoditetut yhdisteet, menetelmä niiden valmistamiseksi, niitä sisältävä varjoaine
FI923407A0 (fi) Menetelmä tiesuolan denaturoimiseksi ja denaturoitu tiesuola
NO902934L (no) Fremgangsmaate for fremstilling av 4h-indolo(1,2-d)(1,2,4)-triazolo(4,3-a)(1,4)benzodiazepiner, samt anvendelse som medikamenter.
DE29519676U1 (de) Einschlagbodenhülse mit dreh- und neigungsverstellbarem Träger
NO900224D0 (no) Anvendelse av blandede polymeriske overflateaktive stoffer
NO983919D0 (no) 7-fenyl-1,4-diazepanderivater, fremgangsmåter for fremstilling av disse samt legemidler inneholdende slike forbindelser
DE69517767D1 (de) IMIDAZOLYLALKYLDERIVATE VON IMIDAZO[1,5-a]INDOL-3-ON UND IHRE VERWENDUNG ALS ARZNEIMITTEL
DE68905998D1 (de) Modulationsart mit linearen phasenspruengen und konstanter umhuellung.