FI93731B - Förfarande för framställning av beta-laktamderivat - Google Patents

Förfarande för framställning av beta-laktamderivat Download PDF

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Publication number
FI93731B
FI93731B FI891700A FI891700A FI93731B FI 93731 B FI93731 B FI 93731B FI 891700 A FI891700 A FI 891700A FI 891700 A FI891700 A FI 891700A FI 93731 B FI93731 B FI 93731B
Authority
FI
Finland
Prior art keywords
methyl
cephem
compound
alkyl
formula
Prior art date
Application number
FI891700A
Other languages
English (en)
Finnish (fi)
Other versions
FI891700A (sv
FI93731C (sv
FI891700A0 (sv
Inventor
Marco Alpegiani
Giovanni Franceschi
Ettore Perrone
Giuseppe Cassinelli
Pierluigi Bissolino
Piergiuseppe Orezzi
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of FI891700A0 publication Critical patent/FI891700A0/sv
Publication of FI891700A publication Critical patent/FI891700A/sv
Application granted granted Critical
Publication of FI93731B publication Critical patent/FI93731B/sv
Publication of FI93731C publication Critical patent/FI93731C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
FI891700A 1988-04-13 1989-04-11 Förfarande för framställning av beta-laktamderivat FI93731C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888808701A GB8808701D0 (en) 1988-04-13 1988-04-13 Beta-lactam derivatives
GB8808701 1988-04-13

Publications (4)

Publication Number Publication Date
FI891700A0 FI891700A0 (sv) 1989-04-11
FI891700A FI891700A (sv) 1989-10-14
FI93731B true FI93731B (sv) 1995-02-15
FI93731C FI93731C (sv) 1995-05-26

Family

ID=10635113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI891700A FI93731C (sv) 1988-04-13 1989-04-11 Förfarande för framställning av beta-laktamderivat

Country Status (23)

Country Link
US (1) US5077286A (sv)
EP (1) EP0337704B1 (sv)
JP (1) JP2840286B2 (sv)
KR (1) KR0138771B1 (sv)
CN (1) CN1037151A (sv)
AT (1) ATE123778T1 (sv)
AU (1) AU615048B2 (sv)
CA (1) CA1325077C (sv)
DE (1) DE68923033T2 (sv)
DK (1) DK175689A (sv)
ES (1) ES2075850T3 (sv)
FI (1) FI93731C (sv)
GB (1) GB8808701D0 (sv)
GR (1) GR3017081T3 (sv)
HU (1) HU206118B (sv)
IE (1) IE67549B1 (sv)
IL (1) IL89929A0 (sv)
MY (1) MY104428A (sv)
NO (1) NO173016C (sv)
NZ (1) NZ228681A (sv)
SU (2) SU1750430A3 (sv)
YU (1) YU47481B (sv)
ZA (1) ZA892629B (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
WO1991004977A1 (en) * 1989-10-06 1991-04-18 Synphar Laboratories, Inc. Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof
GB8928373D0 (en) * 1989-12-15 1990-02-21 Erba Carlo Spa Beta-lactam derivatives
GB9011463D0 (en) * 1990-05-22 1990-07-11 Erba Carlo Spa Process for the preparation of 7 alpha-alkoxycephem derivatives
DK0458537T3 (da) * 1990-05-24 1999-10-18 Zeneca Ltd Anvendelse af en terapeutisk forbindelse til behandling af bronkitis
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
DK0458536T3 (da) * 1990-05-24 1998-10-19 Zeneca Ltd Terapeutisk middel til behandling og forebyggelse af åndedrætsbesværsyndrom hos voksne
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5446037A (en) * 1991-12-05 1995-08-29 Synphar Laboratories, Inc. 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
ATE208374T1 (de) * 1992-02-18 2001-11-15 Otsuka Kagaku Kk Beta-laktam und cepham verbindungen und ihre herstellung
GB9207715D0 (en) * 1992-04-08 1992-05-27 Erba Carlo Spa 2,2-disubstituted cephem sulphones
WO1993024493A1 (fr) * 1992-05-27 1993-12-09 Teijin Limited Derive de cephalosporine
GB2273097B (en) * 1992-12-04 1996-09-18 Erba Carlo Spa 4-Alkyl and 4-alkenyl delta-3-cephem sulphone human leukocyte elastase inhibitors
DE69431290D1 (de) * 1993-02-12 2002-10-10 Avant Immunotherapeutics Inc PULMONÄRE VERABREICHUNG DES LÖSLICHEN KOMPLEMENT-RECEPTORS TYP 1 sCR1
GB9304440D0 (en) * 1993-03-04 1993-04-21 Erba Carlo Spa 2-acyloxycephem derivatives
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
GB9513818D0 (en) * 1995-07-06 1995-09-06 Pharmacia Spa 7,7-Disubstituted cephem-4-ketones
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
JP2007503447A (ja) * 2003-08-25 2007-02-22 リヴァアックス ファーマスーティカルズ，エルエルシー 神経治療セファゾリン経口投与組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799922A (en) * 1971-11-17 1974-03-26 Smithkline Corp 4-substituted 3-cephem compounds
IN149747B (sv) * 1977-06-07 1982-04-03 Pfizer
NZ190797A (en) * 1978-06-06 1982-08-17 Pfizer Combination of penicillanic 1,1-dioxide and 7-(d-2-(4-ethylpiperazin-2 3-dione-1-carboxamido)-2-(4-hydroxphenyl)acetamido)-3-(1-methyl-5-tetrazolyl)-thiomethyl-3-desacetoxymethylcephalosporanic acid
NZ193020A (en) * 1979-03-05 1982-11-23 Pfizer Preparation of penicillanic acid 1,1-dioxide and intermediates therefor
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IN159362B (sv) * 1981-03-23 1987-05-09 Pfizer
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4637999A (en) * 1983-05-02 1987-01-20 Merck & Co., Inc. Substituted cephalosporins as anti-inflammatory and antidegenerative agents
EP0124081A3 (en) * 1983-05-02 1986-11-26 Merck & Co. Inc. New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
JPS62284386A (ja) * 1986-06-03 1987-12-10 日立電子エンジニアリング株式会社 プロ−ビング方式
NZ222399A (en) * 1986-11-12 1991-07-26 Merck & Co Inc Cephalosporin derivatives; pharmaceutical compositions and processes for preparation

Also Published As

Publication number Publication date
NO891516D0 (no) 1989-04-12
AU615048B2 (en) 1991-09-19
KR0138771B1 (ko) 1998-05-15
AU3276289A (en) 1989-10-19
US5077286A (en) 1991-12-31
JP2840286B2 (ja) 1998-12-24
NO173016B (no) 1993-07-05
FI891700A (sv) 1989-10-14
KR890016048A (ko) 1989-11-28
DK175689A (da) 1989-10-14
HU206118B (en) 1992-08-28
DE68923033D1 (de) 1995-07-20
NO173016C (no) 1993-10-13
YU47481B (sh) 1995-10-03
SU1750430A3 (ru) 1992-07-23
DK175689D0 (da) 1989-04-12
NO891516L (no) 1989-10-16
EP0337704A2 (en) 1989-10-18
HUT50348A (en) 1990-01-29
GB8808701D0 (en) 1988-05-18
CA1325077C (en) 1993-12-07
EP0337704B1 (en) 1995-06-14
FI93731C (sv) 1995-05-26
IE891132L (en) 1989-10-13
YU74489A (en) 1991-02-28
IL89929A0 (en) 1989-12-15
ES2075850T3 (es) 1995-10-16
MY104428A (en) 1994-03-31
GR3017081T3 (en) 1995-11-30
DE68923033T2 (de) 1995-10-26
EP0337704A3 (en) 1991-09-25
CN1037151A (zh) 1989-11-15
ATE123778T1 (de) 1995-06-15
IE67549B1 (en) 1996-04-17
SU1766261A3 (ru) 1992-09-30
ZA892629B (en) 1989-12-27
FI891700A0 (sv) 1989-04-11
NZ228681A (en) 1991-07-26
JPH0228183A (ja) 1990-01-30

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Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: PHARMACIA & UPJOHN S.P.A.

MM Patent lapsed
MM Patent lapsed

Owner name: PHARMACIA & UPJOHN S., P.A.