US5716965A
(en)
*
|
1991-05-22 |
1998-02-10 |
Pfizer Inc. |
Substituted 3-aminoquinuclidines
|
PL172054B1
(pl)
*
|
1991-06-20 |
1997-07-31 |
Pfizer |
Sposób wytwarzania nowych pochodnych fluoroalkoksybenzyloaminowych zwiazków heterocyklicznych zawierajacych azot PL PL PL PL PL PL
|
TW202432B
(GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
*
|
1991-06-21 |
1993-03-21 |
Pfizer |
|
MY110227A
(en)
*
|
1991-08-12 |
1998-03-31 |
Ciba Geigy Ag |
1-acylpiperindine compounds.
|
ATE195867T1
(de)
*
|
1991-09-20 |
2000-09-15 |
Glaxo Group Ltd |
Neue medizinische indikation für tachykinin- antagonisten
|
EP0613458B1
(en)
*
|
1991-11-12 |
1998-01-07 |
Pfizer Inc. |
Acyclic ethylenediamine derivatives as substance p receptor antagonists
|
WO1993023380A1
(en)
*
|
1992-05-18 |
1993-11-25 |
Pfizer Inc. |
Bridged aza-bicyclic derivatives as substance p antagonists
|
US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
US5637699A
(en)
*
|
1992-06-29 |
1997-06-10 |
Merck & Co., Inc. |
Process for preparing morpholine tachykinin receptor antagonists
|
US6048859A
(en)
|
1992-06-29 |
2000-04-11 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
JPH07506379A
(ja)
*
|
1992-08-04 |
1995-07-13 |
ファイザー・インコーポレーテッド |
物質p受容体アンタゴニストとしての3−ベンジルアミノ−2−フェニル−ピペリジン
|
GB9216911D0
(en)
*
|
1992-08-10 |
1992-09-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
JP2909214B2
(ja)
*
|
1992-08-19 |
1999-06-23 |
フアイザー・インコーポレイテツド |
置換ベンジルアミノ窒素含有非芳香族複素環化合物
|
US5387595A
(en)
*
|
1992-08-26 |
1995-02-07 |
Merck & Co., Inc. |
Alicyclic compounds as tachykinin receptor antagonists
|
US5344830A
(en)
*
|
1992-12-10 |
1994-09-06 |
Merck & Co., Inc. |
N,N-diacylpiperazine tachykinin antagonists
|
JP2722279B2
(ja)
*
|
1992-12-10 |
1998-03-04 |
ファイザー・インク. |
アミノメチレンで置換した非芳香族複素環式化合物及びサブスタンスpのアンタゴニストとしての使用
|
US5830854A
(en)
*
|
1992-12-14 |
1998-11-03 |
Merck Sharp & Dohme, Limited |
Method of treating cystic fibrosis using a tachykinin receptor antagonist
|
US5340826A
(en)
*
|
1993-02-04 |
1994-08-23 |
Pfizer Inc. |
Pharmaceutical agents for treatment of urinary incontinence
|
US5393762A
(en)
*
|
1993-06-04 |
1995-02-28 |
Pfizer Inc. |
Pharmaceutical agents for treatment of emesis
|
US5854262A
(en)
*
|
1993-10-07 |
1998-12-29 |
Pfizer Inc. |
Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists
|
US5610165A
(en)
*
|
1994-02-17 |
1997-03-11 |
Merck & Co., Inc. |
N-acylpiperidine tachykinin antagonists
|
IL112778A0
(en)
*
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
TW397825B
(en)
*
|
1994-10-14 |
2000-07-11 |
Novartis Ag |
Aroyl-piperidine derivatives
|
FR2725900B1
(fr)
*
|
1994-10-21 |
1997-07-18 |
Sanofi Sa |
Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
|
TW458774B
(en)
|
1995-10-20 |
2001-10-11 |
Pfizer |
Antiemetic pharmaceutical compositions
|
EP0927166A1
(en)
*
|
1997-02-14 |
1999-07-07 |
Bayer Corporation |
Amides as npy5 receptor antagonists
|
US6048900A
(en)
*
|
1998-02-13 |
2000-04-11 |
Bayer Corporation |
Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
|
JP2000510164A
(ja)
*
|
1997-02-14 |
2000-08-08 |
バイエル・コーポレーシヨン |
選択的神経ペプチドy受容体アンタゴニストとしてのアミド誘導体
|
US6245817B1
(en)
|
1997-02-14 |
2001-06-12 |
Bayer Corporation |
NPY5 receptor antagonists and methods for using same
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
MXPA02004330A
(es)
|
1999-11-03 |
2004-07-30 |
Albany Molecular Res Inc |
Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
|
HUP0300413A2
(hu)
*
|
2000-04-10 |
2003-06-28 |
Pfizer Products Inc. |
Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
|
US7119207B2
(en)
|
2000-04-10 |
2006-10-10 |
Pfizer Inc |
Benzoamide piperidine containing compounds and related compounds
|
BR0112350A
(pt)
|
2000-07-11 |
2003-06-24 |
Albany Molecular Res Inc |
Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico
|
EP1324994A4
(en)
*
|
2000-10-10 |
2004-06-16 |
Calyx Therapeutics Inc |
TRICYCLIC COMPOUNDS AND USES THEREOF
|
ZA200701232B
(en)
|
2004-07-15 |
2008-08-27 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
|
US8362075B2
(en)
|
2005-05-17 |
2013-01-29 |
Merck Sharp & Dohme Corp. |
Cyclohexyl sulphones for treatment of cancer
|
DE102005027168A1
(de)
*
|
2005-06-13 |
2006-12-14 |
Merck Patent Gmbh |
Tetrahydrochinoline
|
ZA200800440B
(en)
|
2005-07-15 |
2009-12-30 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
US8293900B2
(en)
|
2005-09-29 |
2012-10-23 |
Merck Sharp & Dohme Corp |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
GB0617867D0
(en)
*
|
2006-09-11 |
2006-10-18 |
Glaxo Group Ltd |
Chemical compounds
|
CA2770486C
(en)
|
2006-09-22 |
2014-07-15 |
Merck Sharp & Dohme Corp. |
Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
MX2009007200A
(es)
|
2007-01-10 |
2009-07-15 |
Angeletti P Ist Richerche Bio |
Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
|
BRPI0807972A2
(pt)
|
2007-01-24 |
2014-06-10 |
Glaxo Group Ltd |
Composições farmacêuticas compreendendo 3,5-diamino-6-(2,3-diclofenil)-l,2,4-triazina ou r(-)-2,4-diamino-5-(2,3-diclorofenil)-6-fluorometilpirim idina e uma nk1
|
WO2008120653A1
(ja)
|
2007-04-02 |
2008-10-09 |
Banyu Pharmaceutical Co., Ltd. |
インドールジオン誘導体
|
WO2009002495A1
(en)
|
2007-06-27 |
2008-12-31 |
Merck & Co., Inc. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
GB0716573D0
(en)
*
|
2007-08-24 |
2007-10-03 |
Glaxo Group Ltd |
Chemical compounds
|
AU2009222122A1
(en)
|
2008-03-03 |
2009-09-11 |
Tiger Pharmatech |
Tyrosine kinase inhibitors
|
GB0804326D0
(en)
*
|
2008-03-07 |
2008-04-16 |
Glaxo Group Ltd |
Novel compounds
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
AR071997A1
(es)
|
2008-06-04 |
2010-07-28 |
Bristol Myers Squibb Co |
Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
|
UA105182C2
(ru)
|
2008-07-03 |
2014-04-25 |
Ньюрексон, Інк. |
Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
|
EP2413932A4
(en)
|
2009-04-01 |
2012-09-19 |
Merck Sharp & Dohme |
INHIBITORS OF AKT ACTIVITY
|
CN102458123A
(zh)
|
2009-05-12 |
2012-05-16 |
阿尔巴尼分子研究公司 |
芳基、杂芳基和杂环取代的四氢异喹啉及其用途
|
WO2010132487A1
(en)
|
2009-05-12 |
2010-11-18 |
Bristol-Myers Squibb Company |
CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
|
SG175420A1
(en)
|
2009-05-12 |
2011-12-29 |
Albany Molecular Res Inc |
7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
|
EA023838B1
(ru)
|
2009-10-14 |
2016-07-29 |
Мерк Шарп Энд Домэ Корп. |
ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ
|
EP2584903B1
(en)
|
2010-06-24 |
2018-10-24 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
AU2011285909B2
(en)
|
2010-08-02 |
2016-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
US9029341B2
(en)
|
2010-08-17 |
2015-05-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
WO2012036997A1
(en)
|
2010-09-16 |
2012-03-22 |
Schering Corporation |
Fused pyrazole derivatives as novel erk inhibitors
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
US20140046059A1
(en)
|
2011-04-21 |
2014-02-13 |
Piramal Enterprises Limited |
Process for the preparation of morpholino sulfonyl indole derivatives
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
WO2013165816A2
(en)
|
2012-05-02 |
2013-11-07 |
Merck Sharp & Dohme Corp. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
US9233979B2
(en)
|
2012-09-28 |
2016-01-12 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
CA2891122C
(en)
|
2012-11-14 |
2021-07-20 |
The Johns Hopkins University |
Methods and compositions for treating schizophrenia
|
PL2925888T3
(pl)
|
2012-11-28 |
2018-03-30 |
Merck Sharp & Dohme Corp. |
Kompozycje i sposoby do stosowania w leczeniu nowotworów
|
WO2014100065A1
(en)
|
2012-12-20 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as hdm2 inhibitors
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
CN104610146A
(zh)
*
|
2015-01-23 |
2015-05-13 |
常州大学 |
一种3-氮杂二环[5,1,0]-7-醛及合成方法
|
CN105330588B
(zh)
*
|
2015-10-16 |
2017-09-26 |
辽宁中医药大学 |
马齿苋中生物碱Oleracone及其提取分离方法
|
WO2018071283A1
(en)
|
2016-10-12 |
2018-04-19 |
Merck Sharp & Dohme Corp. |
Kdm5 inhibitors
|
EP3706747B1
(en)
|
2017-11-08 |
2025-09-03 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
KR20210046009A
(ko)
|
2018-08-07 |
2021-04-27 |
머크 샤프 앤드 돔 코포레이션 |
Prmt5 억제제
|
US11981701B2
(en)
|
2018-08-07 |
2024-05-14 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
CN113121427B
(zh)
*
|
2021-03-19 |
2022-04-01 |
广东工业大学 |
一种喹啉类衍生物及其制备方法和应用
|