FI93012B - Förfarande för framställning av terapeutiskt användbara (1-hydroxi-2-piperidinoalkyl)-2-indolon-, 2-kinolon-, 2-benso/b/-azepinon-, bensimidazolon och 2-kinazolon-derivat - Google Patents
Förfarande för framställning av terapeutiskt användbara (1-hydroxi-2-piperidinoalkyl)-2-indolon-, 2-kinolon-, 2-benso/b/-azepinon-, bensimidazolon och 2-kinazolon-derivat Download PDFInfo
- Publication number
- FI93012B FI93012B FI893365A FI893365A FI93012B FI 93012 B FI93012 B FI 93012B FI 893365 A FI893365 A FI 893365A FI 893365 A FI893365 A FI 893365A FI 93012 B FI93012 B FI 93012B
- Authority
- FI
- Finland
- Prior art keywords
- group
- base
- mixture
- general formula
- process according
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (8)
1. Förfarande för framställning av terapeutiskt användbara föreningar med den allmänna formeln (I): 5 R3 “OQri R1 15 där Z stär för en grupp med formeln -CH2-, -C(CH3)2-, -CH=CH, -(CH2)2-, -(CH2)3-, -NH- eller -N(CH3)CH2- (där kväveatomen är bunden tili karbonylgruppen), R: stär för en väteatom eller en C^-C^-alkylgrupp,
20 R2 stär för en väteatom eller en metylgrupp ooh R3 stär för en fenoxigrupp, som eventuellt är substituerad med en halogenatom eller en metylgrupp, en naftyloxigrupp, en fenylmetoxigrupp, som eventuellt är substituerad med en halogenatom eller en metylgrupp, en 2-naftylmetoxigrupp, ·· 25 en fenoximetylgrupp, som eventuellt är substituerad med en halogenatom eller en metylgrupp, eller en pyridinyloxi-grupp, och R4 stär för en väteatom eller R3 och R4 tillsammans med piperidinringen bildar en spiro-30 (2,3-dihydro-2:4'-bensofuranpiperidino)-grupp, k ä n n e- . t e c k n a t där av, att en halogenerad keton med den allmänna formeln (II) II 29 93012 O Ji X 5 “K’XjJ I / R1 (där Z, Rx och R2 är saituna som ovan och X stdr för en halo-10 genatom, säsom klor eller brom) omsätts med en piperidin, som har den allmänna formeln (III) R3 (111) 15 (där R3 och R4 är samma som ovan) i närvaro av en oorganisk bas, säsom kalium- eller natriumkarbonat, eller med ett överskott av piperidinföreningen med formeln (III) i ett 20 lösningsmedel, säsom i en kortkedjig alkohol eller aceto-nitril och eventuellt i närvaro av vatten, och den sä er-hällna ketonen med den allmänna formeln (IV) R3 ο=3(Ν30ΓΐΓ <iv) /
30 R1 reduceras med kalium- eller natriumborhydrid i en basisk eller sur omgivning.
2. Förfarande enligt patentkravet 1, k ä n n e -35 tecknat därav, att Z är -CH2-. 30
9. U1 2
3. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att Z är -C(CH3)2-.
4. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att Z är -CH=CH-.
5 5. Förfarande enligt patentkrvet 1, känne- t e c k n a t därav, att Z är -(CH2)2-.
6. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att Z är -(CH2)3-.
7. Förfarande enligt patentkravet 1, känne-10 tecknat därav, att Z är -NH-.
8. Förfarande enligt patentkravet 1, känne-tecknat därav, att Z är -N(CH3)CH2-. > · « II
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8809449A FR2634206B1 (fr) | 1988-07-12 | 1988-07-12 | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique |
| FR8809449 | 1988-07-12 | ||
| FR888816373A FR2640266B2 (fr) | 1988-07-12 | 1988-12-13 | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
| FR8816373 | 1988-12-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI893365A0 FI893365A0 (sv) | 1989-07-11 |
| FI893365A FI893365A (sv) | 1990-01-13 |
| FI93012B true FI93012B (sv) | 1994-10-31 |
| FI93012C FI93012C (sv) | 1995-02-10 |
Family
ID=26226791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI893365A FI93012C (sv) | 1988-07-12 | 1989-07-11 | Förfarande för framställning av terapeutiskt användbara (1-hydroxi-2-piperidinoalkyl)-2-indolon-, 2-kinolon-, 2-benso/b/-azepinon-, bensimidazolon och 2-kinazolon-derivat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5034401A (sv) |
| EP (1) | EP0351282B1 (sv) |
| JP (1) | JPH0272173A (sv) |
| KR (1) | KR900001684A (sv) |
| AT (1) | ATE96437T1 (sv) |
| AU (1) | AU618378B2 (sv) |
| CA (1) | CA1317292C (sv) |
| DE (1) | DE68910210T2 (sv) |
| DK (1) | DK341989A (sv) |
| ES (1) | ES2062064T3 (sv) |
| FI (1) | FI93012C (sv) |
| FR (1) | FR2640266B2 (sv) |
| HU (1) | HU201544B (sv) |
| IE (1) | IE62216B1 (sv) |
| IL (1) | IL90908A0 (sv) |
| NO (1) | NO174100C (sv) |
| NZ (1) | NZ229903A (sv) |
| PT (1) | PT91126B (sv) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5182278A (en) * | 1989-02-28 | 1993-01-26 | Adir Et Compagnie | Analgesic benzoxazolinones having at the 6-position a 1-hydroxy-3-morpholinopropyl side chain |
| CA2023492A1 (en) * | 1989-08-31 | 1991-03-01 | Barry Clifford Lange | Herbicidal glutarimides |
| EP0554247B1 (en) * | 1990-05-10 | 2000-04-26 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
| JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
| FR2668149B1 (fr) * | 1990-10-18 | 1994-09-23 | Synthelabo | Le 1-(3,4-dihydro-2-oxo-1h-quinolein-6-yl)-2-[4-(2-phenyl-ethyl)piperidin-1-yl]ethanol, sa preparation et son application en therapeutique. |
| TW197435B (sv) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| EP0524846A1 (fr) * | 1991-06-27 | 1993-01-27 | Synthelabo | Dérivés de 2-(pipéridin-1-y1) éthanol, leur préparation et leur application en thérapeutique |
| FR2678270B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique. |
| PL169884B1 (pl) * | 1991-07-17 | 1996-09-30 | Pfizer | Sposób wytwarzania nowych pochodnych 2-(4-hydroksypiperydyno)-1-alkanolowych PL PL PL |
| TW263504B (sv) * | 1991-10-03 | 1995-11-21 | Pfizer | |
| FR2684379B1 (fr) * | 1991-12-02 | 1995-04-28 | Synthelabo | Derives de piperidine, leur preparation et leur application en therapeutique. |
| US5462934A (en) * | 1992-03-09 | 1995-10-31 | Takeda Chemical Industries | Condensed heterocyclic ketone derivatives and their use |
| TW218875B (sv) * | 1992-03-09 | 1994-01-11 | Takeda Pharm Industry Co Ltd | |
| FR2688504B1 (fr) * | 1992-03-13 | 1995-05-05 | Synthelabo | Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique. |
| US6255322B1 (en) | 1992-06-19 | 2001-07-03 | Pfizer Inc. | 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents |
| US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
| US5852040A (en) * | 1992-10-30 | 1998-12-22 | Pfizer Inc. | Neuroprotective 3,4-dihydro-2(1H)-quinolone compounds |
| US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
| BR9408506A (pt) * | 1994-01-31 | 1997-08-05 | Pfizer | Compostos neuroprotetores |
| DK0709384T3 (da) * | 1994-10-31 | 1999-08-23 | Merck Patent Gmbh | Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder |
| SK31198A3 (en) * | 1995-09-08 | 1998-08-05 | Synthelabo | 4-(cycloalkyl)piperidine and 4-(cycloalkylalkyl)piperidine derivatives, preparation thereof and therapeutical applications thereof |
| FR2738568B1 (fr) * | 1995-09-08 | 1997-10-17 | Synthelabo | Derives de 4-(cycloalkyl)piperidines et 4-(cycloalkylalkyl) piperidines, leur preparation et leur application en therapeutique |
| ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| EP1357121A1 (en) * | 1997-11-05 | 2003-10-29 | Neurosearch A/S | Azaring-ether deritatives and their use as nicotinic ach receptor modulators |
| GB9725541D0 (en) * | 1997-12-02 | 1998-02-04 | Pharmacia & Upjohn Spa | Amino-benzothiazole derivatives |
| AR033485A1 (es) * | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| CA2802733C (en) * | 2010-06-24 | 2017-11-21 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3217011A (en) * | 1965-05-07 | 1965-11-09 | Sterling Drug Inc | 1-(indolyglyoxalyl)-piperidines |
| JPS51125291A (en) * | 1974-12-07 | 1976-11-01 | Otsuka Pharmaceut Co Ltd | A process for preparing novel carbostyryl derivatives |
| JPS51118772A (en) * | 1975-04-09 | 1976-10-18 | Otsuka Pharmaceut Co Ltd | Method for preparing carbostyryl derivatives |
| PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
| FR2528043A1 (fr) * | 1982-06-03 | 1983-12-09 | Roussel Uclaf | Nouveaux derives de la 1,3-dihydro 4-/1-hydroxy-2-amino-ethyl/2h-indol-2-one, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
| FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
| US4788201A (en) * | 1987-01-22 | 1988-11-29 | Hoechst-Roussel Pharmaceuticals Inc. | 3-methylenespiro (benzofuranpiperidines) |
-
1988
- 1988-12-13 FR FR888816373A patent/FR2640266B2/fr not_active Expired - Lifetime
-
1989
- 1989-07-03 EP EP89401898A patent/EP0351282B1/fr not_active Expired - Lifetime
- 1989-07-03 ES ES89401898T patent/ES2062064T3/es not_active Expired - Lifetime
- 1989-07-03 DE DE89401898T patent/DE68910210T2/de not_active Expired - Fee Related
- 1989-07-03 AT AT89401898T patent/ATE96437T1/de not_active IP Right Cessation
- 1989-07-10 IL IL90908A patent/IL90908A0/xx not_active IP Right Cessation
- 1989-07-11 DK DK341989A patent/DK341989A/da not_active Application Discontinuation
- 1989-07-11 FI FI893365A patent/FI93012C/sv not_active IP Right Cessation
- 1989-07-11 PT PT91126A patent/PT91126B/pt active IP Right Grant
- 1989-07-11 KR KR1019890009861A patent/KR900001684A/ko not_active Application Discontinuation
- 1989-07-11 CA CA000605386A patent/CA1317292C/en not_active Expired - Fee Related
- 1989-07-11 IE IE223789A patent/IE62216B1/en not_active IP Right Cessation
- 1989-07-11 HU HU893488A patent/HU201544B/hu not_active IP Right Cessation
- 1989-07-11 JP JP1180140A patent/JPH0272173A/ja active Pending
- 1989-07-11 NZ NZ229903A patent/NZ229903A/en unknown
- 1989-07-11 NO NO892870A patent/NO174100C/no not_active IP Right Cessation
- 1989-07-11 AU AU38029/89A patent/AU618378B2/en not_active Ceased
- 1989-07-11 US US07/378,094 patent/US5034401A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2062064T3 (es) | 1994-12-16 |
| FI893365A (sv) | 1990-01-13 |
| EP0351282B1 (fr) | 1993-10-27 |
| FI93012C (sv) | 1995-02-10 |
| JPH0272173A (ja) | 1990-03-12 |
| DK341989A (da) | 1990-04-25 |
| NO892870L (no) | 1990-01-15 |
| PT91126A (pt) | 1990-02-08 |
| FR2640266A2 (fr) | 1990-06-15 |
| IL90908A0 (en) | 1990-02-09 |
| FI893365A0 (sv) | 1989-07-11 |
| NZ229903A (en) | 1991-04-26 |
| NO892870D0 (no) | 1989-07-11 |
| AU618378B2 (en) | 1991-12-19 |
| CA1317292C (en) | 1993-05-04 |
| DE68910210T2 (de) | 1994-05-11 |
| DE68910210D1 (de) | 1993-12-02 |
| FR2640266B2 (fr) | 1992-07-10 |
| KR900001684A (ko) | 1990-02-27 |
| IE62216B1 (en) | 1995-01-11 |
| NO174100C (no) | 1994-03-16 |
| US5034401A (en) | 1991-07-23 |
| NO174100B (no) | 1993-12-06 |
| HU201544B (en) | 1990-11-28 |
| PT91126B (pt) | 1994-12-30 |
| HUT50328A (en) | 1990-01-29 |
| ATE96437T1 (de) | 1993-11-15 |
| IE892237L (en) | 1990-01-12 |
| DK341989D0 (da) | 1989-07-11 |
| EP0351282A1 (fr) | 1990-01-17 |
| AU3802989A (en) | 1990-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: SANOFI-SYNTHELABO |
|
| PC | Transfer of assignment of patent |
Owner name: SANOFI-AVENTIS |
|
| MA | Patent expired |