KR900001684A - (1-히드록시-2- 피페리딜알킬)-인돌-2-온, 2-퀴놀리논, 2- 벤조[b] 아자피논, 벤즈이미다졸-2-온 및 퀴나졸린-2-온의 유도체, 그의 제조 및 치료요법에서의 그의 적용 - Google Patents

(1-히드록시-2- 피페리딜알킬)-인돌-2-온, 2-퀴놀리논, 2- 벤조[b] 아자피논, 벤즈이미다졸-2-온 및 퀴나졸린-2-온의 유도체, 그의 제조 및 치료요법에서의 그의 적용 Download PDF

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Publication number
KR900001684A
KR900001684A KR1019890009861A KR890009861A KR900001684A KR 900001684 A KR900001684 A KR 900001684A KR 1019890009861 A KR1019890009861 A KR 1019890009861A KR 890009861 A KR890009861 A KR 890009861A KR 900001684 A KR900001684 A KR 900001684A
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South Korea
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group
compound according
methyl group
halogen atom
hydrogen atom
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KR1019890009861A
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English (en)
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프로스트 조나단
라르드느와 패트릭
베르뗑 쟝
사르메 알프레드
루스유 꼬린느
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에 뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Priority claimed from FR8809449A external-priority patent/FR2634206B1/fr
Application filed by 에 뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에 뚜레 레메뜨르
Publication of KR900001684A publication Critical patent/KR900001684A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Furan Compounds (AREA)

Abstract

내용 없음

Description

(1-히드록시-2-피페리딜알킬)-인돌-2-온, 2-퀴놀리논, 2-벤조[b] 아자피논, 벤즈이미다졸-2-온 및 퀴나졸린-2-온의 유도체, 그의 제조 및 치료요법에서의 그이 적용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(I)에 해당하는 순수한 광학 이성질체 또는 그 혼합물 형태의 화합물 및 약리학적으로 허용되는 산과의 부가염.
    상기식에서,Z는 -CH2-,C(CH3)2-, -CH=CH-, -(CH2)2-, -(CH2)3-, -NH- 또는 -N(CH3)CH2-(여기서 질소원자는 카르보닐기에 결합되어 있다)인 식의 기를 나타내고, R1은 수소원자 또는 C1-C4알칼기를 나타내고, R2는 수소원자 또는 메틸기를 나타내고, R3는 할롤겐원자 또는 메틸기로 치환될 수 있는 페녹시기, 또는 나프틸옥시기, 또는 할로겐원자 또는 메틸기로 치환될 수 있는 페닐메틸기, 또는 Z가 -CH=CH-또는 -(CH2)2-인 식의 기를 나타내지 않을때 치환되지 않은 페닐메틸기, 또는 비스(4-플루오로페닐)메틸기, 또는 할로겐원자 또는 메틸기로 치환될 수 있는 페닐메톡시기, 또는 (2-나프틸)메톡시기, 또는 할로겐원자 또는 메틸기로 치환될 수 있는 페녹시메틸기, 또는 피리디닐옥시기이고, R4는 수소원자를 나타내고, 또는 더욱이, R3와 R4가 함께, 그리고 피페리딘 링고 같이 스피로(2,3-디히드로 벤조푸란-2,4′-피페리드-1-일)기를 형성한다.
  2. 제 1 항에 있어서, Z가 -CH2- 를 나타내는 것을 특징으로 하는 화합물.
  3. 제 1 항에 있어서, Z가C(CH3)2-를 나타내는 것을 특징으로 하는 화합물.
  4. 제 1 항에 있어서, Z가 -CH=CH-를 나타내는 것을 특징으로 하는 화합물.
  5. 제 1 항에 있어서, Z가 -(CH2)2-를 나타내는 것을 특징으로 하는 화합물.
  6. 제 1 항에 있어서, Z가 -(CH2)3-를 나타내는 것을 특징으로 하는 화합물.
  7. 제 1 항에 있어서, Z가 -NH- 를 나타내는 것을 특징으로 하는 화합물.
  8. 제 1 항에 있어서, -N(CH3)CH2-를 나타내는 것을 특징으로 하는 화합물.
  9. 제 1 항에 따른 화합물의 제조방법에 있어서, 다음 일반식(II)
    (상기식에서, Z,R1과 R2는 제 1 항에서 정의한 것과 같고 X는 염소 또는 브롬과 같은 할로겐원자를 나타낸다)의 할로겐화 케톤이 탄산나트륨 또는 탄산칼륨과 같은 무기염기 존재하에서 또는 과량의 일반식(III)의 피페리딘의 존재하에서, 저급알코올 또는 아세토니트릴과 같은 용매속에서, 그리고 필요하다면 물의 존재하에서 가장 먼저 일반식(III)
    (상기식에서 R3와 R4는 제 1 항에서 정의한 것과 같다)의 피페리딘과 반응하고, 이와같이 얻어진 일반식(IV)
    의 케톤이 알칼리 또는 산 매질속에서 수소화 붕소나타륨 또는 수소화 붕소칼륨에 의해 환원되는 것을 특징으로 하는 방법.
  10. 제 1 항에 따른 화합물을 함유하는 것을 특징으로 하는 약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009861A 1988-07-12 1989-07-11 (1-히드록시-2- 피페리딜알킬)-인돌-2-온, 2-퀴놀리논, 2- 벤조[b] 아자피논, 벤즈이미다졸-2-온 및 퀴나졸린-2-온의 유도체, 그의 제조 및 치료요법에서의 그의 적용 KR900001684A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8809449A FR2634206B1 (fr) 1988-07-12 1988-07-12 Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique
FR88/16373 1988-07-12
FR88/09449 1988-07-12
FR888816373A FR2640266B2 (fr) 1988-07-12 1988-12-13 Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
KR900001684A true KR900001684A (ko) 1990-02-27

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KR1019890009861A KR900001684A (ko) 1988-07-12 1989-07-11 (1-히드록시-2- 피페리딜알킬)-인돌-2-온, 2-퀴놀리논, 2- 벤조[b] 아자피논, 벤즈이미다졸-2-온 및 퀴나졸린-2-온의 유도체, 그의 제조 및 치료요법에서의 그의 적용

Country Status (18)

Country Link
US (1) US5034401A (ko)
EP (1) EP0351282B1 (ko)
JP (1) JPH0272173A (ko)
KR (1) KR900001684A (ko)
AT (1) ATE96437T1 (ko)
AU (1) AU618378B2 (ko)
CA (1) CA1317292C (ko)
DE (1) DE68910210T2 (ko)
DK (1) DK341989A (ko)
ES (1) ES2062064T3 (ko)
FI (1) FI93012C (ko)
FR (1) FR2640266B2 (ko)
HU (1) HU201544B (ko)
IE (1) IE62216B1 (ko)
IL (1) IL90908A0 (ko)
NO (1) NO174100C (ko)
NZ (1) NZ229903A (ko)
PT (1) PT91126B (ko)

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Also Published As

Publication number Publication date
FI93012B (fi) 1994-10-31
HU201544B (en) 1990-11-28
NZ229903A (en) 1991-04-26
DE68910210T2 (de) 1994-05-11
PT91126B (pt) 1994-12-30
AU3802989A (en) 1990-01-18
CA1317292C (en) 1993-05-04
ATE96437T1 (de) 1993-11-15
ES2062064T3 (es) 1994-12-16
FI93012C (fi) 1995-02-10
FR2640266B2 (fr) 1992-07-10
DK341989A (da) 1990-04-25
JPH0272173A (ja) 1990-03-12
NO892870L (no) 1990-01-15
FI893365A (fi) 1990-01-13
US5034401A (en) 1991-07-23
PT91126A (pt) 1990-02-08
EP0351282B1 (fr) 1993-10-27
DE68910210D1 (de) 1993-12-02
IE892237L (en) 1990-01-12
FI893365A0 (fi) 1989-07-11
IE62216B1 (en) 1995-01-11
DK341989D0 (da) 1989-07-11
HUT50328A (en) 1990-01-29
IL90908A0 (en) 1990-02-09
AU618378B2 (en) 1991-12-19
FR2640266A2 (fr) 1990-06-15
NO892870D0 (no) 1989-07-11
NO174100B (no) 1993-12-06
NO174100C (no) 1994-03-16
EP0351282A1 (fr) 1990-01-17

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