FI92827B - Förfarande för framställning av terapeutiskt användbara 1-heteroaryl-3-acyl-2-oxindolderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara 1-heteroaryl-3-acyl-2-oxindolderivat Download PDF

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Publication number
FI92827B
FI92827B FI913324A FI913324A FI92827B FI 92827 B FI92827 B FI 92827B FI 913324 A FI913324 A FI 913324A FI 913324 A FI913324 A FI 913324A FI 92827 B FI92827 B FI 92827B
Authority
FI
Finland
Prior art keywords
thienyl
furyl
formula
compound
thiazolyl
Prior art date
Application number
FI913324A
Other languages
English (en)
Finnish (fi)
Other versions
FI92827C (sv
FI913324A0 (sv
Inventor
Anthony Marfat
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI913324A0 publication Critical patent/FI913324A0/sv
Application granted granted Critical
Publication of FI92827B publication Critical patent/FI92827B/sv
Publication of FI92827C publication Critical patent/FI92827C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Claims (4)

1. Förfarande för framställning av nya terapeu-tiskt användbara l-heteroaryl-3-acyl-2-oxiindolderivat med 5 formeIn I n3 ° 2 V\ ^C'R OT~Y 10 k R1 väri
15 R1 är tienyl, furyl eller 2-tiazolyl, R2 är tienyl, furyl eller φτ Y väri X är väte, fluor, klor, alkyl med 1-4 kolatomer, alkoxi med 1-4 kolatomer, alkyltio med 1-4 kolatomer, 25 nitro eller trifluormetyl och Y är väte, fluor eller klor, och R3 och R4, vilka kan vara lika eller o lika, beteck-nar väte, fluor, klor, brom, alkyl med 1-4 kolatomer, alkoxi med 1-4 kolatomer, alkyltio med 1-4 kolatomer, 30 nitro eller trifluormetyl, eller för framställning av far-maceutiskt godtagbara bassalt därav, känneteck-n a t därav, att en förening med formeln II 92827 'Ϊϊχ - R< R1 väri R1, R3 och R4 har ovan angivna betydelse, omsätts med en förening med formeln R2C0C1, väri R2 har ovan angivna 10 betydelse; varefter, ifall önskvärt, föreningen med formeln I omvandlas till ett farmaceutiskt godtagbart bassalt.
2. Förfarande enligt patentkrav 1, känne-t e c k n a t därav, att man framställer en förening med 15 formeln I, väri R1 är tienyl, genom omsättning av en förening med formeln c, väri R1 är tienyl, med en förening med formeln R2C0C1.
3. Förfarande enligt patentkrav 1, känne-t e c k n a t därav, att man framställer en förening med 20 formeln I väri R1 är furyl, genom omsättning av en förening med formeln c, väri R1 är furyl, med en formeln R2C0C1 mot-svarande förening.
4. Förfarande enligt patentkrav 1, känne-t e c k n a t därav, att förening med formeln c erhällits 25 genom omsättning av en förening med formeln lOu R4 >1 väri R1, R3 och R4 har den i patentkravet 1 angivna betydel-sen med en N-klorsuccinamid. *
FI913324A 1989-01-10 1991-07-09 Förfarande för framställning av terapeutiskt användbara 1-heteroaryl-3-acyl-2-oxindolderivat FI92827C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8900079 1989-01-10
PCT/US1989/000079 WO1990008145A1 (en) 1989-01-10 1989-01-10 Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles

Publications (3)

Publication Number Publication Date
FI913324A0 FI913324A0 (sv) 1991-07-09
FI92827B true FI92827B (sv) 1994-09-30
FI92827C FI92827C (sv) 1995-01-10

Family

ID=22214772

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913324A FI92827C (sv) 1989-01-10 1991-07-09 Förfarande för framställning av terapeutiskt användbara 1-heteroaryl-3-acyl-2-oxindolderivat

Country Status (18)

Country Link
EP (1) EP0378358B1 (sv)
JP (1) JPH0692400B2 (sv)
KR (1) KR920006785B1 (sv)
AT (1) ATE96793T1 (sv)
AU (1) AU616336B2 (sv)
CA (1) CA2007655C (sv)
DE (1) DE69004272T2 (sv)
DK (1) DK0378358T3 (sv)
ES (1) ES2060007T3 (sv)
FI (1) FI92827C (sv)
HU (1) HU215112B (sv)
IE (1) IE62143B1 (sv)
IL (1) IL92962A (sv)
NO (1) NO179103C (sv)
NZ (1) NZ232039A (sv)
PT (1) PT92800B (sv)
WO (1) WO1990008145A1 (sv)
ZA (1) ZA90139B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2886541A1 (en) * 2013-12-19 2015-06-24 Sanofi Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases
CN108456205B (zh) * 2018-05-21 2021-06-04 深圳市众康动保科技有限公司 一种3,3二取代羟基吲哚化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053613A (en) * 1975-09-17 1977-10-11 E. R. Squibb & Sons, Inc. 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones
ATE63543T1 (de) * 1984-02-07 1991-06-15 Pfizer 2-oxindolzwischenprodukte.
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
IN163263B (sv) * 1984-02-07 1988-08-27 Pfizer
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
HU203350B (en) * 1984-08-24 1991-07-29 Pfizer Process for producing antiinflammatory tricyclic oxindole derivatives
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4686224A (en) * 1984-10-31 1987-08-11 Pfizer Inc. Oxindole antiinflammatory agents
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds

Also Published As

Publication number Publication date
CA2007655A1 (en) 1991-07-12
NO179103C (no) 1996-08-07
DE69004272T2 (de) 1994-02-24
AU4781690A (en) 1990-07-19
HU215112B (hu) 1998-12-28
FI92827C (sv) 1995-01-10
JPH02270868A (ja) 1990-11-05
KR900011762A (ko) 1990-08-02
ATE96793T1 (de) 1993-11-15
CA2007655C (en) 1996-10-22
ZA90139B (en) 1991-08-28
PT92800A (pt) 1990-07-31
HUT62292A (en) 1993-04-28
KR920006785B1 (ko) 1992-08-17
FI913324A0 (sv) 1991-07-09
IL92962A (en) 1995-01-24
IE900075L (en) 1990-07-10
AU616336B2 (en) 1991-10-24
NO912694D0 (no) 1991-07-09
IE62143B1 (en) 1994-12-14
NO179103B (no) 1996-04-29
DK0378358T3 (da) 1993-12-06
NZ232039A (en) 1991-07-26
ES2060007T3 (es) 1994-11-16
JPH0692400B2 (ja) 1994-11-16
NO912694L (no) 1991-07-09
PT92800B (pt) 1995-12-29
EP0378358A1 (en) 1990-07-18
DE69004272D1 (de) 1993-12-09
EP0378358B1 (en) 1993-11-03
WO1990008145A1 (en) 1990-07-26

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