FI924054L - Iso- och heterocykliska foereningar kopplade med imidazol, foerfarande foer framstaellning av dessa och anvaendning av dessa - Google Patents

Iso- och heterocykliska foereningar kopplade med imidazol, foerfarande foer framstaellning av dessa och anvaendning av dessa Download PDF

Info

Publication number
FI924054L
FI924054L FI924054A FI924054A FI924054L FI 924054 L FI924054 L FI 924054L FI 924054 A FI924054 A FI 924054A FI 924054 A FI924054 A FI 924054A FI 924054 L FI924054 L FI 924054L
Authority
FI
Finland
Prior art keywords
dessa
och
kopplade
heterocykliska
foereningar
Prior art date
Application number
FI924054A
Other languages
English (en)
Finnish (fi)
Other versions
FI924054A0 (fi
FI924054A7 (fi
Inventor
Holger Heitsch
Adalbert Wagner
Heinz-Werner Kleemann
Hermann Gerhards
Bernward Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19914131325 external-priority patent/DE4131325A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI924054A0 publication Critical patent/FI924054A0/fi
Publication of FI924054L publication Critical patent/FI924054L/fi
Publication of FI924054A7 publication Critical patent/FI924054A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Detergent Compositions (AREA)
  • Lubricants (AREA)
  • Pyridine Compounds (AREA)
FI924054A 1991-09-14 1992-09-10 Imidatsoliin liitetyt iso- ja heterosyklit, menetelmä niiden valmistamiseksi ja niiden käyttö FI924054A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4130659 1991-09-14
DE19914131325 DE4131325A1 (de) 1991-09-20 1991-09-20 Imidazo-annellierte iso und heterocyclen, verfahren zu deren herstellung, sie enthaltende mittel und ihre verwendung

Publications (3)

Publication Number Publication Date
FI924054A0 FI924054A0 (fi) 1992-09-10
FI924054L true FI924054L (fi) 1993-03-15
FI924054A7 FI924054A7 (fi) 1993-03-15

Family

ID=25907347

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924054A FI924054A7 (fi) 1991-09-14 1992-09-10 Imidatsoliin liitetyt iso- ja heterosyklit, menetelmä niiden valmistamiseksi ja niiden käyttö

Country Status (22)

Country Link
US (2) US5444068A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0533058B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3459659B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930006020A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1070646A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE247644T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU659485B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9203543A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2078058A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ280492A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE59209986D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0533058T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2204888T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI924054A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT62892A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL103141A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO300326B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ244303A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL171766B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT533058E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2076105C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW300219B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223499A (en) * 1989-05-30 1993-06-29 Merck & Co., Inc. 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists
US5210092A (en) * 1990-09-25 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Angiotensin ii antagonizing heterocyclic derivatives
CA2062558A1 (en) * 1991-03-08 1992-09-09 Prasun K. Chakravarty Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists
WO1994001436A1 (en) * 1992-07-10 1994-01-20 The Boots Company Plc Dioxcyclobutene derivatives as angiotensin ii antagonists
TW348175B (en) * 1993-01-06 1998-12-21 Hoechst Ag Process for the preparation of biphenyl derivatives
CA2125251C (en) * 1993-06-07 2005-04-26 Yoshiyuki Inada A pharmaceutical composition for angiotensin ii-mediated diseases
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
DE4320432A1 (de) * 1993-06-21 1994-12-22 Bayer Ag Substituierte Mono- und Bipyridylmethylderivate
FR2708612B1 (fr) * 1993-08-05 1996-03-01 Roussel Uclaf Nouveaux dérivés bicycliques de l'imidazole, leur procédé de préparation, les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant.
WO1996004270A1 (en) 1994-08-04 1996-02-15 Synaptic Pharmaceutical Corporation Novel benzimidazole derivatives
US6122929A (en) * 1996-12-18 2000-09-26 Showa Aluminum Corporation Accumulator
US6495583B1 (en) 1997-03-25 2002-12-17 Synaptic Pharmaceutical Corporation Benzimidazole derivatives
DE69816109T2 (de) * 1997-04-24 2004-04-22 Ortho-Mcneil Pharmaceutical, Inc. Substituierte imidazole zur behandlung von entzündlichen krankheiten
BR9810508A (pt) 1997-07-03 2000-09-05 Du Pont Pharm Co Composto, composição farmacêutica e método de tratamento de uma desordem
US6486190B1 (en) * 1997-11-24 2002-11-26 The Procter & Gamble Company 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability
US6124463A (en) * 1998-07-02 2000-09-26 Dupont Pharmaceuticals Benzimidazoles as corticotropin release factor antagonists
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US20050267148A1 (en) * 1998-07-15 2005-12-01 Teijin Limited Benzimidazole derivative
BR9912098A (pt) 1998-07-15 2001-09-25 Teijin Ltd Derivado de tiobenzimidazol, composição farmacêutica, e, agente preventivo e/ou terapêutico
WO2000019156A1 (en) * 1998-09-29 2000-04-06 Stanhope Products Company Self-positioning adsorbent package for air conditioning accumulators
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6279341B1 (en) * 1999-07-01 2001-08-28 Multisorb Technologies, Inc. Self-retaining adsorbent unit
GB9919778D0 (en) * 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
AU783839B2 (en) * 2000-01-17 2005-12-15 Teijin Limited Human chymase inhibitors
WO2003064414A1 (en) * 2002-01-29 2003-08-07 Vicore Pharma Ab. Tricyclic compounds useful as angiotensin ii agonists
KR20050057404A (ko) * 2002-09-17 2005-06-16 워너-램버트 캄파니 엘엘씨 정신분열증 치료용 헤테로환 치환된 피페라진
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
AU2004266641A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Oxime substituted imidazo-containing compounds
ES2406730T3 (es) 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
WO2005023190A2 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
SG149828A1 (en) 2003-10-03 2009-02-27 3M Innovative Properties Co Alkoxy substituted imidazoquinolines
JP2007511535A (ja) 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ環化合物
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
KR101130928B1 (ko) 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 치환된 이미다조 고리 시스템 및 방법
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
CA2551399A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
TW200612932A (en) 2004-03-24 2006-05-01 3M Innovative Properties Co Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
CA2594674C (en) 2004-12-30 2016-05-17 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
WO2006074003A2 (en) 2004-12-30 2006-07-13 3M Innovative Properties Company CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
ES2764660T3 (es) 2014-12-16 2020-06-04 Axovant Sciences Gmbh Compuestos de amida de quinuclidina sustituida geminal como agonistas de receptores alfa-7 nicotínicos de acetilcolina
RU2017145964A (ru) 2015-06-10 2019-07-10 Аксовант Сайенсиз Гмбх Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов
US10428062B2 (en) 2015-08-12 2019-10-01 Axovant Sciences Gmbh Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
KR102419223B1 (ko) * 2021-11-16 2022-07-08 세진산업(주) 수소유기균열 방지를 위한 초고압 배관
KR102643639B1 (ko) * 2023-02-20 2024-03-05 (주) 범강기연 무용접 가스 파이프 연결 구조 및 방법

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612323A (en) * 1983-06-27 1986-09-16 Sumitomo Chemical Company, Limited Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
IT1173196B (it) * 1984-02-02 1987-06-18 Bellon Roger Schoum Rbs Pharma Composti imidazopiridinici farmacologicamente attivi
JPS61151176A (ja) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
US4728741A (en) * 1985-01-08 1988-03-01 Smithkline Beckman Corporation 1-substituted-2-mercapto benzimidazole compounds and intermediates
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
JPH0273071A (ja) * 1988-09-09 1990-03-13 Sumitomo Chem Co Ltd ベンズイミダゾール誘導体、その製造法およびそれを有効成分とする殺虫、殺ダニ剤
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5223499A (en) * 1989-05-30 1993-06-29 Merck & Co., Inc. 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5102880A (en) * 1989-05-30 1992-04-07 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US5298518A (en) * 1989-09-29 1994-03-29 Eisai Co., Ltd. Biphenylmethane derivative and pharmacological use
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
EP0430709A3 (en) * 1989-12-01 1992-02-12 Glaxo Group Limited Benzthiophen derivatives
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
FR2658511B1 (fr) * 1990-02-16 1992-06-19 Union Pharma Scient Appl Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.
DK0461039T3 (da) * 1990-06-08 1999-06-14 Hoechst Marion Roussel Inc Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so
JPH04235974A (ja) * 1990-06-08 1992-08-25 Roussel Uclaf 新規なイミダゾール誘導体、それらの製造法、得られる新規な中間体、それらの薬剤としての使用及びそれらを含有する製薬組成物
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
DE4025359A1 (de) * 1990-08-10 1992-02-13 Triumph Adler Ag Verfahren zur einstellung der abdruckenergie einer type und schreibmaschine, drucker o. dgl. zur durchfuehrung des verfahrens
US5087702A (en) * 1991-01-30 1992-02-11 Merck & Co., Inc. Microbial transformation process for producing an antihypertensive product
US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5158327A (en) * 1991-10-11 1992-10-27 Neil Rowe Hydraulic hose coupling handle and method of making same
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
DE4304455A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
US5395844A (en) * 1993-06-10 1995-03-07 The Du Pont Merck Pharmaceutical Company Imidazole 5-position substituted angiotensin II antagonists

Also Published As

Publication number Publication date
US5635525A (en) 1997-06-03
DK0533058T3 (da) 2003-11-24
RU2076105C1 (ru) 1997-03-27
EP0533058B1 (de) 2003-08-20
KR930006020A (ko) 1993-04-20
AU659485B2 (en) 1995-05-18
NO923535L (no) 1993-03-15
JP3459659B2 (ja) 2003-10-20
CN1070646A (zh) 1993-04-07
ATE247644T1 (de) 2003-09-15
JPH05262742A (ja) 1993-10-12
US5444068A (en) 1995-08-22
CA2078058A1 (en) 1993-03-15
DE59209986D1 (de) 2003-09-25
PL171766B1 (pl) 1997-06-30
NO300326B1 (no) 1997-05-12
HU9202931D0 (en) 1992-11-30
PL295911A1 (en) 1993-03-22
BR9203543A (pt) 1993-04-13
CZ280492A3 (en) 1993-04-14
IL103141A0 (en) 1993-02-21
FI924054A0 (fi) 1992-09-10
ES2204888T3 (es) 2004-05-01
TW300219B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1997-03-11
EP0533058A1 (de) 1993-03-24
NO923535D0 (no) 1992-09-11
FI924054A7 (fi) 1993-03-15
PT533058E (pt) 2004-01-30
NZ244303A (en) 1995-12-21
AU2353392A (en) 1993-03-18
HUT62892A (en) 1993-06-28

Similar Documents

Publication Publication Date Title
FI924054L (fi) Iso- och heterocykliska foereningar kopplade med imidazol, foerfarande foer framstaellning av dessa och anvaendning av dessa
FI935421A7 (fi) Konstruktionsdel av plaot, byggnadspanel och byggnadsfoerfarande
FI935189A7 (fi) Glasfiberarmerad plastbehaollare, foerfarande och anordning foet tillverkning av en saodan behaollare
FI930970A7 (fi) Imidazolderivat med bifenylsulfonylurea- eller bifenylsulfonyluretansidokedja, foerfaranden foer framstaellning av dessa och anvaendning av dessa
FI932402A7 (fi) Foerfarande och anordning foer saendning, mottagning och oeverfoering av datasignaler med motsvarande programdatasignaler
FI921943L (fi) Poroest bikaksmaterial, foerfarande foer framstaellning av det och anvaendning av det
FI923337L (fi) Organiska fluorenylmetallfoereningar, framstaellning och anvaendning daerav
FI922977L (fi) Heterocykliska foereningar, deras framstaellning och anvaendning
FI923366L (fi) 5-lediga heterocykler, foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel
FI921030L (fi) Cykliska ureaderivat, dessa foereningar innehaollande laekemedel och foerfarande foer deras framstaellning
FI923691L (fi) Cykliska iminoderivat, dessa foereningar innehaollande farmaceutiska blandningar och foerfarande foer deras framstaellning
FI923223A7 (fi) Alkenylgrupper omfattande siloxankopolymerer, deras framstaellning och anvaendning
FI923775L (fi) 2-piperazinonfoereningar, deras framstaellning och anvaendning
FI910665A7 (fi) Foerfarande och anordning foer emballering av rullar, i synnerhet pappersrullar, med foerpackningsomslag.
FI923143L (fi) Homogeniska, stabila och flytande vattenblandningar och anvaendning av naemnda blandningar foer framstaellning av dispersioner av i vatten oloesliga substanser
FI925924L (fi) Hydrerat staerkelsehydrolysat med laog kariesframkallande effekt, foerfarande foer framstaellning av detta och tillaempningen av detta hydrolysat
FI922721A0 (fi) Ammunitionskomponent med laog skade- egenskaper, med en tvaokomponentig explosionsladdning och foerfarande foer uppnaoende av en fragmentationseffekt.
FI920732L (fi) 2-substituerade kinoliner, foerfarande foer framstaellning av dessa och anvaendning av dessa i laekemedel
FI921049L (fi) Hydrazonderivat, deras framstaellning och anvaendning
FI922875L (fi) Foereningar med reninhaemmande egenskaper, foerfarande foer deras framstaellning och deras anvaendning
FI924617A7 (fi) Anordning foer viktinstaellning av instaellning av sittyta och ryggstoed istolar, saerskilt byrosvaengstolar
FI922390L (fi) Initiatorsuspensioner, deras framstaellning och anvaendning
FI923755L (fi) Disulfider, foerfarande foer framstaellning av dessa och anvaendning av dessa
FI923168L (fi) Sammansaettning haerstammande fraon baernstensglykan, framstaellningsfoerfarande och tillaempningar
FI920720A7 (fi) 4-pyrimidinonderivat, framstaellning av dessa och anvaendning av dessa iterapi

Legal Events

Date Code Title Description
FD Application lapsed