FI92334B - Förfarande för producering av cyklosporiner och ny Tolypocladium-stam användbar i förfarandet - Google Patents

Förfarande för producering av cyklosporiner och ny Tolypocladium-stam användbar i förfarandet Download PDF

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Publication number
FI92334B
FI92334B FI925940A FI925940A FI92334B FI 92334 B FI92334 B FI 92334B FI 925940 A FI925940 A FI 925940A FI 925940 A FI925940 A FI 925940A FI 92334 B FI92334 B FI 92334B
Authority
FI
Finland
Prior art keywords
tolypocladium
cyclosporin
strain
cyclosporins
lea3
Prior art date
Application number
FI925940A
Other languages
English (en)
Finnish (fi)
Other versions
FI925940A0 (sv
FI92334C (sv
Inventor
Timo Korpela
Anja Kopio
Juhani Lundell
Matti Ankelo
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of FI925940A0 publication Critical patent/FI925940A0/sv
Priority to FI925940A priority Critical patent/FI92334C/sv
Priority to US08/020,545 priority patent/US5409816A/en
Priority to PT94902795T priority patent/PT677116E/pt
Priority to HU9501951A priority patent/HU217683B/hu
Priority to SG1996005777A priority patent/SG49072A1/en
Priority to KR1019950702677A priority patent/KR100283503B1/ko
Priority to RU95114383A priority patent/RU2112807C1/ru
Priority to ES94902795T priority patent/ES2150980T3/es
Priority to JP51571394A priority patent/JP3530531B2/ja
Priority to DE69329500T priority patent/DE69329500T2/de
Priority to CA002152963A priority patent/CA2152963C/en
Priority to EP94902795A priority patent/EP0677116B1/en
Priority to PCT/FI1993/000568 priority patent/WO1994016091A1/en
Priority to DK94902795T priority patent/DK0677116T3/da
Priority to AU57014/94A priority patent/AU674723B2/en
Priority to PL93309613A priority patent/PL177023B1/pl
Priority to AT94902795T priority patent/ATE196655T1/de
Publication of FI92334B publication Critical patent/FI92334B/sv
Application granted granted Critical
Publication of FI92334C publication Critical patent/FI92334C/sv
Priority to EE9400184A priority patent/EE03114B1/xx
Priority to HK98115143A priority patent/HK1014035A1/xx
Priority to GR20000402825T priority patent/GR3035139T3/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Claims (4)

1. Förfarande för att producera cyklosporiner, speciellt cyklosporin A, kännetecknat därav, att stam- 5 men LeA3 med depositionsnummer CBS 630.92, av en ny Toly-pocladium sp. -art odlas aerobt vid en temperatur av 20 -30 °C i en näringslösning, soin innehäller kolkällor, kvä-vekällor samt mineralsalter, och, om sä önskas, separeras och renas de bildade cyklosporinerna. 10
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man använder melass säsom kolkälla och sojamjöl säsom kvävekälla. 15
3. Förfarande enligt patentkravet 1, känneteck nat därav, att man använder sackaros säsom kolkälla och bomullsfrömjöl säsom kvävekälla.
4. Tolypocladium sp. LeA3 -stam med depositionsnummer CBS 20 630.92.
FI925940A 1992-12-30 1992-12-30 Förfarande för producering av cyklosporiner och ny Tolypocladium-stam användbar i förfarandet FI92334C (sv)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FI925940A FI92334C (sv) 1992-12-30 1992-12-30 Förfarande för producering av cyklosporiner och ny Tolypocladium-stam användbar i förfarandet
US08/020,545 US5409816A (en) 1992-12-30 1993-02-22 Process for producing immunosuppressives and a novel microbial species to be employed therein
CA002152963A CA2152963C (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein
DK94902795T DK0677116T3 (da) 1992-12-30 1993-12-29 Fremgangsmåde til fremstilling af immunosuppressive midler og en ny mikroorganismeart til anvendelse deri
SG1996005777A SG49072A1 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein
KR1019950702677A KR100283503B1 (ko) 1992-12-30 1993-12-29 면역억제제의 제조방법 및 이에 사용되는 신규 미생물
RU95114383A RU2112807C1 (ru) 1992-12-30 1993-12-29 Способ получения иммунодепрессанта циклоспорина а и штамм tolypocladium species свs630.92, продуцирующий циклоспорин а
ES94902795T ES2150980T3 (es) 1992-12-30 1993-12-29 Un procedimiento para producir inmunosupresores y una nueva especie microbiana a emplear en el mismo.
JP51571394A JP3530531B2 (ja) 1992-12-30 1993-12-29 免疫抑制剤の製造方法およびそれに使用される新規微生物種
DE69329500T DE69329500T2 (de) 1992-12-30 1993-12-29 Ein verfahren zur herstellung von immunosuppressiva und eine neuartige mikrobielle spezies, die dabei eingesetzt wird
PT94902795T PT677116E (pt) 1992-12-30 1993-12-29 Processo para a producao de imuno-supressores e uma nova especie microbiana a ser utilizada para esse fim
EP94902795A EP0677116B1 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein
PCT/FI1993/000568 WO1994016091A1 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein
HU9501951A HU217683B (hu) 1992-12-30 1993-12-29 Eljárás Cyclosporin A előállítására és az eljárásnál alkalmazott új mikrobafaj
AU57014/94A AU674723B2 (en) 1992-12-30 1993-12-29 A process for producing immunosuppressives and a novel microbial species to be employed therein
PL93309613A PL177023B1 (pl) 1992-12-30 1993-12-29 Sposób wytwarzania cyklosporyny A
AT94902795T ATE196655T1 (de) 1992-12-30 1993-12-29 Ein verfahren zur herstellung von immunosuppressiva und eine neuartige mikrobielle spezies, die dabei eingesetzt wird
EE9400184A EE03114B1 (et) 1992-12-30 1994-11-16 Meetod tsüklosporiin A tootmiseks
HK98115143A HK1014035A1 (en) 1992-12-30 1998-12-23 A process for producing immunosuppressives and a novel microbial species to be employed therein
GR20000402825T GR3035139T3 (en) 1992-12-30 2000-12-22 A process for producing immunosuppressives and a novel microbial species to be employed therein.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI925940 1992-12-30
FI925940A FI92334C (sv) 1992-12-30 1992-12-30 Förfarande för producering av cyklosporiner och ny Tolypocladium-stam användbar i förfarandet

Publications (3)

Publication Number Publication Date
FI925940A0 FI925940A0 (sv) 1992-12-30
FI92334B true FI92334B (sv) 1994-07-15
FI92334C FI92334C (sv) 1994-10-25

Family

ID=8536483

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925940A FI92334C (sv) 1992-12-30 1992-12-30 Förfarande för producering av cyklosporiner och ny Tolypocladium-stam användbar i förfarandet

Country Status (20)

Country Link
US (1) US5409816A (sv)
EP (1) EP0677116B1 (sv)
JP (1) JP3530531B2 (sv)
KR (1) KR100283503B1 (sv)
AT (1) ATE196655T1 (sv)
AU (1) AU674723B2 (sv)
CA (1) CA2152963C (sv)
DE (1) DE69329500T2 (sv)
DK (1) DK0677116T3 (sv)
EE (1) EE03114B1 (sv)
ES (1) ES2150980T3 (sv)
FI (1) FI92334C (sv)
GR (1) GR3035139T3 (sv)
HK (1) HK1014035A1 (sv)
HU (1) HU217683B (sv)
PL (1) PL177023B1 (sv)
PT (1) PT677116E (sv)
RU (1) RU2112807C1 (sv)
SG (1) SG49072A1 (sv)
WO (1) WO1994016091A1 (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
KR100360675B1 (ko) * 1995-02-28 2003-01-14 내셔널 리서어치 디벨럽먼트 코포레이션 사이클로스포린a제조방법
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
HU223054B1 (hu) * 1997-03-25 2004-03-01 BIOGAL Gyógyszergyár Rt. Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
KR100496929B1 (ko) * 1997-03-25 2005-09-30 테바 기오기스제르갸르 레스즈베니타르사사그 시클로스포린의정제방법
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
NZ502362A (en) 1997-10-08 2001-05-25 Isotechnika Inc Deuterated cyclosporine A derivatives and their use as immunomodulating agents
AU769429C (en) 1998-12-30 2004-10-28 Dexcel Limited Dispersible concentrate for the delivery of cyclosporin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
CA2396381A1 (en) * 2000-01-20 2001-07-26 Akira Yanagawa Nasally administrable cyclic peptide compositions
ATE306558T1 (de) * 2000-02-29 2005-10-15 Biocon Ltd Herstellung und reinigung von cyclosporin-a
WO2003033526A2 (en) * 2001-10-19 2003-04-24 Isotechnika Inc. Synthesis of cyclosporin analogs
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2151450A1 (de) 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
US10945443B2 (en) 2017-09-29 2021-03-16 Valent Biosciences Llc Tolypocladium album strain
RU2679051C1 (ru) * 2018-02-16 2019-02-05 Федеральное государственное учреждение Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук Штамм streptomyces hygroscopicus bkm ac-2737d - продуцент антибиотика рапамицина и способ увеличения его продуктивности

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE295870C (sv) *
US3878047A (en) * 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
DD298276A5 (de) * 1988-10-11 1992-02-13 Institut Fuer Mikrobiologie Und Experimentelle Therapie,De Verfahren zur herstellung von cyclosporin a
DD295870A5 (de) * 1988-10-11 1991-11-14 Arzneimittelwerk Dresden Gmbh,De Verfahren zur mikrobiellen gewinnung von cyclosporinen
HU201577B (en) * 1988-12-20 1990-11-28 Gyogyszerkutato Intezet Process for producing cyclosporin antibiotics
WO1992013094A1 (fr) * 1991-01-25 1992-08-06 Fujisawa Pharmaceutical Co., Ltd. Procede pour produire de la cyclosporine a et/ou c
ES2078374T3 (es) * 1991-04-06 1995-12-16 Dresden Arzneimittel Procedimiento para la produccion por fermentacion y aislamiento de ciclosporina a, y nuevas cepas formadoras de ciclosporina.

Also Published As

Publication number Publication date
CA2152963A1 (en) 1994-07-21
DE69329500D1 (de) 2000-11-02
HU9501951D0 (en) 1995-08-28
PT677116E (pt) 2001-01-31
FI925940A0 (sv) 1992-12-30
ES2150980T3 (es) 2000-12-16
HU217683B (hu) 2000-03-28
ATE196655T1 (de) 2000-10-15
WO1994016091A1 (en) 1994-07-21
AU674723B2 (en) 1997-01-09
US5409816A (en) 1995-04-25
EE03114B1 (et) 1998-08-17
RU2112807C1 (ru) 1998-06-10
PL177023B1 (pl) 1999-09-30
SG49072A1 (en) 1998-05-18
CA2152963C (en) 2003-05-27
EP0677116B1 (en) 2000-09-27
HK1014035A1 (en) 1999-09-17
PL309613A1 (en) 1995-10-30
KR100283503B1 (ko) 2001-03-02
JP3530531B2 (ja) 2004-05-24
AU5701494A (en) 1994-08-15
KR960700346A (ko) 1996-01-19
JPH08505059A (ja) 1996-06-04
HUT72702A (en) 1996-05-28
DK0677116T3 (da) 2000-12-27
FI92334C (sv) 1994-10-25
EP0677116A1 (en) 1995-10-18
GR3035139T3 (en) 2001-04-30
DE69329500T2 (de) 2001-06-07

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Owner name: SANTEN OY

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