FI91638B - Förfarande för framställning av tetracykliska antidepressionsmedel - Google Patents
Förfarande för framställning av tetracykliska antidepressionsmedel Download PDFInfo
- Publication number
- FI91638B FI91638B FI893901A FI893901A FI91638B FI 91638 B FI91638 B FI 91638B FI 893901 A FI893901 A FI 893901A FI 893901 A FI893901 A FI 893901A FI 91638 B FI91638 B FI 91638B
- Authority
- FI
- Finland
- Prior art keywords
- cis
- general formula
- compounds
- oxepino
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (8)
1. Analogiförfarande för framställning av terapeu-tiskt användbara tetracykliska föreningar med den allmänna 5 formeln I "Λ· där
15 R1 betecknar en eller tvä substituenter, vilka är lika eller olika och betecknar väte, hydroxi, halogen, C^-alkyl eller C.,_4-alkoxi; R2 betecknar en eller tvä substituenter, vilka är lika eller olika och betecknar väte, hydroxi, halogen,
20 C^-alkyl eller C^-alkoxi; R3 och R4 är tvä substituenter, vilka föreligger i cis-konfiguration och av vilka den ena är H och den andra är OH; R5 är H eller C^-alkyl; '25 X är O eller S; och n är 0 eller 1; eller funktionella derivat därav, kännetecknat därav, att a) en förening, som har den allmänna formeln V 30 Rl'Ti?V'Xvif^V'r2
35 Mjj-NER5 i 91638 där R1, Rz, R5, n och X betecknar satama som ovan, eller ett sait därav kondenseras i en reaktion med formaldehyd eller en formaldehyd-källa, eller b) en förening, som har den allmänna formeln VI hA A OH 10 «-VV ° VI R5 där R1, R2, R5, n och X betecknar samma som ovan, reduceras, och den sk erhällna föreningen eventuellt omvandlas 15 tili kväveoxid, ett farmaceutiskt godtagbart sait, en O-acyl-c^jQ-ester eller ett kvaternärt ammoniumderivat.
2. Förfarande enligt patentkravet 1, känne-t e c k n a t därav, att man framställer en förening, som har den allmänna formeln II 20 „ “H" Hr\ I3: R5 där R1, R2, R5 och n betecknar samma som ovan, eller ett 30 funktionellt derivat därav.
3. Förfarande enligt patentkravet 1, k ä n n e -t e c k n a t därav, att man framställer en förening, som har formeln III II 35 91638 CH n 0r°iS
5 HO*)- \ / 111 10 eller ett funktionellt derivat därav.
4. Förfarande enligt patentkravet 1, kanne-t e c k n a t därav, att man framställer en förening, som har formeln IV ch3 15 Qf'P 20 ch3 eller ett funktionellt derivat därav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8802109 | 1988-08-26 | ||
| NL8802109 | 1988-08-26 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI893901A0 FI893901A0 (sv) | 1989-08-18 |
| FI893901A FI893901A (sv) | 1990-02-27 |
| FI91638B true FI91638B (sv) | 1994-04-15 |
| FI91638C FI91638C (sv) | 1994-07-25 |
Family
ID=19852805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI893901A FI91638C (sv) | 1988-08-26 | 1989-08-18 | Förfarande för framställning av tetracykliska antidepressionsmedel |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4977158A (sv) |
| EP (1) | EP0357126B1 (sv) |
| JP (1) | JP2521157B2 (sv) |
| KR (1) | KR900003177A (sv) |
| AT (1) | ATE104981T1 (sv) |
| AU (1) | AU618392B2 (sv) |
| CA (1) | CA1325807C (sv) |
| DE (1) | DE68914917T2 (sv) |
| DK (1) | DK415789A (sv) |
| ES (1) | ES2056194T3 (sv) |
| FI (1) | FI91638C (sv) |
| IE (1) | IE62754B1 (sv) |
| MX (1) | MX9203809A (sv) |
| NZ (1) | NZ230128A (sv) |
| PT (1) | PT91555B (sv) |
| ZA (1) | ZA895623B (sv) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0726265T3 (da) * | 1995-02-08 | 2001-10-22 | Novartis Ag | 10-Aminoaliphatyl-dibenz[b,f]oxepiner med antineurodegenerativ virkning |
| AU2418499A (en) * | 1997-12-19 | 1999-07-12 | Akzo Nobel N.V. | Org-5222 in the treatment of depression |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020440B1 (en) | 2002-05-21 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof |
| HRP20020452A2 (en) | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| JP5245428B2 (ja) * | 2007-07-06 | 2013-07-24 | 住友化学株式会社 | トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体 |
| US20090233959A1 (en) * | 2008-02-19 | 2009-09-17 | Adolor Corporation | Beloxepin and analogs for the treatment of pain |
| MX2010009110A (es) * | 2008-02-19 | 2010-11-30 | Adolor Corp | Beloxepina, sus enantiomeros, y analogos de la misma para el tratamiento de dolor. |
| US20090233958A1 (en) * | 2008-02-19 | 2009-09-17 | Adolor Corporation | (+)-beloxepin and methods for its synthesis and use |
| US20090233957A1 (en) * | 2008-02-19 | 2009-09-17 | Adolor Corporation | (-)-beloxepin and methods for its synthesis and use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271177A (en) * | 1976-05-24 | 1981-06-02 | Akzona Incorporated | 2,3,3a,12b-Tetrahydro-1H-dibenzo[2,3;6,7]thiepino[4,5-c]pyrroles and pharmaceutical use thereof |
| US4158059A (en) * | 1976-05-24 | 1979-06-12 | Akzona Incorporated | Tension reducing 2,3,4,4a,9,136-hexahydro-dibenz[1,2;5,6]cyclohepta[3,4-c]py |
| US4271179A (en) * | 1976-05-24 | 1981-06-02 | Akzona Incorporated | 1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof |
| NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| WO1988000049A1 (en) * | 1986-06-26 | 1988-01-14 | Kyowa Hakko Kogyo Co., Ltd. | Antiarrhythmic agent |
-
1989
- 1989-07-20 IE IE236389A patent/IE62754B1/en not_active IP Right Cessation
- 1989-07-24 ZA ZA895623A patent/ZA895623B/xx unknown
- 1989-07-28 NZ NZ230128A patent/NZ230128A/xx unknown
- 1989-08-15 CA CA000608326A patent/CA1325807C/en not_active Expired - Fee Related
- 1989-08-17 AT AT8989202105T patent/ATE104981T1/de active
- 1989-08-17 DE DE68914917T patent/DE68914917T2/de not_active Expired - Lifetime
- 1989-08-17 ES ES89202105T patent/ES2056194T3/es not_active Expired - Lifetime
- 1989-08-17 EP EP89202105A patent/EP0357126B1/en not_active Expired - Lifetime
- 1989-08-18 FI FI893901A patent/FI91638C/sv not_active IP Right Cessation
- 1989-08-18 AU AU40022/89A patent/AU618392B2/en not_active Ceased
- 1989-08-23 DK DK415789A patent/DK415789A/da not_active Application Discontinuation
- 1989-08-23 US US07/397,228 patent/US4977158A/en not_active Expired - Fee Related
- 1989-08-25 JP JP1220140A patent/JP2521157B2/ja not_active Expired - Lifetime
- 1989-08-25 KR KR1019890012102A patent/KR900003177A/ko not_active Application Discontinuation
- 1989-08-25 PT PT91555A patent/PT91555B/pt not_active IP Right Cessation
-
1992
- 1992-06-29 MX MX9203809A patent/MX9203809A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE892363L (en) | 1990-02-26 |
| FI91638C (sv) | 1994-07-25 |
| FI893901A (sv) | 1990-02-27 |
| EP0357126B1 (en) | 1994-04-27 |
| DK415789A (da) | 1990-02-27 |
| MX9203809A (es) | 1992-07-01 |
| NZ230128A (en) | 1990-10-26 |
| AU618392B2 (en) | 1991-12-19 |
| DE68914917T2 (de) | 1994-08-11 |
| JP2521157B2 (ja) | 1996-07-31 |
| IE62754B1 (en) | 1995-02-22 |
| PT91555A (pt) | 1990-03-08 |
| PT91555B (pt) | 1995-05-04 |
| FI893901A0 (sv) | 1989-08-18 |
| ZA895623B (en) | 1990-05-30 |
| CA1325807C (en) | 1994-01-04 |
| EP0357126A1 (en) | 1990-03-07 |
| JPH02111776A (ja) | 1990-04-24 |
| DE68914917D1 (de) | 1994-06-01 |
| ATE104981T1 (de) | 1994-05-15 |
| US4977158A (en) | 1990-12-11 |
| ES2056194T3 (es) | 1994-10-01 |
| AU4002289A (en) | 1990-03-01 |
| DK415789D0 (da) | 1989-08-23 |
| KR900003177A (ko) | 1990-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: AKZO N.V. |