FI912013A - Menetelmä terapeuttisesti käyttökelpoisten heksahydro-2,5 -metano-1H-3a ,6a -syklopenta/c/pyrroli ja heksahydro-2,5 -etano-1H-3a ,6a -syklopenta/c/pyrroliyhdisteiden valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten heksahydro-2,5 -metano-1H-3a ,6a -syklopenta/c/pyrroli ja heksahydro-2,5 -etano-1H-3a ,6a -syklopenta/c/pyrroliyhdisteiden valmistamiseksi Download PDF

Info

Publication number
FI912013A
FI912013A FI912013A FI912013A FI912013A FI 912013 A FI912013 A FI 912013A FI 912013 A FI912013 A FI 912013A FI 912013 A FI912013 A FI 912013A FI 912013 A FI912013 A FI 912013A
Authority
FI
Finland
Prior art keywords
cyclopenta
hexahydro
pyrrole
etano
methano
Prior art date
Application number
FI912013A
Other languages
English (en)
Swedish (sv)
Other versions
FI94530C (fi
FI94530B (fi
FI912013A0 (fi
Inventor
Daniel Paul Becker
Daniel Lee Flynn
Roger Nosal
Dale P Spangler
Daniel Lamar Zabrowski
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of FI912013A0 publication Critical patent/FI912013A0/fi
Publication of FI912013A publication Critical patent/FI912013A/fi
Application granted granted Critical
Publication of FI94530B publication Critical patent/FI94530B/fi
Publication of FI94530C publication Critical patent/FI94530C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
FI912013A 1990-04-27 1991-04-25 Menetelmä terapeuttisesti käyttökelpoisten heksahydro-2,5 -metano-1H-3a ,6a -syklopenta/c/pyrroli ja heksahydro-2,5 -etano-1H-3a ,6a -syklopenta/c/pyrroliyhdisteiden valmistamiseksi FI94530C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51539190A 1990-04-27 1990-04-27
US51539190 1990-04-27
US07/682,993 US5140023A (en) 1990-04-27 1991-04-12 Azatetracycle compounds
US68299391 1991-04-12

Publications (4)

Publication Number Publication Date
FI912013A0 FI912013A0 (fi) 1991-04-25
FI912013A true FI912013A (fi) 1991-10-28
FI94530B FI94530B (fi) 1995-06-15
FI94530C FI94530C (fi) 1995-09-25

Family

ID=27058488

Family Applications (1)

Application Number Title Priority Date Filing Date
FI912013A FI94530C (fi) 1990-04-27 1991-04-25 Menetelmä terapeuttisesti käyttökelpoisten heksahydro-2,5 -metano-1H-3a ,6a -syklopenta/c/pyrroli ja heksahydro-2,5 -etano-1H-3a ,6a -syklopenta/c/pyrroliyhdisteiden valmistamiseksi

Country Status (18)

Country Link
US (2) US5140023A (fi)
EP (1) EP0454121B1 (fi)
JP (1) JP3145728B2 (fi)
KR (1) KR0183423B1 (fi)
AT (1) ATE145207T1 (fi)
AU (1) AU630555B2 (fi)
CA (1) CA2041224C (fi)
DE (1) DE69123076T2 (fi)
DK (1) DK0454121T3 (fi)
ES (1) ES2094166T3 (fi)
FI (1) FI94530C (fi)
GR (1) GR3021607T3 (fi)
IE (1) IE76450B1 (fi)
IL (1) IL97952A0 (fi)
NO (1) NO178765C (fi)
NZ (1) NZ237948A (fi)
PT (1) PT97486B (fi)
ZA (1) ZA913135B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234921A (en) * 1991-03-07 1993-08-10 G. D. Searle & Co. Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals
US5516782A (en) * 1991-03-07 1996-05-14 G. D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
EP0528026A1 (en) * 1991-03-07 1993-02-24 G.D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5280028A (en) * 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
GB9214184D0 (en) * 1992-07-03 1992-08-12 Smithkline Beecham Plc Pharmaceuticals
US5840903A (en) * 1992-07-27 1998-11-24 G. D. Searle & Co. 4-aminomethyl-1-azaadamantane derived benzamides
US5354757A (en) * 1992-12-15 1994-10-11 G. D. Searle & Co. Azanoradamantanes
US5650535A (en) * 1994-06-30 1997-07-22 G. D. Searle & Co. Process for the preparation of azanoradamantane benzamides
JP2000026311A (ja) * 1998-07-02 2000-01-25 Amano Pharmaceut Co Ltd 胃排出能亢進剤組成物
US6451806B2 (en) 1999-09-29 2002-09-17 Adolor Corporation Methods and compositions involving opioids and antagonists thereof
US6469030B2 (en) 1999-11-29 2002-10-22 Adolor Corporation Methods for the treatment and prevention of ileus
US6638928B1 (en) * 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
GB0321091D0 (en) * 2003-09-09 2003-10-08 Alizyme Therapeutics Ltd Synthesis
ES2576643T3 (es) 2007-03-09 2016-07-08 Second Genome, Inc. Compuestos de bicicloheteroarilo como moduladores de P2X7 y usos de los mismos
CA2679870A1 (en) * 2007-03-23 2008-10-02 Abbott Laboratories Azaadamantane ester and carbamate derivatives and methods of use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
GB2111479A (en) * 1981-10-01 1983-07-06 Beecham Group Plc Benzamides
EP0093488A3 (en) * 1982-03-18 1984-05-23 Beecham Group Plc Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
NZ203861A (en) * 1982-04-14 1986-07-11 Beecham Group Plc Bicyclic heterocyclic compounds and pharmaceutical compositions containing such
FI74707C (fi) * 1982-06-29 1988-03-10 Sandoz Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
BG48681A3 (en) * 1982-12-14 1991-04-15 Ciba Geigy Ag Fungicide means
DE3429830A1 (de) * 1983-08-26 1985-03-07 Sandoz-Patent-GmbH, 7850 Lörrach Automatische carbonsaeure- und sulfonsaeureester oder -amide
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
EP0189002B1 (en) * 1984-12-20 1993-03-03 Sandoz Ag Treatment of gastrointestinal disorders using 5-ht3 antagonists
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
EP0405617A3 (en) * 1985-03-14 1992-11-25 Beecham Group P.L.C. Medicaments for the treatment of anxiety
GB8523211D0 (en) * 1985-09-19 1985-10-23 Beecham Group Plc Compounds
EP0220011A3 (en) * 1985-10-12 1990-01-03 Beecham Group Plc Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
DE3687980T2 (de) * 1986-01-07 1993-06-17 Beecham Group Plc Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
EP0235878A3 (en) * 1986-01-16 1989-06-14 Beecham Group Plc Novel compounds
DE3850742T2 (de) * 1987-11-04 1994-10-27 Beecham Group Plc Neue 4-Oxobenzotriazine und 4-Oxochinazoline.
IE63474B1 (en) * 1987-12-24 1995-04-19 Wyeth John & Brother Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
CA2041224C (en) 2002-07-09
IE76450B1 (en) 1997-10-22
ATE145207T1 (de) 1996-11-15
KR0183423B1 (ko) 1999-05-01
FI94530C (fi) 1995-09-25
JPH04225979A (ja) 1992-08-14
DK0454121T3 (da) 1996-12-02
NZ237948A (en) 1994-05-26
EP0454121A2 (en) 1991-10-30
EP0454121B1 (en) 1996-11-13
NO911648L (no) 1991-10-28
PT97486A (pt) 1992-01-31
USRE35218E (en) 1996-04-23
GR3021607T3 (en) 1997-02-28
IL97952A0 (en) 1992-06-21
FI94530B (fi) 1995-06-15
IE911420A1 (en) 1991-11-06
DE69123076T2 (de) 1997-04-03
NO178765B (no) 1996-02-19
KR910018382A (ko) 1991-11-30
NO178765C (no) 1996-05-29
AU7595191A (en) 1991-11-07
US5140023A (en) 1992-08-18
FI912013A0 (fi) 1991-04-25
JP3145728B2 (ja) 2001-03-12
CA2041224A1 (en) 1991-10-28
EP0454121A3 (en) 1992-07-08
NO911648D0 (no) 1991-04-25
DE69123076D1 (de) 1996-12-19
ES2094166T3 (es) 1997-01-16
AU630555B2 (en) 1992-10-29
ZA913135B (en) 1992-07-29
PT97486B (pt) 1998-08-31

Similar Documents

Publication Publication Date Title
FI912013A (fi) Menetelmä terapeuttisesti käyttökelpoisten heksahydro-2,5 -metano-1H-3a ,6a -syklopenta/c/pyrroli ja heksahydro-2,5 -etano-1H-3a ,6a -syklopenta/c/pyrroliyhdisteiden valmistamiseksi
FI102069B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi
FI904730A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo-/2,3-b/indoli-5-yylimorfolinyyli- ja piperidinyylikarbamaatin valmistamiseksi
HUT65618A (en) Process for producing benzylidene-carbamoyl-2-pyrrolidone, -4-oxazolidinone, -4-thiazolidinone and -3-isothiazolidinone analogues
FI943363A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten /1,4/oksatsino/3,4-a//2/bentsatsepiinijohdannaisten valmistamiseksi
FI894169A (fi) Menetelmä valmistaa farmakologisesti arvokasta pyrrolo/3,2,1-jk//1,4/bentsodiatsepiinijohdannaista
YU47121B (sh) Postupak za dobijanje 2-3-dideoksi-2-fluoro-nukleozid'a
PL308545A1 (en) Novel substituted azethydinones as anti-inflammatory and anti-degenerative agents
FI884345A0 (fi) Sackaridderivat.
DK325188D0 (da) Hidtil ukendte benzazepinderivater
FI893682A (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,5-ditiatsosiinijohdannaisten valmistamiseksi
HU906010D0 (en) New substituted alkyl-piperidine derivatives
FI910448A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3b/indolijohdannaisten valmistamiseksi
NZ229300A (en) Substituted-2-ethenyl-3,4,5,6-tetrahydrothieno (4,3,2-cf)(3)benzazepine derivatives and pharmaceutical compositions
PT889044E (pt) Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central
DK0381114T3 (da) Exo-3,4-O-benzyliden-3"-demethylchartreusin og salte deraf
EP0717045A4 (en) METHOD FOR PRODUCING INDOLOCARBAZOL DERIVATIVES
FI912247A (fi) Menetelmä terapeuttisesti käyttökelpoisten pyrrolo/2,3-b/indoliketonijohdannaisten valmistamiseksi
ES2159087T3 (es) Oxindoles sustituidos con adamantilo como agentes farmaceuticos.
ZA885360B (en) Novel(aryl or heteroaromatic methyl)-2,2'-bi-1h-imidazoles

Legal Events

Date Code Title Description
BB Publication of examined application
MA Patent expired