FI90988B - Monoklonala antikroppar mot natridiuretiska, atriala peptider hos däggdjur - Google Patents
Monoklonala antikroppar mot natridiuretiska, atriala peptider hos däggdjur Download PDFInfo
- Publication number
- FI90988B FI90988B FI861128A FI861128A FI90988B FI 90988 B FI90988 B FI 90988B FI 861128 A FI861128 A FI 861128A FI 861128 A FI861128 A FI 861128A FI 90988 B FI90988 B FI 90988B
- Authority
- FI
- Finland
- Prior art keywords
- monoclonal antibodies
- peptides
- antibodies according
- anp
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (9)
1. Monoklonala antikroppar, känneteck- n a d e därav, att de framställts mot natridiuretiska, 5 atriala peptider hos däggdjur, att de inte korsreagerar med angiotensin II, leu-enkefalin, substans P, aldosteron, ACTH, bradykinin, gamma-MSH, insulin, vasopressin och renin och att de kan framställas genom att odla en hybridom-cellinje NCACC 850 314/1 eller NCACC 850 314/2 i ett lämp- 10 ligt odlingsmedium och genom att tillvarata antikropparna frän supematantet.
2. Monoklonala antikroppar enligt patentkrav 1, kännetecknade därav, att de framställts mot natridiuretiska, atriala peptider hos rättor.
3. Monoklonala antikroppar enligt patentkrav 1, kännetecknade därav, att de framställts mot natridiuretiska, atriala peptider hos människan.
4. Hybridomcellinjer, kännetecknade därav, att de producerar monoklonala antikroppar enligt 20 nägot av patentkraven 1-3 och att de har NCACC-deposi-tionsnumren 850 314/1 och 850 314/2.
5. Förfarande för framställning av monoklonala antikroppar enligt nägot av patentkraven 1-3, känne-t e c k n a t därav, att cellinjema enligt patentkrav 25. odlas i ett lämpllgt odlingsmedium och att antikropparna tillvaratas frän supematantet eller att hybridomceller injekteras i syngena eller semisyngena möss och att antikropparna tillvaratas frän blod eller bukhälans askites-vätska.
6. Användning av monoklonala antikroppar enligt nägot av patentkraven 1-3 vid bestämning av natridiuretiska, atriala peptider in vitro ur biologiska vätskor.
7. Användning av monoklonala antikroppar enligt nägot av patentkraven 1-3 vid bestämning av natridiure- 35 tiska, atriala peptider in vitro ur blod, plasma, serum, urin, lymfa eller benmärgsvätska.
8. Användning av monoklonala antikroppar enligt nägot av patentkraven 1-3 vid framställning av immun-analyser.
9. Användning av monoklonala antikroppar enligt 5 nägot av patentkraven 1-3 vid isolering av natridiure- tiska, atriala peptider med hjälp av inununadsorptionskro-matografi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3509958 | 1985-03-20 | ||
| DE19853509958 DE3509958A1 (de) | 1985-03-20 | 1985-03-20 | Monoklonale antikoerper gegen atriale, natriuretische peptide vom menschen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI861128A0 FI861128A0 (sv) | 1986-03-18 |
| FI861128A FI861128A (sv) | 1986-09-21 |
| FI90988B true FI90988B (sv) | 1994-01-14 |
| FI90988C FI90988C (sv) | 1994-04-25 |
Family
ID=6265723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI861128A FI90988C (sv) | 1985-03-20 | 1986-03-18 | Monoklonala antikroppar mot natridiuretiska, atriala peptider hos däggdjur |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5156977A (sv) |
| EP (1) | EP0195331B1 (sv) |
| JP (2) | JPH0648994B2 (sv) |
| KR (1) | KR940010021B1 (sv) |
| CN (1) | CN1017349B (sv) |
| AT (1) | ATE75754T1 (sv) |
| AU (1) | AU570838B2 (sv) |
| CA (1) | CA1340391C (sv) |
| DE (2) | DE3509958A1 (sv) |
| DK (1) | DK165955C (sv) |
| ES (1) | ES8801945A1 (sv) |
| FI (1) | FI90988C (sv) |
| GR (1) | GR860732B (sv) |
| IL (1) | IL78172A (sv) |
| NO (1) | NO170692C (sv) |
| PT (1) | PT82215B (sv) |
| ZA (1) | ZA862029B (sv) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335082C (en) * | 1987-09-01 | 1995-04-04 | Hiroo Imura | Monoclonal antibody recognizing -hanp and a reagent for immunoassay of -hanp |
| JP2724315B2 (ja) * | 1988-02-29 | 1998-03-09 | 塩野義製薬株式会社 | α−ＡＮＰを認識するモノクローナル抗体およびα−ＡＮＰの免疫学的測定法 |
| CA1339210C (en) * | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
| JP2561513B2 (ja) * | 1988-07-04 | 1996-12-11 | 塩野義製薬株式会社 | γ−ＡＮＰを認識するモノクローナル抗体 |
| JP2665850B2 (ja) * | 1991-11-14 | 1997-10-22 | 塩野義製薬株式会社 | ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体 |
| AU2493499A (en) * | 1998-02-03 | 1999-08-16 | Trustees Of Columbia University In The City Of New York, The | Determination of the amount of hlhbeta core fragment in a sample from a subject and uses thereof |
| EP1698901B1 (de) * | 1999-01-29 | 2008-07-30 | Roche Diagnostics GmbH | Verfahren zum Nachweis von N-terminalem proBNP |
| US6949282B2 (en) | 2000-07-07 | 2005-09-27 | Delphi Technologies, Inc. | Contoured crushable composite structural members and methods for making the same |
| US20170363620A1 (en) | 2016-06-17 | 2017-12-21 | Abbott Laboratories | BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4451570A (en) * | 1981-03-26 | 1984-05-29 | The Regents Of The University Of California | Immunoglobulin-secreting human hybridomas from a cultured human lymphoblastoid cell line |
| US4659678A (en) * | 1982-09-29 | 1987-04-21 | Serono Diagnostics Limited | Immunoassay of antigens |
| JPH0794473B2 (ja) * | 1984-03-02 | 1995-10-11 | サントリー株式会社 | 新規なペプチド及びこれを有効成分とする利尿剤 |
| JPS60184098A (ja) * | 1984-03-02 | 1985-09-19 | Suntory Ltd | 新規なペプチド及びこれを有効成分とする利尿剤 |
| US4596769A (en) * | 1984-03-05 | 1986-06-24 | Temple University | Monoclonal antibodies to peptidoglycan and methods of preparing same |
| WO1985004870A1 (en) * | 1984-04-19 | 1985-11-07 | Biotechnology Research Partners, Ltd. | Novel atrial natriuretic/vasodilator polypeptides |
| US4666829A (en) * | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
-
1985
- 1985-03-20 DE DE19853509958 patent/DE3509958A1/de not_active Withdrawn
-
1986
- 1986-03-04 NO NO860804A patent/NO170692C/no not_active IP Right Cessation
- 1986-03-08 EP EP86103100A patent/EP0195331B1/de not_active Expired - Lifetime
- 1986-03-08 AT AT86103100T patent/ATE75754T1/de not_active IP Right Cessation
- 1986-03-08 DE DE8686103100T patent/DE3685145D1/de not_active Expired - Lifetime
- 1986-03-15 CN CN86101671A patent/CN1017349B/zh not_active Expired
- 1986-03-17 IL IL78172A patent/IL78172A/xx unknown
- 1986-03-18 CA CA000504379A patent/CA1340391C/en not_active Expired - Fee Related
- 1986-03-18 PT PT82215A patent/PT82215B/pt not_active IP Right Cessation
- 1986-03-18 FI FI861128A patent/FI90988C/sv not_active IP Right Cessation
- 1986-03-18 AU AU54914/86A patent/AU570838B2/en not_active Expired
- 1986-03-19 ES ES553154A patent/ES8801945A1/es not_active Expired
- 1986-03-19 KR KR1019860002012A patent/KR940010021B1/ko not_active IP Right Cessation
- 1986-03-19 ZA ZA862029A patent/ZA862029B/xx unknown
- 1986-03-19 DK DK127686A patent/DK165955C/da not_active IP Right Cessation
- 1986-03-19 GR GR860732A patent/GR860732B/el unknown
- 1986-03-20 JP JP61061055A patent/JPH0648994B2/ja not_active Expired - Lifetime
-
1989
- 1989-03-14 US US07/323,527 patent/US5156977A/en not_active Expired - Lifetime
-
1994
- 1994-01-14 JP JP6014950A patent/JPH0746999B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: BAYER HEALTHCARE AG |
|
| MA | Patent expired |