FI89927B - Foerfarande foer framstaellning av farmakologiskt anvaendbara vattenloesliga salter av cefemfoereningar - Google Patents

Foerfarande foer framstaellning av farmakologiskt anvaendbara vattenloesliga salter av cefemfoereningar Download PDF

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Publication number
FI89927B
FI89927B FI883696A FI883696A FI89927B FI 89927 B FI89927 B FI 89927B FI 883696 A FI883696 A FI 883696A FI 883696 A FI883696 A FI 883696A FI 89927 B FI89927 B FI 89927B
Authority
FI
Finland
Prior art keywords
cephem
carboxylate
methyl
thiadiazol
isomer
Prior art date
Application number
FI883696A
Other languages
English (en)
Finnish (fi)
Other versions
FI883696A0 (fi
FI89927C (sv
FI883696A (fi
Inventor
Kazuo Sakane
Nobuyoshi Yasuda
Shintaro Nishimura
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878718905A external-priority patent/GB8718905D0/en
Priority claimed from GB878721567A external-priority patent/GB8721567D0/en
Priority claimed from GB878725051A external-priority patent/GB8725051D0/en
Priority claimed from GB878729574A external-priority patent/GB8729574D0/en
Priority claimed from GB888801423A external-priority patent/GB8801423D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of FI883696A0 publication Critical patent/FI883696A0/fi
Publication of FI883696A publication Critical patent/FI883696A/fi
Publication of FI89927B publication Critical patent/FI89927B/fi
Application granted granted Critical
Publication of FI89927C publication Critical patent/FI89927C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

1. Förfarande för framställning av farmakologiskt användbart sait, som innehäller en katjon (katjoner) och en anjon, ooh har formeln Θ OCONH-I -C-CONH-r—f S > V Ä J-A/-R2 or1 coo° där R1 är lägre alkyl eller lägre alkenyl, är en 5 - 10 ledad, mono- eller bicyklisk heterocyklisk grupp, som innehäller en kvaternär kväveatom, som kan uppvisa en karboamoylgrupp, kännetecknat därav, att en cefem-förening med formeln: H2NtlrroNH~rrsXB2 S'" M .0^“ OR1 C0°® där R1 och R2 avser var och en det samma som ovan, eller dess sait omsätts med koldoxid i närvaro av en bas eller kolsyrasalt.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att natrium-7-[2-allyloxiimino-2-(5-karboxyiatoamino- 1,2,4-tiadiazol-3-yl)acetamido]-3-(l-pyridinio)metyl-3-cefem-4-karboxylat (syn-isomer) framstälIs.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att natrium-7-[2-(5-karboxy1atoamino-1,2,4-tiadiazol-3-y1)-2-propy1oxiiminoacetamido]-3-(l-pyridinio)metyl-3-cefem-4-karboxylat (syn-isomer) framställs.
FI883696A 1987-08-10 1988-08-09 Förfarande för framställning av farmakologiskt användbara vattenlöslig a salter av cefemföreningar FI89927C (sv)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB8718905 1987-08-10
GB878718905A GB8718905D0 (en) 1987-08-10 1987-08-10 Salts of new cephem compounds
GB8721567 1987-09-14
GB878721567A GB8721567D0 (en) 1987-09-14 1987-09-14 Salts of cephem compounds
GB878725051A GB8725051D0 (en) 1987-10-26 1987-10-26 Salts of cephem compounds
GB8725051 1987-10-26
GB8729574 1987-12-18
GB878729574A GB8729574D0 (en) 1987-12-18 1987-12-18 Water-soluble antibiotic composition
GB888801423A GB8801423D0 (en) 1988-01-22 1988-01-22 Water-soluble antibiotic composition
GB8801423 1988-01-22

Publications (4)

Publication Number Publication Date
FI883696A0 FI883696A0 (fi) 1988-08-09
FI883696A FI883696A (fi) 1989-02-11
FI89927B true FI89927B (fi) 1993-08-31
FI89927C FI89927C (sv) 1993-12-10

Family

ID=27516755

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883696A FI89927C (sv) 1987-08-10 1988-08-09 Förfarande för framställning av farmakologiskt användbara vattenlöslig a salter av cefemföreningar

Country Status (16)

Country Link
US (1) US5104866A (sv)
EP (1) EP0303223B1 (sv)
JP (1) JP2625937B2 (sv)
KR (1) KR970008127B1 (sv)
AR (1) AR243380A1 (sv)
AU (1) AU616677B2 (sv)
CA (1) CA1338780C (sv)
DE (1) DE3885031T2 (sv)
DK (1) DK445188A (sv)
ES (1) ES2059454T3 (sv)
FI (1) FI89927C (sv)
HU (2) HU210848B (sv)
IE (1) IE61679B1 (sv)
IL (1) IL87364A0 (sv)
NO (1) NO175963C (sv)
PT (1) PT88217B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100572323B1 (ko) 2003-12-11 2006-04-19 삼성전자주식회사 멀티레벨 고전압 발생장치
KR101655961B1 (ko) * 2008-10-31 2016-09-08 시오노기세야쿠 가부시키가이샤 카테콜기를 갖는 세팔로스포린류
JP5852559B2 (ja) * 2010-04-05 2016-02-03 塩野義製薬株式会社 擬似カテコール基を有するセフェム化合物
MX2012011521A (es) 2010-04-05 2013-03-08 Shionogi & Co Compuestos cefem que tienen un grupo catecol.
WO2013036783A2 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
MX2020004205A (es) 2013-03-15 2021-11-16 Merck Sharp & Dohme Llc Composiciones antibioticas de ceftolozano.
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940483A (en) * 1971-02-05 1976-02-24 E. R. Squibb & Sons, Inc. Antibiotic compositions and method
JPS5329936A (en) * 1976-08-31 1978-03-20 Takeda Chem Ind Ltd Antibiotic composition
AU536842B2 (en) * 1978-12-29 1984-05-24 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin antibiotics
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
FR2445833A1 (fr) * 1979-01-04 1980-08-01 Chimie Biolog Nouveaux sels d'antibiotiques amines a cycle beta lactame
US4338313A (en) * 1979-10-12 1982-07-06 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4332800A (en) * 1979-10-12 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4563449A (en) * 1982-07-19 1986-01-07 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ES8502863A1 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IL87364A0 (en) 1989-01-31
DE3885031T2 (de) 1994-02-17
FI883696A0 (fi) 1988-08-09
IE61679B1 (en) 1994-11-16
JPH01110690A (ja) 1989-04-27
KR970008127B1 (ko) 1997-05-21
EP0303223A2 (en) 1989-02-15
NO175963B (no) 1994-10-03
AU2059888A (en) 1989-02-16
CA1338780C (en) 1996-12-10
DK445188A (da) 1989-02-11
NO883530L (no) 1989-02-13
DK445188D0 (da) 1988-08-09
NO175963C (no) 1995-01-11
FI89927C (sv) 1993-12-10
NO883530D0 (no) 1988-08-09
PT88217B (pt) 1995-03-01
HUT47943A (en) 1989-04-28
PT88217A (pt) 1989-06-30
AR243380A1 (es) 1993-08-31
US5104866A (en) 1992-04-14
HU210848B (en) 1995-08-28
HU211940A9 (en) 1996-01-29
IE882365L (en) 1989-02-10
EP0303223A3 (en) 1990-11-28
FI883696A (fi) 1989-02-11
JP2625937B2 (ja) 1997-07-02
ES2059454T3 (es) 1994-11-16
AU616677B2 (en) 1991-11-07
KR890003782A (ko) 1989-04-18
DE3885031D1 (de) 1993-11-25
EP0303223B1 (en) 1993-10-20

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Owner name: FUJISAWA PHARMACEUTICAL CO., LTD.