FI893701A - Förfarande för framställning av antipsykotiska 3-piperazinylbensazolderivat - Google Patents

Förfarande för framställning av antipsykotiska 3-piperazinylbensazolderivat Download PDF

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Publication number
FI893701A
FI893701A FI893701A FI893701A FI893701A FI 893701 A FI893701 A FI 893701A FI 893701 A FI893701 A FI 893701A FI 893701 A FI893701 A FI 893701A FI 893701 A FI893701 A FI 893701A
Authority
FI
Finland
Prior art keywords
preparing
compounds
antipsychotic
piperazinylbenzazole
derivatives
Prior art date
Application number
FI893701A
Other languages
English (en)
Finnish (fi)
Other versions
FI90238B (sv
FI893701A0 (sv
FI90238C (sv
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Josephus Carolus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI893701A0 publication Critical patent/FI893701A0/sv
Publication of FI893701A publication Critical patent/FI893701A/sv
Priority to FI923128A priority Critical patent/FI103406B/sv
Publication of FI90238B publication Critical patent/FI90238B/sv
Application granted granted Critical
Publication of FI90238C publication Critical patent/FI90238C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
FI893701A 1988-08-05 1989-08-04 Förfarande för framställning av antipsykotiska 3-piperazinylbensazolderivat FI90238C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI923128A FI103406B (sv) 1988-08-05 1992-07-07 3-piperazinylbensazolderivat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22841788A 1988-08-05 1988-08-05
US22841788 1988-08-05

Publications (4)

Publication Number Publication Date
FI893701A0 FI893701A0 (sv) 1989-08-04
FI893701A true FI893701A (sv) 1990-02-06
FI90238B FI90238B (sv) 1993-09-30
FI90238C FI90238C (sv) 1994-01-10

Family

ID=22857091

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893701A FI90238C (sv) 1988-08-05 1989-08-04 Förfarande för framställning av antipsykotiska 3-piperazinylbensazolderivat

Country Status (20)

Country Link
EP (1) EP0353821B1 (sv)
JP (1) JP2779216B2 (sv)
KR (1) KR0145706B1 (sv)
CN (1) CN1023602C (sv)
AT (1) ATE122348T1 (sv)
AU (1) AU619877B2 (sv)
CA (1) CA1331609C (sv)
DE (1) DE68922537T2 (sv)
DK (1) DK175124B1 (sv)
ES (1) ES2074462T3 (sv)
FI (1) FI90238C (sv)
HU (1) HU206341B (sv)
IE (1) IE66198B1 (sv)
IL (1) IL91194A (sv)
NO (1) NO176051C (sv)
NZ (1) NZ230045A (sv)
PH (1) PH26550A (sv)
PT (1) PT91364B (sv)
SU (1) SU1687030A3 (sv)
ZA (1) ZA895978B (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
ATE146178T1 (de) * 1991-09-25 1996-12-15 Pfizer Neuroleptisch 2-substituierte perhydro-1h- pyrido(1,2-a>pyrazine
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
EP0794185A4 (en) * 1994-11-25 1998-03-25 Meiji Seika Co BICYCLIC THIAZOLE COMPOUND
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
ATE418542T1 (de) * 2001-03-29 2009-01-15 Schering Corp Als ccr5-antagonisten verwendbare aryloxim- piperazine
CN102164927A (zh) * 2008-09-23 2011-08-24 弗·哈夫曼-拉罗切有限公司 用作多巴胺d3受体调节剂的异唑并[4,5]吡啶-3-基-哌嗪衍生物
US11676855B2 (en) * 2020-02-26 2023-06-13 Taiwan Semiconductor Manufacturing Co., Ltd. Patterning interconnects and other structures by photo-sensitizing method
CN114634479A (zh) * 2020-12-16 2022-06-17 北京盈科瑞创新药物研究有限公司 一种派嗪衍生物、其制备方法及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
HU198036B (en) 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US4524206A (en) 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4590196A (en) 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0302423A3 (en) 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments

Also Published As

Publication number Publication date
ZA895978B (en) 1991-04-24
IL91194A0 (en) 1990-03-19
IL91194A (en) 1994-04-12
EP0353821B1 (en) 1995-05-10
NO893168L (no) 1990-02-06
PT91364B (pt) 1995-03-31
DK175124B1 (da) 2004-06-07
NO176051B (no) 1994-10-17
HU206341B (en) 1992-10-28
EP0353821A3 (en) 1991-07-17
NO893168D0 (no) 1989-08-04
DE68922537T2 (de) 1995-09-14
DK383689D0 (da) 1989-08-04
FI90238B (sv) 1993-09-30
JP2779216B2 (ja) 1998-07-23
IE66198B1 (en) 1995-12-13
HUT55385A (en) 1991-05-28
ATE122348T1 (de) 1995-05-15
KR900003155A (ko) 1990-03-23
EP0353821A2 (en) 1990-02-07
NZ230045A (en) 1990-11-27
KR0145706B1 (ko) 1998-08-17
AU3917189A (en) 1990-03-08
DK383689A (da) 1990-02-06
JPH0288572A (ja) 1990-03-28
CN1023602C (zh) 1994-01-26
CN1040194A (zh) 1990-03-07
FI893701A0 (sv) 1989-08-04
AU619877B2 (en) 1992-02-06
PH26550A (en) 1992-08-19
SU1687030A3 (ru) 1991-10-23
PT91364A (pt) 1990-03-08
DE68922537D1 (de) 1995-06-14
FI90238C (sv) 1994-01-10
IE892535L (en) 1990-02-05
ES2074462T3 (es) 1995-09-16
CA1331609C (en) 1994-08-23
NO176051C (no) 1995-01-25

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: JANSSEN PHARMACEUTICA N.V.

MA Patent expired