FI892702A - Förfarande för framställning av R- eller S-enantiomerer av 2-hydroxi-4-fenylsmörsyra - Google Patents

Förfarande för framställning av R- eller S-enantiomerer av 2-hydroxi-4-fenylsmörsyra Download PDF

Info

Publication number
FI892702A
FI892702A FI892702A FI892702A FI892702A FI 892702 A FI892702 A FI 892702A FI 892702 A FI892702 A FI 892702A FI 892702 A FI892702 A FI 892702A FI 892702 A FI892702 A FI 892702A
Authority
FI
Finland
Prior art keywords
phenylbutyric acid
hydroxy
preparation
enantiomers
dehydrogenase
Prior art date
Application number
FI892702A
Other languages
English (en)
Finnish (fi)
Other versions
FI95047C (sv
FI892702A0 (sv
FI95047B (sv
Inventor
Oreste Ghisalba
Daniel Gygax
Rene Lattmann
Hans-Peter Schaer
Elke Schmidt
Gottfried Sedelmeier
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI892702A0 publication Critical patent/FI892702A0/sv
Publication of FI892702A publication Critical patent/FI892702A/sv
Application granted granted Critical
Publication of FI95047B publication Critical patent/FI95047B/sv
Publication of FI95047C publication Critical patent/FI95047C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/52—Propionic acid; Butyric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI892702A 1988-06-06 1989-06-02 Förfarande för framställning av R- eller S-enantiomerer av 2-hydroxi-4-fenylsmörsyra FI95047C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH213888 1988-06-06
CH213888 1988-06-06

Publications (4)

Publication Number Publication Date
FI892702A0 FI892702A0 (sv) 1989-06-02
FI892702A true FI892702A (sv) 1989-12-07
FI95047B FI95047B (sv) 1995-08-31
FI95047C FI95047C (sv) 1995-12-11

Family

ID=4226761

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892702A FI95047C (sv) 1988-06-06 1989-06-02 Förfarande för framställning av R- eller S-enantiomerer av 2-hydroxi-4-fenylsmörsyra

Country Status (14)

Country Link
US (1) US5098841A (sv)
EP (1) EP0347374B1 (sv)
JP (1) JP2873236B2 (sv)
KR (1) KR0165102B1 (sv)
AT (1) ATE98697T1 (sv)
CA (1) CA1336081C (sv)
DE (1) DE58906409D1 (sv)
DK (1) DK172667B1 (sv)
ES (1) ES2059817T3 (sv)
FI (1) FI95047C (sv)
IE (1) IE63497B1 (sv)
IL (1) IL90527A (sv)
MX (1) MX170725B (sv)
PT (1) PT90747B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256552A (en) * 1988-02-08 1993-10-26 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy-4-phenylbutyric acid
EP0394448B1 (en) * 1988-02-08 1996-05-01 Daicel Chemical Industries, Ltd. Process for preparing optically active 2-hydroxy-4-phenylbutyric acids
US5371014A (en) * 1988-02-12 1994-12-06 Daicel Chemical Industries, Ltd. Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor
WO1993013215A1 (en) * 1991-12-23 1993-07-08 Genzyme Limited Synthesis of homochiral 2-hydroxy acids
US5770410A (en) * 1992-01-30 1998-06-23 Genzyme Corporation Chiral synthesis with modified enzymes
GB9413710D0 (en) * 1994-07-07 1994-08-24 Genzyme Ltd Chiral synthesis
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
WO2002033110A2 (en) * 2000-10-17 2002-04-25 Pcbu Services, Inc. PRODUCTION OF α-HYDROXY-CARBOXYLIC ACIDS USING A COUPLED ENZYME SYSTEM
EP1902084A2 (en) * 2005-06-01 2008-03-26 Yissum Research Development Company, of The Hebrew University of Jerusalem Biodegradable polymers having a pre-determined chirality
EP2066440B1 (en) * 2006-09-29 2015-09-09 Council of Scientific & Industrial Research Process for the preparation of organic-inorganic hybrid chiral sorbent , sorbent obtained by the process and use thereof for separating racemic mixtures
CN101302503B (zh) * 2007-05-08 2011-04-06 上海医药工业研究院 突变的植物乳杆菌d-乳酸脱氢酶及其基因、重组酶和应用
WO2011009849A2 (en) 2009-07-21 2011-01-27 Basf Se Method for preparing optically active hydroxy acid esters
CA3053956C (en) * 2017-03-03 2024-04-23 Gilead Sciences, Inc. Processes for preparing acc inhibitors and solid forms thereof
CN109234325A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种乳酸脱氢酶在不对称合成手性羟基化合物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628009A5 (de) * 1977-07-26 1982-02-15 Hoffmann La Roche Verfahren zur herstellung von optisch aktiven alpha-hydroxycarbonsaeuren.
DE2930087A1 (de) * 1979-07-25 1981-02-26 Biotechnolog Forschung Gmbh Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden alpha -hydroxycarbonsaeuren
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation

Also Published As

Publication number Publication date
IL90527A (en) 1993-05-13
ATE98697T1 (de) 1994-01-15
DK271289D0 (da) 1989-06-02
PT90747A (pt) 1989-12-29
IL90527A0 (en) 1990-01-18
EP0347374B1 (de) 1993-12-15
ES2059817T3 (es) 1994-11-16
JPH0239893A (ja) 1990-02-08
EP0347374A1 (de) 1989-12-20
FI95047C (sv) 1995-12-11
DK271289A (da) 1989-12-07
CA1336081C (en) 1995-06-27
PT90747B (pt) 1994-10-31
FI892702A0 (sv) 1989-06-02
DK172667B1 (da) 1999-05-10
DE58906409D1 (de) 1994-01-27
US5098841A (en) 1992-03-24
KR910001065A (ko) 1991-01-30
IE63497B1 (en) 1995-05-03
IE891821L (en) 1989-12-06
KR0165102B1 (ko) 1999-01-15
FI95047B (sv) 1995-08-31
JP2873236B2 (ja) 1999-03-24
MX170725B (es) 1993-09-09

Similar Documents

Publication Publication Date Title
FI892702A (sv) Förfarande för framställning av R- eller S-enantiomerer av 2-hydroxi-4-fenylsmörsyra
AU2829292A (en) Saccharin derivative proteolytic enzyme inhibitors
Huh et al. Synthesis of l-proline from the racemate by coupling of enzymatic enantiospecific oxidation and chemical non-enantiospecific reducation
AU6328094A (en) Saccharin derivative proteolytic enzyme inhibitors
Radhakrishnan et al. Biosynthesis of valine and isoleucine. II. Formation of α-acetolactate and α-aceto-α-hydroxybutyrate in Neurospora crassa and Escherichia coli
EP0148132B1 (en) Microbiological process for stereoselectively synthesizing l(-)-carnitine
EP0625571A3 (de) Neue Mikroorganismen, deren Verwendung und Verfahren zur Herstellung von L-Alpha-Aminosäuren.
DE58901530D1 (de) Verfahren zur herstellung von lys-plasminogen.
JPH04504362A (ja) 酵素による７―アミノセフアロスポラン酸の製造
AU2932892A (en) Process for producing food and drink
WO1998001568A3 (de) Verfahren zur herstellung von (s)- oder (r)-3,3,3-trifluor-2-hydroxy-2-methylpropionsaüre
AU5911696A (en) Flavoring agent
IE902338L (en) Resolution of pyrrolidone carboxylic acid esters
EP0320460A2 (en) Process for isolating the enzyme carnitinehydrolyase from strains belonging to the family enterobacteriaceae and use of the immobilized enzyme for producing L(-)-carnitine
JPH09224660A (ja) アルデヒド脱水素酵素
EP0189322A3 (en) Enzymatic synthesis of s-adenosylmethionine
AU585703B2 (en) Process for the enzymatic resolution of racemic 2-amino- 1-alkanols
JP2750017B2 (ja) 新規酵素およびその製造方法、並びに光学活性な（ｒ）−２−ヒドロキシ−４−フェニル酪酸の製造方法
JP2538597B2 (ja) 新規な環元酵素
Esaki et al. Preparation of stereoselectively-deuterated NADH and NADPH by coupling of glutamate racemase and glutamate dehydrogenase
JPS61128891A (ja) ギ酸の製造法
STOOLMILLER Formation of a-Ketoglutaric Semialdehyde from G% Keto= 3= deoxyarabonic Acid and Isolation of L-2-Keto-3-deoxyarabonate Dehydratase from
DE59702430D1 (de) Verfahren zur herstellung von d-prolinderivaten mittels mikroorganismen
JPS6368080A (ja) α，ε−ジアミノピメリン酸脱水素酵素及びその製造方法
JPS6030681A (ja) 新規なエステラ−ゼｏν−１及びその製造法

Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: NOVARTIS AG

FG Patent granted

Owner name: NOVARTIS AG