FI881713A - Förfarande för produktion av en plasminogenaktivator av urokinastyp - Google Patents
Förfarande för produktion av en plasminogenaktivator av urokinastyp Download PDFInfo
- Publication number
- FI881713A FI881713A FI881713A FI881713A FI881713A FI 881713 A FI881713 A FI 881713A FI 881713 A FI881713 A FI 881713A FI 881713 A FI881713 A FI 881713A FI 881713 A FI881713 A FI 881713A
- Authority
- FI
- Finland
- Prior art keywords
- plasminogen activator
- urokinase
- producing
- type plasminogen
- human plasminogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8709081 | 1987-04-15 | ||
GB878709081A GB8709081D0 (en) | 1987-04-15 | 1987-04-15 | Production of proteins |
GB878714059A GB8714059D0 (en) | 1987-04-15 | 1987-06-16 | Production of proteins |
GB8714059 | 1987-06-16 | ||
IE329987A IE81116B1 (en) | 1986-12-05 | 1987-12-04 | Hybrid plasminogen activators |
IE329987 | 1987-12-04 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI881713A0 FI881713A0 (sv) | 1988-04-13 |
FI881713A true FI881713A (sv) | 1988-10-16 |
FI98219B FI98219B (sv) | 1997-01-31 |
FI98219C FI98219C (sv) | 1997-05-12 |
Family
ID=27263391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI881713A FI98219C (sv) | 1987-04-15 | 1988-04-13 | Förfarande för produktion av en plasminogenaktivator av urokinastyp |
Country Status (18)
Country | Link |
---|---|
US (1) | US5175105A (sv) |
EP (1) | EP0288435B1 (sv) |
JP (1) | JP2894696B2 (sv) |
AT (1) | ATE102994T1 (sv) |
AU (1) | AU604305B2 (sv) |
CA (1) | CA1341306C (sv) |
DD (1) | DD274053A5 (sv) |
DE (1) | DE3888386T2 (sv) |
DK (1) | DK203588A (sv) |
ES (1) | ES2061719T3 (sv) |
FI (1) | FI98219C (sv) |
HU (1) | HU204557B (sv) |
IL (1) | IL86058A (sv) |
MX (1) | MX168507B (sv) |
MY (1) | MY103358A (sv) |
NO (1) | NO179046C (sv) |
NZ (1) | NZ224243A (sv) |
PT (1) | PT87230B (sv) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2634495B1 (fr) * | 1988-07-01 | 1990-10-26 | Chambon Pierre | Procede de preparation d'une proteine par des levures utilisant un systeme inductible, vecteurs et souches transformees correspondantes |
US5866413A (en) * | 1989-03-06 | 1999-02-02 | Board Of Regents Of The University Of Texas System | Pai-1 mutants |
ATE226636T1 (de) * | 1989-03-06 | 2002-11-15 | Univ Texas | Serpin-resistenter t-pa; mutanten; gene |
EP0387380A1 (en) * | 1989-03-17 | 1990-09-19 | BEHRINGWERKE Aktiengesellschaft | Mutants of urinary plasminogen activator, their production and use |
US5268273A (en) * | 1990-12-14 | 1993-12-07 | Phillips Petroleum Company | Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same |
SE9201544L (sv) * | 1991-05-31 | 1992-12-01 | Ciba Geigy Ag | Saett att framstaella glykosyltransferaser |
GB2256197B (en) * | 1991-05-31 | 1995-11-22 | Ciba Geigy Ag | Yeast as host for expression of heterologous glycosyl transferase enzymes |
JPH0823995A (ja) * | 1994-07-14 | 1996-01-30 | Green Cross Corp:The | 宿主細胞由来のプロテアーゼで低分子化され得る蛋白質の製造方法 |
US20030113271A1 (en) * | 1997-01-29 | 2003-06-19 | University Technology Corporation | Formulations for pulmonary delivery |
US6207442B1 (en) * | 1997-10-16 | 2001-03-27 | Zymogenetics, Inc. | Plasmid construction by homologous recombination |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4245051A (en) * | 1978-03-30 | 1981-01-13 | Rockefeller University | Human serum plasminogen activator |
US4558010A (en) * | 1980-04-03 | 1985-12-10 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom |
US4370417A (en) * | 1980-04-03 | 1983-01-25 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator |
NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
FI88932C (sv) * | 1982-04-15 | 1993-07-26 | Genentech Inc | Framställning av funktionellt mänskligt urokinasprotein |
IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
US5010003A (en) * | 1983-04-25 | 1991-04-23 | Genentech, Inc. | Use of yeast homologous signals to secrete heterologous proteins |
EP0154272B1 (en) * | 1984-02-27 | 1992-01-08 | Green Cross Corporation | Production of human urokinase |
JPS60256385A (ja) * | 1984-05-18 | 1985-12-18 | イーライ・リリー・アンド・カンパニー | 酵母においてヘテロローガスポリペプチドを効率よく発現するための方法、ベクターおよび形質転換体 |
JPS60248181A (ja) * | 1984-05-23 | 1985-12-07 | Shiseido Co Ltd | 酵母発現ベクタ− |
EP0174835A1 (en) * | 1984-09-11 | 1986-03-19 | The Upjohn Company | Human tissue plasminogen activator and recombinant DNA compounds |
DE3680838D1 (de) * | 1985-01-25 | 1991-09-19 | Sagami Chem Res | Stabilisierte menschliche prourokinase. |
US5219569A (en) * | 1985-04-22 | 1993-06-15 | Genentech, Inc. | Protease resistant urokinase |
EP0199574B1 (en) * | 1985-04-22 | 1991-10-23 | Genentech, Inc. | Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants |
FI100106B (sv) * | 1986-12-05 | 1997-09-30 | Novartis Ag | Förfarande för framställning av en enkelsträngad hybridplasminogenakti vator |
DE19736137C1 (de) * | 1997-08-20 | 1998-10-01 | Daimler Benz Ag | Verfahren zum Starten eines Verbrennungsmotors |
-
1988
- 1988-03-30 MY MYPI88000322A patent/MY103358A/en unknown
- 1988-04-08 US US07/179,345 patent/US5175105A/en not_active Expired - Fee Related
- 1988-04-11 ES ES88810234T patent/ES2061719T3/es not_active Expired - Lifetime
- 1988-04-11 EP EP88810234A patent/EP0288435B1/en not_active Expired - Lifetime
- 1988-04-11 DE DE3888386T patent/DE3888386T2/de not_active Expired - Fee Related
- 1988-04-11 AT AT88810234T patent/ATE102994T1/de active
- 1988-04-13 PT PT87230A patent/PT87230B/pt active IP Right Grant
- 1988-04-13 IL IL86058A patent/IL86058A/xx not_active IP Right Cessation
- 1988-04-13 NZ NZ224243A patent/NZ224243A/xx unknown
- 1988-04-13 FI FI881713A patent/FI98219C/sv not_active IP Right Cessation
- 1988-04-13 CA CA000563968A patent/CA1341306C/en not_active Expired - Fee Related
- 1988-04-14 MX MX011116A patent/MX168507B/es unknown
- 1988-04-14 HU HU881922A patent/HU204557B/hu not_active IP Right Cessation
- 1988-04-14 NO NO881615A patent/NO179046C/no not_active IP Right Cessation
- 1988-04-14 JP JP63090433A patent/JP2894696B2/ja not_active Expired - Lifetime
- 1988-04-14 DK DK203588A patent/DK203588A/da not_active Application Discontinuation
- 1988-04-14 AU AU14626/88A patent/AU604305B2/en not_active Ceased
- 1988-04-15 DD DD31480088A patent/DD274053A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0288435A1 (en) | 1988-10-26 |
HU204557B (en) | 1992-01-28 |
CA1341306C (en) | 2001-10-23 |
NO881615L (no) | 1988-10-17 |
DD274053A5 (de) | 1989-12-06 |
NO881615D0 (no) | 1988-04-14 |
HUT46360A (en) | 1988-10-28 |
JP2894696B2 (ja) | 1999-05-24 |
PT87230B (pt) | 1992-08-31 |
JPS63296689A (ja) | 1988-12-02 |
IL86058A (en) | 1993-07-08 |
MX168507B (es) | 1993-05-27 |
NO179046B (no) | 1996-04-15 |
DK203588D0 (da) | 1988-04-14 |
MY103358A (en) | 1993-06-30 |
US5175105A (en) | 1992-12-29 |
FI881713A0 (sv) | 1988-04-13 |
PT87230A (pt) | 1988-05-01 |
ES2061719T3 (es) | 1994-12-16 |
EP0288435B1 (en) | 1994-03-16 |
IL86058A0 (en) | 1988-09-30 |
FI98219C (sv) | 1997-05-12 |
NO179046C (no) | 1996-07-24 |
AU1462688A (en) | 1988-10-20 |
AU604305B2 (en) | 1990-12-13 |
NZ224243A (en) | 1991-02-26 |
ATE102994T1 (de) | 1994-04-15 |
DK203588A (da) | 1988-10-16 |
DE3888386T2 (de) | 1994-07-14 |
DE3888386D1 (de) | 1994-04-21 |
FI98219B (sv) | 1997-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE862178L (en) | Poly-kringle plasminogen activator | |
IL68366A (en) | Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture | |
HUT58798A (en) | Process for producing growth factor of parenchimic hepatic celles, the gen for coding this and transformants for producing this factor | |
NO853012L (no) | Nye genetiske sekvenser, interfenonpeptider av type i uttrykt av disse og organismer som produserer dem. | |
FI881713A (sv) | Förfarande för produktion av en plasminogenaktivator av urokinastyp | |
DE3851035D1 (de) | Interleukin-7. | |
NO910719D0 (no) | Vektorer og forbindelser for ekspresjon av glykosyleringsmutanter av humant protein c. | |
PT86276A (en) | Method for the production of hybrid proteins | |
EP0776972A4 (en) | GENE ENCODING THE IgG-Fc-BINDING PROTEIN | |
DK260188A (da) | Enzymproduktion | |
FI933821A0 (fi) | Foerfarande foer framstaellning av proteasinhibitorer | |
EP0165759A3 (en) | Mammalian promotors useful in yeast expression |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
PC | Transfer of assignment of patent |
Owner name: NOVARTIS AG |
|
MM | Patent lapsed |
Owner name: NOVARTIS AG |