FI873897A0 - Maenniskans erytropoietin som framstaellts medelst rekombinations-dna-teknik. - Google Patents

Maenniskans erytropoietin som framstaellts medelst rekombinations-dna-teknik.

Info

Publication number
FI873897A0
FI873897A0 FI873897A FI873897A FI873897A0 FI 873897 A0 FI873897 A0 FI 873897A0 FI 873897 A FI873897 A FI 873897A FI 873897 A FI873897 A FI 873897A FI 873897 A0 FI873897 A0 FI 873897A0
Authority
FI
Finland
Prior art keywords
rekombinations
maenniskans
erytropoietin
teknik
medelst
Prior art date
Application number
FI873897A
Other languages
English (en)
Other versions
FI873897A (fi
Inventor
Anton K Beck
Raymond Withy
James R Zabrecky
Nicholas C Masiello
Original Assignee
Integrated Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc
Publication of FI873897A0 publication Critical patent/FI873897A0/fi
Publication of FI873897A publication Critical patent/FI873897A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
FI873897A 1986-09-15 1987-09-09 Maenniskans erytropoietin som framstaellts medelst rekombinations-dna-teknik. FI873897A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/907,369 US4954437A (en) 1986-09-15 1986-09-15 Cell encoding recombinant human erythropoietin

Publications (2)

Publication Number Publication Date
FI873897A0 true FI873897A0 (fi) 1987-09-09
FI873897A FI873897A (fi) 1988-03-16

Family

ID=25423973

Family Applications (1)

Application Number Title Priority Date Filing Date
FI873897A FI873897A (fi) 1986-09-15 1987-09-09 Maenniskans erytropoietin som framstaellts medelst rekombinations-dna-teknik.

Country Status (6)

Country Link
US (1) US4954437A (fi)
EP (1) EP0267678A1 (fi)
JP (1) JPS63185396A (fi)
DK (1) DK478287A (fi)
FI (1) FI873897A (fi)
PT (1) PT85699B (fi)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
KR100263845B1 (ko) * 1989-10-13 2000-08-16 스튜어트 엘.왓트 에리트로포이에틴 동형체와 그의 제조방법 및 그를 포함하는제약학적 조성물
JPH07506720A (ja) * 1992-01-07 1995-07-27 アテナ　ニューロサイエンシーズ，　インコーポレイテッド アルツハイマー病のトランスジェニック動物モデル
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6153407A (en) * 1992-07-28 2000-11-28 Beth Israel Deaconess Medical Center Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
US5614184A (en) * 1992-07-28 1997-03-25 New England Deaconess Hospital Recombinant human erythropoietin mutants and therapeutic methods employing them
CN1057534C (zh) * 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
US5459031A (en) * 1993-11-05 1995-10-17 Amgen Inc. Methods for controlling sialic acid derivatives in recombinant glycoproteins
US5919758A (en) * 1994-03-22 1999-07-06 Beth Israel Deaconess Medical Center Modified polypeptides with altered biological activity
US5888774A (en) * 1994-12-19 1999-03-30 Cangene Corporation Recombinant DNA molecules and expression vectors for erythropoietin
GB9506051D0 (en) * 1995-03-24 1995-05-10 Univ Singapore Gene expression
IL118201A (en) * 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
US6717031B2 (en) 1995-06-07 2004-04-06 Kate Dora Games Method for selecting a transgenic mouse model of alzheimer's disease
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
AU753701B2 (en) * 1997-04-21 2002-10-24 Glycozyme, Inc. Determination of recombinant glycosylated proteins and peptides in biological fluids
US6187564B1 (en) 1997-07-10 2001-02-13 Beth Israel Deaconess Medical Center DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
ES2273434T3 (es) * 1997-07-23 2007-05-01 Roche Diagnostics Gmbh Obtencion de la eritropoyetina mediante activacion genica endogena.
US6548296B1 (en) 1997-07-23 2003-04-15 Roche Diagnostics Gmbh Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
PT986644E (pt) 1997-07-23 2007-01-31 Roche Diagnostics Gmbh Preparação de eritropoietina por activação genética endógena com promotores virais
BR9811542A (pt) 1997-07-23 2000-08-22 Roche Diagnostics Gmbh Identificação de linhas de células humanas para a produção de proteìnas humanas mediante ativação de genes endógena
KR100622203B1 (ko) 1997-07-23 2006-09-07 로셰 디아그노스틱스 게엠베하 내인성 유전자 활성화에 의해 사람 단백질을 생성시키는 사람 세포주를 확인하는 방법
ES2208798T3 (es) * 1997-09-01 2004-06-16 Aventis Pharma Deutschland Gmbh Eritropoyetina humana recombinante con un perfil de glicosilacion ventajoso.
AR022358A1 (es) * 1997-12-03 2002-09-04 Roche Olivier Una composicion de epo, un procedimiento para su obtencion, un preparado farmaceutico que la contiene y un procedimiento para aumentar la actividadespecifica de una composicion de epo
US7304150B1 (en) 1998-10-23 2007-12-04 Amgen Inc. Methods and compositions for the prevention and treatment of anemia
KR20010075661A (ko) 1998-10-23 2001-08-09 스티븐 엠. 오드레 빈혈 예방 및 치료 방법과 이를 위한 조성물
PE20010288A1 (es) 1999-07-02 2001-03-07 Hoffmann La Roche Derivados de eritropoyetina
EP1326969B1 (en) 2000-09-25 2009-04-15 Genetronics, Inc. Improved system for regulation of transgene expression
CN100528235C (zh) 2000-12-20 2009-08-19 霍夫曼-拉罗奇有限公司 红细胞生成素共轭物
ES2310684T3 (es) * 2002-08-09 2009-01-16 Merck Patent Gmbh Epitopes de celulas t en eritropoyetina.
BRPI0418326A (pt) 2003-12-30 2007-05-02 Bionethos Holding Gmbh método de regeneração de tecidos
DE102004027816A1 (de) 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
CN101062407A (zh) 2006-04-29 2007-10-31 中国科学院上海生命科学研究院 促红细胞生成素在预防或治疗视网膜损伤中的用途
PL2054074T3 (pl) 2006-08-04 2015-03-31 Prolong Pharmaceuticals Llc Zmodyfikowana erytropoetyna
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN102886052B (zh) 2006-09-14 2014-07-30 迈德詹尼克斯医疗以色列有限公司 长效药物制剂
WO2008068879A1 (en) * 2006-12-06 2008-06-12 Jcr Pharmaceuticals Co., Ltd. Method for production of human erythropoietin
DE102008002209A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
KR101038532B1 (ko) * 2008-07-02 2011-06-02 학교법인 선목학원 인간 적혈구생성촉진인자(ｈＥＰＯ) 유전자를 내장하는레트로바이러스 발현벡터 및 이에 의해 형질전환된동물세포 및 가금
EP2334699B1 (en) 2008-09-23 2013-09-11 F. Hoffmann-La Roche AG Purification of erythropoietin
DE102008054716A1 (de) 2008-12-16 2010-06-17 Evonik Degussa Gmbh Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
PL3421603T3 (pl) 2009-05-02 2022-02-14 Genzyme Corporation Terapia genowa zaburzeń neurodegeneracyjnych
BR112012006602A2 (pt) 2009-09-23 2019-09-24 Biogenerix Ag processo para a purificação de eritropoetina humana recombinante (epo), epo assim purificada e composições farmacêutica compreendendo a mesma
JP2013532152A (ja) 2010-06-15 2013-08-15 メドジェニクス・メディカル・イスラエル・リミテッド 長期持続性の医薬製剤
CN103205478B (zh) * 2013-04-03 2014-03-05 北京四环生物制药有限公司 一种重组人促红素的工业化生产方法
WO2022159414A1 (en) 2021-01-22 2022-07-28 University Of Rochester Erythropoietin for gastroinfestinal dysfunction

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045849B2 (ja) * 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
JPH0686480B2 (ja) * 1983-02-21 1994-11-02 雪印乳業株式会社 エリスロポエチン製造用モノクローナル抗体
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
NZ210501A (en) * 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) * 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
US4732889A (en) * 1985-02-06 1988-03-22 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis
DE3789678T2 (de) * 1986-02-27 1994-08-11 Snow Brand Milk Products Co Ltd Herstellung von erythropoietinproduzierenden Zellen und Verfahren zur Herstellung von Erythropoietin mit Verwendung dieser Zellen.

Also Published As

Publication number Publication date
EP0267678A1 (en) 1988-05-18
PT85699B (pt) 1990-08-31
US4954437A (en) 1990-09-04
AU7842987A (en) 1989-03-16
AU604051B2 (en) 1990-12-06
DK478287D0 (da) 1987-09-14
FI873897A (fi) 1988-03-16
JPS63185396A (ja) 1988-07-30
PT85699A (en) 1987-10-01
DK478287A (da) 1988-03-16

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Legal Events

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Owner name: INTEGRATED GENETICS, INC.