FI85264B - Foerfarande foer framstaellning av n-asyl-l-prolinderivat. - Google Patents
Foerfarande foer framstaellning av n-asyl-l-prolinderivat. Download PDFInfo
- Publication number
- FI85264B FI85264B FI854055A FI854055A FI85264B FI 85264 B FI85264 B FI 85264B FI 854055 A FI854055 A FI 854055A FI 854055 A FI854055 A FI 854055A FI 85264 B FI85264 B FI 85264B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- proline
- carboxylic acid
- bromo
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Claims (7)
1. Förfarande för framställning av N-asyl-L-prolinderivat (I) med formeln i2 i1 ^ X - CH - CH - C - N-L (I) | ^ COOH 0 väri Ri och R2 oberoende av varandra betecknar väte eller Ci_4-alkyl och X betecknar halogen, kännetecknat av att trimetylsilylestern av prolin med formeln (III) 85264 HN-1 COOSi(CH3)3 (III) acyleras med ett reaktivt derivat av en racemisk karboxylsy-ra med formeln (IV) Ro Ri y0 I I / X - CH - CH - C (IV) vari Rj, R2 och X har ovan angivna betydelse, i ett inert organ!skt lösningsmedel i närvaro av ett syrabindande medel, och den erhällna föreningen med formeln (V) I2 I1 X - CH - CH - C - N-4. (V) I XCOOSi(CH3)3 0 väri R^, R2 och X har ovan angivna betydelse, hydrolyseras med vatten företrädesvis utan isolering frdn reaktionsbland-ningen.
2. Förfarande enligt patentkravet 1, kännetecknat av att L-prolin omsättes med trimetylsilylklorid och den erhdllna trimetylsilylestern av prolin med formeln (III) acyleras utan separation frän reaktionsblandningen.
3. Förfarande enligt patentkravet 1, kännetecknat av att det inerta organiska lösningsmedlet är ett klorerat alifa-tiskt kolväte eller ett aromatiskt kolväte.
4. Förfarande enligt patentkravet 3, kännetecknat av att det klorerade alifatlska kolvätet är diklorometan, 1,2-dikloroetan eller kloroform. 16 85264
5. Förfarande enligt patentkravet 3, kännetecknat av att det aromatiska kolvätet är bensen, toluen eller xylen.
6. Förfarande enligt patentkravet 1, kännetecknat av att syrabindemedlet är en organisk bas, företrädesvis trietyl-aminer eller pyridin.
7. Förfarande enligt patentkravet 1, kännetecknat av att syrabindemedlet är en oorganisk bas, företrädesvis ett alka-limetallkarbonat.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU843901A HU196369B (en) | 1984-10-18 | 1984-10-18 | New process for producing n-acylized l-prolin derivatives |
HU390184 | 1984-10-18 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI854055A0 FI854055A0 (fi) | 1985-10-17 |
FI854055L FI854055L (fi) | 1986-04-19 |
FI85264B true FI85264B (fi) | 1991-12-13 |
FI85264C FI85264C (sv) | 1992-03-25 |
Family
ID=10965983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI854055A FI85264C (sv) | 1984-10-18 | 1985-10-17 | Förfarande för framställning av N-asyl-L-prolinderivat |
Country Status (16)
Country | Link |
---|---|
AT (1) | AT383345B (sv) |
BG (1) | BG45852A3 (sv) |
CH (1) | CH666263A5 (sv) |
CS (1) | CS250250B2 (sv) |
DD (1) | DD239200A5 (sv) |
DK (1) | DK477285A (sv) |
ES (1) | ES8704151A1 (sv) |
FI (1) | FI85264C (sv) |
GR (1) | GR852533B (sv) |
HU (1) | HU196369B (sv) |
NO (1) | NO166786C (sv) |
PL (1) | PL145341B1 (sv) |
PT (1) | PT81323B (sv) |
SE (1) | SE466852B (sv) |
SU (1) | SU1470180A3 (sv) |
YU (1) | YU44526B (sv) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1984
- 1984-10-18 HU HU843901A patent/HU196369B/hu unknown
-
1985
- 1985-10-14 CH CH4416/85A patent/CH666263A5/de not_active IP Right Cessation
- 1985-10-16 SE SE8504824A patent/SE466852B/sv not_active IP Right Cessation
- 1985-10-17 DK DK477285A patent/DK477285A/da not_active Application Discontinuation
- 1985-10-17 PT PT81323A patent/PT81323B/pt not_active IP Right Cessation
- 1985-10-17 AT AT0300585A patent/AT383345B/de not_active IP Right Cessation
- 1985-10-17 BG BG072072A patent/BG45852A3/xx unknown
- 1985-10-17 PL PL1985255810A patent/PL145341B1/pl unknown
- 1985-10-17 NO NO854136A patent/NO166786C/no unknown
- 1985-10-17 SU SU853964102A patent/SU1470180A3/ru active
- 1985-10-17 DD DD85281836A patent/DD239200A5/de not_active IP Right Cessation
- 1985-10-17 FI FI854055A patent/FI85264C/sv not_active IP Right Cessation
- 1985-10-17 ES ES547960A patent/ES8704151A1/es not_active Expired
- 1985-10-17 YU YU1655/85A patent/YU44526B/xx unknown
- 1985-10-18 CS CS857466A patent/CS250250B2/cs unknown
- 1985-10-18 GR GR852533A patent/GR852533B/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATA300585A (de) | 1986-11-15 |
PL145341B1 (en) | 1988-09-30 |
SE8504824L (sv) | 1986-04-19 |
YU44526B (en) | 1990-08-31 |
DK477285D0 (da) | 1985-10-17 |
FI854055L (fi) | 1986-04-19 |
PL255810A1 (en) | 1986-09-23 |
FI854055A0 (fi) | 1985-10-17 |
YU165585A (en) | 1987-12-31 |
NO854136L (no) | 1986-04-21 |
NO166786C (no) | 1991-09-04 |
ES547960A0 (es) | 1987-04-01 |
BG45852A3 (en) | 1989-08-15 |
DK477285A (da) | 1986-04-19 |
SU1470180A3 (ru) | 1989-03-30 |
DD239200A5 (de) | 1986-09-17 |
SE466852B (sv) | 1992-04-13 |
GR852533B (sv) | 1986-02-19 |
FI85264C (sv) | 1992-03-25 |
HU196369B (en) | 1988-11-28 |
NO166786B (no) | 1991-05-27 |
HUT38903A (en) | 1986-07-28 |
PT81323B (pt) | 1987-10-20 |
ES8704151A1 (es) | 1987-04-01 |
CH666263A5 (de) | 1988-07-15 |
SE8504824D0 (sv) | 1985-10-16 |
PT81323A (en) | 1985-11-01 |
CS250250B2 (en) | 1987-04-16 |
AT383345B (de) | 1987-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1205476A (en) | Substituted acyl derivatives of octahydro-1h-indole-2- carboxylic acids | |
FR2748026A1 (fr) | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
JPS6059226B2 (ja) | プロリン誘導体および関連化合物 | |
US4154934A (en) | Mercaptoacylamino derivatives of heterocyclic carboxylic acids | |
US6335333B1 (en) | N-arylsulfonylamino acid omega-amides | |
US4788300A (en) | Substituted butanamido acetate compounds for the preparation of pyrrolidone derivatives | |
FI85264B (fi) | Foerfarande foer framstaellning av n-asyl-l-prolinderivat. | |
HU176871B (en) | Process for producing 2-amino-oktahydro-oxasolo-square bracket-3,2-a-square bracket closed-pyrrolo-square bracket-2,1-c-square bracket closed-pyrasine derivatives | |
US6407262B1 (en) | Process for the preparation of Ramipril | |
US4075219A (en) | Epimerization process | |
SI9500140A (en) | Novel n-sulfoxy anhydrides, process for the preparation thereof and its use for the preparation of bioactive substances having ace inhibitory action | |
US4198509A (en) | Mercaptoacylpiperazine carboxylic acid compounds | |
AU637719B2 (en) | Process for preparing 1-((2s)-3-mercapto-methyl-1-oxopropyl)-l-proline | |
CA2363658C (en) | Improved process for the preparation of ramipril | |
US5290947A (en) | Process for the preparation of pyrrole derivates | |
KR20050023444A (ko) | 아미노-피롤리딘 유도체의 제조 방법 | |
HU211101B (en) | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid | |
US4308388A (en) | 4-Azido-1-mercaptoacyl pipecolic acid | |
FI68830C (fi) | Dl- eller d-trans-8-fluor-5-(p-fluorfenyl)-2,3,4,4a,5,9b-heksahydro-1h-pyrido(4,3-b)indol som anvaends som mellanprodukt vid framstaellning av terapeutiskt anvaendbara 2-substituerade dl- och d-trans-8-fluor-5-(p-fluorfenyl)-2,3,4,4a,5,9b-heksahydro-1h-pyrido(4,3-b)indoler | |
SU351369A1 (ru) | Способ получения алкалоидов | |
KR800001133B1 (ko) | 복소환 치환기를 가진 5-설파모일벤조산 유도체의 제조방법 | |
IE47362B1 (en) | New oxime derivatives of 7-amino-thiazolyl-acetic acid,and processes for preparing them | |
PT824512E (pt) | Sintese de aminoindanol opticamente activo | |
HU209820B (en) | Process for producing of 1-/2-methyl-1-oxo-3-rhodanidopropyl/-proline | |
IE43846B1 (en) | Azetidine compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: EGIS GYOGYSZERGYAR |