FI85106B - Foerfarande foer framstaellning av ett transdermalt doseringssystem. - Google Patents
Foerfarande foer framstaellning av ett transdermalt doseringssystem. Download PDFInfo
- Publication number
- FI85106B FI85106B FI861177A FI861177A FI85106B FI 85106 B FI85106 B FI 85106B FI 861177 A FI861177 A FI 861177A FI 861177 A FI861177 A FI 861177A FI 85106 B FI85106 B FI 85106B
- Authority
- FI
- Finland
- Prior art keywords
- adhesive
- pharmaceutically active
- layer
- active drug
- component layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Claims (8)
1. Förfarande för framställning av ett adhesivt transdermalt doseringsskikt avsett för fördröjd frigöring 5 av ett farmaceutiskt ämne, kännetecknat där- av, att a) man blandar ett akryliskt adhesivt ämne och vetten tili en homogen blandning; b) man sätter det farmaceutiskt aktiva läkemedlet 10 tili den homogena blandningen; c) man bildar en jämn homogen blandning av det farmaceutiskt aktiva läkemedlet och den homogena blandningen; d) man tillsätter ett tvärbindningsmedel för det akryliska adhesiva ämnet tili den erhällna jämna homogena 15 blandningen; e) man utför tvärbindningen mellan det tvärbindande ämnet och det akryliska adhesiva ämnet; och f) man avlägsnar tillräckligt med vatten och lös-ningsmedel ur produkten frän steg e) varvid ett adhesivt 20 transdermalt skikt bildas.
2. Förfarande för framställning av ett adhesivt transdermalt doseringsskikt enligt patentkravet 1, kännetecknat därav, att det farmaceutiskt aktiva ämnet är ett vasodilatoriskt ämne. 25
3. Förfarande för framställning av ett adhesivt transdermalt doseringsskikt enligt patentkravet 2, kännetecknat därav, att det vasodilatoriska ämnet är nitroglycerin.
4. Förfarande för framställning av ett adhesivt 30 transdermalt doseringsskikt enligt patentkravet 3, kännetecknat därav, att den närvarande nitro-glycerinmängden utgör 20 - 50 vikt-% beräknat pä vikten av det adhesiva transdermala doseringsskiktet. 21 85106
5. Förfarande för framställning av ett adhesivt transdermalt tväskikts doseringssystem avsett för fördröjd frigöring av ett farmaceutiskt ämne, känneteck-n a t därav, att 5 a) man blandar ett akryliskt adhesivt ämne och vet ten tili en homogen blandning; b) man sätter det farmaceutiskt aktiva läkemedlet tili den homogena blandningen; c) man bildar en jämn homogen blandning av det far-10 maceutiskt aktiva läkemedlet och den homogena blandningen; d) man tillsätter ett tvärbindningsmedel för det akryliska adhesiva ämnet tili den erhällna jämna homogena blandningen; e) man utför tvärbindningen mellan det tvärbindande 15 ämnet och det akryliska adhesiva ämnet; f) man applicerar det frän sted e) erhällna tvär-bundna akryliska adhesiva skiktet pä ett andra skikt; och g) man avlägsnar tillräckligt med vatten och lös-ningsmedel ur det tvärbundna akryliska adhesiva skiktet, 20 varvid ett transdermalt tväskiktsdoseringssystem bildas.
6. Förfarande enligt patentkravet 5, känne-t e c k n a t därav, att det farmaceutiskt aktiva ämnet är ett vasodilatorisk ämne.
7. Förfarande enligt patentkravet 6, känne-25 tecknat därav, att det vasodilatoriska ämnet är nitroglycerin.
8. Förfarande enligt patentkravet 7, känne-tecknat därav, att den närvarande nitroglycerin-mängden utgör 20 - 50 vikt-% beräknat pä vikten av det 30 adhesiva transdermala tväskiktsdoseringssystemet.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63399284A | 1984-07-24 | 1984-07-24 | |
US63399284 | 1984-07-24 | ||
US8501401 | 1985-07-24 | ||
PCT/US1985/001401 WO1986000814A1 (en) | 1984-07-24 | 1985-07-24 | Adhesive transdermal dosage layer |
Publications (4)
Publication Number | Publication Date |
---|---|
FI861177A0 FI861177A0 (fi) | 1986-03-20 |
FI861177A FI861177A (fi) | 1986-03-20 |
FI85106B true FI85106B (fi) | 1991-11-29 |
FI85106C FI85106C (sv) | 1992-03-10 |
Family
ID=24541997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI861177A FI85106C (sv) | 1984-07-24 | 1986-03-20 | Förfarande för framställning av ett transdermalt doseringssystem |
Country Status (11)
Country | Link |
---|---|
US (1) | US5186938A (sv) |
EP (1) | EP0190262B1 (sv) |
JP (1) | JPS61502760A (sv) |
AT (1) | ATE59302T1 (sv) |
AU (1) | AU576889B2 (sv) |
DE (1) | DE3581188D1 (sv) |
FI (1) | FI85106C (sv) |
HK (1) | HK94093A (sv) |
MY (1) | MY100249A (sv) |
NO (1) | NO171950C (sv) |
WO (1) | WO1986000814A1 (sv) |
Families Citing this family (96)
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-
1985
- 1985-07-24 WO PCT/US1985/001401 patent/WO1986000814A1/en active IP Right Grant
- 1985-07-24 AT AT85903926T patent/ATE59302T1/de not_active IP Right Cessation
- 1985-07-24 EP EP85903926A patent/EP0190262B1/en not_active Expired
- 1985-07-24 AU AU46761/85A patent/AU576889B2/en not_active Expired
- 1985-07-24 JP JP60503476A patent/JPS61502760A/ja active Granted
- 1985-07-24 DE DE8585903926T patent/DE3581188D1/de not_active Expired - Fee Related
-
1986
- 1986-03-20 NO NO86861101A patent/NO171950C/no unknown
- 1986-03-20 FI FI861177A patent/FI85106C/sv not_active IP Right Cessation
-
1987
- 1987-09-22 MY MYPI87001848A patent/MY100249A/en unknown
-
1991
- 1991-08-07 US US07/744,632 patent/US5186938A/en not_active Expired - Lifetime
-
1993
- 1993-09-09 HK HK940/93A patent/HK94093A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0190262B1 (en) | 1990-12-27 |
DE3581188D1 (de) | 1991-02-07 |
EP0190262A1 (en) | 1986-08-13 |
JPS61502760A (ja) | 1986-11-27 |
JPH0440326B2 (sv) | 1992-07-02 |
FI861177A0 (fi) | 1986-03-20 |
AU576889B2 (en) | 1988-09-08 |
HK94093A (en) | 1993-09-17 |
NO171950B (no) | 1993-02-15 |
FI85106C (sv) | 1992-03-10 |
AU4676185A (en) | 1986-02-25 |
MY100249A (en) | 1990-07-12 |
FI861177A (fi) | 1986-03-20 |
ATE59302T1 (de) | 1991-01-15 |
WO1986000814A1 (en) | 1986-02-13 |
NO861101L (no) | 1986-03-20 |
US5186938A (en) | 1993-02-16 |
NO171950C (no) | 1993-05-26 |
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Owner name: KEY PHARMACEUTICALS, INC. |