FI84022B - Foerfarande foer framstaellning av hoegaktiva pankreatinpellets. - Google Patents
Foerfarande foer framstaellning av hoegaktiva pankreatinpellets. Download PDFInfo
- Publication number
- FI84022B FI84022B FI801779A FI801779A FI84022B FI 84022 B FI84022 B FI 84022B FI 801779 A FI801779 A FI 801779A FI 801779 A FI801779 A FI 801779A FI 84022 B FI84022 B FI 84022B
- Authority
- FI
- Finland
- Prior art keywords
- pancreatin
- pellets
- isopropanol
- solvent
- acetone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Claims (6)
1. Förfarande för framställning av högaktiva pankreatinpel-lets med en pankreatinhalt över 80 vikt-% ur en formbar massa innehällande pankreatinpulver och isopropanol eller aceton, vilket förfarande omfattar stegen, där den formbara massan efter blandning extruderas, extrudatet skärs 1 stycken, som torkas och avrundas till pellets, varefter dessa pellets even-tuellt överdras med ett magsaftresistent överdrag, kanne-tecknat av att den formbara massan bildas genom att blanda väsentligen endast pankreatinpulver och isopropanol eller aceton eller en blandning av ett av dessa lösningsmedel med flytande klorfluorkolväte, samt eventuellt glidmedel.
2. Förfarande enligt patentkravet 1, kännetecknat av att massan innehäller glidmedel, fördelaktigt magnesium-stearat.
3. Förfarande enligt patentkravet 2, kännetecknat av att isopropanolet eller acetonet används blandat i flytande klorfluorkol väten.
4. Förfarande enligt nägot av patentkraven 1...3, kännetecknat av att tili lösningsmedlet tillsätts sä mycket klorfluorkolväte, att andelen av denna tillsatsmängd är 0...50, heist 15...35 volym-% av den totala mängden använt 1 ös ni ngs medel.
5. Förfarande enligt nägot av patentkraven 1...4, kännetecknat av att för frametällning av massan används 70. . . 200 ml lösningsmedel per 1000 g pankreatinpulver.
6. Förfarande enligt nägot av patentkraven 1...5, kännetecknat av att extrudatstyckena, som erhällits genom att fördela extrudatet, avrundas i anordningar, som är i och för sig kända, genom uppbyggnadsgranulering under tilIsats av pankreatinpulver.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2923279A DE2923279C2 (de) | 1979-06-08 | 1979-06-08 | Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel |
| DE2923279 | 1979-06-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI801779A FI801779A (fi) | 1980-12-09 |
| FI84022B true FI84022B (fi) | 1991-06-28 |
| FI84022C FI84022C (sv) | 1991-10-10 |
Family
ID=6072800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI801779A FI84022C (sv) | 1979-06-08 | 1980-06-03 | Förfarande för framställning av högaktiva pankreatinpellets |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4280971A (sv) |
| EP (1) | EP0021129B2 (sv) |
| JP (1) | JPS55164622A (sv) |
| KR (1) | KR850000625B1 (sv) |
| AR (1) | AR228427A1 (sv) |
| AT (1) | ATE6030T1 (sv) |
| AU (1) | AU532838B2 (sv) |
| CA (1) | CA1142082A (sv) |
| DD (1) | DD151184A5 (sv) |
| DE (2) | DE2923279C2 (sv) |
| DK (1) | DK158932C (sv) |
| ES (1) | ES489967A1 (sv) |
| FI (1) | FI84022C (sv) |
| GR (1) | GR69290B (sv) |
| IE (1) | IE49584B1 (sv) |
| IL (1) | IL59893A (sv) |
| NO (1) | NO158949C (sv) |
| NZ (1) | NZ193476A (sv) |
| PH (1) | PH16898A (sv) |
| PT (1) | PT71136A (sv) |
| SU (1) | SU1256690A3 (sv) |
| ZA (1) | ZA802919B (sv) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61170390A (ja) * | 1985-01-25 | 1986-08-01 | Agency Of Ind Science & Technol | 酵素含有多糖複合体 |
| GB8624628D0 (en) * | 1986-10-14 | 1986-11-19 | Scras | Soluble/splitable tablets |
| DE3642853A1 (de) * | 1986-12-16 | 1988-06-23 | Ulrich Von Dr Ing Pidoll | Arzneimittel |
| IT1205716B (it) * | 1987-01-21 | 1989-03-31 | Samil Spa | Procedimento per la preparazione di microsfere gastroresistenti ed enterosolubili di enzima digestivo e preparato faramceutico a microsfere cosi' prodotto |
| DE3721574A1 (de) * | 1987-06-30 | 1989-01-12 | Kettelhack Riker Pharma Gmbh | Arzneimittel in form von pellets mit enzymatisch kontrollierter arzneistoff-freisetzung |
| US4944944A (en) * | 1987-11-19 | 1990-07-31 | Oklahoma Medical Research Foundation | Dietary compositions and methods using bile salt-activated lipase |
| KR100229754B1 (ko) * | 1989-11-24 | 1999-11-15 | 샬러 한스, 하우스 한스 루돌프 | 판크레아틴구형입자, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| WO1993007859A1 (en) * | 1991-10-23 | 1993-04-29 | Warner-Lambert Company | Novel pharmaceutical pellets and process for their production |
| US5262172A (en) * | 1992-06-19 | 1993-11-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing buffered bile acids |
| US5302400A (en) * | 1992-06-22 | 1994-04-12 | Digestive Care Inc. | Preparation of gastric acid-resistant microspheres containing digestive enzymes and buffered-bile acids |
| US5260074A (en) * | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5578304A (en) * | 1992-06-22 | 1996-11-26 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5234697A (en) * | 1992-06-22 | 1993-08-10 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
| US5460812A (en) * | 1992-06-22 | 1995-10-24 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5415872A (en) * | 1992-06-22 | 1995-05-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
| DE4227385A1 (de) | 1992-08-19 | 1994-02-24 | Kali Chemie Pharma Gmbh | Pankreatinmikropellets |
| US5352682A (en) * | 1993-03-08 | 1994-10-04 | Digestive Care Inc. | Compositions containing salts of bile acid-aminosalicylate conjugates |
| GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
| US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| US5861291A (en) * | 1997-02-24 | 1999-01-19 | Biozymes Inc. | Method for producing pancreatin which contains low amounts of residual organic solvent and product thereof |
| DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
| US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
| KR100367659B1 (ko) * | 2000-05-08 | 2003-01-14 | 주식회사 바이넥스 | 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법 |
| GB0012056D0 (en) * | 2000-05-18 | 2000-07-12 | Consejo Superior Investigacion | Model for neurodegenerative disease |
| US20070053895A1 (en) * | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
| IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
| US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
| KR20020085376A (ko) * | 2001-05-08 | 2002-11-16 | (주) 인터코텍 | 화장품 조성물 |
| US20040197321A1 (en) * | 2002-03-19 | 2004-10-07 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| US20030180279A1 (en) * | 2002-03-19 | 2003-09-25 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| PT1729797E (pt) | 2004-03-22 | 2008-12-17 | Solvay Pharm Gmbh | Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos |
| US7153504B2 (en) * | 2004-07-30 | 2006-12-26 | Can Technologies, Inc. | Stabilized pancreas product |
| US20060198838A1 (en) * | 2004-09-28 | 2006-09-07 | Fallon Joan M | Combination enzyme for cystic fibrosis |
| EP1913138B1 (en) | 2005-07-29 | 2016-08-24 | Abbott Laboratories GmbH | Processes for the manufacture of pancreatin powder with low virus content |
| SI1931316T2 (sl) | 2005-08-15 | 2017-05-31 | Abbott Laboratories Gmbh | Farmacevtski sestavki z nadzorovanim sproščanjem za kislinsko labilna zdravila |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
| US20070116695A1 (en) * | 2005-09-21 | 2007-05-24 | Fallon Joan M | Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| SG186648A1 (en) | 2007-02-20 | 2013-01-30 | Aptalis Pharma Ltd | Stable digestive enzyme compositions |
| DE102007025858A1 (de) | 2007-06-01 | 2008-12-04 | Grünenthal GmbH | Verfahren zur Herstellung einer Arzneimitteldarreichungsform |
| US20090130063A1 (en) * | 2007-11-15 | 2009-05-21 | Solvay Pharmaceuticals Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| US10087493B2 (en) | 2008-03-07 | 2018-10-02 | Aptalis Pharma Canada Ulc | Method for detecting infectious parvovirus in pharmaceutical preparations |
| US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
| US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
| US9320780B2 (en) * | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
| WO2010002972A1 (en) * | 2008-07-01 | 2010-01-07 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
| US20100021505A1 (en) * | 2008-07-28 | 2010-01-28 | Tibor Sipos | Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients |
| US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
| EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
| US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
| KR20170005192A (ko) | 2009-01-06 | 2017-01-11 | 큐어론 엘엘씨 | 스타필로코쿠스 아우레우스 감염의 치료 또는 예방 및 표면 상의 스타필로코쿠스 아우레우스의 박멸 또는 감소를 위한 조성물 및 방법 |
| KR101694931B1 (ko) | 2009-01-06 | 2017-01-10 | 큐어론 엘엘씨 | 이. 콜라이에 의한 구강 감염의 치료 또는 예방을 위한 조성물 및 방법 |
| SI2391382T1 (sl) | 2009-01-29 | 2014-10-30 | Nordmark Arzneimittel Gmbh & Co. Kg | Farmacevtski pripravek, ki vsebuje lipazo bakterijskega izvora |
| US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
| EP2295039B2 (de) | 2009-08-28 | 2022-10-26 | Nordmark Pharma GmbH | Verfahren zur Herstellung von Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und hiernach hergestellte Pankreatin-Pellets |
| US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
| UA111726C2 (uk) | 2010-10-01 | 2016-06-10 | Апталіс Фарма Лімітед | Препарат панкреліпази низької сили з кишковорозчинним покриттям |
| EP2489349B1 (de) | 2011-02-17 | 2014-05-28 | Nordmark Arzneimittel GmbH & Co.KG | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung |
| DE202011000728U1 (de) | 2011-03-30 | 2011-06-09 | Nordmark Arzneimittel GmbH & Co. KG, 25436 | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets |
| CN106310242B (zh) | 2011-04-21 | 2020-02-28 | 柯尔马克有限责任公司 | 用于治疗神经精神障碍的化合物 |
| EP2741766B1 (en) | 2011-08-08 | 2015-10-07 | Aptalis Pharma Limited | Method for dissolution testing of solid compositions containing digestive enzymes |
| US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
| US10993996B2 (en) | 2013-08-09 | 2021-05-04 | Allergan Pharmaceuticals International Limited | Digestive enzyme composition suitable for enteral administration |
| CA2947998A1 (en) | 2014-06-19 | 2015-12-23 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
| US20180028454A1 (en) | 2015-02-04 | 2018-02-01 | Abbvie Inc. | Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency |
| US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3154603A (en) * | 1961-08-02 | 1964-10-27 | American Cyanamid Co | Process for the preparation of spherical contact particles |
| DE1617363B1 (de) * | 1967-12-06 | 1972-05-31 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung hochaktiver Enzym-Verdauungspraeparate |
| DE2035739A1 (en) * | 1970-07-18 | 1972-01-27 | Röhm FmbH, 6100 Darmstadt | Oral enzyme prepsn - consisting of granulate with gastric juices-resistant coating in tablet or capsule form |
| GB1342409A (en) * | 1970-07-23 | 1974-01-03 | Ciba Geigy Ag | Flowable pancreatin preparation of low microorgan ism content and a process for its manufacture |
| BE795766A (fr) * | 1972-02-22 | 1973-08-22 | Lilly Co Eli | Particules de napsylate de propoxyphene retard et procede de fabrication de ces particules |
| US3922339A (en) * | 1974-06-20 | 1975-11-25 | Kv Pharm Co | Sustained release medicant |
| DE2512746C3 (de) * | 1975-03-22 | 1980-04-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin |
| GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| JPS5347513A (en) * | 1976-10-14 | 1978-04-28 | Meiji Seika Kaisha Ltd | Preparation of enzymatic agent |
-
1979
- 1979-06-08 DE DE2923279A patent/DE2923279C2/de not_active Expired
- 1979-10-31 US US06/089,963 patent/US4280971A/en not_active Expired - Lifetime
-
1980
- 1980-03-27 ES ES489967A patent/ES489967A1/es not_active Expired
- 1980-03-28 AR AR280494A patent/AR228427A1/es active
- 1980-04-10 IE IE733/80A patent/IE49584B1/en not_active IP Right Cessation
- 1980-04-17 AU AU57552/80A patent/AU532838B2/en not_active Expired
- 1980-04-18 NZ NZ193476A patent/NZ193476A/xx unknown
- 1980-04-21 SU SU802911402A patent/SU1256690A3/ru active
- 1980-04-22 IL IL59893A patent/IL59893A/xx unknown
- 1980-04-23 PT PT71136A patent/PT71136A/pt not_active IP Right Cessation
- 1980-05-07 PH PH23983A patent/PH16898A/en unknown
- 1980-05-16 ZA ZA00802919A patent/ZA802919B/xx unknown
- 1980-05-28 DD DD80221415A patent/DD151184A5/de unknown
- 1980-05-31 EP EP80103046A patent/EP0021129B2/de not_active Expired
- 1980-05-31 AT AT80103046T patent/ATE6030T1/de not_active IP Right Cessation
- 1980-05-31 DE DE8080103046T patent/DE3066366D1/de not_active Expired
- 1980-06-03 FI FI801779A patent/FI84022C/sv not_active IP Right Cessation
- 1980-06-04 KR KR1019800002205A patent/KR850000625B1/ko active
- 1980-06-06 DK DK244480A patent/DK158932C/da not_active IP Right Cessation
- 1980-06-06 CA CA000353493A patent/CA1142082A/en not_active Expired
- 1980-06-06 GR GR62148A patent/GR69290B/el unknown
- 1980-06-06 JP JP7565880A patent/JPS55164622A/ja active Granted
- 1980-06-06 NO NO801690A patent/NO158949C/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Name/ company changed in patent |
Owner name: SOLVAY PHARMACEUTICALS GMBH |
|
| MA | Patent expired |
Owner name: SOLVAY PHARMACEUTICALS GMBH |