FI80019B - Nya karboxamider. - Google Patents
Nya karboxamider. Download PDFInfo
- Publication number
- FI80019B FI80019B FI840867A FI840867A FI80019B FI 80019 B FI80019 B FI 80019B FI 840867 A FI840867 A FI 840867A FI 840867 A FI840867 A FI 840867A FI 80019 B FI80019 B FI 80019B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- compounds
- compound
- alk
- fluorobenzoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Claims (8)
1. Förfarande för framställning av terapeutiskt an-vändbara N-(piperidinyl-alkyl)karboxamider med formeln I ·-· / \ R-Ar,-CO-NH-alk-N ·~Χ-Αγ, (I), ' \ / 2 ·-· i vilken R betecknar C1_4-alkoxi, hydroxi eller halogen, Ar^ betecknar eventuellt med C1_4-alkyl, halogen, C1_4-alkoxi, cyano, halogen-C1_4-alkyl, karbamoyl, Cj^.g-alkoxikarbonyl, C^^-alkylamino, sulfamoyl, di-C1_4-alkylsulfamoyl, C1-4-alkyltio, C1_4-alkansulfinyl och/eller C1_4-alkansulfonyl substituerad fenylen eller pyridylen, alk betecknar C^y-alkylen, X betecknar karbonyl, hydroximetylen eller metylen och Ar2 betecknar eventuellt med halogen substituerad fenyl eller tienyl, förutsatt att C1_4-alkylamino substituent av Arj inte kan vara bunden i orto-ställning med avseende pä gruppen -CO-NH-, och för framställning av salter därav, kännetecknat därav, att a) en förening med formeln R-A^-Xj^ (Ha), väri betecknar karboxi eller reaktionsduglig funktionellt omvand-lad karboxi, kondenseras med en förening med formeln Hb 45 8001 9 ·-· H-N-alk-N •-X-Ar, (lib) 2 \ / 2 ·-· eller ett salt därav, eller b) föreningar med formlerna Ilia och mb X« ·-· /2 / \ R-Arf-CO-N^ (Ilia) och X^-N *-X-Ar2 (Illb), Xj ·-· i vilka X2 betecknar väte, en av resterna Xj och x4 beteck-nar väte och den andra en grupp med formeln -alk-x5 och x5 är reaktionsduglig förestrad hydroxi, eller för framställ-ning av förenlngarna med formeln I, vari alk betecknar alky-len med 2 eller 3 medlemmar, innehällande 2 till högst 7 C-atomer, föreningar med formlerna Ilia och Illb, i vilka X2 och X3 betecknar tillsammans en rest alk', varvid alk' betecknar alkylen med 2 eller 3 medlemmar, innehällande 2 till högst 7 C-atomer och x4 är väte, eller salter därav, konden-seras intermolekylärt, eller c) för framställning av föreningar med formeln I, vari alk betecknar en alkylengrupp med 2 tili högst 7 kolatomer, vilken ätskiljer de bäda N-atomerna frän varandra med 2-3 C-atomer, en förening med formeln IVa o /\ R-Ar.-C alk' (IVa), 1 \/ N i vilken alk' betecknar en alkylengrupp med 2 tili högst 7 kolatomer, vilken ätskiljer C- och N-atomerna fr&n varandra med 2-3 C-atomer, omsätts med en förening med formeln IVb 46 8001 9 • -· / \ H-N *-X-Ar„ (IVb) \ / 2 • -· eller, om sä önskas, en förening med formeln I eller ett sait därav, väri Ar-L är cyano, hydrolyseras eller alkoholyseras tili en förening med formeln I eller ett sait därav, väri Arj_ är karba-moyl eller respektive C2_5~alkoxikarbonyl, eller en förening med formeln I eller ett sait därav, väri R betecknar C1_4-alkoxi, överförs, med hjälp av eteravspalt-ning i en förening med formeln I, väri R är hydroxi, eller en förening med formeln I eller ett sait därav, väri X betecknar karbonyl, reduceras tili en förening med formeln I eller ett sait därav, väri X är hydroximetylen, eller en fri förening med formeln I överförs i ett sait eller ett sait överförs i en fri förening med formeln I eller i ett annat sait.
2. Förfarande enligt patentkravet 1, känneteck-n a t därav, att man utgär frän föreningarna med formeln Ila, väri X^ är C1_4-alkoxikarbonyl, l-C1_4-alkoxivinyloxi-karbonyl, 2-(N-C1_4-alkylkarbamoyl)-vinyloxikarbonyl, 1,3-dicyklohexyl-2-isoureido-karbonyl, eventuellt med nitro substituerad fenoxikarbonyl, C1_4-alkoxikarbonyloxikarbonyl, halogenkarbonyl eller 1-imidazolylkarbonyl.
3. Förfarande enligt patentkravet 2, känneteck-n a t därav, att man utgär frän föreningarna med formeln Ila, väri betecknar metoxi- eller etoxikarbonyl, 1-etoxi-vinyloxikarbonyl, 2-(N-etylkarbamoyl)-vinyloxikarbonyl, 1,3-dicyklohexyl-2-isoureidokarbonyl, 4-nitro-fenoxikarbo-nyl, etoxi- eller isobutyloxi-karbonyloxikarbonyl, klorkar-bonyl eller 1-imidazolylkarbonyl.
4. Förfarande enligt patentkravet 1 eller 2, k ä n -netecknat därav, att man utgär frän föreningarna med formlerna Ila och Hb och kondenseringen utförs i närva- 47 8001 9 ro av ett basiskt kondenseringsmedel.
5. Förfarande enligt patentkravet l, k ä n n e - t e c k n a t därav, att man utgär frän föreningarna med formlerna Ha och Hb, väri Xx betecknar karboxi och reaktionen utförs med ett dehydratiseringsmedel.
6. Förfarande enligt patentkravet 1, känneteck-n a t därav, att man utgär frän föreningarna med formlerna lila och mb, väri X5 betecknar halogen, och kondenseringen utförs i närvaro av en bas.
7. Förfarande enligt nägot av patentkraven 1-5, k ä n-netecknat därav, att man framställer 5-cyano-N-[2- [4-(p-fluorbensoyl)-piperidinyl]-etyl]-2-metoxi-bensamid el-ler ett sait därav.
8. Förfarande enligt nägot av patentkraven 1-5, k ä n-netecknat därav, att man framställer 4-klor-5-cyano-N-[2-[4-(p-fluorbensoyl)-piperidinyl]-etyl]-2-metoxibensamid eller ett sait därav.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH125883 | 1983-03-09 | ||
| CH392583 | 1983-07-18 | ||
| CH392583 | 1983-07-18 | ||
| CH125883 | 1999-01-28 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI840867A0 FI840867A0 (fi) | 1984-03-05 |
| FI840867A FI840867A (fi) | 1984-09-10 |
| FI80019B true FI80019B (fi) | 1989-12-29 |
| FI80019C FI80019C (sv) | 1990-04-10 |
Family
ID=25687141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI840867A FI80019C (sv) | 1983-03-09 | 1984-03-05 | Förfarande för framställning av terapeutiskt användbara N-(piperidinyl -alkyl)karboxamider |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4559349A (sv) |
| EP (1) | EP0124476B1 (sv) |
| KR (1) | KR900008674B1 (sv) |
| AR (1) | AR242185A1 (sv) |
| AU (1) | AU583470B2 (sv) |
| CA (1) | CA1273929A (sv) |
| CY (1) | CY1576A (sv) |
| DD (1) | DD220308A5 (sv) |
| DE (1) | DE3472251D1 (sv) |
| DK (1) | DK159420C (sv) |
| ES (3) | ES8602659A1 (sv) |
| FI (1) | FI80019C (sv) |
| HK (1) | HK18491A (sv) |
| HU (1) | HU191591B (sv) |
| IE (1) | IE57057B1 (sv) |
| IL (1) | IL71185A (sv) |
| NO (1) | NO164349C (sv) |
| NZ (1) | NZ207428A (sv) |
| PH (1) | PH21416A (sv) |
| PT (1) | PT78212B (sv) |
| SG (1) | SG91490G (sv) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0177078A1 (en) * | 1984-09-12 | 1986-04-09 | Duphar International Research B.V | Spasmolytically active tertiary amine derivatives and method of preparing the same |
| US4772630A (en) * | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
| FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
| US4900841A (en) * | 1987-04-20 | 1990-02-13 | Schering A.G. | 1-[4-[(methyl-sulfonyl)amino]benzoyl]aziridine |
| DE3888727T2 (de) * | 1987-06-02 | 1994-09-01 | Ajinomoto Kk | Verwendung von Äthylamin-Derivaten als antihypertensive Wirkstoffe. |
| US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
| FI97540C (sv) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Förfarande för framställning av terapeutiskt användbara aromatiskt substituerade piperidin- och piperazinderivat |
| FR2676226B1 (fr) * | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. |
| DE69330823T2 (de) * | 1992-02-13 | 2002-05-02 | Merrell Pharmaceuticals Inc., Cincinnati | Thiacyclische piperidinylderivate |
| EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
| US5728835A (en) * | 1993-12-27 | 1998-03-17 | Toa Eiyo, Ltd. | Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| WO2000029377A1 (en) * | 1998-11-17 | 2000-05-25 | F. Hoffmann-La Roche Ag | 4-aroyl-piperidin-ccr-3 receptor antagonists iii |
| BR9915735A (pt) | 1998-11-20 | 2001-09-04 | Hoffmann La Roche | Antagonistas receptores de ccr-3 de piperidina |
| CZ20013451A3 (cs) | 1999-03-26 | 2002-04-17 | Astrazeneca Ab | Nové sloučeniny |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE635597A (sv) * | 1962-03-01 | |||
| US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
| US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| FI853477L (fi) * | 1984-09-14 | 1986-03-15 | Ciba Geigy Ag | Foerfarande foer framstaellning av karbonylfoereningar. |
| DE3563964D1 (en) * | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
-
1984
- 1984-02-28 DK DK114684A patent/DK159420C/da not_active IP Right Cessation
- 1984-03-05 US US06/586,493 patent/US4559349A/en not_active Expired - Lifetime
- 1984-03-05 EP EP84810109A patent/EP0124476B1/de not_active Expired
- 1984-03-05 FI FI840867A patent/FI80019C/sv not_active IP Right Cessation
- 1984-03-05 DE DE8484810109T patent/DE3472251D1/de not_active Expired
- 1984-03-07 ES ES84530358A patent/ES8602659A1/es not_active Expired
- 1984-03-07 DD DD84260660A patent/DD220308A5/de not_active IP Right Cessation
- 1984-03-07 CA CA000449025A patent/CA1273929A/en not_active Expired
- 1984-03-07 PT PT78212A patent/PT78212B/pt not_active IP Right Cessation
- 1984-03-08 AU AU25424/84A patent/AU583470B2/en not_active Ceased
- 1984-03-08 NO NO840889A patent/NO164349C/no unknown
- 1984-03-08 IL IL71185A patent/IL71185A/xx not_active IP Right Cessation
- 1984-03-08 PH PH30367A patent/PH21416A/en unknown
- 1984-03-08 HU HU84935A patent/HU191591B/hu not_active IP Right Cessation
- 1984-03-08 IE IE563/84A patent/IE57057B1/en not_active IP Right Cessation
- 1984-03-08 NZ NZ207428A patent/NZ207428A/en unknown
- 1984-03-09 KR KR1019840001204A patent/KR900008674B1/ko not_active IP Right Cessation
-
1985
- 1985-06-28 ES ES85544713A patent/ES8702890A1/es not_active Expired
-
1986
- 1986-03-14 ES ES553050A patent/ES8800152A1/es not_active Expired
- 1986-08-08 AR AR86304848A patent/AR242185A1/es active
-
1990
- 1990-11-13 SG SG914/90A patent/SG91490G/en unknown
-
1991
- 1991-03-14 HK HK184/91A patent/HK18491A/xx not_active IP Right Cessation
- 1991-12-20 CY CY1576A patent/CY1576A/xx unknown
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