ES8702890A1 - Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas - Google Patents

Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas

Info

Publication number
ES8702890A1
ES8702890A1 ES85544713A ES544713A ES8702890A1 ES 8702890 A1 ES8702890 A1 ES 8702890A1 ES 85544713 A ES85544713 A ES 85544713A ES 544713 A ES544713 A ES 544713A ES 8702890 A1 ES8702890 A1 ES 8702890A1
Authority
ES
Spain
Prior art keywords
thio
halogen
formula
alk
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES85544713A
Other languages
English (en)
Other versions
ES544713A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8702890A1 publication Critical patent/ES8702890A1/es
Publication of ES544713A0 publication Critical patent/ES544713A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms

Abstract

PROCEDIMIENTO PARA PRODUCIR N-(PIPERIDINIL-ALQUIL)-CARBOXAMIDAS. CONSISTE EN CONDENSAR INTRAMOLECULARMENTE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN PRESENCIA DE UNA BASE COMO AMIDAS SODICAS HIDROXIDOS ALCALINOS, EN AUSENCIA DE DISOLVENTE, A UNA TEMPERATURA ENTRE 0 Y 200JC Y EN RECIPIENTE CERRADO BAJO PRESION, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES ACIDAS FARMACEUTICAMENTE UTILIZABLES. SIENDO: AR1 UN RESTO ARILENO O HETEROARILENO MONOCICLICO; AR2 UN RESTO ARILO O HETEROARILO MONOCICLICO; X UN GRUPO CARBONILO LIBRE O CETALIZADO O HIDROXIMETILENO; X2 H, X3 Y X4 H O UN RESTO DE FORMULA ALK-X5; X5 HIDROXI ESTERIFICADO; R HIDROXI, HIDROXI ETERADO CON UN ALCOHOL DIFASICO ALK ALCALI. SE UTILIZAN COMO ANTIPSICOTICOS PARA EL TRATAMIENTO PROFILACTICO EN HUMANOS.
ES85544713A 1983-03-09 1985-06-28 Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas Expired ES8702890A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH125883 1983-03-09
CH392583 1983-07-18

Publications (2)

Publication Number Publication Date
ES8702890A1 true ES8702890A1 (es) 1987-01-16
ES544713A0 ES544713A0 (es) 1987-01-16

Family

ID=25687141

Family Applications (3)

Application Number Title Priority Date Filing Date
ES84530358A Granted ES530358A0 (es) 1983-03-09 1984-03-07 Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas.
ES85544713A Expired ES8702890A1 (es) 1983-03-09 1985-06-28 Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas
ES553050A Expired ES8800152A1 (es) 1983-03-09 1986-03-14 Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES84530358A Granted ES530358A0 (es) 1983-03-09 1984-03-07 Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES553050A Expired ES8800152A1 (es) 1983-03-09 1986-03-14 Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas

Country Status (21)

Country Link
US (1) US4559349A (es)
EP (1) EP0124476B1 (es)
KR (1) KR900008674B1 (es)
AR (1) AR242185A1 (es)
AU (1) AU583470B2 (es)
CA (1) CA1273929A (es)
CY (1) CY1576A (es)
DD (1) DD220308A5 (es)
DE (1) DE3472251D1 (es)
DK (1) DK159420C (es)
ES (3) ES530358A0 (es)
FI (1) FI80019C (es)
HK (1) HK18491A (es)
HU (1) HU191591B (es)
IE (1) IE57057B1 (es)
IL (1) IL71185A (es)
NO (1) NO164349C (es)
NZ (1) NZ207428A (es)
PH (1) PH21416A (es)
PT (1) PT78212B (es)
SG (1) SG91490G (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0177078A1 (en) * 1984-09-12 1986-04-09 Duphar International Research B.V Spasmolytically active tertiary amine derivatives and method of preparing the same
US4772630A (en) * 1984-11-23 1988-09-20 Ciba-Geigy Corp. Benzamides and their salts
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
US4900841A (en) * 1987-04-20 1990-02-13 Schering A.G. 1-[4-[(methyl-sulfonyl)amino]benzoyl]aziridine
DE3888727T2 (de) * 1987-06-02 1994-09-01 Ajinomoto Kk Verwendung von Äthylamin-Derivaten als antihypertensive Wirkstoffe.
US4990511A (en) * 1988-08-03 1991-02-05 Takeda Chemical Industries, Ltd. Amide compounds, their production and use
IE903957A1 (en) * 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
FR2676226B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino.
PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
US5728835A (en) * 1993-12-27 1998-03-17 Toa Eiyo, Ltd. Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
CA2350722A1 (en) * 1998-11-17 2000-05-25 Leyi Gong 4-aroyl-piperidin-ccr-3 receptor antagonists iii
BR9915735A (pt) 1998-11-20 2001-09-04 Hoffmann La Roche Antagonistas receptores de ccr-3 de piperidina
BR0009338A (pt) * 1999-03-26 2001-12-26 Astrazeneca Ab Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença
GB0013060D0 (en) 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
GB0021670D0 (en) 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
GB0117899D0 (en) 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
US6770659B2 (en) * 2002-08-26 2004-08-03 Sk Corporation Benzoyl piperidine compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL289475A (es) * 1962-03-01
US3632767A (en) * 1968-02-12 1972-01-04 Mallinckrodt Chemical Works Treatment of depression with 4-substituted piperidines
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US4335127A (en) * 1979-01-08 1982-06-15 Janssen Pharmaceutica, N.V. Piperidinylalkyl quinazoline compounds, composition and method of use
EP0174654A3 (de) * 1984-09-14 1987-07-22 Ciba-Geigy Ag Carbonylverbindungen
DE3563964D1 (en) * 1984-10-16 1988-09-01 Synthelabo Piperidine derivatives, their preparation and their therapeutical application

Also Published As

Publication number Publication date
EP0124476B1 (de) 1988-06-22
FI840867A0 (fi) 1984-03-05
SG91490G (en) 1991-01-18
NO840889L (no) 1984-09-10
IE57057B1 (en) 1992-04-08
KR840008321A (ko) 1984-12-14
DK159420C (da) 1991-03-11
DD220308A5 (de) 1985-03-27
NZ207428A (en) 1987-03-06
IL71185A (en) 1988-06-30
ES8602659A1 (es) 1985-12-01
FI80019C (fi) 1990-04-10
ES8800152A1 (es) 1987-10-16
FI840867A (fi) 1984-09-10
AU583470B2 (en) 1989-05-04
AR242185A1 (es) 1993-03-31
US4559349A (en) 1985-12-17
PT78212A (en) 1984-04-01
PT78212B (en) 1986-08-12
HK18491A (en) 1991-03-22
NO164349B (no) 1990-06-18
EP0124476A1 (de) 1984-11-07
DK159420B (da) 1990-10-15
AU2542484A (en) 1984-09-13
FI80019B (fi) 1989-12-29
NO164349C (no) 1990-09-26
DE3472251D1 (en) 1988-07-28
IE840563L (en) 1984-09-09
DK114684D0 (da) 1984-02-28
CA1273929A (en) 1990-09-11
ES530358A0 (es) 1985-12-01
KR900008674B1 (ko) 1990-11-26
HU191591B (en) 1987-03-30
ES544713A0 (es) 1987-01-16
DK114684A (da) 1984-09-10
IL71185A0 (en) 1984-06-29
CY1576A (en) 1991-12-20
ES553050A0 (es) 1987-10-16
PH21416A (en) 1987-10-15

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SA1 Expiration date (snapshot 920101)

Free format text: 2006-11-07

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