ES8602659A1 - Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas. - Google Patents
Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas.Info
- Publication number
- ES8602659A1 ES8602659A1 ES84530358A ES530358A ES8602659A1 ES 8602659 A1 ES8602659 A1 ES 8602659A1 ES 84530358 A ES84530358 A ES 84530358A ES 530358 A ES530358 A ES 530358A ES 8602659 A1 ES8602659 A1 ES 8602659A1
- Authority
- ES
- Spain
- Prior art keywords
- thio
- halogen
- formula
- alk
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
- C07D203/18—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carboxylic acids, or by sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE N-(PIPERIDINIL-ALQUIL-CARBOXAMIDAS).CONSISTENTE EN OBTENER COMPUESTOS DE FORMULA (I) DONDE R ES HIDROXI U OTROS VARIOS AR1 ES ARILENO O HETEROARILENO MONOCICLICO, ALK ES ALQUILENO DE UN MINIMO DE 2 CARBONOS, X ES CARBONILO LIBRE U OTROS VARIOS, AR2 ES ARILO O HETEROARILO MONOCICLICO, MEDIANTE LA CONDENSACION, EN PRESENCIA DE UN AGENTE DE CONDENSACION BASICO, DE UN COMPUESTO (IIA) DONDE X1 ES CARBOXI, O CARBOXI MODIFICADO CON UN COMPUESTO DE FORMULA (IIB). DE APLICACION COMO ANTIPSICOTICOS, DE ACCION ANTIDOPAMINERGICA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH125883 | 1983-03-09 | ||
CH392583 | 1983-07-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8602659A1 true ES8602659A1 (es) | 1985-12-01 |
ES530358A0 ES530358A0 (es) | 1985-12-01 |
Family
ID=25687141
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES84530358A Granted ES530358A0 (es) | 1983-03-09 | 1984-03-07 | Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas. |
ES85544713A Expired ES8702890A1 (es) | 1983-03-09 | 1985-06-28 | Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas |
ES553050A Expired ES8800152A1 (es) | 1983-03-09 | 1986-03-14 | Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES85544713A Expired ES8702890A1 (es) | 1983-03-09 | 1985-06-28 | Procedimiento para la obtencion de n-(piperidinil-alquil)- carboxamidas |
ES553050A Expired ES8800152A1 (es) | 1983-03-09 | 1986-03-14 | Procedimiento para la obtencion de n-(piperidinil-alquil)-carboxamidas |
Country Status (21)
Country | Link |
---|---|
US (1) | US4559349A (es) |
EP (1) | EP0124476B1 (es) |
KR (1) | KR900008674B1 (es) |
AR (1) | AR242185A1 (es) |
AU (1) | AU583470B2 (es) |
CA (1) | CA1273929A (es) |
CY (1) | CY1576A (es) |
DD (1) | DD220308A5 (es) |
DE (1) | DE3472251D1 (es) |
DK (1) | DK159420C (es) |
ES (3) | ES530358A0 (es) |
FI (1) | FI80019C (es) |
HK (1) | HK18491A (es) |
HU (1) | HU191591B (es) |
IE (1) | IE57057B1 (es) |
IL (1) | IL71185A (es) |
NO (1) | NO164349C (es) |
NZ (1) | NZ207428A (es) |
PH (1) | PH21416A (es) |
PT (1) | PT78212B (es) |
SG (1) | SG91490G (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0177078A1 (en) * | 1984-09-12 | 1986-04-09 | Duphar International Research B.V | Spasmolytically active tertiary amine derivatives and method of preparing the same |
US4772630A (en) * | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
US4900841A (en) * | 1987-04-20 | 1990-02-13 | Schering A.G. | 1-[4-[(methyl-sulfonyl)amino]benzoyl]aziridine |
DE3888727T2 (de) * | 1987-06-02 | 1994-09-01 | Ajinomoto Kk | Verwendung von Äthylamin-Derivaten als antihypertensive Wirkstoffe. |
US4990511A (en) * | 1988-08-03 | 1991-02-05 | Takeda Chemical Industries, Ltd. | Amide compounds, their production and use |
IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
FR2676226B1 (fr) * | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. |
PT626968E (pt) * | 1992-02-13 | 2002-03-28 | Merrell Pharma Inc | Derivados de piperidinilo tiaciclicos |
EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
US5728835A (en) * | 1993-12-27 | 1998-03-17 | Toa Eiyo, Ltd. | Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same |
IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
CA2350722A1 (en) * | 1998-11-17 | 2000-05-25 | Leyi Gong | 4-aroyl-piperidin-ccr-3 receptor antagonists iii |
BR9915735A (pt) | 1998-11-20 | 2001-09-04 | Hoffmann La Roche | Antagonistas receptores de ccr-3 de piperidina |
BR0009338A (pt) * | 1999-03-26 | 2001-12-26 | Astrazeneca Ab | Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença |
GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL289475A (es) * | 1962-03-01 | |||
US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
EP0174654A3 (de) * | 1984-09-14 | 1987-07-22 | Ciba-Geigy Ag | Carbonylverbindungen |
DE3563964D1 (en) * | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
-
1984
- 1984-02-28 DK DK114684A patent/DK159420C/da not_active IP Right Cessation
- 1984-03-05 FI FI840867A patent/FI80019C/fi not_active IP Right Cessation
- 1984-03-05 DE DE8484810109T patent/DE3472251D1/de not_active Expired
- 1984-03-05 US US06/586,493 patent/US4559349A/en not_active Expired - Lifetime
- 1984-03-05 EP EP84810109A patent/EP0124476B1/de not_active Expired
- 1984-03-07 PT PT78212A patent/PT78212B/pt not_active IP Right Cessation
- 1984-03-07 ES ES84530358A patent/ES530358A0/es active Granted
- 1984-03-07 CA CA000449025A patent/CA1273929A/en not_active Expired
- 1984-03-07 DD DD84260660A patent/DD220308A5/de not_active IP Right Cessation
- 1984-03-08 PH PH30367A patent/PH21416A/en unknown
- 1984-03-08 HU HU84935A patent/HU191591B/hu not_active IP Right Cessation
- 1984-03-08 IE IE563/84A patent/IE57057B1/en not_active IP Right Cessation
- 1984-03-08 AU AU25424/84A patent/AU583470B2/en not_active Ceased
- 1984-03-08 NO NO840889A patent/NO164349C/no unknown
- 1984-03-08 NZ NZ207428A patent/NZ207428A/en unknown
- 1984-03-08 IL IL71185A patent/IL71185A/xx not_active IP Right Cessation
- 1984-03-09 KR KR1019840001204A patent/KR900008674B1/ko not_active IP Right Cessation
-
1985
- 1985-06-28 ES ES85544713A patent/ES8702890A1/es not_active Expired
-
1986
- 1986-03-14 ES ES553050A patent/ES8800152A1/es not_active Expired
- 1986-08-08 AR AR86304848A patent/AR242185A1/es active
-
1990
- 1990-11-13 SG SG914/90A patent/SG91490G/en unknown
-
1991
- 1991-03-14 HK HK184/91A patent/HK18491A/xx not_active IP Right Cessation
- 1991-12-20 CY CY1576A patent/CY1576A/xx unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20001102 |