FI77843B - Foerfarande foer aendring av konfigurationen av optiskt aktiv 1-(2-cyklopentylfenoxi)-3-tert-butylamino-2-propanol och vid foerfarandet som mellanprodukt anvaend 1-tert-butylamino-4- (2-cyklopentylfenoximetyl)oxazoliniumhalogenid. - Google Patents

Foerfarande foer aendring av konfigurationen av optiskt aktiv 1-(2-cyklopentylfenoxi)-3-tert-butylamino-2-propanol och vid foerfarandet som mellanprodukt anvaend 1-tert-butylamino-4- (2-cyklopentylfenoximetyl)oxazoliniumhalogenid. Download PDF

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Publication number
FI77843B
FI77843B FI832788A FI832788A FI77843B FI 77843 B FI77843 B FI 77843B FI 832788 A FI832788 A FI 832788A FI 832788 A FI832788 A FI 832788A FI 77843 B FI77843 B FI 77843B
Authority
FI
Finland
Prior art keywords
tert
formula
configuration
compounds
propanol
Prior art date
Application number
FI832788A
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English (en)
Finnish (fi)
Other versions
FI832788A (fi
FI77843C (sv
FI832788A0 (fi
Inventor
Hans-Juergen Leuchs
Werner Mohler
Hanns-Eberhard Erle
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI832788A0 publication Critical patent/FI832788A0/fi
Publication of FI832788A publication Critical patent/FI832788A/fi
Application granted granted Critical
Publication of FI77843B publication Critical patent/FI77843B/fi
Publication of FI77843C publication Critical patent/FI77843C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
  • Coloring (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Integrated Circuits (AREA)
  • Carbon And Carbon Compounds (AREA)

Claims (5)

1. Förfarande för omvandling av konfigurationen vid den optiskt aktiva kolatomen (*) i en förening med 5 formeln I l J OH CH, X 1 1 >r—O-CH CH-CH -NH-C-™ I " yr · kännetecknat därav, att föreningen med formeln I omvandlas medelst formylering tili en optiskt aktiv 15 förening med formeln II OH 0=C-H CH,
1. I I 3 20 r^j|-0-CH2-CH-CH2-N-C-CHj II CHj varvid konf igurationen vid kolatomen (*) bibehälls oför-ändrad, denna omvandlas genom behandling med en syrahalo-. : 25 genid tili en optiskt aktiv förening med formeln III * O /"s.t·· X \ / CH Ω
30 XX-O-CH -CH-CH, *“"3 *=* III u väri betecknar en halogenidanjon, och detta oxazoli-niumderivat III överförs medelst sur eller alkalisk hyd-35 rolys, eventuellt via en N-formylförening, tiilen optisk aktiv förening med formeln IV
FI832788A 1982-08-04 1983-08-02 Förfarande för ändring av konfigurationen av optiskt aktiv 1-(2-cyklop entylfenoxi)-3-tert-butylamino-2-propanol och vid förfarandet som mell anprodukt använd 1-tert-butylamino-4-(2-cyklopentylfenoximetyl)oxazoli niumhalogenid FI77843C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3229046 1982-08-04
DE19823229046 DE3229046A1 (de) 1982-08-04 1982-08-04 Verfahren zur umkehrung der konfiguration optisch aktiver verbindungen und optisch aktive zwischenprodukte dieses verfahrens

Publications (4)

Publication Number Publication Date
FI832788A0 FI832788A0 (fi) 1983-08-02
FI832788A FI832788A (fi) 1984-02-05
FI77843B true FI77843B (fi) 1989-01-31
FI77843C FI77843C (sv) 1989-05-10

Family

ID=6170062

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832788A FI77843C (sv) 1982-08-04 1983-08-02 Förfarande för ändring av konfigurationen av optiskt aktiv 1-(2-cyklop entylfenoxi)-3-tert-butylamino-2-propanol och vid förfarandet som mell anprodukt använd 1-tert-butylamino-4-(2-cyklopentylfenoximetyl)oxazoli niumhalogenid

Country Status (15)

Country Link
US (1) US4952730A (sv)
EP (1) EP0102520B1 (sv)
JP (1) JPH0662518B2 (sv)
AT (1) ATE23149T1 (sv)
AU (1) AU563871B2 (sv)
CA (1) CA1272213A (sv)
DE (2) DE3229046A1 (sv)
DK (1) DK165319C (sv)
ES (2) ES524665A0 (sv)
FI (1) FI77843C (sv)
HU (2) HU190606B (sv)
IL (1) IL69416A (sv)
NZ (1) NZ205115A (sv)
PH (1) PH21178A (sv)
ZA (1) ZA835663B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254595A (en) * 1988-12-23 1993-10-19 Elf Sanofi Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
AU2007297827B2 (en) * 2006-09-20 2012-09-20 Mallinckrodt Llc Preparation of substituted morphinan-6-ones and salts and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2446192A (en) * 1946-01-26 1948-08-03 Merck & Co Inc Preparation of threonine and derivatives thereof
US2530627A (en) * 1946-09-06 1950-11-21 Merck & Co Inc Production of n-acyl allothreonine esters
US2513346A (en) * 1948-12-21 1950-07-04 Parke Davis & Co Process for obtaining organic amino diols
US4294966A (en) * 1978-07-28 1981-10-13 Ciba-Geigy Corporation Process for inverting the configuration in optically active compounds
US4237304A (en) * 1978-10-26 1980-12-02 The Dow Chemical Company Oxazolinium salts and method of preparation
US4386003A (en) * 1981-09-17 1983-05-31 Sherwood Medical Industries Inc. Blood separating composition

Also Published As

Publication number Publication date
IL69416A (en) 1988-03-31
NZ205115A (en) 1987-10-30
JPH0662518B2 (ja) 1994-08-17
DK354883D0 (da) 1983-08-03
ES8404337A1 (es) 1984-05-01
ATE23149T1 (de) 1986-11-15
CA1272213A (en) 1990-07-31
DE3229046A1 (de) 1984-02-16
DK165319C (da) 1993-03-29
ES527443A0 (es) 1984-11-16
JPS5946276A (ja) 1984-03-15
ES8501379A1 (es) 1984-11-16
US4952730A (en) 1990-08-28
FI832788A (fi) 1984-02-05
DE3367208D1 (en) 1986-12-04
ES524665A0 (es) 1984-05-01
HU190606B (en) 1986-09-29
EP0102520B1 (de) 1986-10-29
IL69416A0 (en) 1983-11-30
ZA835663B (en) 1984-04-25
FI77843C (sv) 1989-05-10
FI832788A0 (fi) 1983-08-02
DK354883A (da) 1984-02-05
AU563871B2 (en) 1987-07-23
EP0102520A1 (de) 1984-03-14
AU1757383A (en) 1984-02-09
HU198460B (en) 1989-10-30
DK165319B (da) 1992-11-09
PH21178A (en) 1987-08-07

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Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH