FI75171C - Förfarande för framställning av vid behandling av kancersjukdomar anvä ndbara samutfällningar. - Google Patents

Förfarande för framställning av vid behandling av kancersjukdomar anvä ndbara samutfällningar. Download PDF

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Publication number
FI75171C
FI75171C FI843745A FI843745A FI75171C FI 75171 C FI75171 C FI 75171C FI 843745 A FI843745 A FI 843745A FI 843745 A FI843745 A FI 843745A FI 75171 C FI75171 C FI 75171C
Authority
FI
Finland
Prior art keywords
phenyl
alkyl
titanium
polyethylene glycol
hydrogen
Prior art date
Application number
FI843745A
Other languages
English (en)
Finnish (fi)
Other versions
FI843745A0 (fi
FI75171B (fi
FI843745L (fi
Inventor
Heimo J Keller
Bernhard Keppler
Uwe Krueger
Rudolf Linder
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of FI843745A0 publication Critical patent/FI843745A0/fi
Publication of FI843745L publication Critical patent/FI843745L/fi
Publication of FI75171B publication Critical patent/FI75171B/fi
Application granted granted Critical
Publication of FI75171C publication Critical patent/FI75171C/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003—Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (5)

1. Förfarande för framställning av vid behandling av kancersjukdomar användbara samutfällningar frän 5 komplexföreningar med formeln /R1(CH_) C(0)CR3C(0)R^)oM(0R4) _ X I ^ 2 m 2 2-n n väri 10 m är titan, zirkonium eller hafnium, R ar väte, C^_g-alkyl eller fenyl, som kan ha 1 eller flera fluor-, klor-, brom-, nitro-, C^_^-alkyl-, C^_4~ alkoxi- eller trifluormetylsubstituenter, 2 R är C^_g-alkyl eller fenyl, som kan ha 1 eller flera 15 fluor-, klor-, brom-, nitro-, C^_4~alkyl-, C^_4~alkoxi- eller trifluormetysubstituenter, 3 R är väte eller fenyl, 4 R är C^_^g-alkyl, som kan vara substituerad med hydr-oxi-, C^_g-alkylamin- eller alkalisulfonatogrupper, el-20 ler Cj._g-cykloalkyl, som kan vara substituerad med C^_^-alkylgrupper, hydroxi- eller alkalisulfonatogrupper, X är fluor, klor eller brom, m är talet 0 eller 1, men kan ej vara 0 ää R är väte, och n är talet 0 eller 1, 4 25 och ifall resten R innehäller en aminogrupp, hydrohalo- genider av dessa föreningar och frän hydrofila polymerer, kännetecknat därav, att en komplexförening 12 3 4 med formeln I, väri M, R,R,R,R,X,m och n betyder 4 samma som ovan, och, ifall R innehäller en aminogrupp, 30 dess hydrohalogenid, löst i ett inert organiskt lösnings-medel, tillsammans med en pä samma sätt löst hydrofil polymer, indunstas.
2. Förfarande enligt patentkravet 1, kännetecknat därav, att den hydrofila polymeren är 35 polyvinylpyrrolidon, polyoxietylensorbitanmonofettsyra- ester eller glycerin-polyetylenglykolricinoleat.
FI843745A 1983-02-09 1984-09-24 Förfarande för framställning av vid behandling av kancersjukdomar anvä ndbara samutfällningar. FI75171C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP8300031 1983-02-09
PCT/EP1983/000031 WO1984003042A1 (en) 1983-02-09 1983-02-09 Process for producing therapeutical antineoplastic preparations

Publications (4)

Publication Number Publication Date
FI843745A0 FI843745A0 (fi) 1984-09-24
FI843745L FI843745L (fi) 1984-09-24
FI75171B FI75171B (fi) 1988-01-29
FI75171C true FI75171C (sv) 1988-05-09

Family

ID=8164872

Family Applications (1)

Application Number Title Priority Date Filing Date
FI843745A FI75171C (sv) 1983-02-09 1984-09-24 Förfarande för framställning av vid behandling av kancersjukdomar anvä ndbara samutfällningar.

Country Status (5)

Country Link
DK (1) DK481584A (sv)
FI (1) FI75171C (sv)
HU (1) HU199679B (sv)
NO (1) NO844029L (sv)
WO (1) WO1984003042A1 (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69808755T2 (de) * 1997-05-14 2003-08-14 Qinetiq Ltd Vorprodukt für cvd
GB0119224D0 (en) * 2001-08-07 2001-09-26 Inorgtech Ltd Precursors for metalorganic chemical vapour deposition
US6562990B1 (en) 2002-07-03 2003-05-13 E. I. Du Pont De Nemours And Company Titanium chelates and processes therefor
US8471049B2 (en) 2008-12-10 2013-06-25 Air Product And Chemicals, Inc. Precursors for depositing group 4 metal-containing films
US20110256314A1 (en) 2009-10-23 2011-10-20 Air Products And Chemicals, Inc. Methods for deposition of group 4 metal containing films
US8952188B2 (en) 2009-10-23 2015-02-10 Air Products And Chemicals, Inc. Group 4 metal precursors for metal-containing films

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134709A1 (de) * 1981-09-02 1983-03-10 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Antineoplastisch wirkende titanverbindung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
FI843745A0 (fi) 1984-09-24
NO844029L (no) 1984-10-08
FI75171B (fi) 1988-01-29
FI843745L (fi) 1984-09-24
HUT33968A (en) 1985-01-28
WO1984003042A1 (en) 1984-08-16
DK481584D0 (da) 1984-10-08
DK481584A (da) 1984-10-08
HU199679B (en) 1990-03-28

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Owner name: BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH