FI71127B - Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och pyrrolidin-3-karboxylsyraamidderivat - Google Patents

Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och pyrrolidin-3-karboxylsyraamidderivat Download PDF

Info

Publication number
FI71127B
FI71127B FI843667A FI843667A FI71127B FI 71127 B FI71127 B FI 71127B FI 843667 A FI843667 A FI 843667A FI 843667 A FI843667 A FI 843667A FI 71127 B FI71127 B FI 71127B
Authority
FI
Finland
Prior art keywords
group
general formula
compounds
carbon atoms
derivative
Prior art date
Application number
FI843667A
Other languages
English (en)
Finnish (fi)
Other versions
FI71127C (fi
FI843667L (fi
FI843667A0 (fi
Inventor
Kalman Hideg
Olga Hankovszky
Laszlo Frank
Ilona Bodi
Jozsef Csak
Original Assignee
Alkaloida Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar
Publication of FI843667L publication Critical patent/FI843667L/fi
Publication of FI843667A0 publication Critical patent/FI843667A0/fi
Application granted granted Critical
Publication of FI71127B publication Critical patent/FI71127B/fi
Publication of FI71127C publication Critical patent/FI71127C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Claims (5)

1. Förfarande för framställning av 2,2,5,5-tetramety1-pyrrolin- och pyrrolidin-3-karboxylsyraamidderivat, vilka är 5 användbara som hjärtläkemedel och har den allmänna formeln I --B —]-CO-N-A1-R2 C.H fH3 I C„AnA„3
10. N 3 H väri A^ är en valensbindning eller en rakkedjad eller för- grenad alkylengrupp med 1-5 kolatomer, vilken kan vara subs- tituerad med en hydroxyl- eller aminokarbonylgrupp,
15 B är en enkelbindning eller en dubbelbindning, 2 R är en aromatisk eller aryloxigrupp, vilka kan vara subs- tituerade med en eller flera 1-4 kolatomer innehällande alkyl- eller alkoxigrupper eller halogenatomer, eller är en aminogrupp eller en difenylmetylgrupp eller en R4-NH-CO- 20 grupp, väri 4 R är en eventuellt med en alkylgrupp substituerad fenyl- grupp, 3 R är väte eller en alkylgrupp med 1-4 kolatomer, och salter därav, kännetecknat därav, att man omsätter ett 25 piperidinonderivat med formeln II Br CH34 LCH3 11 CH, 2
30. H eller ett sait därav, med en amin med den allmänna formeln III HN-A1 -R2 XH
35 I 3 Ir
FI843667A 1983-01-20 1984-09-19 Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat FI71127C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU17883 1983-01-20
HU83178A HU189214B (en) 1983-01-20 1983-01-20 Process for preparing pyrroline and pyrrolidine carboxamide derivatives
PCT/HU1984/000004 WO1984002906A1 (en) 1983-01-20 1984-01-20 New amino derivatives of 2- adn-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl) bd
HU8400004 1984-01-20

Publications (4)

Publication Number Publication Date
FI843667L FI843667L (fi) 1984-09-19
FI843667A0 FI843667A0 (fi) 1984-09-19
FI71127B true FI71127B (fi) 1986-08-14
FI71127C FI71127C (fi) 1986-11-24

Family

ID=10948332

Family Applications (1)

Application Number Title Priority Date Filing Date
FI843667A FI71127C (fi) 1983-01-20 1984-09-19 Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat

Country Status (9)

Country Link
US (1) US4731376A (sv)
EP (1) EP0134795B1 (sv)
JP (1) JPS60500668A (sv)
DE (1) DE3473443D1 (sv)
DK (1) DK166776B1 (sv)
FI (1) FI71127C (sv)
HU (1) HU189214B (sv)
SU (1) SU1333236A3 (sv)
WO (1) WO1984002906A1 (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3473442D1 (de) * 1983-01-21 1988-09-22 Alkaloida Vegyeszeti Gyar New alkyl diamine derivatives
US5047555A (en) * 1988-12-13 1991-09-10 Tanabe Seiyaku Co., Ltd. 4-aminophenol derivatives and processes for preparing the same
HUP9700392A1 (hu) * 1997-02-10 1999-09-28 ICN Magyarország Részvénytársaság Egy vagy két hatóanyagot tartalmazó kardioprotektív hatású gyógyszerkészítmények
TWI243162B (en) * 2000-11-10 2005-11-11 Taisho Pharmaceutical Co Ltd Cyanopyrrolidine derivatives
US6827226B2 (en) * 2002-12-09 2004-12-07 Wmc Holdings Incorporated Storage apparatus for sportboards with variable widths
RU2606622C2 (ru) 2010-08-31 2017-01-10 Бионуре Фарма, С.Л. Агонисты рецепторов нейротрофинов и их применение в качестве лекарственных средств
WO2017038552A1 (ja) * 2015-09-04 2017-03-09 Dic株式会社 安定剤化合物、液晶組成物および表示素子
WO2017038617A1 (ja) 2015-09-04 2017-03-09 Dic株式会社 液晶組成物及びそれを使用した液晶表示素子

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE109345C (sv) *
DE109347C (sv) *
DE109346C (sv) *
US3020288A (en) * 1962-02-06 Hypotensive compounds
GB190004799A (en) * 1900-03-13 1900-05-19 George William Johnson The Manufacture of Para-amidophenyl Glyoxylic Acid, its Substitution Products and Homologues.
CH336068A (de) * 1955-04-06 1959-02-15 Bofors Ab Verfahren zur Herstellung von Amiden von N-Alkyl-piperidin-monocarbonsäuren oder N-Alkyl-pyrrolidin-a-monocarbonsäuren
GB983134A (en) * 1962-06-13 1965-02-10 American Cyanamid Co Cyclic nitroxides and process for preparing same
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
US3299097A (en) * 1963-04-29 1967-01-17 Upjohn Co 4-alkylhygric acid hydrazides
US3313801A (en) * 1965-10-18 1967-04-11 Upjohn Co Process for inhibiting n-alkylation of pyrrolidines and substituted pyrrolidines by microorganisms, and products produced thereby
US3624081A (en) * 1967-02-15 1971-11-30 Sterling Drug Inc 1-acyl-2-ethylidenepyrrol-idine-3-carboxamides
US4111901A (en) * 1977-06-06 1978-09-05 Borg-Warner Corporation Hindered five-membered nitrogen rings as polyolefin stabilizers
US4302383A (en) * 1980-05-19 1981-11-24 Borg-Warner Chemicals, Inc. Stabilized olefin polymers

Also Published As

Publication number Publication date
JPH0471067B2 (sv) 1992-11-12
DK166776B1 (da) 1993-07-12
FI71127C (fi) 1986-11-24
JPS60500668A (ja) 1985-05-09
FI843667L (fi) 1984-09-19
EP0134795A1 (en) 1985-03-27
DE3473443D1 (en) 1988-09-22
HU189214B (en) 1986-06-30
WO1984002906A1 (en) 1984-08-02
SU1333236A3 (ru) 1987-08-23
DK447284A (da) 1984-11-20
EP0134795B1 (de) 1988-08-17
FI843667A0 (fi) 1984-09-19
US4731376A (en) 1988-03-15
DK447284D0 (da) 1984-09-19

Similar Documents

Publication Publication Date Title
CN112689629B (zh) 用于抑制Nav1.8的哒嗪化合物
FI67369B (fi) Foerfarande foer framstaellning av nya terapeutiskt aktiva derivat av 3,4-dehydroprolin
FI71127B (fi) Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och pyrrolidin-3-karboxylsyraamidderivat
KR100352899B1 (ko) 새로운3-페닐설포닐-3,7-디아자바이사이클로[3,3,1]노난-화합물을함유하는약제
NO129464B (sv)
FI86845C (sv) Förfarande för framställning av en terapeutiskt användbar fluorallylam in
MXPA02001215A (es) Derivados sustituidos de pirrolidin-2, 3, 4-trion-3-oxima utiles como antagonistas del receptor nmda.
CA1136136A (en) Triazinones
US3972935A (en) Antiarrhythmic agents
JP4030578B2 (ja) 新規の抗痙攣作用を有する４位に二置換アミン基を有する１−アリール（アラルキル）−イミダゾリン−２−オンおよびその製法
FI61484B (fi) Foerfarande foer framstaellning av z-3-(4-bromfenyl)-n-metyl-3-(3-pyridyl)-allylamin med antidepressiv och aongestdaempande verkan
US5804603A (en) Synthesized β-adrenergic blockers derivatives of guaiacol
KR940011528B1 (ko) Nn-디메틸에틸아민의 n-옥사이드, 및 이를 함유하는 약제조성물의 제조방법
US6838580B2 (en) Opioid derivative
EP0167245A1 (en) Anti-arrhythmic agents
SU1517759A3 (ru) Способ получени 4-амино-2-(2-бутанон-3-ил)-окси-5-хлор-N-[2-(диэтиламино)этил]бензамида или его солей
KR0182276B1 (ko) 나프톡사진의 약학적 용도
US4587360A (en) Anti-arrhythmic agents
FI57254C (fi) Analogifoerfarande foer framstaellning av antiarytmiskt aktiva primaera aminoacylanilider
KR890000621B1 (ko) 불소화된 디아미노알켄 유도체의 제조방법
Rzeszotarski et al. Cardioselectivity of. beta.-adrenoceptor blocking agents. 1. 1-[(4-Hydroxyphenethyl) amino]-3-(aryloxy) propan-2-ols
US4018897A (en) Antiarrhythmic agents
FI71137C (fi) Foerfarande foer framstaellning av nya cardiovasculaert aktiva1-(2-propynyloxi)-2-amino-3-propanoleterderivat
FI63399B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2'-hydroxi-2-(5-isoxazolylmetyl)-6,7-bensomorfaner och derassyraadditionssalter
SE465675B (sv) Basiska oximetrar, foerfarande foer framstaellning daerav och farmaceutiska kompositioner innehaallande desamma

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: ALKALOIDA VEGYéSZETI GYAR