FI71127C - Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat - Google Patents

Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat Download PDF

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Publication number
FI71127C
FI71127C FI843667A FI843667A FI71127C FI 71127 C FI71127 C FI 71127C FI 843667 A FI843667 A FI 843667A FI 843667 A FI843667 A FI 843667A FI 71127 C FI71127 C FI 71127C
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FI
Finland
Prior art keywords
group
general formula
compounds
carbon atoms
derivatives
Prior art date
Application number
FI843667A
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English (en)
Finnish (fi)
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FI843667L (fi
FI843667A0 (fi
FI71127B (fi
Inventor
Kalman Hideg
Olga Hankovszky
Laszlo Frank
Ilona Bodi
Jozsef Csak
Original Assignee
Alkaloida Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar
Publication of FI843667L publication Critical patent/FI843667L/fi
Publication of FI843667A0 publication Critical patent/FI843667A0/fi
Publication of FI71127B publication Critical patent/FI71127B/fi
Application granted granted Critical
Publication of FI71127C publication Critical patent/FI71127C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (5)

1. Förfarande för framställning av 2,2,5,5-tetramety1-pyrrolin- och pyrrolidin-3-karboxylsyraamidderivat, vilka är 5 användbara som hjärtläkemedel och har den allmänna formeln I --B —]-CO-N-A1-R2 C.H fH3 I C„AnA„3
10. N 3 H väri A^ är en valensbindning eller en rakkedjad eller för- grenad alkylengrupp med 1-5 kolatomer, vilken kan vara subs- tituerad med en hydroxyl- eller aminokarbonylgrupp,
15 B är en enkelbindning eller en dubbelbindning, 2 R är en aromatisk eller aryloxigrupp, vilka kan vara subs- tituerade med en eller flera 1-4 kolatomer innehällande alkyl- eller alkoxigrupper eller halogenatomer, eller är en aminogrupp eller en difenylmetylgrupp eller en R4-NH-CO- 20 grupp, väri 4 R är en eventuellt med en alkylgrupp substituerad fenyl- grupp, 3 R är väte eller en alkylgrupp med 1-4 kolatomer, och salter därav, kännetecknat därav, att man omsätter ett 25 piperidinonderivat med formeln II Br CH34 LCH3 11 CH, 2
30. H eller ett sait därav, med en amin med den allmänna formeln III HN-A1 -R2 XH
35 I 3 Ir
FI843667A 1983-01-20 1984-09-19 Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat FI71127C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU83178A HU189214B (en) 1983-01-20 1983-01-20 Process for preparing pyrroline and pyrrolidine carboxamide derivatives
HU17883 1983-01-20
PCT/HU1984/000004 WO1984002906A1 (en) 1983-01-20 1984-01-20 New amino derivatives of 2- adn-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl) bd
HU8400004 1984-01-20

Publications (4)

Publication Number Publication Date
FI843667L FI843667L (fi) 1984-09-19
FI843667A0 FI843667A0 (fi) 1984-09-19
FI71127B FI71127B (fi) 1986-08-14
FI71127C true FI71127C (fi) 1986-11-24

Family

ID=10948332

Family Applications (1)

Application Number Title Priority Date Filing Date
FI843667A FI71127C (fi) 1983-01-20 1984-09-19 Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat

Country Status (9)

Country Link
US (1) US4731376A (sv)
EP (1) EP0134795B1 (sv)
JP (1) JPS60500668A (sv)
DE (1) DE3473443D1 (sv)
DK (1) DK166776B1 (sv)
FI (1) FI71127C (sv)
HU (1) HU189214B (sv)
SU (1) SU1333236A3 (sv)
WO (1) WO1984002906A1 (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0615527B2 (ja) * 1983-01-21 1994-03-02 アルカロイダ ベギエスゼテイ ギヤル アルキルジアミン誘導体、その製造法および抗不整脈剤
US5047555A (en) * 1988-12-13 1991-09-10 Tanabe Seiyaku Co., Ltd. 4-aminophenol derivatives and processes for preparing the same
HUP9700392A1 (hu) * 1997-02-10 1999-09-28 ICN Magyarország Részvénytársaság Egy vagy két hatóanyagot tartalmazó kardioprotektív hatású gyógyszerkészítmények
TWI243162B (en) * 2000-11-10 2005-11-11 Taisho Pharmaceutical Co Ltd Cyanopyrrolidine derivatives
US6827226B2 (en) * 2002-12-09 2004-12-07 Wmc Holdings Incorporated Storage apparatus for sportboards with variable widths
PT2611775E (pt) 2010-08-31 2016-06-07 Consejo Superior De Investig Científicas Agonistas dos recetores de neurotrofina e sua utilização como medicamentos
CN107835802B (zh) * 2015-09-04 2022-04-22 Dic株式会社 稳定剂化合物、液晶组合物和显示元件
WO2017038617A1 (ja) 2015-09-04 2017-03-09 Dic株式会社 液晶組成物及びそれを使用した液晶表示素子

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE109345C (sv) *
DE109346C (sv) *
US3020288A (en) * 1962-02-06 Hypotensive compounds
DE109347C (sv) *
GB190004799A (en) * 1900-03-13 1900-05-19 George William Johnson The Manufacture of Para-amidophenyl Glyoxylic Acid, its Substitution Products and Homologues.
CH336068A (de) * 1955-04-06 1959-02-15 Bofors Ab Verfahren zur Herstellung von Amiden von N-Alkyl-piperidin-monocarbonsäuren oder N-Alkyl-pyrrolidin-a-monocarbonsäuren
GB983134A (en) * 1962-06-13 1965-02-10 American Cyanamid Co Cyclic nitroxides and process for preparing same
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
US3299097A (en) * 1963-04-29 1967-01-17 Upjohn Co 4-alkylhygric acid hydrazides
US3313801A (en) * 1965-10-18 1967-04-11 Upjohn Co Process for inhibiting n-alkylation of pyrrolidines and substituted pyrrolidines by microorganisms, and products produced thereby
US3624081A (en) * 1967-02-15 1971-11-30 Sterling Drug Inc 1-acyl-2-ethylidenepyrrol-idine-3-carboxamides
US4111901A (en) * 1977-06-06 1978-09-05 Borg-Warner Corporation Hindered five-membered nitrogen rings as polyolefin stabilizers
US4302383A (en) * 1980-05-19 1981-11-24 Borg-Warner Chemicals, Inc. Stabilized olefin polymers

Also Published As

Publication number Publication date
US4731376A (en) 1988-03-15
DE3473443D1 (en) 1988-09-22
FI843667L (fi) 1984-09-19
EP0134795B1 (de) 1988-08-17
DK447284A (da) 1984-11-20
EP0134795A1 (en) 1985-03-27
FI843667A0 (fi) 1984-09-19
DK166776B1 (da) 1993-07-12
SU1333236A3 (ru) 1987-08-23
JPH0471067B2 (sv) 1992-11-12
WO1984002906A1 (en) 1984-08-02
FI71127B (fi) 1986-08-14
HU189214B (en) 1986-06-30
JPS60500668A (ja) 1985-05-09
DK447284D0 (da) 1984-09-19

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Owner name: ALKALOIDA VEGYéSZETI GYAR