FI71127C - Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat - Google Patents
Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat Download PDFInfo
- Publication number
- FI71127C FI71127C FI843667A FI843667A FI71127C FI 71127 C FI71127 C FI 71127C FI 843667 A FI843667 A FI 843667A FI 843667 A FI843667 A FI 843667A FI 71127 C FI71127 C FI 71127C
- Authority
- FI
- Finland
- Prior art keywords
- group
- general formula
- compounds
- carbon atoms
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (5)
1. Förfarande för framställning av 2,2,5,5-tetramety1-pyrrolin- och pyrrolidin-3-karboxylsyraamidderivat, vilka är 5 användbara som hjärtläkemedel och har den allmänna formeln I --B —]-CO-N-A1-R2 C.H fH3 I C„AnA„3
10. N 3 H väri A^ är en valensbindning eller en rakkedjad eller för- grenad alkylengrupp med 1-5 kolatomer, vilken kan vara subs- tituerad med en hydroxyl- eller aminokarbonylgrupp,
15 B är en enkelbindning eller en dubbelbindning, 2 R är en aromatisk eller aryloxigrupp, vilka kan vara subs- tituerade med en eller flera 1-4 kolatomer innehällande alkyl- eller alkoxigrupper eller halogenatomer, eller är en aminogrupp eller en difenylmetylgrupp eller en R4-NH-CO- 20 grupp, väri 4 R är en eventuellt med en alkylgrupp substituerad fenyl- grupp, 3 R är väte eller en alkylgrupp med 1-4 kolatomer, och salter därav, kännetecknat därav, att man omsätter ett 25 piperidinonderivat med formeln II Br CH34 LCH3 11 CH, 2
30. H eller ett sait därav, med en amin med den allmänna formeln III HN-A1 -R2 XH
35 I 3 Ir
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU83178A HU189214B (en) | 1983-01-20 | 1983-01-20 | Process for preparing pyrroline and pyrrolidine carboxamide derivatives |
HU17883 | 1983-01-20 | ||
PCT/HU1984/000004 WO1984002906A1 (en) | 1983-01-20 | 1984-01-20 | New amino derivatives of 2- adn-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl) bd |
HU8400004 | 1984-01-20 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI843667A0 FI843667A0 (fi) | 1984-09-19 |
FI843667L FI843667L (fi) | 1984-09-19 |
FI71127B FI71127B (fi) | 1986-08-14 |
FI71127C true FI71127C (fi) | 1986-11-24 |
Family
ID=10948332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI843667A FI71127C (fi) | 1983-01-20 | 1984-09-19 | Foerfarande foer framstaellning av som hjaertlaekemedel anvaendbara 2,2,5,5-tetrametylpyrrolin- och -pyrrolidin-3-karboxylsyraamidderivat |
Country Status (9)
Country | Link |
---|---|
US (1) | US4731376A (sv) |
EP (1) | EP0134795B1 (sv) |
JP (1) | JPS60500668A (sv) |
DE (1) | DE3473443D1 (sv) |
DK (1) | DK166776B1 (sv) |
FI (1) | FI71127C (sv) |
HU (1) | HU189214B (sv) |
SU (1) | SU1333236A3 (sv) |
WO (1) | WO1984002906A1 (sv) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3473442D1 (de) * | 1983-01-21 | 1988-09-22 | Alkaloida Vegyeszeti Gyar | New alkyl diamine derivatives |
US5047555A (en) * | 1988-12-13 | 1991-09-10 | Tanabe Seiyaku Co., Ltd. | 4-aminophenol derivatives and processes for preparing the same |
HUP9700392A1 (hu) * | 1997-02-10 | 1999-09-28 | ICN Magyarország Részvénytársaság | Egy vagy két hatóanyagot tartalmazó kardioprotektív hatású gyógyszerkészítmények |
TWI243162B (en) * | 2000-11-10 | 2005-11-11 | Taisho Pharmaceutical Co Ltd | Cyanopyrrolidine derivatives |
US6827226B2 (en) * | 2002-12-09 | 2004-12-07 | Wmc Holdings Incorporated | Storage apparatus for sportboards with variable widths |
PL2611775T3 (pl) | 2010-08-31 | 2016-11-30 | Agoniści receptorów neurotrofiny i ich zastosowanie jako leki | |
CN107835802B (zh) | 2015-09-04 | 2022-04-22 | Dic株式会社 | 稳定剂化合物、液晶组合物和显示元件 |
CN107849458B (zh) | 2015-09-04 | 2021-07-27 | Dic株式会社 | 液晶组合物及使用其的液晶显示元件 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE109345C (sv) * | ||||
DE109347C (sv) * | ||||
US3020288A (en) * | 1962-02-06 | Hypotensive compounds | ||
DE109346C (sv) * | ||||
GB190004799A (en) * | 1900-03-13 | 1900-05-19 | George William Johnson | The Manufacture of Para-amidophenyl Glyoxylic Acid, its Substitution Products and Homologues. |
CH336068A (de) * | 1955-04-06 | 1959-02-15 | Bofors Ab | Verfahren zur Herstellung von Amiden von N-Alkyl-piperidin-monocarbonsäuren oder N-Alkyl-pyrrolidin-a-monocarbonsäuren |
GB983134A (en) * | 1962-06-13 | 1965-02-10 | American Cyanamid Co | Cyclic nitroxides and process for preparing same |
US3250771A (en) * | 1962-12-17 | 1966-05-10 | Geigy Chem Corp | 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof |
US3299097A (en) * | 1963-04-29 | 1967-01-17 | Upjohn Co | 4-alkylhygric acid hydrazides |
US3313801A (en) * | 1965-10-18 | 1967-04-11 | Upjohn Co | Process for inhibiting n-alkylation of pyrrolidines and substituted pyrrolidines by microorganisms, and products produced thereby |
US3624081A (en) * | 1967-02-15 | 1971-11-30 | Sterling Drug Inc | 1-acyl-2-ethylidenepyrrol-idine-3-carboxamides |
US4111901A (en) * | 1977-06-06 | 1978-09-05 | Borg-Warner Corporation | Hindered five-membered nitrogen rings as polyolefin stabilizers |
US4302383A (en) * | 1980-05-19 | 1981-11-24 | Borg-Warner Chemicals, Inc. | Stabilized olefin polymers |
-
1983
- 1983-01-20 HU HU83178A patent/HU189214B/hu not_active IP Right Cessation
-
1984
- 1984-01-20 US US06/898,723 patent/US4731376A/en not_active Expired - Fee Related
- 1984-01-20 WO PCT/HU1984/000004 patent/WO1984002906A1/en active IP Right Grant
- 1984-01-20 JP JP59500631A patent/JPS60500668A/ja active Granted
- 1984-01-20 DE DE8484900529T patent/DE3473443D1/de not_active Expired
- 1984-01-20 EP EP84900529A patent/EP0134795B1/de not_active Expired
- 1984-09-19 FI FI843667A patent/FI71127C/fi not_active IP Right Cessation
- 1984-09-19 DK DK447284A patent/DK166776B1/da active
- 1984-09-20 SU SU843800100A patent/SU1333236A3/ru active
Also Published As
Publication number | Publication date |
---|---|
FI843667A0 (fi) | 1984-09-19 |
US4731376A (en) | 1988-03-15 |
DK447284A (da) | 1984-11-20 |
WO1984002906A1 (en) | 1984-08-02 |
EP0134795A1 (en) | 1985-03-27 |
EP0134795B1 (de) | 1988-08-17 |
JPS60500668A (ja) | 1985-05-09 |
DK166776B1 (da) | 1993-07-12 |
FI71127B (fi) | 1986-08-14 |
JPH0471067B2 (sv) | 1992-11-12 |
FI843667L (fi) | 1984-09-19 |
SU1333236A3 (ru) | 1987-08-23 |
HU189214B (en) | 1986-06-30 |
DK447284D0 (da) | 1984-09-19 |
DE3473443D1 (en) | 1988-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: ALKALOIDA VEGYéSZETI GYAR |