FI71077C - Foerfarande foer kontinuerlig framstaellning av mikrokapslar - Google Patents
Foerfarande foer kontinuerlig framstaellning av mikrokapslar Download PDFInfo
- Publication number
- FI71077C FI71077C FI824350A FI824350A FI71077C FI 71077 C FI71077 C FI 71077C FI 824350 A FI824350 A FI 824350A FI 824350 A FI824350 A FI 824350A FI 71077 C FI71077 C FI 71077C
- Authority
- FI
- Finland
- Prior art keywords
- capsule
- microcapsules
- reactor
- droplets
- core material
- Prior art date
Links
- 239000002775 capsule Substances 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000000839 emulsion Substances 0.000 claims abstract description 16
- 239000003094 microcapsule Substances 0.000 claims abstract description 15
- 230000008569 process Effects 0.000 claims abstract description 15
- MBHRHUJRKGNOKX-UHFFFAOYSA-N [(4,6-diamino-1,3,5-triazin-2-yl)amino]methanol Chemical compound NC1=NC(N)=NC(NCO)=N1 MBHRHUJRKGNOKX-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 10
- 229920000867 polyelectrolyte Polymers 0.000 claims abstract description 9
- 239000006185 dispersion Substances 0.000 claims abstract description 8
- 239000011162 core material Substances 0.000 claims description 18
- 239000003995 emulsifying agent Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 239000002243 precursor Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 5
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims description 4
- 229920000877 Melamine resin Polymers 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 230000001804 emulsifying effect Effects 0.000 claims description 2
- JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000005518 polymer electrolyte Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 abstract description 10
- 238000004945 emulsification Methods 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 229920000642 polymer Polymers 0.000 abstract description 3
- 238000005538 encapsulation Methods 0.000 description 23
- 238000012360 testing method Methods 0.000 description 12
- 238000010924 continuous production Methods 0.000 description 8
- 239000002609 medium Substances 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 238000010923 batch production Methods 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 239000012736 aqueous medium Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- KXGFMDJXCMQABM-UHFFFAOYSA-N 2-methoxy-6-methylphenol Chemical class [CH]OC1=CC=CC([CH])=C1O KXGFMDJXCMQABM-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003593 chromogenic compound Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000007771 core particle Substances 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- GPBLVTFWNRNYKR-UHFFFAOYSA-N 3-(1-ethyl-2-methylindol-3-yl)-3h-2-benzofuran-1-one Chemical compound C12=CC=CC=C2N(CC)C(C)=C1C1C2=CC=CC=C2C(=O)O1 GPBLVTFWNRNYKR-UHFFFAOYSA-N 0.000 description 1
- OPRBLKARUKXAET-UHFFFAOYSA-N CNC1=CC=C(C=C1)C1(OC(=O)C2=CC(=CC=C12)NC)C1=CC=C(C=C1)NC Chemical compound CNC1=CC=C(C=C1)C1(OC(=O)C2=CC(=CC=C12)NC)C1=CC=C(C=C1)NC OPRBLKARUKXAET-UHFFFAOYSA-N 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000011824 nuclear material Substances 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- -1 poly (methyl vinyl Chemical group 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005549 size reduction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M5/00—Duplicating or marking methods; Sheet materials for use therein
- B41M5/124—Duplicating or marking methods; Sheet materials for use therein using pressure to make a masked colour visible, e.g. to make a coloured support visible, to create an opaque or transparent pattern, or to form colour by uniting colour-forming components
- B41M5/165—Duplicating or marking methods; Sheet materials for use therein using pressure to make a masked colour visible, e.g. to make a coloured support visible, to create an opaque or transparent pattern, or to form colour by uniting colour-forming components characterised by the use of microcapsules; Special solvents for incorporating the ingredients
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/14—Polymerisation; cross-linking
- B01J13/18—In situ polymerisation with all reactants being present in the same phase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
- Y10T428/2985—Solid-walled microcapsule from synthetic polymer
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Containers Having Bodies Formed In One Piece (AREA)
- Color Printing (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/332,385 US4454083A (en) | 1981-12-21 | 1981-12-21 | Continuous microencapsulation |
| US33238581 | 1981-12-21 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI824350A0 FI824350A0 (fi) | 1982-12-17 |
| FI824350L FI824350L (fi) | 1983-06-22 |
| FI71077B FI71077B (fi) | 1986-08-14 |
| FI71077C true FI71077C (fi) | 1986-11-24 |
Family
ID=23297992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI824350A FI71077C (fi) | 1981-12-21 | 1982-12-17 | Foerfarande foer kontinuerlig framstaellning av mikrokapslar |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4454083A (es) |
| EP (1) | EP0082635B1 (es) |
| JP (1) | JPS58112042A (es) |
| AT (1) | ATE28273T1 (es) |
| CA (1) | CA1188163A (es) |
| DE (1) | DE3276744D1 (es) |
| ES (1) | ES518369A0 (es) |
| FI (1) | FI71077C (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3532878A1 (de) * | 1985-09-14 | 1987-03-26 | Basf Ag | Kontinuierliches verfahren zur herstellung von mikrokapseln mit waenden aus melamin-formaldehydkondensaten in waessriger dispersion |
| US4978483A (en) * | 1987-09-28 | 1990-12-18 | Redding Bruce K | Apparatus and method for making microcapsules |
| CN1042015A (zh) * | 1988-10-11 | 1990-05-09 | 米德公司 | 包胶过程中改变内相的浓度制造包胶光敏组合物的方法 |
| JP2630501B2 (ja) * | 1990-11-19 | 1997-07-16 | 富士写真フイルム株式会社 | 乳化方法及び装置 |
| JP2729538B2 (ja) * | 1991-02-13 | 1998-03-18 | 富士写真フイルム株式会社 | マイクロカプセルの製造方法 |
| JP3164919B2 (ja) * | 1991-10-29 | 2001-05-14 | ゼロックス コーポレーション | 二色性ボールの形成方法 |
| JP3306095B2 (ja) * | 1992-05-25 | 2002-07-24 | 富士写真フイルム株式会社 | マイクロカプセルの製造方法 |
| US5340680A (en) * | 1992-09-10 | 1994-08-23 | Appleton Papers Inc. | Desensitizable record material |
| US5585438A (en) * | 1995-08-29 | 1996-12-17 | Esu; Charles S. | Remeltable thermoset resin |
| US6001312A (en) * | 1996-04-17 | 1999-12-14 | Wang; Taylor G. | Reactor for making uniform capsules |
| CA2304096C (en) * | 1997-09-18 | 2003-09-09 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| AU752802C (en) | 1997-11-14 | 2006-04-13 | Pacira Pharmaceuticals, Inc. | Production of multivesicular liposomes |
| DE10010264A1 (de) * | 2000-03-02 | 2001-09-13 | Novosom Gmbh | Stabilisierte Liposomen und Hüllstrukturen |
| DE10049777A1 (de) * | 2000-10-09 | 2002-04-18 | Fraunhofer Ges Forschung | Mit einem Aminoplast mikroverkapselte Feststoffe und Verfahren zu deren Herstellung |
| ITMI20110784A1 (it) * | 2011-05-09 | 2012-11-10 | Sipcam Spa | Processo per l'ottenimento di microcapsule |
| KR102143571B1 (ko) * | 2013-07-02 | 2020-08-12 | 다이킨 고교 가부시키가이샤 | 전해질 용액 및 그 제조 방법, 연속 용해 장치, 전해질막, 전극 촉매층, 막 전극 접합체, 및 연료 전지 |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| EP4415713A4 (en) | 2021-10-14 | 2025-08-06 | Pacira Pharmaceuticals Inc | MULTIVESICULAR LIPOSOME FORMULATIONS OF BUPIVACAINE AND THEIR USES |
| US12156940B1 (en) | 2024-05-20 | 2024-12-03 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12280149B1 (en) | 2024-05-20 | 2025-04-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776267A (en) * | 1951-11-17 | 1957-01-01 | Interchem Corp | Spherical pigments and method of preparing same |
| US3577515A (en) * | 1963-12-13 | 1971-05-04 | Pennwalt Corp | Encapsulation by interfacial polycondensation |
| US3464926A (en) * | 1965-04-26 | 1969-09-02 | Pennwalt Corp | Process for encapsulation |
| US3812056A (en) * | 1972-07-05 | 1974-05-21 | Ncr | Continuous encapsulation |
| US3816331A (en) * | 1972-07-05 | 1974-06-11 | Ncr | Continuous encapsulation and device therefor |
| JPS5222829A (en) * | 1975-08-15 | 1977-02-21 | Hitachi Ltd | Method to identify the contact |
| GB1507739A (en) * | 1975-11-26 | 1978-04-19 | Wiggins Teape Ltd | Capsules |
| US4100103A (en) * | 1976-12-30 | 1978-07-11 | Ncr Corporation | Capsule manufacture |
| FR2413123A1 (fr) * | 1977-12-30 | 1979-07-27 | Philagro Sa | Procede d'encapsulation par polycondensation interfaciale |
| GB2073132B (en) * | 1980-04-08 | 1983-12-14 | Wiggins Teape Group Ltd | Production of microcapsules |
| US4396670A (en) * | 1980-04-08 | 1983-08-02 | The Wiggins Teape Group Limited | Process for the production of microcapsules |
| JPS5784740A (en) * | 1980-11-17 | 1982-05-27 | Jujo Paper Co Ltd | Preparation of microcapsule |
-
1981
- 1981-12-21 US US06/332,385 patent/US4454083A/en not_active Expired - Lifetime
-
1982
- 1982-11-26 CA CA000416519A patent/CA1188163A/en not_active Expired
- 1982-12-08 DE DE8282306552T patent/DE3276744D1/de not_active Expired
- 1982-12-08 AT AT82306552T patent/ATE28273T1/de not_active IP Right Cessation
- 1982-12-08 EP EP82306552A patent/EP0082635B1/en not_active Expired
- 1982-12-17 FI FI824350A patent/FI71077C/fi not_active IP Right Cessation
- 1982-12-20 ES ES518369A patent/ES518369A0/es active Granted
- 1982-12-21 JP JP57224768A patent/JPS58112042A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FI824350L (fi) | 1983-06-22 |
| JPS58112042A (ja) | 1983-07-04 |
| ES8401331A1 (es) | 1983-12-01 |
| DE3276744D1 (en) | 1987-08-20 |
| EP0082635B1 (en) | 1987-07-15 |
| ATE28273T1 (de) | 1987-08-15 |
| EP0082635A1 (en) | 1983-06-29 |
| CA1188163A (en) | 1985-06-04 |
| ES518369A0 (es) | 1983-12-01 |
| FI71077B (fi) | 1986-08-14 |
| JPH0346170B2 (es) | 1991-07-15 |
| US4454083A (en) | 1984-06-12 |
| FI824350A0 (fi) | 1982-12-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: APPLETON PAPERS INC. |