FI70574C - Foerfarande foer framstaellning av nya farmaceutiskt anvaendbara derivat av 2-7(4-kinolinyl)-amino/-5-fluorbensoesyra - Google Patents
Foerfarande foer framstaellning av nya farmaceutiskt anvaendbara derivat av 2-7(4-kinolinyl)-amino/-5-fluorbensoesyra Download PDFInfo
- Publication number
- FI70574C FI70574C FI783833A FI783833A FI70574C FI 70574 C FI70574 C FI 70574C FI 783833 A FI783833 A FI 783833A FI 783833 A FI783833 A FI 783833A FI 70574 C FI70574 C FI 70574C
- Authority
- FI
- Finland
- Prior art keywords
- trifluoromethyl
- quinolinylamino
- acid
- ester
- fluoro
- Prior art date
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- 239000000543 intermediate Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- QVDHDLGBWADBND-UHFFFAOYSA-N methyl 2-[(8-chloroquinolin-4-yl)amino]-5-fluorobenzoate Chemical compound COC(=O)C1=CC(F)=CC=C1NC1=CC=NC2=C(Cl)C=CC=C12 QVDHDLGBWADBND-UHFFFAOYSA-N 0.000 description 1
- PUDDYSBKCDKATP-UHFFFAOYSA-N methyl 2-amino-5-fluorobenzoate Chemical compound COC(=O)C1=CC(F)=CC=C1N PUDDYSBKCDKATP-UHFFFAOYSA-N 0.000 description 1
- FRLHRTUBWUUAFG-UHFFFAOYSA-N methyl 5-fluoro-2-[[8-(trifluoromethyl)quinolin-4-yl]amino]benzoate Chemical compound COC(=O)C1=CC(F)=CC=C1NC1=CC=NC2=C(C(F)(F)F)C=CC=C12 FRLHRTUBWUUAFG-UHFFFAOYSA-N 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- WHQSYGRFZMUQGQ-UHFFFAOYSA-N n,n-dimethylformamide;hydrate Chemical compound O.CN(C)C=O WHQSYGRFZMUQGQ-UHFFFAOYSA-N 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 239000002687 nonaqueous vehicle Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7737835A FR2411832A1 (fr) | 1977-12-15 | 1977-12-15 | Nouveaux derives de l'acide 2/(4-quinoleinyl) amino/5-fluorobenzoique, leur procede de preparation et leur application comme medicament. |
| FR7737836A FR2411833A1 (fr) | 1977-12-15 | 1977-12-15 | Nouveaux derives de l'acide 2(/4-quinoleinyl/amino) 5-fluoro benzoique, leur procede de preparation et leur application comme medicament |
| FR7737835 | 1977-12-15 | ||
| FR7737836 | 1977-12-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI783833A7 FI783833A7 (fi) | 1979-06-16 |
| FI70574B FI70574B (fi) | 1986-06-06 |
| FI70574C true FI70574C (fi) | 1986-09-24 |
Family
ID=26220343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI783833A FI70574C (fi) | 1977-12-15 | 1978-12-13 | Foerfarande foer framstaellning av nya farmaceutiskt anvaendbara derivat av 2-7(4-kinolinyl)-amino/-5-fluorbensoesyra |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4233305A (en, 2012) |
| JP (1) | JPS5488277A (en, 2012) |
| AR (1) | AR224116A1 (en, 2012) |
| AT (1) | AT365578B (en, 2012) |
| AU (1) | AU520983B2 (en, 2012) |
| CA (1) | CA1115276A (en, 2012) |
| CH (1) | CH636350A5 (en, 2012) |
| DE (1) | DE2854341A1 (en, 2012) |
| DK (1) | DK149845C (en, 2012) |
| ES (1) | ES475686A1 (en, 2012) |
| FI (1) | FI70574C (en, 2012) |
| GB (1) | GB2010243B (en, 2012) |
| HU (1) | HU177031B (en, 2012) |
| IE (1) | IE47618B1 (en, 2012) |
| IL (1) | IL56156A (en, 2012) |
| IT (1) | IT1107671B (en, 2012) |
| LU (1) | LU80660A1 (en, 2012) |
| NL (1) | NL7812206A (en, 2012) |
| PT (1) | PT68916A (en, 2012) |
| SE (1) | SE448091B (en, 2012) |
| SU (1) | SU837322A3 (en, 2012) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6322584A (ja) * | 1986-07-15 | 1988-01-30 | Senjiyu Seiyaku Kk | １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類 |
| IL89029A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them |
| IS4164A (is) * | 1993-06-11 | 1994-12-12 | Ab Astra | Efnasambönd sem hindra flæði magasýru |
| US5578607A (en) * | 1993-12-17 | 1996-11-26 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3232944A (en) * | 1966-02-01 | Monoglycerides 0f (carbgxy pl-ienyl amtno) chlgroqukngltnes | ||
| CH408915A (fr) * | 1962-02-16 | 1966-03-15 | Roussel Uclaf | Procédé de préparation d'un nouveau composé utilisable, notamment, pour le traitement des manifestations inflammatoires et/ou douloureuses |
| CA731646A (en) * | 1962-05-08 | 1966-04-05 | Roussel-Uclaf | 4-(2'(.beta.-MORPHOLYLETHOXYCARBONYL) PHENYLAMINE) 7-CHLORO QUINOLEINE ET SES SELS, AINSI QUE LEUR PROCEDE DE PREPARATION |
| FR6935M (en, 2012) * | 1967-12-29 | 1969-05-05 | ||
| FR7870M (en, 2012) * | 1968-11-08 | 1970-04-27 | ||
| ZA726593B (en) * | 1971-10-19 | 1973-06-27 | Abbott Lab | Novel derivatives of 2,3-dihydroxypropyl-n-(7 or 8-chloro-4-quinolinyl)anthranilate |
| CH585221A5 (en, 2012) * | 1972-07-28 | 1977-02-28 | Synthelabo | |
| US3971789A (en) * | 1972-10-21 | 1976-07-27 | John Wyeth & Brother Limited | O-(4-Quinolylamino)benzamides |
| FR2233059B1 (en, 2012) * | 1973-06-13 | 1976-09-03 | Roussel Uclaf | |
| GB1474296A (en) * | 1975-01-23 | 1977-05-18 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
-
1978
- 1978-11-16 SE SE7811839A patent/SE448091B/sv not_active IP Right Cessation
- 1978-12-04 ES ES475686A patent/ES475686A1/es not_active Expired
- 1978-12-06 US US05/966,964 patent/US4233305A/en not_active Expired - Lifetime
- 1978-12-07 SU SU782696357A patent/SU837322A3/ru active
- 1978-12-08 IL IL56156A patent/IL56156A/xx unknown
- 1978-12-13 FI FI783833A patent/FI70574C/fi not_active IP Right Cessation
- 1978-12-14 DK DK561278A patent/DK149845C/da not_active IP Right Cessation
- 1978-12-14 HU HU78RO1003A patent/HU177031B/hu not_active IP Right Cessation
- 1978-12-14 PT PT68916A patent/PT68916A/pt unknown
- 1978-12-14 JP JP15380478A patent/JPS5488277A/ja active Granted
- 1978-12-14 LU LU80660A patent/LU80660A1/xx unknown
- 1978-12-14 IE IE2476/78A patent/IE47618B1/en unknown
- 1978-12-14 AU AU42528/78A patent/AU520983B2/en not_active Expired
- 1978-12-14 GB GB7848546A patent/GB2010243B/en not_active Expired
- 1978-12-14 AR AR274807A patent/AR224116A1/es active
- 1978-12-14 IT IT52296/78A patent/IT1107671B/it active
- 1978-12-14 CA CA317,952A patent/CA1115276A/fr not_active Expired
- 1978-12-15 AT AT0897378A patent/AT365578B/de not_active IP Right Cessation
- 1978-12-15 CH CH1279478A patent/CH636350A5/fr not_active IP Right Cessation
- 1978-12-15 DE DE19782854341 patent/DE2854341A1/de active Granted
- 1978-12-15 NL NL7812206A patent/NL7812206A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AT365578B (de) | 1982-01-25 |
| SE448091B (sv) | 1987-01-19 |
| DK561278A (da) | 1979-06-16 |
| CA1115276A (fr) | 1981-12-29 |
| DK149845B (da) | 1986-10-13 |
| ES475686A1 (es) | 1979-04-16 |
| SE7811839L (sv) | 1979-06-16 |
| SU837322A3 (ru) | 1981-06-07 |
| AR224116A1 (es) | 1981-10-30 |
| DE2854341C2 (en, 2012) | 1990-05-23 |
| GB2010243A (en) | 1979-06-27 |
| LU80660A1 (fr) | 1979-07-20 |
| GB2010243B (en) | 1982-05-19 |
| HU177031B (hu) | 1981-06-28 |
| US4233305A (en) | 1980-11-11 |
| JPS5488277A (en) | 1979-07-13 |
| FI70574B (fi) | 1986-06-06 |
| DK149845C (da) | 1987-03-02 |
| IE47618B1 (en) | 1984-05-02 |
| NL7812206A (nl) | 1979-06-19 |
| AU520983B2 (en) | 1982-03-11 |
| IL56156A0 (en) | 1979-03-12 |
| IT7852296A0 (it) | 1978-12-14 |
| DE2854341A1 (de) | 1979-06-28 |
| AU4252878A (en) | 1979-06-21 |
| IE782476L (en) | 1979-06-15 |
| JPS631305B2 (en, 2012) | 1988-01-12 |
| ATA897378A (de) | 1981-06-15 |
| CH636350A5 (fr) | 1983-05-31 |
| PT68916A (fr) | 1979-01-01 |
| IL56156A (en) | 1984-11-30 |
| FI783833A7 (fi) | 1979-06-16 |
| IT1107671B (it) | 1985-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: ROUSSEL UCLAF SOCIETE ANONYME |