FI69464C - Foerfarande foer framstaellning av farmakologiskt verksamma 10bromsandvicin och 10-bromisosandvicin - Google Patents
Foerfarande foer framstaellning av farmakologiskt verksamma 10bromsandvicin och 10-bromisosandvicin Download PDFInfo
- Publication number
- FI69464C FI69464C FI803088A FI803088A FI69464C FI 69464 C FI69464 C FI 69464C FI 803088 A FI803088 A FI 803088A FI 803088 A FI803088 A FI 803088A FI 69464 C FI69464 C FI 69464C
- Authority
- FI
- Finland
- Prior art keywords
- process according
- brominated
- bromine
- bromo
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Confectionery (AREA)
- Prostheses (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Claims (16)
1. Förfarande för framställning av farmakologiskt verksamma 10-brom-sandvicin och 10-bromisosandvicin med den allmänna formeln (I) “"Ai fPfi d» “» ly X eller deras syraadditionssalter, kännetecknatav att sandvicin med formeln (II) rHnRi ........ k LIA c2.5 bromeras med ett lämpligt bromeringsämne för framställning av 10-bromsandvicin med formeln (Ia) li KV 4* Ci·) CHj il is 69 4 6 4 varefter den sä erhällna föreningen om sä önskas isomeriseras till 10-bromisosandvicin med formeln (lb) CS l \ 1 och om sä önskas de sä erhällna föreningarna enligt formeln (I) omvandlas till sinä motsvarande syraadditionssalter med en farma-ceutiskt acceptabel syra.
2. Förfarande enligt patentkravet 1, kännetecknat av att man bromerar i ett inert lösningsmedel.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att man bromerar under användning av brom i form av grund-ämnet.
4. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att man bromerar med vattenfri koppar(II)-bromid.
5. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att man bromerar med 2,4,4,6-tetrabrom-2,5-cyklo-hexadien- 1-on.
6. Förfarande enligt nägot av patentkraven 1...3, kännetecknat av att man bromerar i en blandning av metylenklorid och meta-nol.
7. Förfarande enligt nägot av patentkraven 1...3 eller 6, kännetecknat av att man bromerar i dimetylformamid.
8. Förfarande enligt nägot av patentkraven 1, 2 eller 5, kännetecknat av att man bromerar i en blandning av tetrahydrofuran och metylenklorid, tili vilken kan tillsättas en aning metanol.
9. Förfarande enligt nägot av patentkraven 1, 2, 3 eller 8, k ä n -netecknat av att man bromerar i 0 °C.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792941531 DE2941531A1 (de) | 1979-10-13 | 1979-10-13 | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
| DE2941531 | 1979-10-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI803088A FI803088A (fi) | 1981-01-14 |
| FI69464B FI69464B (fi) | 1985-10-31 |
| FI69464C true FI69464C (fi) | 1986-02-10 |
Family
ID=6083414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI803088A FI69464C (fi) | 1979-10-13 | 1980-09-30 | Foerfarande foer framstaellning av farmakologiskt verksamma 10bromsandvicin och 10-bromisosandvicin |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4558052A (sv) |
| EP (1) | EP0029117B1 (sv) |
| JP (1) | JPS5681584A (sv) |
| AT (1) | ATE3113T1 (sv) |
| AU (1) | AU536185B2 (sv) |
| CA (1) | CA1147331A (sv) |
| DD (2) | DD201681A5 (sv) |
| DE (2) | DE2941531A1 (sv) |
| DK (2) | DK430780A (sv) |
| ES (2) | ES495651A0 (sv) |
| FI (1) | FI69464C (sv) |
| GR (1) | GR70381B (sv) |
| HU (1) | HU184332B (sv) |
| IE (1) | IE50131B1 (sv) |
| IL (1) | IL61224A (sv) |
| NO (2) | NO154669C (sv) |
| NZ (1) | NZ195218A (sv) |
| PH (1) | PH16518A (sv) |
| PT (1) | PT71896B (sv) |
| SU (2) | SU986298A3 (sv) |
| ZA (1) | ZA806169B (sv) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2941531A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
| JPH0512883Y2 (sv) * | 1988-06-28 | 1993-04-05 | ||
| JPH0513599Y2 (sv) * | 1988-09-13 | 1993-04-09 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582627A (en) * | 1976-01-16 | 1981-01-14 | Inverni Della Beffa Spa | Derivatives of sandwicine and isosandwicine and pharmaceutical compositions comprising sandwicine isosandwicine and derivatives thereof |
| DE2611162A1 (de) * | 1976-03-17 | 1977-10-06 | Kali Chemie Pharma Gmbh | Neue quartaere derivate von sandwicin und verfahren zu ihrer herstellung |
| DE2941531A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
| DE2941530A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate |
| DE2941529A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate |
-
1979
- 1979-10-13 DE DE19792941531 patent/DE2941531A1/de not_active Withdrawn
-
1980
- 1980-09-30 FI FI803088A patent/FI69464C/fi not_active IP Right Cessation
- 1980-10-02 SU SU802983701A patent/SU986298A3/ru active
- 1980-10-06 ZA ZA00806169A patent/ZA806169B/xx unknown
- 1980-10-06 ES ES495651A patent/ES495651A0/es active Granted
- 1980-10-07 IE IE2046/80A patent/IE50131B1/en unknown
- 1980-10-07 IL IL61224A patent/IL61224A/xx unknown
- 1980-10-09 PT PT71896A patent/PT71896B/pt unknown
- 1980-10-09 DD DD80233315A patent/DD201681A5/de unknown
- 1980-10-09 PH PH24693A patent/PH16518A/en unknown
- 1980-10-09 DD DD80224432A patent/DD154488A5/de unknown
- 1980-10-10 DK DK430780A patent/DK430780A/da not_active Application Discontinuation
- 1980-10-10 CA CA000362117A patent/CA1147331A/en not_active Expired
- 1980-10-10 EP EP80106152A patent/EP0029117B1/de not_active Expired
- 1980-10-10 DE DE8080106152T patent/DE3062840D1/de not_active Expired
- 1980-10-10 NZ NZ195218A patent/NZ195218A/xx unknown
- 1980-10-10 AT AT80106152T patent/ATE3113T1/de not_active IP Right Cessation
- 1980-10-10 NO NO803043A patent/NO154669C/no unknown
- 1980-10-10 HU HU802473A patent/HU184332B/hu not_active IP Right Cessation
- 1980-10-11 GR GR63124A patent/GR70381B/el unknown
- 1980-10-13 AU AU63207/80A patent/AU536185B2/en not_active Ceased
- 1980-10-13 JP JP14215680A patent/JPS5681584A/ja active Granted
- 1980-12-25 SU SU803220196A patent/SU996416A1/ru active
- 1980-12-29 ES ES498188A patent/ES498188A0/es active Granted
-
1984
- 1984-06-08 US US06/618,908 patent/US4558052A/en not_active Expired - Fee Related
-
1986
- 1986-03-19 NO NO86861078A patent/NO156326C/no unknown
-
1988
- 1988-05-19 DK DK273988A patent/DK273988A/da unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: KALI-CHEMIE PHARMA GMBH |