FI69463C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner Download PDF

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Publication number
FI69463C
FI69463C FI783327A FI783327A FI69463C FI 69463 C FI69463 C FI 69463C FI 783327 A FI783327 A FI 783327A FI 783327 A FI783327 A FI 783327A FI 69463 C FI69463 C FI 69463C
Authority
FI
Finland
Prior art keywords
formula
halogen
alkyl
compound
trifluoromethyl
Prior art date
Application number
FI783327A
Other languages
English (en)
Finnish (fi)
Other versions
FI69463B (fi
FI783327A (fi
Inventor
Schneur Rachlin
Edoardo Arrigoni-Martelli
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of FI783327A publication Critical patent/FI783327A/fi
Publication of FI69463B publication Critical patent/FI69463B/fi
Application granted granted Critical
Publication of FI69463C publication Critical patent/FI69463C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FI783327A 1977-11-07 1978-11-01 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner FI69463C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4616677 1977-11-07
GB4616677 1977-11-07

Publications (3)

Publication Number Publication Date
FI783327A FI783327A (fi) 1979-05-08
FI69463B FI69463B (fi) 1985-10-31
FI69463C true FI69463C (fi) 1986-02-10

Family

ID=10440127

Family Applications (1)

Application Number Title Priority Date Filing Date
FI783327A FI69463C (fi) 1977-11-07 1978-11-01 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner

Country Status (24)

Country Link
US (1) US4293549A (pt)
JP (1) JPS5473784A (pt)
AT (1) AT366368B (pt)
AU (1) AU517670B2 (pt)
BE (1) BE871807A (pt)
CA (1) CA1120929A (pt)
CH (1) CH645354A5 (pt)
DE (1) DE2847792A1 (pt)
DK (1) DK153950C (pt)
ES (1) ES474900A1 (pt)
FI (1) FI69463C (pt)
FR (1) FR2407930A1 (pt)
GR (1) GR65010B (pt)
IE (1) IE47458B1 (pt)
IT (1) IT1100075B (pt)
LU (1) LU80476A1 (pt)
NL (1) NL7811035A (pt)
NZ (1) NZ188770A (pt)
PH (1) PH16296A (pt)
PT (1) PT68750A (pt)
SE (1) SE446267B (pt)
SU (1) SU828967A3 (pt)
YU (1) YU41129B (pt)
ZA (1) ZA786175B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306846B1 (en) * 1972-05-31 2001-10-23 John R. J. Sorenson Anti-inflammatory and anti-ulcer compounds and process
IT1205640B (it) * 1983-04-06 1989-03-23 Yason Srl Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US4563460A (en) * 1984-01-13 1986-01-07 William H. Rorer, Inc. Quinoline and quinazoline derivatives for treating gastrointestinal motility dysfunctions
HU195487B (en) * 1985-06-04 1988-05-30 Egyt Gyogyszervegyeszeti Gyar Process for producing quinoline derivatives
EP0259085B1 (en) * 1986-08-29 1991-08-21 Pfizer Inc. 2-guanidino-4-arylthiazoles for treatment of peptic ulcers
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
US6410561B1 (en) * 1998-03-26 2002-06-25 Japan Tobacco Inc. Amide derivatives and nociceptin antagonists
CA2389773A1 (en) * 1999-11-05 2001-05-10 Robert Glen Activators of soluble guanylate cyclase
US7186725B2 (en) * 2003-01-03 2007-03-06 Genzyme Corporation Anti-inflammatory compositions and methods
JP4613157B2 (ja) * 2003-01-14 2011-01-12 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
GB0404434D0 (en) * 2004-02-27 2004-03-31 Novartis Ag Organic compounds
WO2007022964A2 (de) * 2005-08-24 2007-03-01 Abbott Gmbh & Co. Kg Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
CN117677386A (zh) * 2021-07-23 2024-03-08 瓦伦塔有限责任公司 具有亲溶酶体和抗病毒活性的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889282A (en) * 1957-05-07 1962-02-14 Air Reduction Preparation of hexafluorodiethyl ether and medicinal compositions containing it
GB889262A (en) * 1959-07-03 1962-02-14 Ciba Ltd Quinoline compounds
US3159676A (en) * 1962-02-07 1964-12-01 Smith Kline French Lab Naphthyl containing guanidines
US3852293A (en) 1972-06-21 1974-12-03 Uniroyal Inc 4-phenyl-2-(3-pyridyl)-thiazole carboxamides
US4000279A (en) * 1974-10-29 1976-12-28 Armour Pharmaceutical Company Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same

Also Published As

Publication number Publication date
AT366368B (de) 1982-04-13
SU828967A3 (ru) 1981-05-07
FR2407930B1 (pt) 1983-03-18
DE2847792C2 (pt) 1988-02-04
BE871807A (fr) 1979-05-07
CH645354A5 (de) 1984-09-28
SE446267B (sv) 1986-08-25
NL7811035A (nl) 1979-05-09
AU517670B2 (en) 1981-08-20
DK493378A (da) 1979-05-08
IT7829514A0 (it) 1978-11-07
GR65010B (en) 1980-06-12
JPS5473784A (en) 1979-06-13
AU4137678A (en) 1979-05-17
ES474900A1 (es) 1980-04-16
DK153950B (da) 1988-09-26
NZ188770A (en) 1984-07-31
CA1120929A (en) 1982-03-30
SE7811457L (sv) 1979-05-08
FI69463B (fi) 1985-10-31
IT1100075B (it) 1985-09-28
PH16296A (en) 1983-09-05
US4293549A (en) 1981-10-06
DE2847792A1 (de) 1979-05-10
DK153950C (da) 1989-02-20
JPS6348873B2 (pt) 1988-09-30
ZA786175B (en) 1979-10-31
YU257578A (en) 1983-01-21
FR2407930A1 (fr) 1979-06-01
LU80476A1 (fr) 1979-06-15
IE47458B1 (en) 1984-03-21
FI783327A (fi) 1979-05-08
PT68750A (en) 1978-12-01
IE782084L (en) 1979-05-07
ATA773278A (de) 1981-08-15
YU41129B (en) 1986-12-31

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Legal Events

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MM Patent lapsed

Owner name: LEO PHARMACEUTICAL PRODUCTS LTD A/S (LOEVENS KEMIS