FI69463C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner Download PDF

Info

Publication number
FI69463C
FI69463C FI783327A FI783327A FI69463C FI 69463 C FI69463 C FI 69463C FI 783327 A FI783327 A FI 783327A FI 783327 A FI783327 A FI 783327A FI 69463 C FI69463 C FI 69463C
Authority
FI
Finland
Prior art keywords
formula
halogen
alkyl
compound
trifluoromethyl
Prior art date
Application number
FI783327A
Other languages
English (en)
Finnish (fi)
Other versions
FI783327A7 (fi
FI69463B (fi
Inventor
Schneur Rachlin
Edoardo Arrigoni-Martelli
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of FI783327A7 publication Critical patent/FI783327A7/fi
Application granted granted Critical
Publication of FI69463B publication Critical patent/FI69463B/fi
Publication of FI69463C publication Critical patent/FI69463C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FI783327A 1977-11-07 1978-11-01 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner FI69463C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4616677 1977-11-07
GB4616677 1977-11-07

Publications (3)

Publication Number Publication Date
FI783327A7 FI783327A7 (fi) 1979-05-08
FI69463B FI69463B (fi) 1985-10-31
FI69463C true FI69463C (fi) 1986-02-10

Family

ID=10440127

Family Applications (1)

Application Number Title Priority Date Filing Date
FI783327A FI69463C (fi) 1977-11-07 1978-11-01 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner

Country Status (24)

Country Link
US (1) US4293549A (en, 2012)
JP (1) JPS5473784A (en, 2012)
AT (1) AT366368B (en, 2012)
AU (1) AU517670B2 (en, 2012)
BE (1) BE871807A (en, 2012)
CA (1) CA1120929A (en, 2012)
CH (1) CH645354A5 (en, 2012)
DE (1) DE2847792A1 (en, 2012)
DK (1) DK153950C (en, 2012)
ES (1) ES474900A1 (en, 2012)
FI (1) FI69463C (en, 2012)
FR (1) FR2407930A1 (en, 2012)
GR (1) GR65010B (en, 2012)
IE (1) IE47458B1 (en, 2012)
IT (1) IT1100075B (en, 2012)
LU (1) LU80476A1 (en, 2012)
NL (1) NL7811035A (en, 2012)
NZ (1) NZ188770A (en, 2012)
PH (1) PH16296A (en, 2012)
PT (1) PT68750A (en, 2012)
SE (1) SE446267B (en, 2012)
SU (1) SU828967A3 (en, 2012)
YU (1) YU41129B (en, 2012)
ZA (1) ZA786175B (en, 2012)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306846B1 (en) * 1972-05-31 2001-10-23 John R. J. Sorenson Anti-inflammatory and anti-ulcer compounds and process
IT1205640B (it) * 1983-04-06 1989-03-23 Yason Srl Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US4563460A (en) * 1984-01-13 1986-01-07 William H. Rorer, Inc. Quinoline and quinazoline derivatives for treating gastrointestinal motility dysfunctions
HU195487B (en) * 1985-06-04 1988-05-30 Egyt Gyogyszervegyeszeti Gyar Process for producing quinoline derivatives
ES2031514T3 (es) * 1986-08-29 1992-12-16 Pfizer Inc. 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
EP0928793B1 (en) * 1998-01-02 2002-05-15 F. Hoffmann-La Roche Ag Thiazole derivatives
RU2202344C2 (ru) 1998-03-26 2003-04-20 Джапан Тобакко Инк. Антагонисты ноцицептина, производные амида, аналгетик, способ инициирования антагонистического действия к ноцицептину, способ лечения боли, фармацевтические композиции
EP1237849A1 (en) * 1999-11-05 2002-09-11 University College London Activators of soluble guanylate cyclase
AU2003303678A1 (en) * 2003-01-03 2004-08-10 Genzyme Corporation Urea derivatives and their use as anti-inflammatory agents
ES2387909T3 (es) * 2003-01-14 2012-10-03 Cytokinetics, Inc. Compuestos, composiciones y procedimientos de tratamiento de la insuficiencia cardiaca
GB0404434D0 (en) 2004-02-27 2004-03-31 Novartis Ag Organic compounds
US9296697B2 (en) * 2005-08-24 2016-03-29 Abbott Laboratories Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
WO2023003497A1 (ru) * 2021-07-23 2023-01-26 Общество С Ограниченной Ответственностью "Валента-Интеллект" Соединения с лизосомотропной и противовирусной активностью

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889282A (en) * 1957-05-07 1962-02-14 Air Reduction Preparation of hexafluorodiethyl ether and medicinal compositions containing it
GB889262A (en) * 1959-07-03 1962-02-14 Ciba Ltd Quinoline compounds
US3159676A (en) * 1962-02-07 1964-12-01 Smith Kline French Lab Naphthyl containing guanidines
US3852293A (en) 1972-06-21 1974-12-03 Uniroyal Inc 4-phenyl-2-(3-pyridyl)-thiazole carboxamides
US4000279A (en) * 1974-10-29 1976-12-28 Armour Pharmaceutical Company Pharmaceutical preparations containing 5'-(8'-hydroxyquinolyl)guanidine compounds and methods of using same

Also Published As

Publication number Publication date
PH16296A (en) 1983-09-05
JPS6348873B2 (en, 2012) 1988-09-30
ZA786175B (en) 1979-10-31
DK153950C (da) 1989-02-20
DK153950B (da) 1988-09-26
PT68750A (en) 1978-12-01
IE47458B1 (en) 1984-03-21
SE7811457L (sv) 1979-05-08
US4293549A (en) 1981-10-06
NZ188770A (en) 1984-07-31
DK493378A (da) 1979-05-08
GR65010B (en) 1980-06-12
ATA773278A (de) 1981-08-15
IT1100075B (it) 1985-09-28
LU80476A1 (fr) 1979-06-15
ES474900A1 (es) 1980-04-16
DE2847792C2 (en, 2012) 1988-02-04
FR2407930A1 (fr) 1979-06-01
AT366368B (de) 1982-04-13
FI783327A7 (fi) 1979-05-08
IE782084L (en) 1979-05-07
DE2847792A1 (de) 1979-05-10
AU4137678A (en) 1979-05-17
SU828967A3 (ru) 1981-05-07
NL7811035A (nl) 1979-05-09
IT7829514A0 (it) 1978-11-07
FR2407930B1 (en, 2012) 1983-03-18
YU257578A (en) 1983-01-21
CA1120929A (en) 1982-03-30
YU41129B (en) 1986-12-31
JPS5473784A (en) 1979-06-13
CH645354A5 (de) 1984-09-28
BE871807A (fr) 1979-05-07
SE446267B (sv) 1986-08-25
FI69463B (fi) 1985-10-31
AU517670B2 (en) 1981-08-20

Similar Documents

Publication Publication Date Title
FI69463C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolylguanidiner
SU1681728A3 (ru) Способ получени производных N-(бензтиазолил-2)амидов бензойной или тиазол-4-карбоновой кислоты
SU1400508A3 (ru) Способ получени производных арилтиазолов
SE435837B (sv) 4-amino-3-kinolinkarboxylsyror och estrar derav med antisekretorisk och anti-ulceros aktivitet
AU683151B2 (en) Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them
CY1446A (en) Chemical compounds derived from cyclobutene
HU187478B (en) Process for preparing new imidazolyl-phenyl-amidines and pharmaceutical compositions containing thereof
US4824848A (en) Pyrazolo[3,4-d]pyrimidine derivatives, their production and use
US6380229B1 (en) 2-(N-cyanoimino)thiazolidin-4-one derivatives
EP0172608B1 (en) Novel triazine derivative, process for preparing same and pharmaceutical preparations containing same
CA1054600A (en) Amino derivatives of imidazo (4,5-b) pyridines
JPH0260671B2 (en, 2012)
CZ129693A3 (en) Novel thienothiazine derivatives, process of their preparation and pharmaceutical preparations in which they are comprised
US3767674A (en) Cyclohexeno thioxanthones
Islip et al. Antiparasitic 5-nitrothiazoles and 5-nitro-4-thiazolines. 4
PL231063B1 (pl) Pochodne 1-(podstawionej sulfonylo)-2-aminoimidazoliny jako środki przeciwnowotworowe
US3962437A (en) 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
FI79847B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara akridanon-derivat.
FI63415C (fi) Foerfarande foer framstaellning av antiartritiska och antireumatiska 2,6-bis-(aminoalylamino)-benzo-(1,2-d:5,4-d')-bistiazoler och 2-amino-6-(aminoacylamino)-benzo-(1,2-d:5,4-d')-bistiazoler
Shafik et al. Synthesis of novel 2-[2-(substituted amino) phenethyl]-1H-benzimidazoles; 3, 4-dihydro and 1, 2, 3, 4,-tetrahydropyrimido [1, 6-a]-benzimidazoles as potential antiulcer agents
US3901901A (en) 5(6)-benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
Malešíč et al. Transformations of methyl L‐(—)‐thiazolidine‐4‐carboxylate, 2‐amino‐2‐thiazoline and 2‐aminothiazole into thiazoloazines and azolothiazoles
US4532137A (en) 2-Thiazolamine derivatives, process for preparing same, and pharmaceutical compositions comprising same
US4473577A (en) 2-Thiazolamine derivatives, process for preparing same, and pharmaceutical compositions comprising same
IE58583B1 (en) 6-aminomethyl-furo-(3,4-c)-pyridine derivatives

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: LEO PHARMACEUTICAL PRODUCTS LTD A/S (LOEVENS KEMIS