FI69303C - Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat - Google Patents

Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat Download PDF

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Publication number
FI69303C
FI69303C FI840209A FI840209A FI69303C FI 69303 C FI69303 C FI 69303C FI 840209 A FI840209 A FI 840209A FI 840209 A FI840209 A FI 840209A FI 69303 C FI69303 C FI 69303C
Authority
FI
Finland
Prior art keywords
reaction
product
glipizide
procedure
framework
Prior art date
Application number
FI840209A
Other languages
English (en)
Swedish (sv)
Other versions
FI840209A0 (fi
FI840209A (fi
FI69303B (fi
Inventor
Mikael Ulf Dahlstroem
Yngve Valdemar Malmen
Original Assignee
Medica Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medica Pharma Co Ltd filed Critical Medica Pharma Co Ltd
Publication of FI840209A0 publication Critical patent/FI840209A0/fi
Priority to FI840209A priority Critical patent/FI69303C/fi
Priority to ZA8410079A priority patent/ZA8410079B/xx
Priority to DK18985A priority patent/DK18985A/da
Priority to CS30785A priority patent/CS249534B2/cs
Priority to SU853837681A priority patent/SU1340584A3/ru
Priority to EP85850019A priority patent/EP0149592A3/en
Priority to DD27262785A priority patent/DD228251A5/de
Priority to NO850217A priority patent/NO850217L/no
Priority to PL25160585A priority patent/PL251605A1/xx
Publication of FI840209A publication Critical patent/FI840209A/fi
Publication of FI69303B publication Critical patent/FI69303B/fi
Application granted granted Critical
Publication of FI69303C publication Critical patent/FI69303C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Claims (3)

1. Förfarande för fraraställning av N- 4- 2- (5-iretylpyrazinyl - 2-karboxamicb) - etylj - bensensulfonyl ^ - N' -cyklobexylurea med blodsockersänkartde effekt med kemiska stxukturformeln (I), där man later 4- J^2-(5-metylpyrazinyl - 2-karboxamido) -etyl j - bensensulfonamid med formeln (II) 0!3 .S C0-NH-CH2-CH2-^Qy-S02NH2 II reagera med N-cyklohexyl - triklorättiksyra-amid med farmein (III) ^ y-NHCOCCl3 III kännetecknat därav, att reaktionen utföres i närvaro av polära, aprotiska lösningsmedel sasom N-metylpyrro-lidon (NMP), Ν,Ν-dimetylformamid (DMF), N,N-dirnetylacetamid (DMA.) eller dimetylsulfoxid (DMSO) under vattenfria betingelser i närvaro av baser sasom aikai ime tali - alkoholater, - amider eller - hydrider II 69303 under äterlopp vid en reaktionsternperatur om 40-100°C, fördelak-tigtvis roellan 50-80°C, under en tid av 2-5 timmar. 69303 12 PATENTTIVAATIMUS
1. Menetelmä N- 4- jX- (5-metyylipyratsinyyli - 2-karboksiamido) -etyyli^ - bentseenisulfonyyli - N'-sykloheksyylivirtsa-ainaen valmistamiseksi, jolla on verensokeria alentava vaikutus ja jonka kania Uinen kaava on (I), “Hfl _ ^ N^V<OONH-CH2-CH2-/ Q V-so2-nh-co-nh- / \ jossa annetaan 4- £ 2- (5-metyylipyratsinyyli - 2-karboksiamido) -etyyli J - bentseenisulfonamidin, jonka kaava on (II), CH-, 'X. jX -ToV-
00-NH-CH2-CH2-/ Q V—S02NH2 II reagoida N-sykloheksyyli-trikloorietikkahappoaniidin kanssa, jonka kaava on (III) ^ ^-NFICOCC13 III tunnettu siitä, että reaktio suoritetaan polaaristen, aproottisten liuottimien kuten N-rnetyylipyrrolidonin (NMP), N,N^imetyyliforrnamidin (DMF), N,N^imetyyliasetamidin (DMA) tai dimetyylisul f oksidin (DMSO) läsnäollessa vedettömässä tilassa II
FI840209A 1984-01-19 1984-01-19 Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat FI69303C (fi)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FI840209A FI69303C (fi) 1984-01-19 1984-01-19 Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat
ZA8410079A ZA8410079B (en) 1984-01-19 1984-12-27 Process for the preparation of a pharmacologically active sulphonylurea derivative
DK18985A DK18985A (da) 1984-01-19 1985-01-15 Fremgangsmaade til fremstilling af et farmakologisk virksomt sulfonylurinstofderivat
SU853837681A SU1340584A3 (ru) 1984-01-19 1985-01-16 Способ получени N- @ 4-[2-(5-метилпиразинил-2-карбоксамидо)-этил]-бензосульфонил @ -N-циклогексилмочевины
CS30785A CS249534B2 (en) 1984-01-19 1985-01-16 Method of cyclohexylurea's sulphonyled derivatives production
EP85850019A EP0149592A3 (en) 1984-01-19 1985-01-17 Process for the preparation of a pharmacologically active sulphonylurea derivative
DD27262785A DD228251A5 (de) 1984-01-19 1985-01-17 Verfahren zur herstellung von glipizid
NO850217A NO850217L (no) 1984-01-19 1985-01-18 Fremgangsmaate for fremstilling av et farmatologisk aktivert sulfonylurinstoff-derivat
PL25160585A PL251605A1 (en) 1984-01-19 1985-01-18 Method of obtaining pharmacologically active derivative of sulfonylurea

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI840209A FI69303C (fi) 1984-01-19 1984-01-19 Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat
FI840209 1984-01-19

Publications (4)

Publication Number Publication Date
FI840209A0 FI840209A0 (fi) 1984-01-19
FI840209A FI840209A (fi) 1985-07-20
FI69303B FI69303B (fi) 1985-09-30
FI69303C true FI69303C (fi) 1986-01-10

Family

ID=8518397

Family Applications (1)

Application Number Title Priority Date Filing Date
FI840209A FI69303C (fi) 1984-01-19 1984-01-19 Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat

Country Status (9)

Country Link
EP (1) EP0149592A3 (fi)
CS (1) CS249534B2 (fi)
DD (1) DD228251A5 (fi)
DK (1) DK18985A (fi)
FI (1) FI69303C (fi)
NO (1) NO850217L (fi)
PL (1) PL251605A1 (fi)
SU (1) SU1340584A3 (fi)
ZA (1) ZA8410079B (fi)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107434788B (zh) * 2017-09-11 2018-06-15 威海迪素制药有限公司 一种格列吡嗪的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU162761B (fi) * 1971-04-06 1973-04-28

Also Published As

Publication number Publication date
CS249534B2 (en) 1987-03-12
ZA8410079B (en) 1985-08-28
FI840209A0 (fi) 1984-01-19
EP0149592A2 (en) 1985-07-24
EP0149592A3 (en) 1986-06-04
PL251605A1 (en) 1985-10-22
FI840209A (fi) 1985-07-20
DD228251A5 (de) 1985-10-09
NO850217L (no) 1985-07-22
FI69303B (fi) 1985-09-30
DK18985D0 (da) 1985-01-15
SU1340584A3 (ru) 1987-09-23
DK18985A (da) 1985-07-20

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Owner name: LAEKEMEDELSFABRIKEN-MEDICA AB