FI69303B - Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat - Google Patents
Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat Download PDFInfo
- Publication number
- FI69303B FI69303B FI840209A FI840209A FI69303B FI 69303 B FI69303 B FI 69303B FI 840209 A FI840209 A FI 840209A FI 840209 A FI840209 A FI 840209A FI 69303 B FI69303 B FI 69303B
- Authority
- FI
- Finland
- Prior art keywords
- reaction
- product
- glipizide
- ethyl
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Claims (3)
1. Förfarande för fraraställning av N- 4- 2- (5-iretylpyrazinyl - 2-karboxamicb) - etylj - bensensulfonyl ^ - N' -cyklobexylurea med blodsockersänkartde effekt med kemiska stxukturformeln (I), där man later 4- J^2-(5-metylpyrazinyl - 2-karboxamido) -etyl j - bensensulfonamid med formeln (II) 0!3 .S C0-NH-CH2-CH2-^Qy-S02NH2 II reagera med N-cyklohexyl - triklorättiksyra-amid med farmein (III) ^ y-NHCOCCl3 III kännetecknat därav, att reaktionen utföres i närvaro av polära, aprotiska lösningsmedel sasom N-metylpyrro-lidon (NMP), Ν,Ν-dimetylformamid (DMF), N,N-dirnetylacetamid (DMA.) eller dimetylsulfoxid (DMSO) under vattenfria betingelser i närvaro av baser sasom aikai ime tali - alkoholater, - amider eller - hydrider II 69303 under äterlopp vid en reaktionsternperatur om 40-100°C, fördelak-tigtvis roellan 50-80°C, under en tid av 2-5 timmar. 69303 12 PATENTTIVAATIMUS
1. Menetelmä N- 4- jX- (5-metyylipyratsinyyli - 2-karboksiamido) -etyyli^ - bentseenisulfonyyli - N'-sykloheksyylivirtsa-ainaen valmistamiseksi, jolla on verensokeria alentava vaikutus ja jonka kania Uinen kaava on (I), “Hfl _ ^ N^V<OONH-CH2-CH2-/ Q V-so2-nh-co-nh- / \ jossa annetaan 4- £ 2- (5-metyylipyratsinyyli - 2-karboksiamido) -etyyli J - bentseenisulfonamidin, jonka kaava on (II), CH-, 'X. jX -ToV-
00-NH-CH2-CH2-/ Q V—S02NH2 II reagoida N-sykloheksyyli-trikloorietikkahappoaniidin kanssa, jonka kaava on (III) ^ ^-NFICOCC13 III tunnettu siitä, että reaktio suoritetaan polaaristen, aproottisten liuottimien kuten N-rnetyylipyrrolidonin (NMP), N,N^imetyyliforrnamidin (DMF), N,N^imetyyliasetamidin (DMA) tai dimetyylisul f oksidin (DMSO) läsnäollessa vedettömässä tilassa II
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI840209A FI69303C (fi) | 1984-01-19 | 1984-01-19 | Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat |
ZA8410079A ZA8410079B (en) | 1984-01-19 | 1984-12-27 | Process for the preparation of a pharmacologically active sulphonylurea derivative |
DK18985A DK18985A (da) | 1984-01-19 | 1985-01-15 | Fremgangsmaade til fremstilling af et farmakologisk virksomt sulfonylurinstofderivat |
CS30785A CS249534B2 (en) | 1984-01-19 | 1985-01-16 | Method of cyclohexylurea's sulphonyled derivatives production |
SU853837681A SU1340584A3 (ru) | 1984-01-19 | 1985-01-16 | Способ получени N- @ 4-[2-(5-метилпиразинил-2-карбоксамидо)-этил]-бензосульфонил @ -N-циклогексилмочевины |
DD27262785A DD228251A5 (de) | 1984-01-19 | 1985-01-17 | Verfahren zur herstellung von glipizid |
EP85850019A EP0149592A3 (en) | 1984-01-19 | 1985-01-17 | Process for the preparation of a pharmacologically active sulphonylurea derivative |
NO850217A NO850217L (no) | 1984-01-19 | 1985-01-18 | Fremgangsmaate for fremstilling av et farmatologisk aktivert sulfonylurinstoff-derivat |
PL25160585A PL251605A1 (en) | 1984-01-19 | 1985-01-18 | Method of obtaining pharmacologically active derivative of sulfonylurea |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI840209A FI69303C (fi) | 1984-01-19 | 1984-01-19 | Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat |
FI840209 | 1984-01-19 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI840209A0 FI840209A0 (fi) | 1984-01-19 |
FI840209A FI840209A (fi) | 1985-07-20 |
FI69303B true FI69303B (fi) | 1985-09-30 |
FI69303C FI69303C (fi) | 1986-01-10 |
Family
ID=8518397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI840209A FI69303C (fi) | 1984-01-19 | 1984-01-19 | Foerfarande foer framstaellning av ett farmakologiskt verksamtsulfonylureaderivat |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0149592A3 (fi) |
CS (1) | CS249534B2 (fi) |
DD (1) | DD228251A5 (fi) |
DK (1) | DK18985A (fi) |
FI (1) | FI69303C (fi) |
NO (1) | NO850217L (fi) |
PL (1) | PL251605A1 (fi) |
SU (1) | SU1340584A3 (fi) |
ZA (1) | ZA8410079B (fi) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107434788B (zh) * | 2017-09-11 | 2018-06-15 | 威海迪素制药有限公司 | 一种格列吡嗪的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU162761B (fi) * | 1971-04-06 | 1973-04-28 |
-
1984
- 1984-01-19 FI FI840209A patent/FI69303C/fi not_active IP Right Cessation
- 1984-12-27 ZA ZA8410079A patent/ZA8410079B/xx unknown
-
1985
- 1985-01-15 DK DK18985A patent/DK18985A/da not_active Application Discontinuation
- 1985-01-16 CS CS30785A patent/CS249534B2/cs unknown
- 1985-01-16 SU SU853837681A patent/SU1340584A3/ru active
- 1985-01-17 EP EP85850019A patent/EP0149592A3/en not_active Withdrawn
- 1985-01-17 DD DD27262785A patent/DD228251A5/de unknown
- 1985-01-18 NO NO850217A patent/NO850217L/no unknown
- 1985-01-18 PL PL25160585A patent/PL251605A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CS249534B2 (en) | 1987-03-12 |
DK18985A (da) | 1985-07-20 |
FI840209A (fi) | 1985-07-20 |
DK18985D0 (da) | 1985-01-15 |
DD228251A5 (de) | 1985-10-09 |
NO850217L (no) | 1985-07-22 |
SU1340584A3 (ru) | 1987-09-23 |
FI69303C (fi) | 1986-01-10 |
PL251605A1 (en) | 1985-10-22 |
EP0149592A2 (en) | 1985-07-24 |
ZA8410079B (en) | 1985-08-28 |
EP0149592A3 (en) | 1986-06-04 |
FI840209A0 (fi) | 1984-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: LAEKEMEDELSFABRIKEN-MEDICA AB |