FI68832C - Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido(5,4-d)(2)bensazepiner - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido(5,4-d)(2)bensazepiner Download PDFInfo
- Publication number
- FI68832C FI68832C FI800367A FI800367A FI68832C FI 68832 C FI68832 C FI 68832C FI 800367 A FI800367 A FI 800367A FI 800367 A FI800367 A FI 800367A FI 68832 C FI68832 C FI 68832C
- Authority
- FI
- Finland
- Prior art keywords
- compound
- chloro
- mixture
- ether
- methylene chloride
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (8)
1. Förfarande för framställning av farmaceutiskt använd-bara pyrimidoZJ) ,H-d7ZT27bensazepiner med den allmänna formeln I R1 <0)n L IL / x I ^ (o) o" väri R·'· är väte, lägre alkyl, amino, di-lägre-alkylamino, mer-kapto eller lägre-alkylmerkapto, X är väte eller halogen, Y är väte eller halogen, n är 0 eller 1, varvid de grupper som kallas "lägre" betecknar högst 7 kolatomer innehallande grupper, med förbehäll, att dä n är 1, är p 1 och betecknar ej merkapto eller lägre-alkyl-merkapto, och deras farmaceutiskt godtagbara syraadditionssalter, k ä n -netecknat därav, att a) för framställning av en förening med formeln I, väri n är 0, omsätts en förening med den allmänna formeln IV 21
0 CH-R fTr^< IV I ^ (0) (X 21 van p, X och Y har ovan angiven betydelse och R är di-lägre-alkylamino, med en förening med den allmänna formeln V 42 68832 ^NH R1-C If V 2 ^NH vari R"*" har ovan angiven betydelse, eller b) för framställning av en förening med formeln I, vari R·*" är amino eller di-lägre-alkylamino och n är 0 , omsätts en förening med formeln IV med cyanamid, eller c) för framställning av en förening med formeln I, vari p är 0, R·*· är väte, lägre alkyl, amino eller di-lägre-alkylamino och n är 0, 1. cykliseras en förening med den alimänna formeln II R11 I X CH2-NH2 χ"· 0 dr väri X och Y har ovan angiven betydelse och är väte, lägre alkyl, amino eller di-lägre-alkylamino, eller 2. dehydrogeneras en förening med den allmänna formeln III R11 f ] / 111 x Γ a li 68832 *+3 väri X, Y och har ovan angiven betydelse, och, om sä Önskas, d) deoxideras en förening med den allmänna formeln II 11 R -N iif / vari R^, X och Y har ovan angiven betydelse, eller, om.; sä önskas, e) oxideras en förening med den allmänna formeln Ic, R11 \ >^=rN Q x xjy/ Y Ic vari R^, X och Y har ovan angiven betydelse, och/eller, om sä önskas, f) omvandlas en förening med formeln I till ett farma-ceutiskt godtagbart salt.
2. Förfarande enligt patentkravet 1 för framställning av en förening med formeln I, vari p är 1, R1 är amino, n är 0, X är väte , fluor, klor eller brom och Y är väte, fluor, klor eller brom, kännet ecknat därav, att föreningen fram-ställs enligt utföringsformen a), varvid X och Y har i detta
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1011879A | 1979-02-07 | 1979-02-07 | |
US1011879 | 1979-02-07 | ||
US1670979A | 1979-03-01 | 1979-03-01 | |
US1670979 | 1979-03-01 | ||
CH51080 | 1980-01-22 | ||
CH51080 | 1980-01-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI800367A FI800367A (fi) | 1980-08-08 |
FI68832B FI68832B (fi) | 1985-07-31 |
FI68832C true FI68832C (fi) | 1985-11-11 |
Family
ID=27172162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI800367A FI68832C (fi) | 1979-02-07 | 1980-02-06 | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido(5,4-d)(2)bensazepiner |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0014470B1 (sv) |
AT (1) | ATE14225T1 (sv) |
AU (1) | AU535233B2 (sv) |
CA (1) | CA1138863A (sv) |
DD (1) | DD149066A5 (sv) |
DE (2) | DE3070847D1 (sv) |
ES (1) | ES8101590A1 (sv) |
FI (1) | FI68832C (sv) |
FR (1) | FR2450833A1 (sv) |
GB (1) | GB2043636B (sv) |
HU (1) | HU182662B (sv) |
IE (1) | IE49630B1 (sv) |
IL (1) | IL59316A (sv) |
IN (1) | IN151574B (sv) |
IT (1) | IT1140535B (sv) |
LU (1) | LU82143A1 (sv) |
MC (1) | MC1314A1 (sv) |
MT (1) | MTP864B (sv) |
NL (1) | NL8000715A (sv) |
NO (1) | NO153138C (sv) |
NZ (1) | NZ192803A (sv) |
PT (1) | PT70794B (sv) |
RO (1) | RO79168A (sv) |
SE (1) | SE8000964L (sv) |
SU (1) | SU1181547A3 (sv) |
YU (1) | YU32380A (sv) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1172630A (en) * | 1980-08-05 | 1984-08-14 | Rodney I. Fryer | Benzazepine derivatives |
EP0273697A3 (en) * | 1986-12-30 | 1989-11-29 | Merck & Co. Inc. | 2-benzazepines with 5- and 6- membered heterocyclic rings |
US5013333A (en) * | 1990-04-13 | 1991-05-07 | Tennant Company | Unattended air cleaning system for surface maintenance machine |
WO2005113494A2 (en) * | 2004-05-07 | 2005-12-01 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
ATE381566T1 (de) | 2004-05-14 | 2008-01-15 | Millennium Pharm Inc | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
US7718648B2 (en) | 2006-08-09 | 2010-05-18 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
WO2010074724A1 (en) | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
CA2788774A1 (en) | 2010-02-19 | 2011-08-25 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate |
US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
US9724354B2 (en) | 2013-03-22 | 2017-08-08 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3947585A (en) * | 1974-06-03 | 1976-03-30 | Ciba-Geigy Corporation | Pyrazolobenzazepines |
-
1980
- 1980-02-05 FR FR8002469A patent/FR2450833A1/fr active Granted
- 1980-02-05 NL NL8000715A patent/NL8000715A/nl not_active Application Discontinuation
- 1980-02-05 CA CA000345062A patent/CA1138863A/en not_active Expired
- 1980-02-05 NZ NZ192803A patent/NZ192803A/en unknown
- 1980-02-05 SU SU802879255A patent/SU1181547A3/ru active
- 1980-02-05 IL IL59316A patent/IL59316A/xx unknown
- 1980-02-06 AT AT80100610T patent/ATE14225T1/de not_active IP Right Cessation
- 1980-02-06 SE SE8000964A patent/SE8000964L/sv not_active Application Discontinuation
- 1980-02-06 MT MT864A patent/MTP864B/xx unknown
- 1980-02-06 LU LU82143A patent/LU82143A1/de unknown
- 1980-02-06 AU AU55296/80A patent/AU535233B2/en not_active Ceased
- 1980-02-06 IT IT19740/80A patent/IT1140535B/it active
- 1980-02-06 PT PT70794A patent/PT70794B/pt unknown
- 1980-02-06 ES ES488311A patent/ES8101590A1/es not_active Expired
- 1980-02-06 MC MC801426A patent/MC1314A1/xx unknown
- 1980-02-06 IN IN138/CAL/80A patent/IN151574B/en unknown
- 1980-02-06 EP EP80100610A patent/EP0014470B1/de not_active Expired
- 1980-02-06 DE DE8080100610T patent/DE3070847D1/de not_active Expired
- 1980-02-06 NO NO800316A patent/NO153138C/no unknown
- 1980-02-06 IE IE227/80A patent/IE49630B1/en unknown
- 1980-02-06 DD DD80218921A patent/DD149066A5/de unknown
- 1980-02-06 HU HU80271A patent/HU182662B/hu unknown
- 1980-02-06 FI FI800367A patent/FI68832C/fi not_active IP Right Cessation
- 1980-02-06 DE DE19803004381 patent/DE3004381A1/de not_active Withdrawn
- 1980-02-06 GB GB8003910A patent/GB2043636B/en not_active Expired
- 1980-02-07 YU YU00323/80A patent/YU32380A/xx unknown
- 1980-02-07 RO RO80100118A patent/RO79168A/ro unknown
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Legal Events
Date | Code | Title | Description |
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MM | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE & CO. |