ES8101590A1 - Un procedimiento para la preparacion de pirimido-2-benzace- pinas - Google Patents

Un procedimiento para la preparacion de pirimido-2-benzace- pinas

Info

Publication number
ES8101590A1
ES8101590A1 ES488311A ES488311A ES8101590A1 ES 8101590 A1 ES8101590 A1 ES 8101590A1 ES 488311 A ES488311 A ES 488311A ES 488311 A ES488311 A ES 488311A ES 8101590 A1 ES8101590 A1 ES 8101590A1
Authority
ES
Spain
Prior art keywords
hydrogen
lower alkyl
hydroxy
group
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488311A
Other languages
English (en)
Other versions
ES488311A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES488311A0 publication Critical patent/ES488311A0/es
Publication of ES8101590A1 publication Critical patent/ES8101590A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE PIRIMIDO-2-BENZACEPINAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I), DONDE R ELEVADO A 21 REPRESENTA DI-ALQUILAMINO INFERIOR, CON CIANAMIDA O CON UN COMPUESTO DE FORMULA GENERAL (II), SIENDO R ELEVADO A 12 HIDROGENO, MERCAPTO, MERCAPTO DE ALQUILO INFERIOR, *FORMULA* ALQUILO INFERIOR O NR ELEVADO A 8 R ELEVADO A 9. SE OBTIENE UN COMPUESTO DE FORMULA GENERAL (III) EN QUE SE PUEDE TRANSFORMAR EN UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE. L
ES488311A 1979-02-07 1980-02-06 Un procedimiento para la preparacion de pirimido-2-benzace- pinas Expired ES8101590A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1011879A 1979-02-07 1979-02-07
US1670979A 1979-03-01 1979-03-01
CH51080 1980-01-22

Publications (2)

Publication Number Publication Date
ES488311A0 ES488311A0 (es) 1980-12-16
ES8101590A1 true ES8101590A1 (es) 1980-12-16

Family

ID=27172162

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488311A Expired ES8101590A1 (es) 1979-02-07 1980-02-06 Un procedimiento para la preparacion de pirimido-2-benzace- pinas

Country Status (26)

Country Link
EP (1) EP0014470B1 (es)
AT (1) ATE14225T1 (es)
AU (1) AU535233B2 (es)
CA (1) CA1138863A (es)
DD (1) DD149066A5 (es)
DE (2) DE3004381A1 (es)
ES (1) ES8101590A1 (es)
FI (1) FI68832C (es)
FR (1) FR2450833A1 (es)
GB (1) GB2043636B (es)
HU (1) HU182662B (es)
IE (1) IE49630B1 (es)
IL (1) IL59316A (es)
IN (1) IN151574B (es)
IT (1) IT1140535B (es)
LU (1) LU82143A1 (es)
MC (1) MC1314A1 (es)
MT (1) MTP864B (es)
NL (1) NL8000715A (es)
NO (1) NO153138C (es)
NZ (1) NZ192803A (es)
PT (1) PT70794B (es)
RO (1) RO79168A (es)
SE (1) SE8000964L (es)
SU (1) SU1181547A3 (es)
YU (1) YU32380A (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK347781A (da) * 1980-08-05 1982-02-06 Hoffmann La Roche Fremgangsmaade til fremstilling af pyrimido-(4,5-d) (2)-benzezepiner eller farmaceutisk acceptable salte deraf
EP0273697A3 (en) * 1986-12-30 1989-11-29 Merck & Co. Inc. 2-benzazepines with 5- and 6- membered heterocyclic rings
US5013333A (en) * 1990-04-13 1991-05-07 Tennant Company Unattended air cleaning system for surface maintenance machine
EP1751136B1 (en) * 2004-05-07 2014-07-02 Amgen Inc. Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer
EA012112B1 (ru) 2004-05-14 2009-08-28 Миллениум Фармасьютикалз, Инк. Соединения и способы для ингибирования митотической прогрессии
JP2010500352A (ja) 2006-08-09 2010-01-07 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 有糸分裂の進行を阻止するためのピリドベンゾアゼピン化合物および方法
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
KR101741168B1 (ko) 2008-12-22 2017-05-29 밀레니엄 파머슈티컬스 인코퍼레이티드 오로라 키나아제 억제제 및 항­ｃｄ 항체의 병용
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
CN104031049A (zh) 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
EP2976086B1 (en) 2013-03-22 2020-10-14 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947585A (en) * 1974-06-03 1976-03-30 Ciba-Geigy Corporation Pyrazolobenzazepines

Also Published As

Publication number Publication date
NO800316L (no) 1980-08-08
NL8000715A (nl) 1980-08-11
SU1181547A3 (ru) 1985-09-23
MC1314A1 (fr) 1981-03-10
HU182662B (en) 1984-02-28
IN151574B (es) 1983-05-28
MTP864B (en) 1981-04-29
IE49630B1 (en) 1985-11-13
PT70794A (en) 1980-03-01
IT8019740A0 (it) 1980-02-06
EP0014470A2 (de) 1980-08-20
FR2450833B1 (es) 1983-06-10
FI68832C (fi) 1985-11-11
NO153138B (no) 1985-10-14
RO79168A (ro) 1982-06-25
YU32380A (en) 1983-12-31
ATE14225T1 (de) 1985-07-15
DE3070847D1 (en) 1985-08-14
FI68832B (fi) 1985-07-31
PT70794B (en) 1981-06-11
EP0014470A3 (en) 1982-02-10
NZ192803A (en) 1984-08-24
IL59316A (en) 1983-07-31
CA1138863A (en) 1983-01-04
IE800227L (en) 1980-08-07
DE3004381A1 (de) 1980-09-04
GB2043636A (en) 1980-10-08
GB2043636B (en) 1983-05-11
IT1140535B (it) 1986-10-01
FR2450833A1 (fr) 1980-10-03
SE8000964L (sv) 1980-08-08
DD149066A5 (de) 1981-06-24
AU5529680A (en) 1980-08-14
NO153138C (no) 1986-01-22
IL59316A0 (en) 1980-05-30
FI800367A (fi) 1980-08-08
ES488311A0 (es) 1980-12-16
AU535233B2 (en) 1984-03-08
LU82143A1 (de) 1981-09-10
EP0014470B1 (de) 1985-07-10

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