FI66840C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alfa-fluormetyl-alfa-aminoalkansyror - Google Patents

Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alfa-fluormetyl-alfa-aminoalkansyror Download PDF

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Publication number
FI66840C
FI66840C FI781674A FI781674A FI66840C FI 66840 C FI66840 C FI 66840C FI 781674 A FI781674 A FI 781674A FI 781674 A FI781674 A FI 781674A FI 66840 C FI66840 C FI 66840C
Authority
FI
Finland
Prior art keywords
fluoromethyl
hydroxymethyl
formula
tyrosine
compound
Prior art date
Application number
FI781674A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI66840B (fi
FI781674A (fi
Inventor
Janos Kollonitsch
Arthur Allan Patchett
Stephen Marburg
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/802,391 external-priority patent/US4325961A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI781674A publication Critical patent/FI781674A/fi
Publication of FI66840B publication Critical patent/FI66840B/fi
Application granted granted Critical
Publication of FI66840C publication Critical patent/FI66840C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
FI781674A 1977-06-01 1978-05-26 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alfa-fluormetyl-alfa-aminoalkansyror FI66840C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80238977A 1977-06-01 1977-06-01
US80239177 1977-06-01
US80238977 1977-06-01
US05/802,391 US4325961A (en) 1977-06-01 1977-06-01 Fluorinated amino acids

Publications (3)

Publication Number Publication Date
FI781674A FI781674A (fi) 1978-12-02
FI66840B FI66840B (fi) 1984-08-31
FI66840C true FI66840C (fi) 1984-12-10

Family

ID=27122442

Family Applications (1)

Application Number Title Priority Date Filing Date
FI781674A FI66840C (fi) 1977-06-01 1978-05-26 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara alfa-fluormetyl-alfa-aminoalkansyror

Country Status (26)

Country Link
JP (1) JPS5416423A (pl)
AR (1) AR223463A1 (pl)
AT (1) AT360509B (pl)
AU (1) AU518479B2 (pl)
CA (1) CA1120040A (pl)
CH (1) CH639639A5 (pl)
DD (1) DD138651A5 (pl)
DE (1) DE2824116A1 (pl)
DK (1) DK149841C (pl)
ES (1) ES470296A1 (pl)
FI (1) FI66840C (pl)
FR (1) FR2392958A1 (pl)
GB (1) GB1602525A (pl)
GR (1) GR64495B (pl)
HK (1) HK18184A (pl)
HU (1) HU181911B (pl)
IE (1) IE46983B1 (pl)
IT (1) IT1104709B (pl)
LU (1) LU79750A1 (pl)
NL (1) NL190485C (pl)
NO (1) NO147382C (pl)
NZ (1) NZ187377A (pl)
PL (1) PL115731B1 (pl)
PT (1) PT68102B (pl)
SE (1) SE7806440L (pl)
YU (1) YU129178A (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59481A0 (en) * 1977-07-11 1980-05-30 Merrell Toraude & Co -halomethyl amino acids
ZA783273B (en) * 1977-07-11 1979-06-27 Merrell Toraude & Co A-halomethyl amino acids
CA1091661A (en) * 1977-07-11 1980-12-16 Philippe Bey .alpha.-HALOMETHYL DERIVATIVES OF .alpha.-AMINO ACIDS
US4315095A (en) * 1977-07-28 1982-02-09 Merrell Toraude Et Compagnie α-Halomethyl derivatives of amino acids
DK309479A (da) * 1978-07-24 1980-02-19 Merck & Co Inc Fremgangsmaade til fremstilling af alfadifluormethylaminosyrer og estere deraf
IE49522B1 (en) * 1979-04-26 1985-10-16 Merrell Toraude & Co Alpha-halomethylaminoacids
NZ194347A (en) * 1979-07-26 1982-11-23 Merrell Toraude & Co Fluorinated alkenylamines intermediate alkenyl fluorinated methyl ketimine magnesium halides and preparation of certain amino alkanoic acids
ZA813018B (en) * 1980-05-09 1982-05-26 Merrell Toraude & Co Fluoromethylated tyrosine methyl ester
CA1174603A (en) * 1980-06-16 1984-09-18 Albert Sjoerdsma Method of inhibiting the growth of protozoa
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
GB9325368D0 (en) * 1993-12-10 1994-02-16 Univ Bristol Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046300A (en) * 1960-10-21 1962-07-24 Merck & Co Inc alpha-trifluoromethyloxyphenylalanines

Also Published As

Publication number Publication date
NZ187377A (en) 1981-05-15
IT7849637A0 (it) 1978-05-31
DE2824116A1 (de) 1978-12-14
ATA393278A (de) 1980-06-15
AR223463A1 (es) 1981-08-31
JPS5416423A (en) 1979-02-07
FI66840B (fi) 1984-08-31
DK149841C (da) 1987-04-21
HK18184A (en) 1984-03-09
IT1104709B (it) 1985-10-28
SE7806440L (sv) 1978-12-02
DD138651A5 (de) 1979-11-14
PT68102A (en) 1978-06-01
DK149841B (da) 1986-10-13
NO147382B (no) 1982-12-20
AU3658678A (en) 1979-12-06
DK237978A (da) 1979-01-19
CA1120040A (en) 1982-03-16
PL207242A1 (pl) 1979-04-23
NO781892L (no) 1978-12-04
IE781078L (en) 1978-12-01
NO147382C (no) 1983-03-30
NL190485B (nl) 1993-10-18
ES470296A1 (es) 1979-09-16
HU181911B (en) 1983-11-28
IE46983B1 (en) 1983-11-16
AU518479B2 (en) 1981-10-01
LU79750A1 (fr) 1979-02-02
PT68102B (en) 1982-06-08
DE2824116C2 (pl) 1989-04-27
GB1602525A (en) 1981-11-11
FR2392958B1 (pl) 1980-10-24
CH639639A5 (en) 1983-11-30
GR64495B (en) 1980-03-31
FR2392958A1 (fr) 1978-12-29
PL115731B1 (en) 1981-04-30
FI781674A (fi) 1978-12-02
NL190485C (nl) 1994-03-16
YU129178A (en) 1983-01-21
AT360509B (de) 1981-01-12
NL7805981A (nl) 1978-12-05
JPS641474B2 (pl) 1989-01-11

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MM Patent lapsed

Owner name: MERCK & CO., INC.