FI65260C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-1h-tetrazol-5-yl)-4h-pyrimido(2,1-b)benzotiazolderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-1h-tetrazol-5-yl)-4h-pyrimido(2,1-b)benzotiazolderivat Download PDF

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Publication number
FI65260C
FI65260C FI791411A FI791411A FI65260C FI 65260 C FI65260 C FI 65260C FI 791411 A FI791411 A FI 791411A FI 791411 A FI791411 A FI 791411A FI 65260 C FI65260 C FI 65260C
Authority
FI
Finland
Prior art keywords
formula
compound
pyrimido
tetrazol
give
Prior art date
Application number
FI791411A
Other languages
English (en)
Finnish (fi)
Other versions
FI791411A (fi
FI65260B (fi
Inventor
Robert R Covington
Jr Davis L Temple
Joseph P Yevich
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI791411A publication Critical patent/FI791411A/fi
Publication of FI65260B publication Critical patent/FI65260B/fi
Application granted granted Critical
Publication of FI65260C publication Critical patent/FI65260C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
FI791411A 1978-05-05 1979-05-02 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-1h-tetrazol-5-yl)-4h-pyrimido(2,1-b)benzotiazolderivat FI65260C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/903,265 US4223031A (en) 1978-05-05 1978-05-05 Azolopyrimidinones
US90326578 1978-05-05

Publications (3)

Publication Number Publication Date
FI791411A FI791411A (fi) 1979-11-06
FI65260B FI65260B (fi) 1983-12-30
FI65260C true FI65260C (fi) 1984-04-10

Family

ID=25417203

Family Applications (1)

Application Number Title Priority Date Filing Date
FI791411A FI65260C (fi) 1978-05-05 1979-05-02 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-1h-tetrazol-5-yl)-4h-pyrimido(2,1-b)benzotiazolderivat

Country Status (18)

Country Link
US (1) US4223031A (de)
JP (1) JPS54145696A (de)
AU (1) AU528715B2 (de)
BE (1) BE876059A (de)
CA (1) CA1109870A (de)
CH (2) CH641460A5 (de)
DE (1) DE2918085A1 (de)
DK (1) DK185079A (de)
FI (1) FI65260C (de)
FR (1) FR2424924A1 (de)
GB (1) GB2020654B (de)
GR (1) GR72717B (de)
IE (1) IE47976B1 (de)
LU (1) LU81231A1 (de)
NL (1) NL7903535A (de)
SE (2) SE445642B (de)
YU (1) YU103679A (de)
ZA (1) ZA792130B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491587A (en) * 1978-05-05 1985-01-01 Mead Johnson & Company Tetrazole derivatives
US4297355A (en) * 1979-11-15 1981-10-27 Schering Corporation (1H,3H,5H)-(1)-Benzopyrano-(2,3-d)-pyrimidine-4-one-2-thiones and their use as anti-allergy agents
US4414388A (en) * 1979-11-23 1983-11-08 Pfizer Inc. 1-Oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides
DK151811C (da) * 1979-11-23 1988-06-06 Pfizer Analogifremgangsmaade til fremstilling af n-(5-tetrazolyl)-1-oxo-1h-thiazolooe3,2-aaa-pyrimidin-2-carboxamider eller farmaceutisk acceptable kationsalte deraf samt 1-oxo-1h-thiazolooe3,2-aaapyrimidin-2-carboxylsyrer til anvendelse som udgangsmaterialer ved fremgangsmaaden
JPS57165318A (en) * 1981-04-03 1982-10-12 Mochida Pharmaceut Co Ltd Remedy for asthma
US4510143A (en) * 1982-02-17 1985-04-09 Roussel Uclaf Antiallergic pyrimido[1,2-a]quinoxalin-2-carboxylic acid derivatives
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them
US4476130A (en) * 1982-09-09 1984-10-09 Riker Laboratories, Inc. 3-(1H-Tetrazol-5-yl)-4H-pyrimido[2,1-b]benzoxazol-4-one compounds exhibiting anti-allergic activity
US4507477A (en) * 1982-09-09 1985-03-26 Riker Laboratories, Inc. Process for tetrazolyl-pyrimidinone derivatives
US4474953A (en) * 1982-09-09 1984-10-02 Riker Laboratories, Inc. Process and intermediates for the preparation of 3(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-ones
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
GB8334210D0 (en) * 1983-12-22 1984-02-01 Roussel Lab Ltd Imidazo(1 2-c)pyrimidines
US4762840A (en) * 1984-02-13 1988-08-09 Roussel Uclaf Pyrimido[2,1-b]benzothiazoles having antiallergic activity
JPS60226887A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd トリアゾロピリミジン誘導体
GB8422918D0 (en) * 1984-09-11 1984-10-17 May & Baker Ltd Compositions of matter
GB8422916D0 (en) * 1984-09-11 1984-10-17 May & Baker Ltd Compositions of matter
CA1270840A (en) * 1985-01-29 1990-06-26 Wolfgang Wehner Triazole derivatives and the use thereof for stabilising organic polymers
IL78017A (en) * 1986-03-03 1989-06-30 Yissum Res Dev Co Sustained release tablets of theophylline
JPS6357522A (ja) * 1986-08-28 1988-03-12 Mect Corp ピリミド〔２，１−ｄ〕ベンゾチアゾ−ル誘導体からなる血小板凝集抑制剤
IL85207A (en) * 1987-02-06 1992-06-21 Daiichi Seiyaku Co 6-substituted thiazolo-(and 1,3,4-thiadiazolo-)(3,2-a)-(1,2,3)triazolo(4,5-d)pyrimidin-9(1h)-ones and their preparation
US8349846B2 (en) * 2008-01-11 2013-01-08 Glenmark Pharmaceuticals, S.A. Fused pyrimidine derivatives as TRPV3 modulators
US8119647B2 (en) * 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1070243A (en) * 1964-07-15 1967-06-01 Smith Kline French Lab S-triazolopyrimidones, their preparation and compositions containing them
CH491944A (de) * 1966-11-29 1970-06-15 Ciba Geigy Verfahren zur Herstellung von benzheterocyclischen Verbindungen
IE33549B1 (en) * 1968-09-13 1974-08-07 Ici Ltd S-triazolo (1,5-a) pyrimidine derivatives
US3888983A (en) * 1970-08-14 1975-06-10 Seperic Derivatives of thiazolino-pyrimidin-6-ones, in inducing analgesia
US3907799A (en) * 1971-08-16 1975-09-23 Icn Pharmaceuticals Xanthine oxidase inhibitors
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation
DE2557425A1 (de) * 1975-12-19 1977-06-30 Boehringer Sohn Ingelheim Chinazolonderivate
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
US4072679A (en) * 1976-06-15 1978-02-07 E. R. Squibb & Sons, Inc. 1,4- AND 4,10-DIHYDRO-4-OXO-PYRIMIDO (1,2-A)-benzimidazole-3-carboxylic acids, esters and amides
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones

Also Published As

Publication number Publication date
GB2020654A (en) 1979-11-21
AU4666779A (en) 1979-11-22
JPS54145696A (en) 1979-11-14
ZA792130B (en) 1980-06-25
GR72717B (de) 1983-12-01
YU103679A (en) 1983-02-28
AU528715B2 (en) 1983-05-12
US4223031A (en) 1980-09-16
SE8404151L (sv) 1984-08-20
FI791411A (fi) 1979-11-06
SE8404151D0 (sv) 1984-08-20
FR2424924A1 (fr) 1979-11-30
DE2918085A1 (de) 1979-11-15
BE876059A (fr) 1979-11-05
FI65260B (fi) 1983-12-30
IE47976B1 (en) 1984-08-08
SE7903927L (sv) 1979-11-06
CA1109870A (en) 1981-09-29
LU81231A1 (fr) 1979-12-06
DK185079A (da) 1979-11-06
NL7903535A (nl) 1979-11-07
CH641460A5 (de) 1984-02-29
IE790912L (en) 1979-11-05
SE445642B (sv) 1986-07-07
GB2020654B (en) 1982-08-04
CH651300A5 (de) 1985-09-13
FR2424924B1 (de) 1983-01-14

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MM Patent lapsed

Owner name: BRISTOL-MYERS CO