FI65069C - Foerfarande foer framstaellning av kristallvattenfri ny-kristallin form av natrium-7-(d-alfa-formyloxi-alfa-fenylacetamido)-3-(1-metyl-1h-tetrazol-5-yltiometyl)-3-cefem-4-karboxylat - Google Patents

Foerfarande foer framstaellning av kristallvattenfri ny-kristallin form av natrium-7-(d-alfa-formyloxi-alfa-fenylacetamido)-3-(1-metyl-1h-tetrazol-5-yltiometyl)-3-cefem-4-karboxylat Download PDF

Info

Publication number
FI65069C
FI65069C FI760788A FI760788A FI65069C FI 65069 C FI65069 C FI 65069C FI 760788 A FI760788 A FI 760788A FI 760788 A FI760788 A FI 760788A FI 65069 C FI65069 C FI 65069C
Authority
FI
Finland
Prior art keywords
sodium
methyl
isopropanol
phenylacetamido
formyloxy
Prior art date
Application number
FI760788A
Other languages
English (en)
Finnish (fi)
Other versions
FI65069B (fi
FI760788A (fr
Inventor
Kuo-Shang Yang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI760788A publication Critical patent/FI760788A/fi
Publication of FI65069B publication Critical patent/FI65069B/fi
Application granted granted Critical
Publication of FI65069C publication Critical patent/FI65069C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI760788A 1975-04-11 1976-03-24 Foerfarande foer framstaellning av kristallvattenfri ny-kristallin form av natrium-7-(d-alfa-formyloxi-alfa-fenylacetamido)-3-(1-metyl-1h-tetrazol-5-yltiometyl)-3-cefem-4-karboxylat FI65069C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/567,324 US4006138A (en) 1975-04-11 1975-04-11 Crystalline form of sodium O-formylcefamandole
US56732475 1975-04-11

Publications (3)

Publication Number Publication Date
FI760788A FI760788A (fr) 1976-10-12
FI65069B FI65069B (fi) 1983-11-30
FI65069C true FI65069C (fi) 1984-03-12

Family

ID=24266692

Family Applications (1)

Application Number Title Priority Date Filing Date
FI760788A FI65069C (fi) 1975-04-11 1976-03-24 Foerfarande foer framstaellning av kristallvattenfri ny-kristallin form av natrium-7-(d-alfa-formyloxi-alfa-fenylacetamido)-3-(1-metyl-1h-tetrazol-5-yltiometyl)-3-cefem-4-karboxylat

Country Status (31)

Country Link
US (1) US4006138A (fr)
JP (1) JPS51123812A (fr)
AR (1) AR210880A1 (fr)
AT (1) AT343806B (fr)
AU (1) AU500013B2 (fr)
BE (1) BE840179A (fr)
CA (1) CA1045114A (fr)
CH (1) CH621554A5 (fr)
CS (1) CS191970B2 (fr)
DD (1) DD125950A5 (fr)
DE (1) DE2614669C2 (fr)
DK (1) DK148022C (fr)
ES (1) ES446907A1 (fr)
FI (1) FI65069C (fr)
FR (1) FR2306698A1 (fr)
GB (1) GB1546898A (fr)
GR (1) GR59912B (fr)
HU (1) HU175592B (fr)
IL (1) IL49100A (fr)
LU (1) LU74740A1 (fr)
MX (1) MX3687E (fr)
NL (1) NL184258C (fr)
NO (1) NO151748C (fr)
OA (1) OA05290A (fr)
PL (1) PL104803B1 (fr)
PT (1) PT64917B (fr)
RO (1) RO68501A (fr)
SE (1) SE435290B (fr)
SU (1) SU668608A3 (fr)
YU (1) YU40643B (fr)
ZA (1) ZA761103B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7503274L (sv) * 1974-04-11 1975-10-13 Ciba Geigy Ag Cefalosporin
US4085277A (en) * 1975-01-30 1978-04-18 Fujisawa Pharmaceutical Co., Ltd. 7(2-Phenyl or thienyl-2-isonicotinoyloxyacetamido)-3-(1-methyl-1-H tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid
FR2400519A1 (fr) * 1977-08-17 1979-03-16 Roussel Uclaf Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
US4168376A (en) * 1978-06-05 1979-09-18 Eli Lilly And Company Process for crystalline sodium cefamandole
US4946838A (en) * 1981-07-13 1990-08-07 E. R. Squibb & Sons, Inc. Crystalline anhydrous aztreonam
EP0432297A1 (fr) * 1989-12-13 1991-06-19 Technologitschen Kombinat Sa Promischlena Mikrobiologia Méthode pour la préparation du sel de sodium de O-formylcéfamandole
US5492903A (en) * 1990-06-19 1996-02-20 Takeda Chemical Industries Ltd. Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
WO2013057196A1 (fr) * 2011-10-20 2013-04-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Procédé de préparation de nafate de céfamandole
CN104530086B (zh) * 2014-12-16 2015-12-09 天津大学 头孢孟多酯钠化合物的新晶型及其结晶制备方法
CN105037392A (zh) * 2015-08-13 2015-11-11 青岛蓝盛洋医药生物科技有限责任公司 一种杀菌药物头孢孟多酯钠化合物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3887551A (en) * 1964-11-04 1975-06-03 Glaxo Lab Ltd Crystalline forms of cephaloridine
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
PT64917B (en) 1977-08-24
PL104803B1 (pl) 1979-09-29
ZA761103B (en) 1977-10-26
CA1045114A (fr) 1978-12-26
FR2306698B1 (fr) 1979-10-05
NO151748C (no) 1985-06-05
CS191970B2 (en) 1979-07-31
JPS6110474B2 (fr) 1986-03-29
SU668608A3 (ru) 1979-06-15
AR210880A1 (es) 1977-09-30
DE2614669C2 (de) 1984-09-27
JPS51123812A (en) 1976-10-28
AU1143576A (en) 1977-09-01
NO761017L (fr) 1976-10-12
NL184258B (nl) 1989-01-02
YU79276A (en) 1982-10-31
IL49100A (en) 1979-03-12
YU40643B (en) 1986-04-30
FI65069B (fi) 1983-11-30
AT343806B (de) 1978-06-26
SE7602565L (sv) 1976-10-12
HU175592B (hu) 1980-09-28
IL49100A0 (en) 1976-04-30
DK148022B (da) 1985-02-04
GR59912B (en) 1978-03-20
ATA258476A (de) 1977-10-15
PT64917A (en) 1976-04-01
FI760788A (fr) 1976-10-12
DD125950A5 (fr) 1977-06-01
NL7603660A (nl) 1976-10-13
FR2306698A1 (fr) 1976-11-05
DK148022C (da) 1985-07-22
BE840179A (fr) 1976-09-30
OA05290A (fr) 1981-02-28
US4006138A (en) 1977-02-01
GB1546898A (en) 1979-05-31
CH621554A5 (fr) 1981-02-13
SE435290B (sv) 1984-09-17
DK150676A (da) 1976-10-12
AU500013B2 (en) 1979-05-10
MX3687E (es) 1981-04-29
DE2614669A1 (de) 1976-10-21
NL184258C (nl) 1989-06-01
ES446907A1 (es) 1977-09-16
RO68501A (fr) 1981-04-30
NO151748B (no) 1985-02-18
LU74740A1 (fr) 1976-11-11

Similar Documents

Publication Publication Date Title
NL192041C (nl) Geneesmiddel met antibacteriële werking, alsmede 7-£2-(2-aminothiazool-4-yl)-2-(veretherd oxyimino)-aceetamido|-3-cefem -4-carbonzuurderivaten.
RU2118959C1 (ru) ГИДРОХЛОРИД 7β-[(Z)-2-(2-АМИНО-4-ТИАЗОЛИЛ)-2-ГИДРОКСИИМИНОАЦЕТАМИДО]-3-(1,2,3-ТРИАЗОЛ-4-ИЛ)-ТИОМЕТИЛТИО-3-ЦЕФЕМ-4-КАРБОНОВОЙ КИСЛОТЫ, ЕГО КРИСТАЛЛОГИДРАТ И СПОСОБ ИХ ПОЛУЧЕНИЯ
KR840001776B1 (ko) 세프타지딤 펜타하이드레이트의 제조방법
JP5852562B2 (ja) 新規なセフェム誘導体
CH634578A5 (de) Verfahren zur herstellung von neuen cephalosporinderivaten.
FI65069C (fi) Foerfarande foer framstaellning av kristallvattenfri ny-kristallin form av natrium-7-(d-alfa-formyloxi-alfa-fenylacetamido)-3-(1-metyl-1h-tetrazol-5-yltiometyl)-3-cefem-4-karboxylat
NL8900111A (nl) Cefalosporinezouten en injecteerbare composities.
CS207646B2 (en) Method of making the crystallic hydrated form of the sodium salt of the oximine derivative of the 7-aminothiazolylacetamidocephalosporan acid
HU183089B (en) Process for preparing cef-3-em-4-carboxylic acid derivatives
JPH01110690A (ja) 水溶性抗生物質組成物および新規セフェム化合物の水溶性塩類
FI66874B (fi) Foerfarande foer framstaellning av kristallina salter av 7beta-(2-(2-amino-4-tiazolyl)-2-metoxi-iminoacetamido)-3-cefem-4-karboxylsyra-pivaloyloximetylester
BG60439B2 (bg) Твърда цефалоспоринова сол
US4061853A (en) Virtually solvent-free crystal form of the sodium salt of Cephacetril
JPS58103392A (ja) ３位においてチオメチルヘテロ環基により置換されたセフアロスポリンの新規な誘導体、これら化合物の製造方法およびこれらを含有する薬学的組成物
JP2575590B2 (ja) トリアゾリルチオメチルチオセファロスポリン塩酸塩およびその水和物結晶ならびにそれらの製法
WO2006109324A2 (fr) Procedes de preparation de sels d'addition acides de cefepime amorphes
HU182498B (en) Process for producing 7-bracket-iminoacetamido-bracket closed-3-thiomethyl-ceph-3-eme-4-caraoxylic acid
US4734408A (en) Crystalline cephalosporin antibiotic salts and solvates
JP2572563B2 (ja) セファロスポリン中間生成物の新規安定な結晶形
EP0883621A1 (fr) Derives de cephalosporines et leurs procedes de preparation
US5079241A (en) Cephalosporin derivatives and pharmaceutical compositions in which they are present
KR830001415B1 (ko) 세팔로스포린 유도체의 제조방법
KR20160081964A (ko) 결정성 베타-락타마아제 억제제
JPH06247974A (ja) セファロスポリン塩及びその製造方法
WO2008056221A2 (fr) Sel de sulfate cristallin d'antibiotique céphalosporine

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: ELI LILLY AND COMPANY