FI64598C - Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazo(1,2-a)-purin-9-onderivat - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazo(1,2-a)-purin-9-onderivat Download PDFInfo
- Publication number
- FI64598C FI64598C FI780427A FI780427A FI64598C FI 64598 C FI64598 C FI 64598C FI 780427 A FI780427 A FI 780427A FI 780427 A FI780427 A FI 780427A FI 64598 C FI64598 C FI 64598C
- Authority
- FI
- Finland
- Prior art keywords
- formula
- compound
- purin
- methyl
- imidazo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Claims (2)
1. Förfarande för framställning av terapeutiskt användbara imidazo/I,2-a/purin-9-onderivat med formeln I och farmaceutiskt godtagbara salter därav
2 H Π R -"X9^N8--1 7 1 i»3 ii 4 I87>R N “ ·\5Αν Kr 6 R4 2 4 där R är väte, lägre alkyl eller trifluormetyl, R Mr lägre alkyl, bensyl, som kan vara substituerad med halogen eller lägre 6 7 alkoxij pyridylmetyl eller fenoxietyl och R och R betecknar väte, metyl eller etyl, kännetecknat därav, att en förening med formeln 0 ON il f5 7* 3]— R7 III l<7 8 1.12 nh^N^nAr6 4 g 7 där R , R och R betecknar samma som ovan, reduceras under formyleningsbetingelsen, varvid erhälles en monoformyldiamino-förening med formeln HCO-NH J 's, IV ί ΐ~μ*7 2 ! *6 R4 4 6 7 där R*, R° och R# betecknar sanana som ovan, och den erhällna föreningen med formeln IV cykliseras pyrolytiskt eller genom upphettning med en syraanhydrid eventuellt i närvaro av trietylortoformiat, och om sä önskas omvandlas den erhällna föreningen med formeln I tili ett farmaceutiskt godtagbart sait.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76829177A | 1977-02-14 | 1977-02-14 | |
| US76829177 | 1977-02-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI780427A FI780427A (fi) | 1978-08-15 |
| FI64598B FI64598B (fi) | 1983-08-31 |
| FI64598C true FI64598C (fi) | 1983-12-12 |
Family
ID=25082078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI780427A FI64598C (fi) | 1977-02-14 | 1978-02-09 | Foerfarande foer framstaellning av terapeutiskt anvaendbara imdazo(1,2-a)-purin-9-onderivat |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS53103497A (sv) |
| AR (1) | AR229078A1 (sv) |
| AT (1) | AT363948B (sv) |
| AU (1) | AU519271B2 (sv) |
| BE (1) | BE863525A (sv) |
| CS (1) | CS207499B2 (sv) |
| DD (1) | DD138211A5 (sv) |
| DE (1) | DE2806199A1 (sv) |
| DK (1) | DK60578A (sv) |
| ES (1) | ES466981A1 (sv) |
| FI (1) | FI64598C (sv) |
| FR (1) | FR2380282A1 (sv) |
| GB (1) | GB1596320A (sv) |
| GR (1) | GR72456B (sv) |
| HU (1) | HU182460B (sv) |
| IE (1) | IE46456B1 (sv) |
| IL (1) | IL54037A (sv) |
| NO (1) | NO780504L (sv) |
| PH (1) | PH14777A (sv) |
| SE (2) | SE7801637L (sv) |
| YU (4) | YU40578A (sv) |
| ZA (1) | ZA78870B (sv) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU45690B (sh) * | 1984-12-22 | 1992-07-20 | Krka Tovarna Zdraviln.Sol.O. | Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina |
| CA2028235C (en) * | 1989-10-20 | 1997-01-21 | Fumio Suzuki | Condensed purine derivatives |
| NZ238609A (en) * | 1990-06-21 | 1993-12-23 | Schering Corp | Polycyclic guanine derivatives; preparation, pharmaceutical compositions, |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| US7772232B2 (en) | 2004-04-15 | 2010-08-10 | Bristol-Myers Squibb Company | Quinazolinyl compounds as inhibitors of potassium channel function |
| CA2656039A1 (en) | 2006-06-23 | 2007-12-27 | Incyte Corporation | Purinone derivatives as hm74a agonists |
-
1978
- 1978-01-31 BE BE184799A patent/BE863525A/xx not_active IP Right Cessation
- 1978-02-08 GR GR55383A patent/GR72456B/el unknown
- 1978-02-09 FI FI780427A patent/FI64598C/fi not_active IP Right Cessation
- 1978-02-10 DK DK60578A patent/DK60578A/da not_active Application Discontinuation
- 1978-02-13 IE IE310/78A patent/IE46456B1/en unknown
- 1978-02-13 DD DD78203684A patent/DD138211A5/xx unknown
- 1978-02-13 GB GB5629/78A patent/GB1596320A/en not_active Expired
- 1978-02-13 HU HU78BI561A patent/HU182460B/hu unknown
- 1978-02-13 AR AR271079A patent/AR229078A1/es active
- 1978-02-13 IL IL54037A patent/IL54037A/xx unknown
- 1978-02-13 SE SE7801637A patent/SE7801637L/sv unknown
- 1978-02-13 AU AU33221/78A patent/AU519271B2/en not_active Expired
- 1978-02-14 FR FR7804165A patent/FR2380282A1/fr active Granted
- 1978-02-14 ZA ZA00780870A patent/ZA78870B/xx unknown
- 1978-02-14 AT AT0106778A patent/AT363948B/de not_active IP Right Cessation
- 1978-02-14 JP JP1505778A patent/JPS53103497A/ja active Pending
- 1978-02-14 ES ES466981A patent/ES466981A1/es not_active Expired
- 1978-02-14 DE DE19782806199 patent/DE2806199A1/de not_active Withdrawn
- 1978-02-14 CS CS78959A patent/CS207499B2/cs unknown
- 1978-02-14 NO NO780504A patent/NO780504L/no unknown
- 1978-02-15 PH PH20777A patent/PH14777A/en unknown
- 1978-02-22 YU YU00405/78A patent/YU40578A/xx unknown
-
1982
- 1982-09-02 YU YU01987/82A patent/YU198782A/xx unknown
- 1982-09-02 YU YU01988/82A patent/YU198882A/xx unknown
- 1982-09-02 YU YU01986/82A patent/YU198682A/xx unknown
-
1983
- 1983-03-15 SE SE8301408A patent/SE8301408D0/sv not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU182460B (en) | 1984-01-30 |
| FI64598B (fi) | 1983-08-31 |
| AU3322178A (en) | 1979-08-23 |
| CS207499B2 (en) | 1981-07-31 |
| AR229078A1 (es) | 1983-06-15 |
| IL54037A (en) | 1982-02-28 |
| FR2380282A1 (fr) | 1978-09-08 |
| DD138211A5 (de) | 1979-10-17 |
| AU519271B2 (en) | 1981-11-19 |
| ZA78870B (en) | 1979-01-31 |
| PH14777A (en) | 1981-12-09 |
| DK60578A (da) | 1978-08-15 |
| IE46456B1 (en) | 1983-06-15 |
| ES466981A1 (es) | 1979-08-16 |
| FI780427A (fi) | 1978-08-15 |
| FR2380282B1 (sv) | 1982-03-05 |
| YU40578A (en) | 1983-04-30 |
| YU198782A (en) | 1983-04-30 |
| SE7801637L (sv) | 1978-08-15 |
| GR72456B (sv) | 1983-11-09 |
| SE8301408L (sv) | 1983-03-15 |
| BE863525A (fr) | 1978-07-31 |
| ATA106778A (de) | 1981-02-15 |
| YU198682A (en) | 1983-04-30 |
| NO780504L (no) | 1978-08-15 |
| IE780310L (en) | 1978-08-14 |
| AT363948B (de) | 1981-09-10 |
| SE8301408D0 (sv) | 1983-03-15 |
| IL54037A0 (en) | 1978-04-30 |
| GB1596320A (en) | 1981-08-26 |
| DE2806199A1 (de) | 1978-08-17 |
| YU198882A (en) | 1983-04-30 |
| JPS53103497A (en) | 1978-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: BRISTOL-MYERS CO |