FI64597C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-ubstituerade 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karbox ylyror av motsvarande nya nitriler - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-ubstituerade 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karbox ylyror av motsvarande nya nitriler Download PDF

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Publication number
FI64597C
FI64597C FI782307A FI782307A FI64597C FI 64597 C FI64597 C FI 64597C FI 782307 A FI782307 A FI 782307A FI 782307 A FI782307 A FI 782307A FI 64597 C FI64597 C FI 64597C
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FI
Finland
Prior art keywords
pyrrolo
dihydro
pyrrole
nitrile
mixture
Prior art date
Application number
FI782307A
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English (en)
Finnish (fi)
Other versions
FI64597B (fi
FI782307A (fi
Inventor
Horn Albert R Van
Pasquale G Gallegra
Original Assignee
Syntex Inc
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Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI782307A publication Critical patent/FI782307A/fi
Application granted granted Critical
Publication of FI64597B publication Critical patent/FI64597B/fi
Publication of FI64597C publication Critical patent/FI64597C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI782307A 1977-07-25 1978-07-21 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-ubstituerade 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karbox ylyror av motsvarande nya nitriler FI64597C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81837777A 1977-07-25 1977-07-25
US81837777 1977-07-25

Publications (3)

Publication Number Publication Date
FI782307A FI782307A (fi) 1979-01-26
FI64597B FI64597B (fi) 1983-08-31
FI64597C true FI64597C (fi) 1983-12-12

Family

ID=25225403

Family Applications (1)

Application Number Title Priority Date Filing Date
FI782307A FI64597C (fi) 1977-07-25 1978-07-21 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5-ubstituerade 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-karbox ylyror av motsvarande nya nitriler

Country Status (27)

Country Link
US (1) US4140698A (el)
EP (1) EP0000649B1 (el)
JP (1) JPS5424889A (el)
AT (1) AT364843B (el)
AU (1) AU515352B2 (el)
CA (1) CA1111431A (el)
CS (1) CS201015B2 (el)
DD (1) DD137229A5 (el)
DE (1) DE2860560D1 (el)
DK (1) DK146720C (el)
ES (1) ES472002A1 (el)
FI (1) FI64597C (el)
GR (1) GR63733B (el)
HK (1) HK17186A (el)
HU (1) HU178354B (el)
IE (1) IE47138B1 (el)
IL (1) IL55181A (el)
IT (1) IT1160443B (el)
MY (1) MY8800142A (el)
NO (2) NO166863C (el)
NZ (1) NZ187924A (el)
PL (1) PL111419B1 (el)
PT (1) PT68328A (el)
SG (1) SG31884G (el)
SU (1) SU1138029A3 (el)
YU (1) YU40717B (el)
ZA (1) ZA784216B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
EP0034481B1 (en) * 1980-02-14 1984-05-30 Grigg, Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4397862A (en) * 1981-10-13 1983-08-09 Syntex (U.S.A.) Inc. Gastrointestinal sparing thioester drugs
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
EP0117675B1 (en) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
JPH09503997A (ja) * 1993-07-08 1997-04-22 シグナス，インコーポレイテッド モノリシックなマトリックス経皮送達システム
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
JP2002520313A (ja) * 1998-07-10 2002-07-09 マリンクロッド・インコーポレイテッド ケトロラクの製造に有用な化合物の合成

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539789A (en) * 1976-07-14 1978-01-28 Syntex Inc Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative
US4087539A (en) * 1976-07-14 1978-05-02 Syntex (U.S.A.) Inc. 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof

Also Published As

Publication number Publication date
YU174178A (en) 1983-01-21
FI64597B (fi) 1983-08-31
GR63733B (en) 1979-12-04
CA1111431A (en) 1981-10-27
AU515352B2 (en) 1981-04-02
HK17186A (en) 1986-03-21
NO155244B (no) 1986-11-24
ES472002A1 (es) 1984-07-16
EP0000649B1 (en) 1981-03-25
DD137229A5 (de) 1979-08-22
AT364843B (de) 1981-11-25
DE2860560D1 (en) 1981-04-16
FI782307A (fi) 1979-01-26
DK146720C (da) 1984-08-20
ATA528978A (de) 1981-04-15
NO851935L (no) 1979-01-26
IL55181A0 (en) 1978-09-29
NO782545L (no) 1979-01-26
AU3826978A (en) 1980-01-31
US4140698A (en) 1979-02-20
MY8800142A (en) 1988-12-31
JPS6337793B2 (el) 1988-07-27
NO166863C (no) 1991-09-11
NZ187924A (en) 1980-03-05
PL111419B1 (en) 1980-08-30
IT1160443B (it) 1987-03-11
ZA784216B (en) 1980-02-27
HU178354B (en) 1982-04-28
IL55181A (en) 1981-12-31
NO166863B (no) 1991-06-03
CS201015B2 (en) 1980-10-31
YU40717B (en) 1986-04-30
DK325078A (da) 1979-01-26
IE781473L (en) 1979-01-25
IE47138B1 (en) 1983-12-28
IT7868765A0 (it) 1978-07-24
PL208576A1 (pl) 1979-05-07
EP0000649A1 (en) 1979-02-07
SU1138029A3 (ru) 1985-01-30
NO155244C (no) 1987-03-04
SG31884G (en) 1985-09-13
JPS5424889A (en) 1979-02-24
PT68328A (en) 1978-08-01
DK146720B (da) 1983-12-12

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Owner name: SYNTEX (U.S.A.) INC.